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1 6, originally NKT), a major kidney-expressed drug transporter.
2 of Sav1866, a bacterial ATP-binding cassette drug transporter.
3 rug design based on knockout metabolomics of drug transporters.
4 volume address the structure and function of drug transporters.
5 est in mice proficient and deficient of mdr1 drug transporters.
6 ble structural data for this family of multi-drug transporters.
7 calization, and function of major intestinal drug transporters.
8 pread phosphotyrosine-mediated regulation of drug transporters.
9 ZD2461 was developed as a poor substrate for drug transporters.
10  of OATP1B1, MRP2, MDR1, and other important drug transporters.
11 believed to belong to the category of single-drug transporters.
12 some of which are handled by DMEs, including drug transporters.
13 l role controlling these two important renal drug transporters.
14 other EGFR TKI, erlotinib, with selected ABC drug transporters.
15 AT3 (SLC22A8) among the main multi-specific "drug" transporters.
16 sult of overexpression of the P-glycoprotein drug transporter, a product of the MDR1 gene, is a signi
17 kout mutant of the sea urchin homolog of the drug transporter ABCB1, a major player in xenobiotic dis
18    Sulfite oxidase (SUOX) expression and the drug-transporter ABCC1 (MRP1) were linked to thiopurine
19 ildenafil affect the function of another ABC drug transporter, ABCC1.
20                The role of the ATP-dependent drug transporter ABCG2 in CPT-11 cytotoxicity is unclear
21 n of adenosine triphosphate-binding cassette drug transporter ABCG2 in DLBCL correlated inversely wit
22    Cell line studies have suggested that the drug transporter ABCG2 may be a mediator of IM resistanc
23 n of the breast cancer resistance-associated drug transporter (ABCG2), reversing resistance to campto
24         Consequently, the oligomers suppress drug transporter activity and increase sensitivity to do
25 hyperactivated STAT5 signaling and increased drug transporter activity-with demonstrated efficacy in
26 on is not directly involved in regulation of drug transporter activity.
27 that P-glycoprotein, an ATP-dependent efflux drug transporter and an integrated component of the occl
28        Our results identify ABCB5 as a novel drug transporter and chemoresistance mediator in human m
29 oma cell line known to overexpress the ABCB1 drug transporter and was also unaffected by overexpressi
30 ganelle membranes, and function as important drug transporters and as viral receptors.
31               It regulates the expression of drug transporters and drug metabolizing enzymes in a pro
32 a parasites have been identified in putative drug transporters and in target enzymes.
33 cell surface receptors, cytokeratin markers, drug transporters and the efficient efflux of the Hoechs
34                 Recent work has investigated drug transporters and the variants of genes encoding dru
35 hosphorylation-dependent interaction between drug transporters and tyrosine kinase inhibitors (TKIs),
36 ing resistance associated with expression of drug transporters and/or antiapoptotic proteins.
37 chrome P450s, glutathione S-transferases and drug transporters, and investigated the regulation of ge
38 ded cytokine-cytokine receptor interactions, drug transporters, and mitogen-activated protein kinase,
39  CD44, the EGF receptor, the ABCB1 and ABCG2 drug transporters, and the MCT4 monocarboxylate transpor
40 ls were also significantly enriched in known drug transporters annotated in DrugBank for more than 60
41                                              Drug transporters are an important part of the defense o
42            Along with OCT2, other SLC-family drug transporters are potentially part of an extensive '
43 g CYP3A, and multiple intestinal and hepatic drug transporters are thought to mediate this process, b
44                                        Other drug transporters are well known to transport lipids, bu
45                                              Drug transporters at the blood-cerebrospinal fluid (CSF)
46 rrent understanding of the regulation of ABC drug transporters at the level of transcription.
47 tein showed 87% homology with the bacitracin drug transporter BcrA of Staphylococcus hominis.
48 l as unfavorable drug disposition exerted by drug transporters before the drug reach retina.
49 ng interest in using endogenous compounds as drug transporter biomarkers to facilitate drug-drug inte
50 HCMV UL138 curtails the activity of the MRP1 drug transporter by reducing its steady-state levels, le
51 action profiles between drugs and intestinal drug transporters can be obtained by modulating transpor
52 hat such chemoresistance via cytochrome P450/drug transporters can be reversed with the use of antago
53                                              Drug transporters can be specific to a particular drug,
54 ts, discovered in recent years, that inhibit drug transporters can potentially be used to overcome ef
55 he pulling velocity in force distance cycles drug-transporter complexes were ruptured at different fo
56            We determined that nine potential drug transporters contribute to drug resistance of Salmo
57                                              Drug transporters could play a significant role in the e
58 l sorting analysis suggests that these three drug transporters do little to reduce the cellular accum
59 gene-centered network-including SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs),
60 ilability through PXR-mediated regulation of drug transporters (e.g., by other drugs) has the potenti
61 to Bac8c (including biofilm formation, multi-drug transporters, etc).
62 tein binding, and the combination of MSI and drug transporter expression suggests that multiple mecha
63 ification of MRP1, another member of the ABC drug transporter family, led to the realization that the
64 ll goal is to facilitate an understanding of drug transporters for PrEP optimization.
65 el-free alternative for direct assessment of drug transporter function in DDIs and toxicities as well
66                             We also measured drug transporter gene expression in these tissues to det
67 lyzed here transcriptional regulation of the drug transporter gene PDR5 in a drug-resistant pdr1-3 st
68   Deletion of silencer regions linked to the drug transporter genes ABCC2 and ABCG2 caused chemo-resi
69  primary transcription activator of multiple drug transporter genes in S. cerevisiae, including PDR5.
70  resistance as a result of overexpression of drug transporter genes presents a major obstacle in the
71  underlying transcriptional up-regulation of drug transporter genes remains elusive.
72 romyces cerevisiae, transcription of several drug transporter genes, including the major transporter
73 g and Signaling Theory, which describes how "drug" transporters help optimize levels of metabolites a
74                            Compared to other drug transporters, however, no valid biomarker for hepat
75 -ATP binding and hydrolysis to function as a drug transporter; however, the mechanism(s) defining the
76                                          The drug transporter hypothesis for refractory epilepsy prop
77                In summary, the expression of drug transporters (i) is markedly changed in HNSCC tumor
78 tic insights into the role of OAT1 and other drug transporters implicated in metabolic diseases like
79 cassette (ABC) transporter LmrA is a primary drug transporter in Lactococcus lactis that can function
80 rganic cation transporter-3), a polyspecific drug transporter in the solute carrier 22 family.
81 are compatible with the hypothesized role of drug transporters in remote inter-organ and inter-organi
82                 In conclusion, modulation of drug transporters in sandwich-cultured rat hepatocytes b
83 gh examination of the expression of the main drug transporters in the kidney throughout all stages of
84 uld modify the expression and/or activity of drug transporters in the liver.
85 mining the evolutionary relationship between drug transporters in zebrafish and humans.
86 olutes and supports the centrality of these "drug" transporters in independently and synergistically
87 9 standard anticancer drugs identified known drug-transporter interactions and suggested novel ones.
88                                   To examine drug-transporter interactions at the molecular level, we
89 und lipids enter the OF vestibule and weaken drug-transporter interactions facilitating drug release.
90                                        Novel drug-transporter interactions were discovered, such as l
91 ional drugs, the model identified 58 unknown drug-transporter interactions, 7 of which (out of 8 test
92 ural basis of alternating access, details of drug-transporter interactions, and the scale of drug mov
93         For 24 drugs with well-characterized drug-transporter interactions, the model achieved 100% c
94 ng polypeptides (OATPs) are a superfamily of drug transporters involved in the uptake and disposition
95 to be a substrate of human P-glycoprotein, a drug-transporter involved in all steps of pharmacokineti
96 verexpression of the gene encoding the ABCC3 drug transporter is responsible for conferring in vitro
97 considered beyond simple competition for the drug transporter itself and may explain aspects of drug-
98 e hyaluronan-CD44 interactions contribute to drug transporter localization and function at the plasma
99 nd ATP binding cassette (ABC) multispecific "drug" transporters maintain effective organ and body flu
100                    Although the functions of drug transporters may involve both the protection of bac
101 remic toxins, such as IS, through effects on drug transporters, may modify the nonrenal clearance of
102 ase II (gstalpha, gstpi) drug metabolism and drug transporters mdr1 and mrp2.
103                                      In vivo drug transporter-mediated alterations in efficacy are we
104 questered into the Golgi apparatus through a drug transporter-mediated process.
105 was not detected in cells overexpressing the drug transporters MRP1 or MXR.
106 ions of glutathione S-transferase P1 and the drug transporter multidrug resistance associated protein
107 together, our data provide evidence that the drug transporter OATP1B3 functions as a determinant of t
108  kynurenine, creatinine, urate) include two "drug" transporters of the organic anion transporter (OAT
109 r physiological importance of multispecific "drug" transporters of the SLC and ABC transporter famili
110         To help understand the role of these drug transporters on metabolism across scales ranging fr
111      Herein we show that among this class of drug transporters, only ABCG2 was expressed at highly in
112 expression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsi
113                          Localization of the drug transporter P-glycoprotein (Pgp) to the plasma memb
114 notably cytochrome p450 isozymes) and/or the drug transporter P-glycoprotein include garlic (Allium s
115 tory reaction and maintained assembly of the drug transporter p-gp.
116 O refractory patients frequently express the drug transporters P-glycoprotein (Pgp) and/or multidrug
117 any detectable expression of the three major drug transporters P-glycoprotien, multidrug resistance-a
118  hepatic enzyme, cytochrome P450 3A, and the drug transporter, P-glycoprotein, which predisposes thes
119 suggests that multiple mechanisms, including drug transporters, participate in determining local accu
120                                              Drug transporters play a crucial role in pharmacokinetic
121 s, and support testing of CYP450 enzymes and drug transporter polymorphisms to guide precise dosing o
122 n of several key cytochrome P450 enzymes and drug transporter proteins in liver and intestine in a sp
123 battery of genes encoding cytoprotective and drug transporter proteins in response to chemical and ra
124      High expression of antiapoptotic and/or drug transporter proteins induced by oncogenic signaling
125 ation of DOX and decreases the expression of drug transporter proteins MDR1, MRP1, and ABCG2.
126 st 33342 is mediated by ATP binding cassette drug transporter proteins that also contribute to chemor
127 ss high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance;
128 siderably more complex picture of how renal "drug" transporters regulate metabolism across the organe
129     This study identifies numerous potential drug-transporter relationships and supports a prominent
130 ied via a random forest model trained on the drug-transporter relationships.
131 tein SACOL2566 (5.2-fold), and the BcrA-like drug transporter SACOL2525 (5.7-fold) genes.
132 tion and expression of both major classes of drug transporters, SLC and ABC, in resting human blood n
133                                   Additional drug transporters, such as the multidrug resistance-asso
134 angement that regulates expression of an ABC drug transporter, suggesting a new target for circumvent
135   ABCG2 is a half-ATP binding cassette (ABC) drug transporter that consists of a nucleotide binding d
136 ting polypeptide OATP1B3 is a membrane-bound drug transporter that facilitates cellular entry of a va
137 ic drugs by inducing expression of the ABCB1 drug transporter that prevents intracellular drug accumu
138 pplied to other SLC and ATP-binding cassette drug transporters to define their nonredundant physiolog
139 genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate
140  of the ATP-binding cassette (ABC) family of drug transporters, was first identified almost three dec
141               None of the known T. b. brucei drug transporters were required for trypanocidal activit
142 e MDR1 gene product P-glycoprotein (P-gp), a drug transporter which severely impedes the efficacy of
143  (WHITE), member 2 (ABCG2), an anthracycline drug transporter, which lead to significantly increased
144 anic anion transporter 1 (OAT1/SLC22A6) is a drug transporter with numerous xenobiotic and endogenous
145 e Sensing and Signaling Theory suggests that drug transporters with compatible ligand preferences can

 
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