ライフサイエンスコーパス: dry eye

1 sociated keratoconjunctivitis sicca (KCS, or dry eye).

2 tandard deviation = 0.02 mm in normal and in dry eyes).

3 tary NTX-001 was more effective at reversing dry eye.

4 e include greater tectonic strength and less dry eye.

5 outcome measures were symptoms and signs of dry eye.

6 isease (MGD), as well as its relationship to dry eye.

7 ular surface impact, and the relationship to dry eye.

8 promising new approach for the management of dry eye.

9 y are important when evaluating and managing dry eye.

10 ammation and oxidative stress in age-related dry eye.

11 ed using the keywords inflammatory cycle and dry eye.

12 vators as a novel prosecretory treatment for dry eye.

13 t CFTR can correct the abnormal tear film in dry eye.

14 versing it when started after development of dry eye.

15 ress, suggesting protective effects of PS on dry eye.

16 cin deficiency observed in aqueous-deficient dry eye.

17 r SS in patients with clinically significant dry eye.

18 eyes, from patients with moderate to severe dry eye.

19 f dry eye as well as an increase of signs of dry eye.

20 ays will be valuable in treating age-related dry eye.

21 C57BL/6J mice to induce moderate and severe dry eye.

22 d PSP occur in some patients with idiopathic dry eyes.

23 Of the 162 patients, 51 developed dry eyes.

24 ere assigned to 2 groups based on normal and dry eyes.

25 nced K-readings significantly, especially in dry eyes.

26 gnificantly higher in tears of patients with dry eye (0.38 ng/mug total protein, range 0.04-1.36) com

27 - 0.27), the ratio became slightly higher in dry eye (2.04 +/- 1.12 vs 1.99 +/- 1.21 in control) afte

28 From 2015 through 2016, dry eye (29.5%) and glaucoma (42.7%) medications account

29 42 [29%]), peripheral neuropathy (33 [22%]), dry eye (32 [22%]), and abdominal pain (30 [20%]).

30 is were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34%), cataract (32%

31 In 19 of 47 patients confirmed with dry eye (40.4%) and in 3 of 54 controls (5.6%), the MMP-

32 46 patients), conjunctivitis (45 [31%]), and dry eye (45 [31%]).

33 ions of treatment were cataracts (12.1%) and dry eye (8.5%).

34 litus (DM, 11.52%), eye trauma (10.55%), and dry eye (8.72%).

35 In normal and dry eyes, a statistically significant increase in measur

36 Dry eye affects millions of individuals.

37 e (11 eyes), graft-vs-host disease (2 eyes), dry eye after keratomileusis in situ (2 eyes), and undif

38 Physicians should be aware of the risk of dry eye after ptosis surgery and discuss dry eye as a co

39 A total of 176 patients with dry eye and 33 control subjects >=50 years old were incl

40 with respect to both parameters between the dry eye and control groups after sustained gazing (161 v

41 Baseline scans of the dry eye and control groups did not show any statistical

42 ations of a mite infestation with individual dry eye and lid parameters were assessed.

43 o evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry

44 lity and quantity that can cause evaporative dry eye and ocular surface disruption, leading to dry ey

45 may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions ar

46 nd dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease sev

47 d sXBP1 expression was found in experimental dry eye and Sjogren syndrome models and was GC specific.

48 All subjects were required to fill in dry eye and smoking questionnaires, in addition to ocula

49 mmonly reported symptoms are blurred vision, dry eye and watering of the eye.

50 ded lower eyelid ectropion (6 malignancies), dry eye and/or exposure symptoms (8 malignancies), unila

51 to the salivary and lacrimal glands causing dry eyes and dry mouth.

52 She subsequently started to experience dry eyes and mouth, difficulty chewing, and mild dysphag

53 charts were screened for cataract formation, dry eye, and other anterior and posterior segment diseas

54 nt of ADD placement, diagnosis of uveitis or dry eye, and prior conjunctival surgery were not correla

55 is associated with epithelial dysfunction in dry eye, and that galectin-3 proteolytic cleavage may co

56 of dry eye after ptosis surgery and discuss dry eye as a complication of MMCR surgery with their pat

57 ses an increase in the subjective feeling of dry eye as well as an increase of signs of dry eye.

58 effective in relieving symptoms and signs of dry eye as well as improving QOL in aging patients.

59 umbers, were made when patients had not only dry eye but also dry mouth.

60 ial therapeutic indications in constipation, dry eye, cholestatic liver diseases, and inflammatory lu

61 Patients from a dry eye clinic and normal controls were assessed by Schi

62 Ongitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands.

63 ents with ocular discomfort from an Austrian dry eye clinic were investigated for the presence of Dem

64 Variability of K-readings appeared higher in dry eyes compared with normal eyes.

65 s were those who showed 3 of the following 4 dry eye criteria: ocular surface disease index (OSDI) sc

66 risk factors that have been associated with dry eye cross-sectionally, such as psychiatric comorbidi

67 n half (53%) experienced severe dry eye (ie, dry eye daily/almost daily with major impact on their li

68 Dry eye (DE) disease is an uprising health epidemic that

69 : Somatosensory dysfunction likely underlies dry eye (DE) symptoms in many individuals yet remains an

70 However, in long-term, signs and symptoms of dry eye decrease and dry eye test values return to preop

71 ation of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains

72 with disease for less than 2 years and mild dry eyes did not express anti-Ro or anti-La, while 25% e

73 al patients and those with aqueous deficient dry eye disease (ADDE).

74 ent estimates of the prevalence of diagnosed dry eye disease (DED) and associated demographics among

75 the severity of ocular pain in patients with dry eye disease (DED) and evaluate factors associated wi

76 ent characteristics, including age, sex, and dry eye disease (DED) diagnostic parameters were collect

77 Dry eye disease (DED) is a common ocular disorder affect

78 Dry eye disease (DED) is a highly prevalent, ocular diso

79 Dry Eye Disease (DED) is a multifactorial disease of the

80 Dry eye disease (DED) is a prevalent complication of dia

81 Dry eye disease (DED) is multifactorial, affecting 5-34

82 Dry eye disease (DED) represents a heterogeneous group o

83 e of SP was described in the pathogenesis of dry eye disease (DED) through its role in the maturation

84 he association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomi

85 o initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and pat

86 act, glaucoma, diabetic retinopathy (DR) and dry eye disease (DED) was assessed.

87 Diagnostic tests for dry eye disease (DED), including ocular surface disease

88 of discordance between symptoms and signs in dry eye disease (DED).

89 mediating the ocular surface autoimmunity in dry eye disease (DED).

90 nd triacylglyceride (fish oil), for treating dry eye disease (DED).

91 tagonist developed to reduce inflammation in dry eye disease (DED).

92 erve densities in the cornea were reduced in dry eye disease (DED).

93 T-cell-mediated inflammation associated with dry eye disease (DED).

94 represents the primary cause of evaporative dry eye disease (DED).

95 tion (MGD) is the major cause of evaporative dry eye disease (EDED) and dysfunction is widely thought

96 compromising visual acuity, is a hallmark of dry eye disease affecting 7 to 10% of individuals worldw

97 nctionality in 757 patients (1514 eyes) with dry eye disease and 29 healthy controls (58 eyes).

98 autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial d

99 For dry eye disease and depression, the odds ratio was 2.9 (

100 Separate odds ratios were calculated for dry eye disease and each of anxiety and depression.

101 rapeutic target for the management of severe dry eye disease and ocular inflammation in pSS patients.

102 hich can be further developed as a model for dry eye disease and therapeutic evaluation.

103 Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jorda

104 of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD and allow us to test its

105 cular surface inflammation and may influence dry eye disease development and progression.

106 free on the ocular surface of patients with dry eye disease during 60 days of intervention.

107 o examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD.

108 dvances in understanding the pathogenesis of dry eye disease has revealed that inflammation is a core

109 Inflammation was induced to mimic dry eye disease in the coculture model system.

110 the high incidence of cataract formation and dry eye disease in this population, this study proposes

111 The prevalence as well as the severity of dry eye disease increase with age.

112 In experimental models, dry eye disease is associated with T helper cell 17-medi

113 The prevalence of dry eye disease is high worldwide and poses a great burd

114 Dry eye disease is the prominent ocular sequel of cGVHD

115 oliferation and germinal center formation in dry eye disease mice, suggesting that a stable Ag-depend

116 cytotoxic effect and showed improvements on dry eye disease models by stabilizing the tear film, sca

117 tegy to abrogate the severe exacerbations of dry eye disease observed in aged mice.

118 smolarity measurement could not discriminate dry eye disease pathological scores.

119 Immune-driven dry eye disease primarily affects women; the cause for t

120 ectors and, in turn, preventing key signs of dry eye disease such as aqueous tear secretion, conjunct

121 Dry eye disease was defined from the validated Short Que

122 nd seven eligible patients with a history of dry eye disease were randomized 1:1:1:1 to 1 of 4 treatm

123 tudies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1

124 diseases like corneal transplant rejection, dry eye disease, and allergy.

125 ribution of memory Th17 cells to age-related dry eye disease, and evaluated memory Th17 cell depletio

126 8 is also involved in the pathophysiology of dry eye disease, and TRPM8 activation has antiallodynic

127 dered complications after surgery, including dry eye disease, anterior or epithelial basement membran

128 In a model of dry eye disease, the expression of TRPV1 in TRPM8(+) col

129 Using a preclinical model of IL-17-mediated dry eye disease, we demonstrate that upon encountering b

130 s and has potential as a novel treatment for dry eye disease.

131 ies against desmosomal cadherins, often have dry eye disease.

132 splants, treatment of atopic dermatitis, and dry eye disease.

133 e and summarizes the role of inflammation in dry eye disease.

134 glycol/propylene glycol in the treatment of dry eye disease.

135 ease tear secretion and prevent experimental dry eye disease.

136 l activation and initiation of immune-driven dry eye disease.

137 tic approach in the treatment of age-related dry eye disease.

138 sive outcome measures for moderate to severe dry eye disease.

139 )) drive the chronic and relapsing course of dry eye disease.

140 dies of the pathophysiological mechanisms of dry eye disease.

141 a specialized in vitro model of evaporative dry-eye disease for high-content drug screening.

142 lly delivered 12 may be efficacious in human dry eye diseases.

143 tic approach for allergic conjunctivitis and dry eye diseases.

144 Dry eye disorders are a significant health problem for w

145 Dry eye disorders, including Sjogren's syndrome, constit

146 should be examined carefully and treated for dry eye during follow-up.

147 Fifty patients with dry eye from a tertiary eye center in northern Thailand

148 A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLO

149 The pathogenic mechanisms of the 2 forms of dry eye give an account for the different MMP9 and TG2 e

150 t baseline (0.75 +/- 0.52) compared with the dry eye group (0.41 +/- 0.27), the ratio became slightly

151 ed lesion size without causing leukocytosis, dry eye, hair loss, or a reduced life span.

152 plugs improve symptoms of moderate to severe dry eye; however, retention rates differ significantly.

153 e dry eye, those who experienced significant dry eye (ie, daily/almost daily dry eye) more often agre

154 More than half (53%) experienced severe dry eye (ie, dry eye daily/almost daily with major impac

155 ictors is helpful in assessing patients with dry eye in clinical practice.

156 Dry eye in T1D rats was reversed within hours of a singl

157 mon of which were blepharitis in 12 (30.8%), dry eyes in 12 (30.8%), and history of ocular surgery in

158 er the past few decades have discovered that dry eye is a chronic inflammatory disease that can be in

159 Dry eye is a common problem in Ophthalmology and may occ

160 Dry eye is a complicated ocular surface disease whose ex

161 Aqueous tear-deficient dry eye is a multifactorial chronic disorder in which th

162 eatest impact on patient life, the impact of dry eye is comparable to that of other systemic manifest

163 MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and

164 Sjogren-related dry eye is more burdensome than systemic manifestations

165 undesirable phenotypes, including hair loss, dry eye, leukocytosis, xanthomatosis, and a reduced life

166 The second costliest category, dry eye medications, was attributable mostly to a single

167 rved in human subjects with various forms of dry eye, MG dysfunction and blepharitis.

168 We show the closed dry eye microbiome is distinct from the healthy closed e

169 mice and showed efficacy in an experimental dry eye model.

170 unctival GC loss occurs in both experimental dry eye models and patients with keratoconjunctivitis si

171 significant dry eye (ie, daily/almost daily dry eye) more often agreed that living with Sjogren synd

172 respondents with DED completed the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire; the othe

173 A majority of men reported dry eye on presentation (92%), albeit less chronic compa

174 When the same analysis was repeated in the dry eye or control groups, the ratio was significantly h

175 However, blurred vision (p = 0.003) and dry eye (p = 0.004) are higher among the REG than the NC

176 ific symptoms: double vision (P = .04), very dry eyes (P < .0001), and trouble seeing when wearing gl

177 Patients with low-delivery MGD had worse dry eye parameters and ocular symptoms than those with h

178 Dry eye parameters including tear meniscus height, nonin

179 in regulatory T cells (Treg), and increased dry eye pathogenesis.

180 baseline, there were no differences between dry eye patients and control subjects with respect to re

181 In this study 60% of the dry eye patients expressed one of these autoantibodies.

182 After silent reading, the dry eye patients had decreased reading speed and increas

183 Fourteen female SS dry eye patients were exposed for 2 hours to a controlle

184 Dry eye patients who have had established signs or sympt

185 lar surface inflammation in 40% of confirmed dry eye patients.

186 n of the lacrimal function unit in female SS dry eye patients.

187 linically significant inflammation in 40% of dry eye patients.

188 ble negative impact on visual performance of dry eye patients.

189 ABX + DS mice had a significantly worse dry eye phenotype compared to controls, a decrease in Cl

190 and no evidence of systemic diseases from a dry eye practice have these autoantibodies.

191 e cases all had BCVA of 20/20 and mild or no dry eye problems.

192 d abandoned contact lenses because of latent dry eye problems.

193 In a mouse model of aqueous-deficient dry eye produced by lacrimal ablation, topical administr

194 Lacrimal gland excision (LGE) induced dry eye produces more severe corneal damage in female mi

195 questionnaire; the other half completed the Dry Eye Questionnaire 5 (DEQ-5) and Standardized Patient

196 io [OR], 3.80; 95% CI, 1.00-14.49; P = .05), Dry Eye Questionnaire 5 score (OR, 1.15; 95% CI, 1.02-1.

197 ere dry eye symptoms at 1 year, defined as a Dry Eye Questionnaire 5 score of 12 or more.

198 ere dry eye symptoms at 1 year, defined as a Dry Eye Questionnaire 5 score of 12 or more.

199 tionnaires regarding ocular symptoms (5-Item Dry Eye Questionnaire [DEQ5], Ocular Surface Disease Ind

200 01 restored corneal sensitivity and reversed dry eye relative to values measured in diabetic rats rec

201 seal corneal incisions, and Lifitegrast for dry eye represent some of the major developments in the

202 An international survey was distributed to dry eye researchers and expert practitioners via an inte

203 es from healthy subjects, whereas 50% of the dry eye samples were characterized by the additional pre

204 ar osmolarity, and the Symptom Assessment in Dry Eye (SANDE) questionnaire scores were determined at

205 sease Index (OSDI) and Symptom Assessment in Dry Eye (SANDE) questionnaires.

206 SPEED), McMonnies, and Symptom Assessment in Dry Eye (SANDE) questionnaires.

207 bers alters tear production and often causes dry eye sensation.

208 Normal subjects with no symptoms of dry eyes served as controls.

209 The patients were classified into dry eye severity level (DESL) 1-4 based on symptoms and

210 ificant correlations between corneal ECD and dry eye severity parameters including the OSDI score (rs

211 ophthalmic system enables the assessment of dry eye severity stages and the differentiation of its s

212 Visual acuity, dry eye severity, and scarring of the ocular surface and

213 onal studies have evaluated risk factors for dry eye severity, but few have assessed risk factors or

214 sfunction, all in both eyes, and a composite dry eye signs severity score was calculated from these 6

215 score of the OSDI and the rank score of the dry eye signs severity score.

216 Dry eye signs were assessed by tear osmolarity, Schirmer

217 experiments, elevated expression of MMP9 in dry eye subjects correlated with the ability of active M

218 ea, an important area for visual function in dry eye sufferers, was shown to have the most benefit fr

219 y during 1 year, as assessed by responses to dry eye symptom questionnaires administered at the initi

220 y during 1 year, as assessed by responses to dry eye symptom questionnaires administered at the initi

221 Change in dry eye symptom severity during 1 year, as assessed by r

222 Main Outcomes and Measures: Change in dry eye symptom severity during 1 year, as assessed by r

223 Dry eye symptomatology along and clinical parameters wer

224 Dry eye symptoms (Ocular Surface Disease Index [OSDI]),

225 han half (55%) of the participants presented dry eye symptoms (OSDI > 12).

226 00 points in OSDI), office workers presented dry eye symptoms 4.15 times more frequently than constru

227 ted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors.

228 Patients with severe dry eye symptoms and ocular pain at baseline were more l

229 clusions and Relevance: Patients with severe dry eye symptoms and ocular pain at baseline were more l

230 There were also significant improvements in dry eye symptoms and quality of life as assessed by the

231 Seven of 10 had only mild or no dry eye symptoms and scarring sequelae.

232 rans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from none to severe)

233 rans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from none to severe)

234 Baseline ocular risk factors for severe dry eye symptoms at 1 year included more severe dry eye

235 as baseline risk factor analysis for severe dry eye symptoms at 1 year, defined as a Dry Eye Questio

236 as baseline risk factor analysis for severe dry eye symptoms at 1 year, defined as a Dry Eye Questio

237 cular pain, were also associated with severe dry eye symptoms at 1 year.

238 The proportion with dry eye symptoms at 1, 2, or 3 years after LASIK was not

239 % CI, 19%-37%) had mild, moderate, or severe dry eye symptoms at 3 months.

240 erall, the prevalence of visual symptoms and dry eye symptoms decreased, although a substantial perce

241 o investigate and contrast the prevalence of dry eye symptoms in construction workers and office work

242 ye and ocular surface disruption, leading to dry eye symptoms in some individuals.

243 associations between the NEI-VFQ-25 and the dry eye symptoms measured by the OSDI and SANDE question

244 e were more likely to have persistent severe dry eye symptoms on 1-year follow-up.

245 e were more likely to have persistent severe dry eye symptoms on 1-year follow-up.

246 kers have four times less risk of presenting dry eye symptoms than people working in the average offi

247 ival staining, visual analog scale (VAS) for dry eye symptoms VAS severity, and Ocular Surface Diseas

248 -corrected visual acuity (BCVA) of 20/20, no dry eye symptoms, and no scarring sequelae.

249 ell as an improvement in the patients' BCVA, dry eye symptoms, and quality of life.

250 ight driving, did not significantly increase dry eye symptoms, and resulted in higher levels of satis

251 , and outcomes with regard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 month

252 eye symptoms at 1 year included more severe dry eye symptoms, ocular pain, and neuropathic pain-like

253 le images, glare, halos, and/or starbursts), dry eye symptoms, participant satisfaction (with vision

254 ouble images, glare, halos, and starbursts), dry eye symptoms, satisfaction with vision, and satisfac

255 equency of patient-reported visual symptoms, dry eye symptoms, satisfaction with vision, and satisfac

256 s due to persistent ocular pain secondary to dry eye symptoms.

257 ant risk for the development or worsening of dry eye symptoms.

258 5%), topical corticosteroid use (35.4%), and dry eye syndrome (37.5%).

259 The risk of dry eye syndrome (adjusted incidence rate ratio [IRR] 4.

260 were linked to widespread ocular pathologies-dry eye syndrome (DES) and MG dysfunction (MGD).

261 ansplant significantly increased the risk of dry eye syndrome (P < 0.05).

262 d from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED

263 nts with corneal diseases (12 patients each: dry eye syndrome [DES], contact lens wear, post-laser re

264 To assess symptom progression in dry eye syndrome and determine risk factors associated w

265 Objectives: To assess symptom progression in dry eye syndrome and determine risk factors associated w

266 surgery and who had not been diagnosed with dry eye syndrome at ours or another institution were inc

267 ating room predisposes surgical residents to dry eye syndrome because of environmental conditions.

268 to determine the prevalence and severity of dry eye syndrome in a group of Mexican residents of diff

269 stance was the only variable associated with dry eye syndrome in the absence of DVH for the lachrymal

270 Dry eye syndrome is a common condition that affects mill

271 Importance: Dry eye syndrome is a common condition that affects mill

272 A higher number of residents with dry eye syndrome was found in the cardiothoracic surgery

273 t of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular deg

274 The increased risk of dry eye syndrome, cataracts, glaucoma, episcleritis and

275 atients with SLE and to evaluate the risk of dry eye syndrome, cataracts, glaucoma, episcleritis and

276 se Index, together with diagnostic tests for dry eye syndrome, such as tear breakup time, Oxford Sche

277 st disease was a significant risk factor for dry eye syndrome.

278 s of lacritin that is deficient or absent in dry eye tears appears to play a key role in preventing t

279 Stability of these and dry eye tears is rescuable with C- but not N-terminal pr

280 ars promotes loss of stability akin to human dry eye tears.

281 , signs and symptoms of dry eye decrease and dry eye test values return to preoperative values.

282 It correlated well with other dry eye tests and identified the presence of ocular surf

283 s MGD cannot be diagnosed using conventional dry eye tests and requires morphologic assessment of mei

284 The following dry eye tests were performed before and after the exposu

285 ve and preoperative objective and subjective dry eye tests.

286 s improve the signs and symptoms of moderate dry eye that are not improved with topical lubrication,

287 mized clinical trial of a non-pharmaceutical dry eye therapy and used 16S rRNA metabarcoding to chara

288 these therapies represent a major advance in dry eye therapy, they are not effective in improving dis

289 ompared with patients who did not experience dry eye, those who experienced significant dry eye (ie,

290 mean mite count per patient in this Austrian dry eye unit population is lower compared with previousl

291 iopters in 13.2% of normal eyes and 34.4% in dry eyes using eye drops of high viscosity.

292 apeutic evaluation and pathogenesis study of dry eye, we established an in vitro three-dimensional (3

293 f their diagnosis relative to that of SS and dry eye were assessed.

294 Adjusted ORs for the impact of dry eye were generally lower than those for fatigue, but

295 1 patients were screened; 7207 patients with dry eye were included, while 20 004 patients with anxiet

296 In Taiwan, DM, eye trauma, and dry eye were key predisposing factors for microbial kera

297 A total of 15 subjects (5 normal and 10 dry eye) were enrolled in a 3-visit study consisting of

298 D difficult by standard clinical measures of dry eye, whereas morphologic analysis of MGs reveals an

299 , attenuation of ocular neuropathic pain and dry eye will take place.

300 onjunctiva and lid margins and also moderate dry eyes with severe photophobia.