ライフサイエンスコーパス: dsRNA

1 dsRNA binding induces allosteric structural changes in O

2 dsRNA molecules targeting the cp gene of ToMV were topic

3 ontaining a genetically engineered segment 7 dsRNA.IMPORTANCE Previous studies generated recombinant

4 toplasm triggers host defence mechanisms(9), dsRNA viruses retain their genomes within a core particl

5 SIDT2 functions as a dsRNA transporter and is required to traffic internalize

6 e antiviral activity of DHX30 and contains a dsRNA-binding domain, and that the NS1-DHX30 interaction

7 ydomonas reinhardtii for the expression of a dsRNA cassette targeting a shrimp yellow head viral gene

8 eraction in vitro requires the presence of a dsRNA platform that binds both NS1 RBD and DHX30N.

9 Individual cells differentially activate dsRNA responses revealing variation that can affect cell

10 In addition, dsRNA-induced H3K23me3 can persist for multiple generati

11 ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inos

12 ly in its antagonism of type I IFN, but also dsRNA-mediated mitochondrial apoptosis.Importance Respon

13 on of synthetic [poly(I:C)] or genetic (Alu) dsRNA induces human osteoblast cell death.

14 e life cycles of double-stranded (ds)DNA and dsRNA viruses are dissimilar.

15 ammasome, prevents DICER1 dysregulation- and dsRNA-induced osteoblast cell death.

16 o-noise ratio in cellular force imaging, and dsRNA-based tension sensor exhibited strong non-specific

17 eled mRNA-specific anti-sense RNA probes and dsRNA-binding protein to identify the expression of spec

18 APDH), starvation (RPL12 and alpha-TUB), and dsRNA exposure (alpha-TUB and RPL12).

19 respectively, that colocalized with VP3 and dsRNA, consistent with VFs.

20 y was to use microalgae expressing antiviral dsRNA as a sustainable feed supplement for shrimp offeri

21 xpectedly discovered that ADAR proteins bind dsRNA substrates tandemly in vivo, each with a 50-bp foo

22 ngly, the capacity of sigma3 protein to bind dsRNA does not impact its capacity to diminish productio

23 On binding dsRNA, PKR dimerizes, autophosphorylates, and then phosp

24 Upon binding dsRNA, OAS undergoes a conformational change and is acti

25 Although nc886 inhibited PKR activation by dsRNA, it was required for PKR phosphorylation during T

26 ivation of MDA5/MAVS signaling was driven by dsRNA from live A. fumigatus serving as a key vitality-s

27 ence- and structure-specifically enhanced by dsRNAs, including the influenza viral RNA panhandle dupl

28 ) in human infant AECs exposed to (poly(I:C) dsRNA) under different experimental conditions (n = 8 do

29 rated independently of SGs and the canonical dsRNA-induced SG biogenesis pathway, because RLBs did no

30 e complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity.

31 labeled dsRNA, we demonstrate that chitosan/dsRNA polyplex nanoparticles are considerably more effec

32 Further, we show that chitosan/dsRNA polyplex nanoparticles introduce dsRNA into cells

33 prisingly, we found that both enzymes cleave dsRNA at preferred sites, among which a guanine nucleoti

34 The RNase L-cleaved dsRNAs signal to Rig-like helicases to amplify IFN produ

35 phenotype was found in a subset of PAMAM-CNT-dsRNA(alphatub) injected larvae, relative to the level s

36 double-stranded RNA bound to CNTs (PAMAM-CNT-dsRNA), compared to those injected with target dsRNA alo

37 rence systems, and other proteins containing dsRNA-binding domains and helicase domains.

38 Conversely, dsRNA-derived siRNA populations (mainly 21- and 22-nt) w

39 Active OAS proteins detect cytoplasmic dsRNA and synthesize short 2'-5'-linked oligoadenylates

40 ified TRIM28 potentiates canonical cytosolic dsRNA-activated IFN-mediated defenses that rely on RIG-I

41 However, the structure of a pre-unwound D1D2:dsRNA complex remains elusive, and thus, the mechanism o

42 anded RNA complex, and the structure of a D2:dsRNA complex that is thought to represent a pre-unwound

43 tidylic acid (Poly I:C) indicating defective dsRNA receptor signaling.

44 s to the functional forms of plant-delivered dsRNA for the protection of transgenic maize from WCR fe

45 nonself RNA sensors recognize virus-derived dsRNA as danger signals and initiate innate immune respo

46 ncies in ADAR1 (which edits and destabilizes dsRNA), PDE12 or AKAP7 (which degrade 2-5A), or by ioniz

47 Sensors that detect dsRNA stimulate IFN responses as a defense against viral

48 the sensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IFNalpha/beta secretion and tra

49 lexes: double-stranded DNA (dsDNA), PNA/DNA, dsRNA (modified RNA) and PNA/RNA, were tested and evalua

50 The results showed that all PNA/DNA, dsRNA and PNA/RNA exhibited strong resistance to both so

51 The cDNA sequences revealed that dsRNA1 dsRNA is 1,683 bp in length with an open reading frame (

52 o acids (molecular mass of 62.7 kDa); dsRNA2 dsRNA is 1,524 bp in length with an ORF that encodes 434

53 ith functional VP1-VP2 interaction(s) during dsRNA synthesis.

54 ide new information on VF trafficking during dsRNA virus coinfection, we rescued two recombinant infe

55 ries that sense, transport, process, or edit dsRNAs.

56 6)A modification protects against endogenous dsRNA formation and a deleterious innate immune response

57 Exogenous dsRNA inhibits KRT9 expression in early passage volar ke

58 y the administration of unspecific exogenous dsRNA.

59 Transgenic maize plants expressing dsRNA targeting western corn rootworm (WCR, Diabrotica v

60 ut that they do not respond to extracellular dsRNA.

61 t, whereas SIDT1 can transport extracellular dsRNA into the cytoplasm following endocytosis in vitro,

62 gest that the use of functionalised CNTs for dsRNA delivery could increase the efficacy of RNA interf

63 ctivated (PKR) is a cytoplasmic receptor for dsRNA, and as such is involved in detection of viral inf

64 lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA

65 n nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum.

66 ormally tasked with the detection of foreign dsRNAs.

67 t produce bidirectional RNAs, which may form dsRNA.

68 The aberrantly formed dsRNAs were long, highly m(6)A modified in their native

69 athogen-associated molecular patterns (e.g., dsRNA) activate expression of IFN-stimulated genes (ISGs

70 SE 2, which partners with Pol IV to generate dsRNA precursors of the 24 nt siRNAs that guide RdDM.

71 The generated dsRNA-expressing microalgal strain was then used in a sh

72 ing sites of recombinant VP6 and the genomic dsRNA binding sites of capsid-associated VP6.

73 assembling virus capsid, triggering genomic dsRNA synthesis.

74 results have important implications for how dsRNA sensing is important outside of immune pathways.

75 animal model for osteomyelitis and identify dsRNA as a new treatment target for this debilitating bo

76 n to degrade virus-derived immunostimulatory dsRNA in biochemical assays.

77 NP degrades virus-derived, immunostimulatory dsRNA in biochemical assays to eliminate the danger sign

78 were required to restrict immunostimulatory dsRNA accumulation.

79 catalyze adenosine to inosine conversion in dsRNA, a common form of RNA editing.

80 c primers revealed a lower infection rate in dsRNA-expressing algae treated shrimp (55.6 +/- 11.1%) c

81 immune activation, but the role of SIDT1 in dsRNA transport and in the innate immune response to vir

82 for endogenous conservative transcription in dsRNA viruses.

83 hese repeat classes were also represented in dsRNAs from cells not expressing DUX4.

84 X4-induced transcripts and from DUX4-induced dsRNA-forming intergenic transcripts enriched for endoge

85 We found that a subset of DUX4-induced dsRNAs originate from inverted Alu repeats embedded with

86 e determined the composition of DUX4-induced dsRNAs.

87 hylococcus isolated from chicken BCO induces dsRNA accumulation and cell death in human osteoblast ce

88 we confirm the ability of N(pro) to inhibit dsRNA-mediated apoptosis and show that N(pro) is also ab

89 of transgenic maize expressing insecticidal dsRNA.

90 rter and is required to traffic internalized dsRNA from endocytic compartments into the cytosol for i

91 a cells selectively respond to intracellular dsRNA by expressing type I interferons (IFNs) and induci

92 pathway and the accumulation of intranuclear dsRNA foci.

93 tosan/dsRNA polyplex nanoparticles introduce dsRNA into cells via a different mechanism than the cano

94 We applied this approach to investigate dsRNA dissipation (including dilution, degradation, and

95 An example involves dsRNA produced by the multiple cloning site (MCS) of L44

96 rough a mechanism that is independent of its dsRNA binding capacity.IMPORTANCE We use mammalian reovi

97 The segmented 18.5-kbp dsRNA genome of rotavirus expresses 6 structural and 6 n

98 henotype and uptake of fluorescently labeled dsRNA, we demonstrate that chitosan/dsRNA polyplex nanop

99 y, LASV NP alone was not sufficient to limit dsRNA accumulation.

100 tween LASV NP ExoN and L protein in limiting dsRNA accumulation.

101 sosomal compartment, interacts with the long dsRNA analog poly(I:C), and, when overexpressed, enhance

102 Although long-dsRNA remained in the treated leaves for at least 10 day

103 T can cross-bridge RIG-I filaments on longer dsRNAs, inducing aggregate-like RIG-I assemblies.

104 e successfully developed nucleobase-modified dsRNA-binding PNAs (dbPNAs) to facilitate structure-spec

105 JUNV and MACV NPs also have the ExoN motif, dsRNA readily accumulated in infected cells and often co

106 of JUNV and MACV also harbor the ExoN motif, dsRNA readily formed during JUNV and MACV infections, ac

107 a whole body concentration basis than naked dsRNA.

108 the level seen in larvae injected with naked dsRNA(alphatub) alone.

109 ld quantify dsRNA amounts as low as 0.003 ng(dsRNA)/g(soil).

110 When we applied a low amount of dsRNA (1 ng(dsRNA)/g(soil)) to the soils, we observed that a greater

111 RNAs co-localized with DUX4-induced nuclear dsRNA foci and with intranuclear aggregation of EIF4A3 a

112 58-null mice are resistant to the ability of dsRNA to inhibit KRT9 expression.

113 ere required to diminish the accumulation of dsRNA and the IFN response in JUNV infection.

114 V coinfection diminished the accumulation of dsRNA and the IFN response in JUNV-infected cells.

115 When we applied a low amount of dsRNA (1 ng(dsRNA)/g(soil)) to the soils, we observed th

116 ells can either receive different amounts of dsRNA from the same source or use different RdRPs to per

117 the antiviral state induced by an analog of dsRNA or by IFN treatment.

118 3 ribonucleotides upstream and 7 or 8 bp of dsRNA downstream of the cleavage site, and bacterial End

119 ellite II (HSATII) repeats formed a class of dsRNA specific to the DUX4 expressing cells.

120 PP nanoparticles may be used for delivery of dsRNA to mosquito larvae.

121 applied to assess the environmental fate of dsRNA biopesticides at concentrations relevant to their

122 necessitates an understanding of the fate of dsRNA molecules in receiving environments, among which a

123 oils, we observed that a greater fraction of dsRNA was adsorbed to and extractable from soil particle

124 The genomes of dsRNA viruses vary greatly in the degree of segmentation

125 e phenomena by antagonising the induction of dsRNA-mediated apoptosis.

126 eetle feeding bioassay for oral ingestion of dsRNA, we measured the expression and demonstrated knock

127 An unusual crystal lattice interaction of dsRNA with its symmetry mate is reminiscent of the RNA a

128 concentrations as low as a few nanograms of dsRNA per gram of soil by both Cerenkov counting (to qua

129 A that allows studying key fate processes of dsRNA in soils with unprecedented sensitivity.

130 The encapsulation efficiency, protection of dsRNA from nucleases, cellular uptake, in vivo biodistri

131 To allow quantification of dsRNA adsorbed to particles, we also developed a protoco

132 ucture-specific and selective recognition of dsRNA over single-stranded RNA (ssRNA) and dsDNA regions

133 bution to SG assembly, and its regulation of dsRNA stress-induced mRNAs are unknown.

134 Because the release of dsRNA into the cytoplasm triggers host defence mechanism

135 These results show that the sensing of dsRNA is critical for loss of cell-specific gene express

136 f the primitive keratin 7 and a signature of dsRNA sensing, including the double-stranded RNA (dsRNA)

137 Impact of specificity of dsRNA targeting DvSSJ1 mRNA on insecticidal activities w

138 Because of the target specificity of dsRNA, RNAi-based control measures are an attractive alt

139 ry and inaugural studies of a novel taxon of dsRNA viruses in five different planarian species.

140 vement of the primer, the primer terminus of dsRNA is not blocked from reaching the active site of RT

141 nformation that adds to our understanding of dsRNA virus VF trafficking.

142 The unwinding of dsRNA intermediates is critical for the replication of f

143 Nase IIIs, we performed in vitro cleavage of dsRNAs by Ec and Aquifex aeolicus (Aa) enzymes and delin

144 ng impedes MDA5 sensing and sequestration of dsRNAs encoding membrane proteins, which promote ER home

145 NA editing by adenosine deaminases acting on dsRNA (ADAR) has become of increasing medical relevance,

146 y of enzymes, adenosine deaminases acting on dsRNA (ADARs).

147 nitially, RV-induced IFN responses depend on dsRNA receptor activation and then are amplified via IFN

148 e and ubiquitinate RIG-I pre-oligomerized on dsRNA.

149 c-Abl activity, DNA-RNA hybrid formation or dsRNA processing impairs CTD Y1P foci formation, attenua

150 nding on its location, suggesting that other dsRNA features are necessary for correct presentation of

151 d by phosphorimaging (to detect intact (32)P-dsRNA and its (32)P-containing degradation products).

152 We demonstrate that (32)P-dsRNA and its degradation products are quantifiable at c

153 f a D1D2 core in complex with a 23-base pair dsRNA at pre-unwound state, revealing that two DDXs reco

154 AF3IP3 suppresses cytosolic poly(I:C), 5'ppp-dsRNA, and vesicular stomatitis virus (VSV) triggers IFN

155 amily regulate gene expression by processing dsRNAs.

156 assembly intermediate of certain prokaryotic dsRNA viruses.

157 Our approach could quantify dsRNA amounts as low as 0.003 ng(dsRNA)/g(soil).

158 e field-applicable approach able to quantify dsRNA biopesticides down to environmentally relevant con

159 nments, we developed an approach to quantify dsRNA in agricultural soils using quantitative reverse t

160 ach using phosphorus-32 ((32)P)-radiolabeled dsRNA that allows studying key fate processes of dsRNA i

161 two amino-acid residues required for NS1 RBD dsRNA-binding activity.

162 st time present evidence that LASV restricts dsRNA accumulation during infection.

163 , we discovered that LASV potently restricts dsRNA accumulation during infection and minigenome repli

164 by exogenous delivery of double-strand RNA (dsRNA) it is necessary to understand the generation of s

165 a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA).

166 receptors detect viral double-stranded RNA (dsRNA) and 5'-triphosphorylated RNA to activate the tran

167 ne sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infect

168 le enzymes that require double-stranded RNA (dsRNA) as a cofactor.

169 y of directly targeting double-stranded RNA (dsRNA) by triplex-formation is relatively underexplored

170 says (IFA) specific for double-stranded RNA (dsRNA) demonstrated the presence of double-stranded vira

171 berrant accumulation of double-stranded RNA (dsRNA) due to increased sensor levels (MDA5, RIG-I and P

172 to accommodate and bind double-stranded RNA (dsRNA) during unwinding.

173 n hub that involves the double-stranded RNA (dsRNA) editing enzyme adenosine deaminase RNA specific (

174 Double-stranded RNA (dsRNA) exhibits a smooth transition in contrast to the o

175 otype to each of the 11 double-stranded RNA (dsRNA) genome segments.

176 iruses with a segmented double-stranded RNA (dsRNA) genome that replicate in discrete cytoplasmic vir

177 viruses with segmented double-stranded RNA (dsRNA) genomes.

178 enosines to inosines in double-stranded RNA (dsRNA) in animals.

179 how increased levels of double-stranded RNA (dsRNA) in infected bone in a Staphylococcus-induced chic

180 ng by reducing the MDA5-double-stranded RNA (dsRNA) interaction.

181 performed by injecting double-stranded RNA (dsRNA) into female Aedes aegypti mosquitoes.

182 n of viral proteins and double-stranded RNA (dsRNA) is inhibited in infected neurons in resistant mou

183 Double-stranded RNA (dsRNA) molecules are used as a novel class of biopestici

184 induced by an analog of double-stranded RNA (dsRNA) or by IFN treatment.

185 x was applied either as double-stranded RNA (dsRNA) or RNAi plasmid DNA (dsDNA).

186 Double-stranded RNA (dsRNA) pesticides are a new generation of crop protectan

187 sensing, including the double-stranded RNA (dsRNA) receptor DExD/H-Box Helicase 58 (DDX58/RIG-I).

188 icant protection of the double-stranded RNA (dsRNA) replication intermediate against the dsRNA-specif

189 o the activation of the double-stranded RNA (dsRNA) response pathway and the accumulation of intranuc

190 partite, containing two double-stranded RNA (dsRNA) segments designated as dsRNA1 and dsRNA2.

191 e responses through the double-stranded RNA (dsRNA) sensor MDA5, unleashing endoplasmic reticulum (ER

192 e R (PKR), a known host double-stranded RNA (dsRNA) sensor.

193 ng a plasmid expressing double-stranded RNA (dsRNA) targeting a gene of interest.

194 ding affinity for their double-stranded RNA (dsRNA) targets.

195 ene, the formation of a double-stranded RNA (dsRNA) transcript and siRNAs in transgenic plants.

196 r pathways, and applied double-stranded RNA (dsRNA) virology.

197 s, and between a fungal double-stranded RNA (dsRNA) virus and an insect virus, in the yeast host.

198 taxon of monosegmented double-stranded RNA (dsRNA) viruses in five planarian species, including the

199 scription characterizes double-stranded RNA (dsRNA) viruses in the Reoviridae, a family that is exemp

200 segmented, multipartite double-stranded RNA (dsRNA) viruses that until recently were only known to in

201 rial RNAs that may form double-stranded RNA (dsRNA), as has been observed in mammalian antiviral resp

202 foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase

203 to viral RNA, including double-stranded RNA (dsRNA), RIG-I and MDA5 undergo cytosol-to-membrane reloc

204 , but not intracellular double-stranded RNA (dsRNA), was inhibited by RV.

205 nd act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PKR) related to innate

206 ts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR.

207 egulating activation of double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) and recruit the

208 Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees revealed these behaviors ar

209 re required for binding double-stranded RNA (dsRNA).

210 ining DNA/RNA hybrid or double-stranded RNA (dsRNA).

211 TV), are multisegmented double-stranded RNA (dsRNA).

212 tion of progeny genomic double-stranded RNA (dsRNA).

213 ne deaminases acting on double-stranded RNA (dsRNA)] together with the endogenous RNA interference (R

214 ile genome replication (double-stranded RNA [dsRNA] synthesis) by VP1 occurs within assembly intermed

215 By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundant, multifunctional VA

216 5 and RIG-I sensing of double-stranded RNAs (dsRNAs).

217 ormation of endogenous double-stranded RNAs (dsRNAs).

218 -electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) in two states pert

219 structure of a catalytically active HIV-1 RT/dsRNA complex that mimics the state of the RTIC before t

220 the non-A-tailed transcripts of a segmented dsRNA virus and the transcriptome of the infected cell.

221 the viral RNA-packaging motif of a segmented dsRNA virus for the first time.

222 ber of the Reoviridae, a family of segmented dsRNA viruses characterized by endogenous RNA transcript

223 Self dsRNA accumulation in DNMTi-treated cells leads to type

224 t of defined sequence changes within a short dsRNA that strongly activates OAS1.

225 y are presented dictate the ability of short dsRNAs to activate OAS1.

226 We propose that a similar dsRNA platform functions in interactions of the NS1 prot

227 In both soils, dsRNA dissipated on the timescale of hours.

228 RNA containing substrates, including ssRNA, dsRNA, RNA:DNA hybrids, and R-loops.

229 by using sequence-specific double-stranded (dsRNA) designed to knock down key viral genes.

230 suppresses PKR activation despite its strong dsRNA character, and inhibits the crucial antiviral kina

231 assayed them for the capacity to synthesize dsRNA in vitro in the presence of rVP2.

232 RNA), compared to those injected with target dsRNA alone.

233 ree to fivefold, more abundant in dsDNA than dsRNA treatments.

234 We also found that dsRNA knockdown of LRP-1 increased intracellular cholest

235 We show that dsRNA molecules added to soil suspensions undergo adsorp

236 e 6 of the Cystoviridae family, we show that dsRNA viruses can adopt a dsDNA-like single-spooled geno

237 artificial diet-feeding study indicates that dsRNAs greater than or equal to approximately 60 base-pa

238 n persist for multiple generations after the dsRNA exposure has stopped.

239 (dsRNA) replication intermediate against the dsRNA-specific RNase III.

240 rases do not direct genome ordering, and the dsRNA can adopt multiple conformations.

241 A specific (ADAR), the RNase DICER1, and the dsRNA-activated kinase protein activator of PKR (PACT) m

242 s that the entire type I IFN pathway and the dsRNA-activated kinase, PKR, are required for the lethal

243 able antiviral response was triggered by the dsRNA from a begomovirus genome, suggesting the method i

244 own to antagonise apoptosis triggered by the dsRNA-homolog poly(I:C), however the exact mechanism by

245 also found to be necessary to establish the dsRNA-induced transcriptional and translational programs

246 pressed at each level of signaling, from the dsRNA sensors RIG-I and MDA5, the adaptor MAVS, transcri

247 Here, we identified the dsRNA binding protein ILF3 as an essential host factor r

248 ion with a virus harboring a mutation in the dsRNA binding domain of sigma3 does not result in enhanc

249 ransposable elements, with activation of the dsRNA sensor RIG-I and interferon regulatory factor (IRF

250 nnate immune signaling upon detection of the dsRNA-binding VSR of Drosophila C virus (DCV).

251 Importantly, overexpression of the dsRNA-containing circRNA in PBMCs or T cells derived fro

252 e NS1-DHX30 interaction in vivo requires the dsRNA-binding activity of both DHX30N and the NS1 RBD.

253 sing cryo-electron microscopy to resolve the dsRNA genome structure of the tri-segmented bacteriophag

254 dited PK-15 cell lines were used to show the dsRNA-sensing pathogen recognition receptors (PRRs) TLR3

255 istent with this idea, we also find that the dsRNA binding position is dictated by an established con

256 of both IFN and NF-kappaB responses via the dsRNA sensors, RIG-I, and TLR3.

257 ed by the NS1 protein, and establish why the dsRNA-binding activity of NS1 is required for its bindin

258 Following challenge of HeLa cells with the dsRNA-analog poly(I:C), PGAM5 oligomers and high levels

259 ogical or autoinflammatory responses through dsRNA sensing and gene-regulatory roles and are controll

260 tal stage, exposure of neonate and adults to dsRNA, exposure of adults to different temperatures, dif

261 for the packing of dsDNA can be extended to dsRNA viruses.

262 sm of sequence-independent binding of Hfq to dsRNA stems, a function that is critical for proper ribo

263 ption of LASV NP ExoN with a mutation led to dsRNA accumulation and impaired LASV replication in mini

264 ee RLRs within the intracellular response to dsRNA and RNA virus infection.

265 drives translational shut-off in response to dsRNA by promoting widespread turnover of mRNAs.

266 ion distinct from that of SGs in response to dsRNA lipofection in human cells.

267 acutely synthesized by cells in response to dsRNA sensing, which immediately triggered cellular RNA

268 Remarkably, in response to dsRNA treatment or RNA virus infection, LGP2 is rapidly

269 tudy, we show that the beta-cell response to dsRNA, a viral replication intermediate known to activat

270 ze the RNase L activator 2-5A in response to dsRNA.

271 Nase L reprograms translation in response to dsRNA.

272 nts because of an antiviral RNAi response to dsRNA.

273 oteins that synthesize 2'-5'A in response to dsRNA.

274 IFN-lambda responses to dsRNA in the human infant airway epithelium are regulate

275 showed knockdown of a target gene in CS-TPP-dsRNA nanoparticle fed larvae.

276 revealed the distribution of the fed CS-TPP-dsRNA nanoparticles in midgut, fat body and epidermis of

277 lity and gene knockdown efficiency of CS-TPP-dsRNA nanoparticles were determined.

278 CS-TPP-dsRNA nanoparticles were prepared by ionic gelation meth

279 ignificant mortality of larvae fed on CS-TPP-dsRNA nanoparticles.

280 es, we also developed a protocol to transfer dsRNA from particles to the extraction buffer by changin

281 , revealing that two DDXs recognize a 2-turn dsRNA, each DDX mainly recognizes a single RNA strand, a

282 r to measure the stem length between the two dsRNA-ssRNA junctions.

283 Mutational analysis uncovered two dsRNA-binding domains of RHA that are necessary to tethe

284 hile no protection was achieved when 0-16 ug dsRNA were used, maximum rates of resistance (60 and 63%

285 domain similar to MDA5 that senses unedited dsRNAs in mammalian Adar1 mutants.

286 ffinity while discriminating against uniform dsRNA.

287 alytical challenges in quantifying unlabeled dsRNA and its degradation products in soils.

288 The protection was quickly activated upon dsRNA application and lasted for up to 4 days.

289 ipitation studies using biotin-labeled viral dsRNA or poly(I.C) and cell lysate-derived or in vitro t

290 nown as HnRNPU) functions as a nuclear viral dsRNA sensor for both DNA and RNA viruses.

291 Upon recognition of viral dsRNA, SAFA oligomerizes and activates the enhancers of

292 ntercalation of this compound into the viral dsRNA and its interaction with the RNA polymerase of bac

293 tational day 8.5) by administering the viral dsRNA mimic polyinosinic:polycytidylic acid (PolyI:C).

294 es is limited unless expression of the viral dsRNA-binding protein NS1 is abrogated.

295 -1 can compensate for the lack of RRF-1 when dsRNA from neurons is used to silence genes in intestina

296 in infected cells and often colocalized with dsRNA sensors.

297 experienced reduced aggression compared with dsRNA-immunostimulated bees, facilitating entry into sus

298 arge and adding constituents to compete with dsRNA for adsorption sites.

299 n organizations to potentially interact with dsRNA of variable length, providing diversity in viral R

300 Shrimps treated with dsRNA-expressed algal cells prior to YHV infection had 5