ライフサイエンスコーパス: ductus

1 produced greater relaxation in the immature ductus.

2 lective EP receptor agonists in the immature ductus.

3 itum (dpc) in the mesenchyme surrounding the ductus.

4 ement using INDO or surgical ligation of the ductus.

5 very 12 hours x 3 in an attempt to close the ductus.

6 l persists in the smooth muscle layer of the ductus and immunostaining colocalizes with SM2 expressio

7 h with congestive heart failure from a large ductus, and one lamb was electively euthanized 5 days af

8 , atrial septal defects (20/47, 43%), patent ductus arteriosus (16/47, 34%), persistent left superior

9 The narrowest diameter of the ductus arteriosus (4.3 +/- 0.4 mm vs. 6.9 +/- 2.6 mm, p

10 n group than in the placebo group had patent ductus arteriosus (adjusted relative risk, 1.65; 95% CI,

11 o [AOR], 0.81; 95% CI, 0.67-0.98) and patent ductus arteriosus (AOR, 0.74; 95% CI, 0.62-0.89).

12 Neural crest-derived SMCs populating the ductus arteriosus (DA) and great arteries exhibited a ce

13 How the ductus arteriosus (DA) closes at birth remains unclear.

14 Wild-type embryonic ductus arteriosus (DA) exhibited high levels of PRDM6, w

15 The ductus arteriosus (DA) is a vessel whose patency is requ

16 Closure of the ductus arteriosus (DA) is essential for the transition f

17 The ductus arteriosus (DA) of newborn infants exposed in ute

18 Ductus arteriosus (DA) tortuosity was present in signifi

19 as in the fetus, PGs maintain patency of the ductus arteriosus (DA), a vascular shunt that transmits

20 occurs is the closure and remodeling of the ductus arteriosus (DA), an arterial connection in the fe

21 placental mammals depends on closure of the ductus arteriosus (DA), an arterial connection in the fe

22 tic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fe

23 nd neonate, including adverse effects on the ductus arteriosus (DA).

24 Fetal aortic and pulmonary valve; ductus arteriosus (DA); and right (RPA), left (LPA), and

25 ation was observed between PM(10) and patent ductus arteriosus (for an interquartile range increase i

26 ationale: Hemodynamically significant patent ductus arteriosus (hsPDA) in premature infants has been

27 Transcatheter closure of the patent ductus arteriosus (PDA) has increasingly been adopted in

28 of buttoned device (BD) occlusion of patent ductus arteriosus (PDA) in a large number of patients wi

29 us for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants.

30 The management of patent ductus arteriosus (PDA) in preterm infants is controvers

31 ibitor ibuprofen may be used to treat patent ductus arteriosus (PDA) in preterm infants.

32 Nonsyndromic patent ductus arteriosus (PDA) is a common congenital heart def

33 Patent ductus arteriosus (PDA) is a common congenital heart dis

34 t pulmonary vascular development, and patent ductus arteriosus (PDA) is a factor potentially associat

35 Patent ductus arteriosus (PDA) is a relatively common form of c

36 Stenting of the patent ductus arteriosus (PDA) is an established palliative opt

37 Patent ductus arteriosus (PDA) is associated with increased mor

38 Observational studies have associated patent ductus arteriosus (PDA) ligation among preterm infants w

39 old female with a history of neonatal patent ductus arteriosus (PDA) ligation, left-sided choreiform

40 Patent ductus arteriosus (PDA) poses a diagnostic and therapeut

41 rformed to determine the frequency of patent ductus arteriosus (PDA) reopening and the factors that m

42 ated with growth after days 1-8, with patent ductus arteriosus (PDA) showing negative associations wi

43 A patent ductus arteriosus (PDA) shunt may be a modifiable risk f

44 may undergo palliation with either a patent ductus arteriosus (PDA) stent or a modified Blalock-Taus

45 y blood flow, initial palliation with patent ductus arteriosus (PDA) stent or modified Blalock-Taussi

46 theter closure of a moderate to large patent ductus arteriosus (PDA) using conventional techniques is

47 matic echocardiographic screening for patent ductus arteriosus (PDA) vs those who did not undergo scr

48 The patent ductus arteriosus (PDA) was the first congenital heart l

49 ne atrial septal defect (ASD) and two patent ductus arteriosus (PDA) were missed by DSCT.

50 We found that patent ductus arteriosus (PDA), a common congenital heart disea

51 ors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs

52 il occlude the moderate to large size patent ductus arteriosus (PDA).

53 eceiving indomethacin (INDO) to close patent ductus arteriosus (PDA).

54 ), coarctation of the aorta (CoA) and patent ductus arteriosus (PDA).

55 neurysmal dilatation of the aorta and patent ductus arteriosus (PDA).

56 ut died prior to postnatal day 3 from patent ductus arteriosus (PDA).

57 locus at 16p for TAAD associated with patent ductus arteriosus (PDA).

58 eptal defect (ASD); device closure of patent ductus arteriosus (PDA); pulmonary valvuloplasty; aortic

59 use of Gianturco coils to close large patent ductus arteriosus (PDAs) (> or = 3.5 mm) and describes t

60 right and left pulmonary arteries (QP), and ductus arteriosus (QDA) were calculated in 63 normal fet

61 ect (aORs ranging from 1.29 to 2.17), patent ductus arteriosus [aORs = 1.54, 1.63; 95% confidence int

62 PGT plays a critical role in closure of the ductus arteriosus after birth by ensuring a reduction in

63 etal ductus arteriosus and in closure of the ductus arteriosus after birth.

64 normal patterning and differentiation of the ductus arteriosus and adjacent descending aorta.

65 differentiation in the vascular wall of the ductus arteriosus and adjacent descending aorta.

66 In other areas, such as patent ductus arteriosus and atrioventricular septal defect, th

67 banding with catheterization stenting of the ductus arteriosus and balloon atrial septostomy, especia

68 l relationship exists between patency of the ductus arteriosus and chronic lung disease and other mor

69 h epilepsy and other signs, including patent ductus arteriosus and coagulopathy, while hemizygous mal

70 Patent ductus arteriosus and coarctation of aorta occurred >3 t

71 All patients had persistent ductus arteriosus and congenital mydriasis, and variable

72 al valve inflow and direction of flow in the ductus arteriosus and descending aorta were unrelated to

73 599+1delG) was identified in familial patent ductus arteriosus and found to disrupt normal splicing o

74 ole both in maintaining patency of the fetal ductus arteriosus and in closure of the ductus arteriosu

75 riosus to close after birth is termed patent ductus arteriosus and is one of the most common congenit

76 oth muscle differentiation in the developing ductus arteriosus and may promote precocious expression

77 cular interest because it also causes patent ductus arteriosus and moyamoya disease.

78 s describing an association between a patent ductus arteriosus and the development of morbidities, su

79 Neonatal ductus arteriosus aneurysm (DAA) is a rare abnormality t

80 Therapies designed to close the ductus arteriosus are contraindicated in some settings a

81 Much of the normoxic contraction of the ductus arteriosus at birth is related to calcium entry t

82 Closure of the ductus arteriosus at birth, essential for postnatal adap

83 ambs (126+/-3 d; 147 d, term) we ligated the ductus arteriosus at surgery, and treated animals with e

84 re infants with than in those without patent ductus arteriosus because afterload is lower in the form

85 ation, P62R, had a high prevalence of patent ductus arteriosus but had only mild abnormalities of fac

86 y intense beta-gal staining localizes to the ductus arteriosus but is absent or minimal in the pulmon

87 ght to establish and maintain patency of the ductus arteriosus by a new method of transvascular forma

88 ion of this pathway may contribute to patent ductus arteriosus by affecting the development of smooth

89 nificant role in control of major vessel and ductus arteriosus caliber in the rat fetus.

90 In the vast majority of infants, the ductus arteriosus closes by 3 days of life.

91 erization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expre

92 Incidence of spontaneous ductus arteriosus closure was increased, likely contribu

93 To determine the role of PGT in ductus arteriosus closure, we used a gene-targeting stra

94 ductus arteriosus vessels, VU0542270 induced ductus arteriosus constriction in a dose-dependent manne

95 ghts into the genetic programs that underlie ductus arteriosus development and closure.

96 y artery diameter Z score <or=-2.5 or patent ductus arteriosus diameter <or=2 mm was 97% sensitive an

97 nly one infant required ligation of a patent ductus arteriosus during ECMO.

98 r morphogenetic development of the aorta and ductus arteriosus during embryonic and postnatal surviva

99 oth muscle layers of the tunica media in the ductus arteriosus exhibit positive beta-gal staining.

100 001 to 7.5 per mille in 2012-2013, of patent ductus arteriosus from 1.9 per mille to 4.1 per mille, a

101 amicin clearance was decreased in the patent ductus arteriosus group vs. the control group (40.02 vs.

102 nce of a haemodynamically significant patent ductus arteriosus had a significant independent impact o

103 The infants with patent ductus arteriosus had higher values for ventricular perf

104 hough transcatheter coil occlusion of patent ductus arteriosus has gained popularity, few follow-up d

105 r the prevention and treatment of the patent ductus arteriosus have not documented a decrease in the

106 transcription factor associated with patent ductus arteriosus in humans, was uniquely expressed in m

107 ms underlying O2-induced constriction of the ductus arteriosus in late-gestation fetal rabbits.

108 PRRs of ASD and persistent ductus arteriosus in term infants increased with materna

109 hysiologic flow across the atrial septum and ductus arteriosus in the human fetus.

110 ns (P .05) and with medically managed patent ductus arteriosus in the white matter and deep gray matt

111 Ligation of the ductus arteriosus in utero produces pulmonary hypertensi

112 ) receptor antagonist, after ligation of the ductus arteriosus in utero.

113 f aortic branch defects, ASD, and persistent ductus arteriosus increase with maternal obesity severit

114 nchopulmonary dysplasia, surgery, and patent ductus arteriosus interventions (all p < 0.01/p < 0.01),

115 the effector mechanism for O2 sensing in the ductus arteriosus involves the coordinated action of del

116 The ductus arteriosus is a specialized blood vessel containi

117 The ductus arteriosus is a vessel that connects the pulmonar

118 The ductus arteriosus is a vital fetal structure allowing bl

119 The ductus arteriosus is an arterial vessel that shunts bloo

120 opment and persists in the neonate until the ductus arteriosus is completely closed.

121 In the preterm newborn, a patent ductus arteriosus is in large part a result of the incre

122 an pulmonary artery pressure (PAP) 8 d after ductus arteriosus ligation (78+/-2, HTN vs. 70+/-4 mmHg,

123 Patent ductus arteriosus ligation among preterm neonates younge

124 Since the first patent ductus arteriosus ligation by Robert Gross of Boston in

125 All 14 premature infants undergoing patent ductus arteriosus ligation in a 1-year period at our ins

126 In preterm infants, patency of the ductus arteriosus may represent a normal physiologic ada

127 istance associated with ligation of a patent ductus arteriosus might worsen ventricular performance i

128 Patent ductus arteriosus occlusion can be accomplished by umbre

129 ersal of the physiologic shunting across the ductus arteriosus or atrial septum in utero (i.e., left

130 Patients with persistent ductus arteriosus or congenital mydriasis with a label o

131 Impaired development of the ductus arteriosus or disruption of signaling pathways th

132 termine whether the presence and duration of ductus arteriosus patency differs between extremely pret

133 oth the presence of and a longer duration of ductus arteriosus patency were associated with the devel

134 olume of distribution was greater for patent ductus arteriosus patients (0.61 L/kg) than for controls

135 an average difference of 19% +/- 12 between ductus arteriosus plus isthmus flow versus descending ao

136 Maintaining patency of the ductus arteriosus postnatally is necessary with many for

137 r leukomalacia, chronic lung disease, patent ductus arteriosus requiring surgery, retinopathy of prem

138 nce of a haemodynamically significant patent ductus arteriosus results in a deeper impairment of cere

139 Although a persistent patent ductus arteriosus results in diminished cardiac function

140 s been controversy as to whether or when the ductus arteriosus should be closed by either pharmacolog

141 ts who were delivered alive from the reverse ductus arteriosus shunt group and 4 of 12 from the rever

142 Reversed ductus arteriosus shunting was found with severe right h

143 Medical treatment for patent ductus arteriosus significantly decreased over the study

144 ther modified Blalock-Taussig shunt (BTS) or ductus arteriosus stent (DAS).

145 Failure of the ductus arteriosus to close after birth is termed patent

146 ng should be altered in neonates with patent ductus arteriosus to reflect the impact of higher volume

147 AOR, 65.24; 95% CI, 5.70-748.18), and patent ductus arteriosus treatment after 72 hours of life vs ea

148 sure myography experiments on isolated mouse ductus arteriosus vessels, VU0542270 induced ductus arte

149 t transvascular formalin infiltration of the ductus arteriosus wall has been applied successfully to

150 The ductus arteriosus wall was successfully infiltrated and

151 f transvascular formalin infiltration of the ductus arteriosus wall.

152 d cases regardless of whether preterm patent ductus arteriosus was included.

153 ts who required surgical closure of a patent ductus arteriosus was lower in the budesonide group than

154 ficant constriction of the great vessels and ductus arteriosus was observed with L-NIL, whereas both

155 A functionally closed ductus arteriosus was traversed with a specially designe

156 asthma, smoking in the household, and patent ductus arteriosus were predictive of wheezing in the pre

157 age, including congenital mydriasis, patent ductus arteriosus with ligation, dysautonomia, low blood

158 Necropsy revealed patent ductus arteriosus with normal intimal thickening but dil

159 21, 261); superior vena cava, 137 (77, 197); ductus arteriosus, 187 (109, 265); descending aorta, 252

160 4 with atrial septal defects, 2 with patent ductus arteriosus, 2 with tetralogy of Fallot, and 1 wit

161 ransposition of the great vessels, 3 patient ductus arteriosus, 3 partial anomalous pulmonary venous

162 1 (29, 53); superior vena cava, 29 (15, 43); ductus arteriosus, 41 (25, 57); descending aorta, 55 (35

163 ngenital heart disease that results when the ductus arteriosus, a muscular artery, fails to remodel a

164 and Cx43 knockout mice an attenuation of the ductus arteriosus, a phenotype which may be indicative o

165 ending, transverse and descending aorta, the ductus arteriosus, and across the aortic and mitral valv

166 comitant cardiac lesion, for example, patent ductus arteriosus, and aortic cross-clamp time were dete

167 ents with interatrial communications, patent ductus arteriosus, and pulmonary artery stenosis requiri

168 ung age at angioplasty, presence of a patent ductus arteriosus, and the diameters of the aortic isthm

169 ng the aorta, pulmonary arteries, and patent ductus arteriosus, are each amenable to transcatheter in

170 on being stenting or stent redilation of the ductus arteriosus, balloon aortic valvuloplasty, and ste

171 onates subsequently diagnosed to have patent ductus arteriosus, based on clinical suspicion and echoc

172 and atrioventricular septal defects, patent ductus arteriosus, bicuspid aortic valve, and coarctatio

173 are common after coil embolization of patent ductus arteriosus, but most close spontaneously.

174 dysmorphology, osteochondrodysplasia, patent ductus arteriosus, cardiomegaly, pericardial effusion, a

175 somal dominant trait characterized by patent ductus arteriosus, facial dysmorphism and hand anomalies

176 in cardiopulmonary defects, including patent ductus arteriosus, in 30 to 40% of the mice.

177 dities, including perinatal jaundice, patent ductus arteriosus, intraventricular hemorrhage, perinata

178 ight represent novel therapeutics for patent ductus arteriosus, migraine headache, and sepsis; howeve

179 rses of gentamicin were administered (patent ductus arteriosus, n = 106; control, n = 216).

180 n with secundum atrial septal defect, patent ductus arteriosus, or pulmonic stenosis have had infecti

181 fetal development, a specialized vessel the ductus arteriosus, shunts blood from the pulmonary arter

182 septal defects, patent foramen ovale, patent ductus arteriosus, stent placement for pulmonary artery

183 sure can result in persistent patency of the ductus arteriosus, the third most common congenital hear

184 increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lung

185 ion, hypoplastic left heart syndrome, patent ductus arteriosus, valvar pulmonary stenosis, tetralogy

186 aging (secundum atrial septal defect, patent ductus arteriosus, ventricular septal defect, pulmonary

187 rsistent left superior vena cava, and patent ductus arteriosus, were present in 32% of patients.

188 opment of better therapy to close the patent ductus arteriosus, which constitutes approximately 10% o

189 n was a useful marker for presence of patent ductus arteriosus, with a 92% specificity for patent duc

190 of indomethacin to treat symptomatic patent ductus arteriosus.

191 all groups, as was acute constriction of the ductus arteriosus.

192 ung disease, there is delayed closure of the ductus arteriosus.

193 nt, despite success in closure of the patent ductus arteriosus.

194 ous lobar pulmonary veins or a silent patent ductus arteriosus.

195 on (PPHN) following prenatal ligation of the ductus arteriosus.

196 ension (PPHN) after prenatal ligation of the ductus arteriosus.

197 rta, suggesting little effect on tone of the ductus arteriosus.

198 neonates without clinically suspected patent ductus arteriosus.

199 predictive value for the presence of patent ductus arteriosus.

200 rteriosus, with a 92% specificity for patent ductus arteriosus.

201 phy (RVH) caused by prolonged closure of the ductus arteriosus.

202 shed techniques for coil occlusion of patent ductus arteriosus.

203 essels, SM2 is precociously expressed in the ductus arteriosus.

204 , we observe a strong beta-gal signal in the ductus arteriosus.

205 ed calcium channels, and constriction of the ductus arteriosus.

206 ribute to the unique muscle phenotype of the ductus arteriosus.

207 shunting following coil occlusion of patent ductus arteriosus.

208 h those of 14 preterm infants without patent ductus arteriosus.

209 e-dimensional image of the great vessels and ductus arteriosus.

210 with intraventricular hemorrhage and patent ductus arteriosus.

211 onary artery stenoses, and persistent patent ductus arteriosus.

212 ath or bronchopulmonary dysplasia and patent ductus arteriosus.

213 d as they may cause premature closure of the ductus arteriosus.

214 atal necrotizing enterocolitis or persistent ductus arteriosus.

215 a Notch ligand, die postnatally from patent ductus arteriosus.

216 the development of smooth muscle within the ductus arteriosus.

217 and atrioventricular septal defects; patent ductus arteriosus; pulmonary stenosis; aortic stenosis;

218 rmore, SM2 expression can be detected in the ductus as early as 15.5 dpc.

219 3, and abnormal persistence of the bilateral ductus caroticus and right dorsal aorta.

220 domly assigned to delivery according to late ductus changes (133 [95%] of 140, 95%, 95% CI 90-98) wer

221 ated for sex, birth weight, gestational age, ductus closure, occurrence of NEC, bowel perforation, an

222 ethacin; we hypothesized that this is due to ductus constriction in utero, with subsequent remodeling

223 natally as the number of VSMCs necessary for ductus contraction increased.

224 Treatment of hamster ductus deferens (DDT1MF-2) cells and porcine aortic smoo

225 ryptorchidism and abnormal tortuosity of the ductus deferens, and female transheterozygotes exhibited

226 thelial cells of: lung, oviduct, epididymis, ductus deferens, and seminiferous tubules.

227 nal vesicle, bulbourethral gland, and caudal ductus deferens.

228 males at the junction of the epididymis and ductus deferens.

229 in Purkinje cell bodies and cells lining the ductus deferens.

230 4 receptor densities were higher in immature ductus, despite similar receptor mRNA and protein conten

231 The ductus differs primarily from the great vessels in that

232 pus bursa and the heavy muscular area of the ductus ejaculatorius simplex before and after mating, an

233 ells of reproductive tracts, the oviduct and ductus epididymis.

234 g and a vascular ring formed by a left-sided ductus from the descending aorta (n = 5); right aortic a

235 o the endothelium of the aortic arch and the ductus in VEGFR2(SHF-KO) mutants.

236 cacy of atrial septal defect devices, patent ductus occluders, and stents to treat coarctation of the

237 ly of atrial septal, ventricular septal, and ductus occluding devices shows particular promise.

238 Ductus relaxation and cAMP generation were augmented in

239 Surgical ligation and division of the ductus remains the gold standard for consistently achiev

240 ild-type protein in epigenetic regulation of ductus remodeling.

241 pressed in the urticulo-saccular foramen,the ductus reuniens, and Reissner's membrane, suggesting tha

242 Using ductus ring experiments, calcium imaging, reverse-transc

243 oxic contraction is an intrinsic property of ductus smooth muscle.

244 roduction, and isometric tension in rings of ductus taken from immature (65% gestation) and mature (9

245 or the increased sensitivity of the immature ductus to PGE2.

246 in the increased sensitivity of the immature ductus to PGE2: (1) increased cAMP production because of

247 of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2).

248 Absent ductus venosus (ADV) is a rare condition, but it should

249 Finally, we observed normal closure of the ductus venosus (DV) in DREC null mice.

250 ure of a hepatic vascular shunt known as the ductus venosus (DV).

251 patent developmental structure known as the ductus venosus (DV).

252 of a fetal hepatovascular shunt known as the ductus venosus (DV).

253 mutations in the Ahr locus display a patent ductus venosus and smaller livers throughout life.

254 d less blood away from the liver through the ductus venosus at 36 weeks gestation.

255 aimed to assess whether changes in the fetal ductus venosus Doppler waveform (DV) could be used as in

256 sing the tricuspid valve, foramen ovale, and ductus venosus Doppler).

257 imilar approach was used for measurements of ductus venosus flow.

258 The stream that originated from the narrowed ductus venosus had a higher velocity than that from the

259 is consistent with the existence of a patent ductus venosus in adult animals.

260 -type portal-caval, portohepatic, and patent ductus venosus patients had a successful 1-stage ligatio

261 This may be coupled with an increased ductus venosus shunt, the combination leading to a marke

262 eustachian valve and the septum primum, the ductus venosus stream preferentially passed through the

263 onstrated that ARNT hypomorphs have a patent ductus venosus, identical to that observed in the Ahr nu

264 ast echocardiography to evaluate flow in the ductus venosus, in both venae cavae, and through the for

265 s necessary for developmental closure of the ductus venosus, whereas AHR signaling in hepatocytes is

266 e of a fetal vascular structure known as the ductus venosus.

267 hunts (portohepatic), and 2 had a persistent ductus venosus.

268 At postmortem study, the ductus was patent, and histologic analysis showed variab

269 The ductus was then further dilated with either a 7- or 8-mm

270 isms involved in normoxic contraction of the ductus will permit the development of better therapy to