ライフサイエンスコーパス: durable

1 tumor shrinkage, the response is usually not durable.

2 zumab is associated with high response rate, durable activity, and a manageable safety profile in pat

3 ative approaches in designing and developing durable and biocompatible materials.

4 hile maintaining radial strength), different durable and biodegradable polymers - and in some cases n

5 Entrectinib induced durable and clinically meaningful responses in patients

6 This approach achieves specific, durable and controlled reduction of neutrophils in vivo,

7 Plant disease resistance that is durable and effective against diverse pathogens (broad-s

8 an oncogenic driver event in cancer and its durable and efficacious inhibition is a focus in the dev

9 e taken into consideration for screening the durable and efficient candidates.

10 ound to be safe and induced a broad, strong, durable and functional immune response targeting the con

11 fic Ab response from this regimen was highly durable and functionally diverse for the duration of the

12 and a vaccine regimen that induces a highly durable and polyfunctional V2-focused Ab response in rhe

13 st an unmet need for glaucoma therapies with durable and predictable actions.

14 le in conditioning plant tolerance, the most durable and promising category of host plant resistance,

15 cocci strains where its activity proved more durable and remarkably better than many current therapie

16 Resistance Locus O (MLO) is known to confer durable and robust resistance to powdery mildew (Blumeri

17 posal practices, and the development of more durable and sustainable alternatives.

18 oma hold promise but responses are often not durable, and tumors frequently relapse.

19 cs can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or i

20 anding of how different vaccine types elicit durable antibody responses is lacking.

21 IC31 vaccinations at the lowest dose induced durable antigen-specific CD4 T-cell responses with accep

22 19-BBz(86) CAR T cells produces a potent and durable antilymphoma response without causing neurotoxic

23 rolizumab provided clinically meaningful and durable antitumor activity with a manageable safety prof

24 ragine to phenylalanine (CD28-YMFM) promoted durable antitumor control.

25 8-costimulatory CARs in an effort to improve durable antitumor effects.

26 ion in tumors, induced tumor regression with durable antitumor immunity, and synergized with anti-PD-

27 tumor-specific T(mem) that are essential for durable antitumor immunity.

28 Mice bearing ER(+) xenografts displayed a durable antitumor response to palbociclib; however, over

29 id) ester prodrugs are less toxic and induce durable antitumor responses.

30 Pembrolizumab monotherapy showed durable antitumour activity and manageable safety in pat

31 In this group, protection was durable as the animals resisted six more challenges 5 mo

32 ollowing questions: 1) Is transplantation or durable assist device placement indicated?

33 ansit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends.

34 blation catheter for focal ablation produced durable atrial lesions and showed lower vulnerability to

35 s used to create contiguous, transmural, and durable atrial lesions can result in serious complicatio

36 BTKi therapy achieved durable benefit for patients with the BCL2 Gly101Val ven

37 mental window for treatment which may have a durable benefit for some time even after withdrawal.

38 or an adverse mutation profile had the most durable benefit.

39 with erlotinib after recurrence experienced durable benefit.

40 CSCs into a therapeutic vaccine, leading to durable benefits.

41 rapeutic and delivery strategies that ensure durable bioavailability need to be developed to translat

42 competent mice resulting in the expansion of durable bnAb memory and long-lived plasma cells.

43 Although, achieving durable brain exposures of ispinesib is critical for ade

44 The durable, broad-spectrum disease resistance is caused by

45 based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to

46 Most CRs were durable but the probability of treatment failure was 27%

47 drivers of antitumor immunity, but promoting durable CAR T cell responses remains challenging.

48 d of employing a metabolically expensive but durable carbon (C)-based skeleton, flowers may rely pred

49 toms exhibit a superior thermal stability as durable catalysts.

50 g(cat.) (-1) , as well as good stability and durable catalytic activity.

51 eened for the degradation of DMNP and showed durable catalytic reactivity.

52 ng the bottom-up design of high-performance, durable catalytic systems for various catalysis needs.

53 vaccination led to strong cross-priming and durable CD8 T cell immunity.

54 sed by MSC bioreactor culture confirmed by a durable change in their immunophenotype and function.

55 effects of prolonged treatments, indicating durable changes in cellular physiologic identity.

56 ymosan treatment, implying the occurrence of durable chromatin changes.

57 able to identify which patients will achieve durable clinical benefit (DCB).

58 Early samples from patients with durable clinical benefit demonstrated overexpression of

59 cantly and negatively associated with higher durable clinical benefit, reduced hyperprogression, and

60 tment, only a subset of patients demonstrate durable clinical benefit.

61 atients either do not respond or do not have durable clinical benefit.

62 wed that tumors from patients who achieved a durable clinical response displayed a permissive microen

63 st-line pembrolizumab confers meaningful and durable clinical response in cisplatin-ineligible patien

64 Despite compelling rates of durable clinical responses to programmed cell death-1 (P

65 blood CAR-NK cells induce high rates of non-durable clinical responses without CRS or neurotoxicity.

66 dings indicate that BTKi therapy can provide durable CLL control after disease progression on venetoc

67 Here, a high-power and durable Co-N-C nanofiber catalyst synthesized through el

68 h antiretroviral therapy, showed consistent, durable control of simian immunodeficiency virus (SIV) i

69 ssue has been attempted but does not achieve durable correction of the patients' hypoparathyroidism d

70 es that are synthesized by plants to provide durable coverings for the delicate cells they encase.

71 bjective of this study is to make strong and durable dental adhesives that are free from 2 symbolic m

72 favourable properties, such as flexibility, durable dielectric insulation, barrier properties agains

73 on in electrical grids requires reliable and durable dielectric polymers for wire insulation(1,2).

74 Entrectinib is active with durable disease control in patients with ROS1 fusion-pos

75 based methodology to more accurately predict durable disease control with immunotherapy.

76 al toxicity, substantial 2-HG reduction, and durable disease control.

77 in the context of immune system renewal and durable disease remission in MS.

78 elopment of new technologies for engineering durable disease resistance against major pathogens of po

79 ted in multilineage, high level (up to 50%), durable, donor-derived hematopoietic chimerism after tra

80 l and biological prostheses as they are more durable, due to the superior properties of novel polymer

81 These improvements were durable during 36 months of follow-up.

82 lticentric Castleman disease on the basis of durable efficacy and safety data.

83 n this phase 1-2 trial, selpercatinib showed durable efficacy with mainly low-grade toxic effects in

84 We report durable efficacy, long-term safety, and clinical and bio

85 ion with stable operation, highly robust and durable electrodes are urgently desired to facilitate wa

86 engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infe

87 V-1 prevention will likely be required for a durable end to the global AIDS pandemic.

88 Durable engraftment and donor-specific tolerance can be

89 engineered T cells into patients resulted in durable engraftment with edits at all three genomic loci

90 long-term cardiac function despite a lack of durable engraftment.

91 RAF dimerization, leading to more potent and durable ERK pathway suppression that promotes BIM-depend

92 ture spines may be important for maintaining durable expectations.

93 ture spines may be important for solidifying durable expectations.

94 d an additional two of 59 patients (3%) with durable FICS undergoing definitive total hip arthroplast

95 psychological research can establish a more durable foundation for replicating the effects of social

96 Lanadelumab efficacy was durable-HAE attack rate was consistently lower vs placeb

97 extreme risk for surgery was associated with durable hemodynamics and excellent clinical outcomes.

98 The w-LED also displays a highly durable high-power-driving capability, and its working c

99 Synthetic DNA is rapidly emerging as a durable, high-density information storage platform.

100 e of microbicide noncompliance and lack of a durable, highly effective vaccine, a combined approach m

101 sed as CO(2), between 8 and 24% is stored in durable household goods or becomes part of other urban s

102 ens containing an EBOV insert induce strong, durable humoral and cellular immune responses.

103 Generating durable humoral immunity through vaccination depends upo

104 ate the ability of V160 to induce robust and durable humoral memory responses to HCMV, justifying fur

105 However, durable hydroxide-conducting polymer electrolytes in hig

106 2 to 28 months prior to rechallenge elicit a durable immune response that protected from detectable p

107 key cell population capable of facilitating durable immune tolerance.

108 e potential for PD-1 blockade to bring about durable immune-mediated tumor control in chronically imm

109 ucts for ACT and implicates IL6 in promoting durable immunity of Th17 cells against large, establishe

110 out evidence of genetic instability, induced durable immunity, and primed for anamnestic antibody res

111 noninvasive multiparameter assay (DIREct-On, Durable Immunotherapy Response Estimation by immune prof

112 re discontinued, resulted in significant and durable improvement in progression-free survival in pati

113 Local control was durable in 24 of 30 patients (two-year LPFS, 62%).

114 duration VenR are sustained and particularly durable in patients who achieve uMRD.

115 P immobilized on the fluoropolymer is highly durable in physiological flow conditions for over 60 day

116 ing the hypothesis that RDN is effective and durable in these high-risk populations.

117 temic plasmablast responses and significant, durable increases in RSV-specific serum antibody in heal

118 e is an attractive alternative for dense and durable information storage, which is sorely needed to d

119 ive properties, that can achieve instant and durable intra-arterial hemostasis regardless of coagulop

120 Invasive remapping demonstrated durable isolation (defined by entrance block) in 82 of 8

121 Durable isolation improved from 61.5% PF(LD) to 100% wit

122 We demonstrate robust and durable knockdown of endogenous genes in such neurons an

123 Nano-structured shunts were durable, leak-proof, and demonstrated biocompatibility a

124 nts performed, 7,904 (32%) were bridged with durable left ventricular assist devices (LVADs), 177 (0.

125 lantation means that more patients remain on durable left ventricular support for longer periods of t

126 This research further demonstrates a durable Li-Se/S pouch cell with high specific capacity,

127 ogist, and creates an opportunity to achieve durable local control of liver tumours that might not ot

128 Despite its use in complex AWR, ADM provides durable long-term outcomes with relatively low recurrenc

129 Even transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the gener

130 ion of RAP1, which promotes the formation of durable lumens(4,5).

131 cally Assisted Circulatory Support requiring durable LVAD between 2008 and 2017 were included.

132 ansplant was 90 +/- 0.4% and 77 +/- 0.7% for durable LVAD, 84 +/- 3% and 71 +/- 4% for all TCS-VAD ty

133 his unique reactivity from a tunable, highly durable macrocyclic framework was studied via a series o

134 produces high clinical responses, including durable maintenance after treatment withdrawal in some p

135 The Durable MCS after ECLS registry is a multicenter retrosp

136 The outcome in patients receiving durable MCS after ECLS remains limited, yet preoperative

137 hese data highlight concerns with the use of durable MCS for patients with ACM.

138 rimary endpoint was survival at 1 year after durable MCS implantation.

139 ents with DCM or nonamyloid RCM who received durable MCS, those with ACM experienced the highest use

140 A total of 531 durable MCSs after ECLS were implanted during this perio

141 hy (ACM) develop advanced heart failure, and durable mechanical circulatory support (MCS) may be a co

142 real membrane oxygenation (ECMO) who undergo durable mechanical circulatory support implantation (dMC

143 erapies, including heart transplantation and durable mechanical circulatory support, are available to

144 The decision to implant durable mechanical circulatory systems (MCSs) in patient

145 rmeable to liquids, but not to gases, inert, durable, mechanically stable and flexible.

146 nique personal history, our brains must form durable memories from single brief exposures to the patt

147 ate that HIV-1 protein immunogens can elicit durable memory T- and B-cell responses and that strong t

148 of evolutionary biologists and inspired the durable metaphor of the coevolutionary arms race.

149 icantly greater number of patients exhibited durable MI block in the VOM-Et group (62.9% [22/35] vers

150 Although induction of durable mixed chimerism is required for murine skin allo

151 otocols and, in most cases, does not lead to durable modulation of the allergic immune response.

152 Here we show that durable neoantigen-specific immunity is regulated by mRN

153 oring of captive naked mole-rats, we found a durable nest, characterized by high CO(2) levels, where

154 l HA stalk-specific IgG2c antibodies and for durable neutralizing titers to influenza.

155 ards the development of high performance and durable non-platinum direct methanol fuel cell.

156 Achieving a functional and durable non-platinum group metal-based methanol oxidatio

157 Efficient and durable nonprecious metal electrocatalysts for the oxyge

158 a time during which the microbiota imprints durable oral tolerance.

159 n magnitude than in the initial analysis and durable over time.

160 Durable overall response at day 56 was higher in the rux

161 The key secondary end point was durable overall response at day 56.

162 oam, which serves as an eminently active and durable oxygen evolution reaction catalyst for alkaline

163 , tapping into local knowledge, and building durable partnerships between scientists and communities.

164 The joining of a durable PD-1 blockage significantly boosted the efficacy

165 ed subcutaneously in mice self-organize into durable pericyte-coated vessels that functionally anasto

166 elopment of simultaneously highly active and durable platinum group metal-free (PGM-free) catalysts a

167 insights and useful leads for development of durable pod borer resistance.

168 , Xience, an everolimus-eluting stent with a durable polymer coating, regarding clinical outcomes wit

169 en patients treated with polymer-free versus durable polymer DES.

170 hether stenting is done with polymer-free or durable polymer DES.

171 e sirolimus- and probucol-eluting stents and durable polymer zotarolimus-eluting stents (DOCE: 43.8%

172 - and probucol-eluting stents (n = 2,002) or durable polymer zotarolimus-eluting stents (n = 1,000).

173 V-CTLs from a different donor achieved CR or durable PR (60%) and survived longer than 1 year.

174 provides an effective palliative result and durable prevention for impending pathologic fractures of

175 Tregs) to allo-activated Tconvs, and provide durable prevention of xenogeneic GVHD.

176 Evidence from this study demonstrates a durable primary anatomic retinal reattachment rate with

177 Memory CD8 T cells provide durable protection against diverse intracellular pathoge

178 pe CSP vaccines could confer better and more durable protection against malaria.

179 utralizing antibody (bNAb) 10-1074 conferred durable protection against repeated penile exposures to

180 ding the immunologic mechanisms that provide durable protection against skin infections has the poten

181 protective universal influenza vaccines with durable protection are under way.

182 -generation influenza vaccines for broad and durable protection.

183 hold of nAbs required to confer superior and durable protection.

184 he task is the creation of highly active and durable Pt-based catalysts for the cathodic oxygen reduc

185 s worth revisiting how the JCI has created a durable publication model for free access to research an

186 ariable patient anatomy to achieve acute and durable pulmonary vein (PV) isolation.

187 file of PFA potentiated efficient, safe, and durable PVI and LAPW ablation.

188 25%; 95% confidence interval, 16%-37%) had a durable reduction in baseline antihypertensive medicatio

189 IL-23 may transiently reduce AVI, with more durable reduction in inflammatory cytokines associated w

190 aches is required to achieve substantial and durable reductions in HIV transmission.

191 R/R FL with or without transformation, with durable remission in a high proportion of FL patients.

192 effective therapeutic approach for promoting durable remission of PTSD, particularly in patients with

193 is able to ameliorate, cure, and sustain the durable remission of the disease.

194 non-Hodgkin lymphoma in part on the basis of durable remission rates of approximately 40% in a clinic

195 inations to identify molecular correlates of durable remission, response followed by relapse (adaptiv

196 hown unprecedented response rates, including durable remissions after drug discontinuation.

197 b monotherapy was well-tolerated and induced durable remissions and transfusion independence in patie

198 in, we discuss the factors that can preclude durable remissions following CAR T cell therapy, with a

199 KTE-X19 induced durable remissions in a majority of patients with relaps

200 treatment landscape for oncology, leading to durable remissions in a subset of patients, but also a b

201 High response rates and durable remissions were typically associated with NPM1 o

202 hich of these patients are likely to achieve durable remissions with FCR chemoimmunotherapy.

203 ortality-have limited the ability to achieve durable remissions.

204 unity can eliminate cancer cells and provide durable remissions.

205 tability of response but higher fractions of durable remissions.

206 ) in unselected patients has shown a lack of durable remissions.

207 be used to assess the significance of QR for durable resistance in crops.

208 goal of breeding next-generation crops with durable resistance to pathogens is achievable, and will

209 mission-3% of the auto-HCT-failed cohort-had durable response (11 or more, 14 or more, and 17 months)

210 rch 29, 2019, and 28 of these patients had a durable response (lasting >=1 year).

211 ICI provide a strategy for identification of durable response early during the course of treatment an

212 has resulted in complete remission (CR) and durable response in highly refractory patients.

213 generated either only transient responses or durable response in only a minority subset of patients.

214 r studies are needed to define predictors of durable response in patients with and without exposure t

215 and reactivates cytotoxic T cells to elicit durable response in some cancer patients.

216 h cancer survivorship has extended, rates of durable response of ICB remain poor; furthermore, cardia

217 5% confidence interval (CI) 72.7%-84.0%] had durable response to FMT at one year.

218 Majority of patients had a durable response to FMT despite exposure to CDI risk fac

219 Durable response to FMT was defined as lack of CDI episo

220 prognosis, a subset of patients demonstrate durable response to immune checkpoint inhibitors.

221 riven by auto-activated, mutant KIT and have durable response to KIT tyrosine kinase inhibitor.

222 vast majority of PDAC cases do not harbor a durable response to monotherapy of CDK4/6 inhibitor.

223 the majority of patients fail to maintain a durable response to treatment, in part, due to drug resi

224 d to checkpoint inhibitors tend to develop a durable response, <15% of patients with HNSCC respond to

225 nstrom macroglobulinaemia who had an initial durable response, reuse of a previous regimen or another

226 ival is strongly associated with achieving a durable response, which can be maintained after treatmen

227 mpact glioblastoma tumorigenesis and prevent durable response.

228 nstrated significant antitumor activity with durable responses and a favorable safety profile in pati

229 gest that axicabtagene ciloleucel can induce durable responses and a median overall survival of great

230 Ruxolitinib produced durable responses and encouraging survival compared with

231 oIpi demonstrated manageable toxicities with durable responses and encouraging survival in patients w

232 Single-drug oral selinexor induced durable responses and had a manageable adverse events pr

233 exhibited promising anti-CSCC activity, with durable responses and manageable safety.

234 sis, daratumumab 16 mg/kg monotherapy showed durable responses and there were no new safety concerns

235 at monotherapy showed clinically meaningful, durable responses and was generally well tolerated in he

236 cancer who do not respond or fail to achieve durable responses following treatment with immune checkp

237 ce of improved tumor immune infiltration and durable responses in a subset of patients with available

238 1 and CTLA-4 inhibitory receptors can induce durable responses in a wide range of human cancers.

239 the first modern immunotherapies to produce durable responses in patients with advanced cancer, but

240 hibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leuke

241 rated and provided clinically meaningful and durable responses in patients with mUC; survival data ar

242 We previously reported durable responses in relapsed or refractory (R/R) chroni

243 LA-4, PD-1, or its ligand PD-L1, can produce durable responses in some patients.

244 e overcome if we are to achieve complete and durable responses in the clinic.

245 in melanoma, the biological features of the durable responses initiated by these drugs remain unknow

246 Ebola is not yet established, and eliciting durable responses may require additional booster vaccina

247 n followed by CD30.CAR-Ts had a high rate of durable responses with an excellent safety profile, high

248 int inhibitors (ICIs) can produce remarkably durable responses, most patients develop early disease p

249 However, only a subset of patients achieves durable responses, suggesting that the mechanisms of the

250 single course of treatment produced high and durable responses, with low complications.

251 e antitumor activity; clinically meaningful, durable responses; and acceptable safety in primarily el

252 PORTANCE The development of an effective and durable SARS-CoV-2 vaccine is essential for combating th

253 Estimates indicate that infection induces durable sero-protection against H1N1pdm09 but not H3N2Pe

254 Evidence of durable single-agent efficacy in human clinical trials v

255 escribe the development and application of a durable small-diameter vascular graft with tailored rege

256 asting high-temperature and high-input-power durable solid-state light-emitting diodes is illustrated

257 y, and scientific support and collaboration, durable solutions to the clinical, regulatory, and econo

258 -lock functional cure approaches, aimed at a durable state of latency.

259 The main idea is to model each stable (durable) state of a given temporal network as a communit

260 SSIS is a safe, effective, and durable strictureplasty in patients with extensive fibro

261 its ligand (PD-L1) continue to show limited durable success in clinical cases despite widespread app

262 ulatory T cells, which are necessary for the durable suppression of antigen-specific immune responses

263 We found that ZL0580 induces potent and durable suppression of both induced and basal HIV transc

264 lecule modulator, ZL0580, induces potent and durable suppression of HIV in human microglial and monoc

265 Durable survival is observed in patients undergoing adre

266 Generating effective and durable T cell immunity is a critical prerequisite for v

267 Mechanistically, alphaCD40/ICB primed durable T cell responses, and efficacy required DCs and

268 equire catalysts that are more efficient and durable than present ones.

269 f the mechanisms of resistance, complete and durable therapeutic responses to PARPi-ATRi that signifi

270 (BRAFi) remains a major hurdle in attaining durable therapeutic responses.

271 he optimal use of immune reconstitution as a durable therapeutic strategy.

272 h anti-PD-1, beta3-integrin depletion led to durable therapy and elicited an abscopal immunotherapeut

273 All functionalities measured were highly durable through the study period.

274 r the development of an effective, safe, and durable toxoplasmosis vaccine.

275 achieve a more comprehensive lesion set with durable transmural lesions.

276 The most effective and durable treatment for Class III obesity (body mass index

277 r alafenamide as a safe, well tolerated, and durable treatment for people living with chronic HIV.

278 r alafenamide as a safe, well tolerated, and durable treatment for people with HIV, with no emergent

279 iscovery of cellular factors associated with durable treatment.

280 Pembrolizumab demonstrated durable tumor control, a generally manageable safety pro

281 ral cDC1 maturation, ultimately resulting in durable tumor cures.

282 geting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients.

283 1 and inoperable plexiform neurofibromas had durable tumor shrinkage and clinical benefit from selume

284 o, while CAR-T cell treatment alone achieves durable tumor-free survival even upon tumor re-challenge

285 ctivate tumour-associated T cells can induce durable tumour control and result in the long-term survi

286 fine a set of markers that identify the most durable vaccine-reactive memory-precursor CD8(+) T cells

287 nt improvement in outcomes now possible with durable ventricular assist devices has led to a signific

288 xtracorporeal life support, percutaneous and durable ventricular assist devices, transplantation capa

289 ue deposition, suggesting vessel healing and durable vessel occlusion.

290 Significant improvements in durable viral suppression were observed over time; howev

291 t outcomes and may be less likely to achieve durable viral suppression.

292 We report a highly active and durable water oxidation electrocatalyst based on cubic n

293 Pursuing active and durable water splitting electrocatalysts is of vital sig

294 s, and the bypass procedure may lead to more durable weight loss and glycemic control.

295 -nonmutant and BRAF-mutant patients and were durable, with a 1-year survival of 52.1% in the PD-L1-po

296 Responses were deep and durable, with most complete responders achieving mIDH1 m

297 Responses were durable, with no acquired resistance to date.

298 Here, we report a flexible and durable wood-based triboelectric nanogenerator for self-

299 d to the environment the use of good design, durable woods and properly treated or modified woods wil

300 Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV an