ライフサイエンスコーパス: dwell time

1 patient has lived with the precursor (i.e., dwell time).

2 echnical success of retrieval increases with dwell time.

3 ation can be used to estimate a patient's BE dwell time.

4 er important aspect is to minimize the total dwell time.

5 fide bridges that decreased the channel open dwell time.

6 d reverses for leads with <40 years expected dwell time.

7 pore conductance and a prolonged fusion pore dwell time.

8 lity for infection increased with additional dwell time.

9 reby account for lower limits of attentional dwell time.

10 externalization exceeding 20% at >5 years of dwell time.

11 0 mum by 110 mum with a highly uniform pixel dwell time.

12 ude longer than the average agonist pMHC-TCR dwell time.

13 udes every experimental data point, not only dwell times.

14 is less mechanosensitive and has longer open dwell times.

15 d mean open dwell times and shortened closed dwell times.

16 spotted masses of DNA, and droplet retrieval dwell times.

17 ferentially enhancing alpha7beta2-nAChR open-dwell times.

18 s in the measured diffusion coefficients and dwell times.

19 ole ICP-MS system using a sufficiently short dwell time (0.1 ms).

20 II-restricted TCRs require a shorter antigen dwell time (0.2 s) to initiate negative selection compar

21 s (SEP) or interlaced lines (INT), different dwell times (2.5-75 micros), and repetition numbers (10

22 e oligomerized Dvl2 complexes have increased dwell time, 2 ~ 3 min, compared to less than 1 s for mon

23 portion of long bursts), and enhanced closed dwell times (3- to 6-fold increase)].

24 Optimized GC-qMS parameters (dwell time 70 ms, 2 most abundant ions) resulted in stan

25 signaling, with changes in receptor binding dwell-times affecting more profoundly STAT1 than STAT3 p

26 e a Robust Iterative Fourier Transform-based dwell time Algorithm (RIFTA) that automatically fulfills

27 a comparison with the other state-of-the-art dwell time algorithms.

28 Dwell time analysis indicated that about three hidden st

29 A detailed dwell time analysis of the fluorescence and FRET traject

30 Dwell time analysis reveals that PNU introduces two nove

31 Dwell-time analysis of fluorescence trajectories recorde

32 Dwell-time analysis showed that the affinity of MAP65-1

33 nts for each pathway have been determined by dwell-time analysis, revealing that intramolecular trans

34 In contrast to dwell-time analysis, which is the current standard metho

35 With a 5 ms dwell time and 200 mus settling time, the size detection

36 hy-mass spectrometry acquisition with a 3-ms dwell time and a 1.55-s duty cycle time.

37 Prolonged dwell time and catheter insertion under emergent conditi

38 isplay a linear relationship between average dwell time and dNTP concentration.

39 receptors can be targeted to modulate T cell dwell time and inflammation at effector sites, revealing

40 y useful because EAC risk may change with BE dwell time and it is generally not known how long a pati

41 li MscL, plays a major role in both the open dwell time and mechanosensitivity of the channel.

42 special emphasis on procedural factors like dwell time and needle-pleural angle was analysed.

43 ation, and TNF inhibition reduced neutrophil dwell time and ROS production, as well as renal injury.

44 ingle-molecule sensitivity, detection rates, dwell time and scalability.

45 er system in urine samples, in dependence on dwell time and temperature exposition.

46 ed that E2 treatment selectively reduced the dwell time and thereby decreased the confinement of GABA

47 the formed adhesion cluster as a function of dwell time and thereby determine the precise size of the

48 Specifically, their event mean dwell times and amplitudes were sufficiently distinct to

49 We detect two populations of transient dwell times and determine via binding-interface mutants

50 We quantify myosin II filament dwell times and processivity as functions of ATP concent

51 vide a dynamic migration assay with distinct dwell times and relative cell occupancy as readouts, whi

52 ity (P(o)) than WT, with prolonged mean open dwell times and shortened closed dwell times.

53 ho-dependent termination by increasing pause dwell times and the kinetic window for Rho action.

54 The closed conformation minimized TCR dwell times and thereby prevented activation by membrane

55 are able to measure the binding statistics (dwell times) and binding energies of the initial RAG bin

56 t the promoter, resulting in longer promoter dwell time, and an increase in the steady-state populati

57 in (BSA) sample provided narrow peaks, short dwell time, and good peptide coverage.

58 ation, depending on the D(2)O concentration, dwell time, and temperature and enables a method to corr

59 ded on the magnitude of the applied voltage, dwell time, and writing speed.

60 sector field ICP-MS (ICP-SF-MS), microsecond dwell times, and dry aerosol sample introduction systems

61 types, the pore-blocking current and inverse dwell time are shown to scale linearly at low electric f

62 concentrations of two ligands with different dwell times are adjusted to equalize the level of LAT ph

63 angle, higher-grade perforation, and longer dwell times are associated with complicated IVC filter r

64 gle-molecule binding events whose individual dwell times are broadly distributed.

65 , Padi4-specific T cell receptors with short dwell times are expressed on CD4(+) T cells, while long

66 Deposition rates (spot dwell time) are determined by the chromatographic resolu

67 nation of a precise (1)t(R), considering the dwell-time arising from modulation and (2)t(R).

68 mma(j)) of the main open state, reduced open dwell time at +/-40 mV, and absence of a long-lived subs

69 CLIP-170-EB1 complex also indicates a short dwell time at growing plus-ends, an observation inconsis

70 inding of dNTP to captured complexes affects dwell time at higher dNTP concentrations.

71 hen initially captured predominantly affects dwell time at low dNTP concentrations.

72 nding to microtubules, implying an increased dwell time at microtubule plus ends.

73 o individual synapses increases alpha7-nAChR dwell time at presynaptic sites.

74 creatinine peak area up to 35% after 24 h of dwell time at room temperature (RT) using 25% (v/v) D(2)

75 orylation is associated with a longer pol II dwell time at start sites and reduced transcriptional po

76 e retention of MinD and MinE and explain its dwell time at this region of bacterial cells.

77 We also show that dwell times at intersections depend on the angle between

78 ting because it has a high affinity and long dwell-time at its target site.

79 ttributable to extraction of leads with high dwell time because of infection, recall, or subsequent l

80 tistical analysis did not suggest an optimal dwell time, because this parameter did not significantly

81 Prolonged emergency department (ED) dwell time before admission to a critical care unit has

82 reversed by the L224A mutation with reduced dwell times between T cells and DCs.

83 that T cell activation hinges on rare, long-dwell time binding events that are an order of magnitude

84 the frequency of LCC reopening and the open dwell time, both of which are modulated by Ca(2+) influx

85 onged retrievable inferior vena cava filters dwell time by determining the inflection point when the

86 Remarkably, extending CB1R dwell times by preventing endocytosis substantially incr

87 monstrate with an experiment that, using the dwell time calculated by the RIFTA, the total dwell time

88 crucial step that guides the IBF process is dwell time calculation.

89 ted, including tandem mass spectrometry (MS) dwell time, CBS spray time, and extraction time.

90 The distribution of discrete dwell times, collected from an "ensemble" of 300 single

91 to arrive next injured patient decreases ED dwell times, complications, HLOS, and in-hospital mortal

92 ions for each conductance level required two dwell-time components, indicating that at each conductan

93 of the receptor complexes displayed multiple dwell-time components.

94 orm-like-chain analysis is hindered by brief dwell times compounded with thermal and instrumental noi

95 etics at the bilayer surfaces on the channel dwell time, concluding that the change would have to be

96 We show that dwell time contributes significantly to the quality of d

97 ith defined conformations, we found that TCR dwell times controlled Zap70 activity.

98 Finally, we uncovered that the longest codon dwell times could be explained by aminoacylation levels

99 -1-FAK1 decreased T-cell-dendritic cell (DC) dwell times dependent on LAT-Y171, leading to reduced DO

100 Gal4 dwell time depends on the affinity of the binding site a

101 nd IPSA2-0, identical to IPSA2 but without a dwell-time deviation constraint.

102 e; IPSA1-0, identical to IPSA1 but without a dwell-time deviation constraint; IPSA2, without a constr

103 The dwell time distribution of all observable pauses was ind

104 sensing the tail end of the pMHC-TCR binding dwell time distribution rather than its average properti

105 s that make significant contributions to the dwell-time distribution remain.

106 d globular actin exhibited a monoexponential dwell-time distribution, whereas CaMKII bound to F-actin

107 dy binding kinetics, rotational freedom, and dwell time distributions of a Cy5-labeled OTD (L1Cy5-7OT

108 Single-molecule dwell time distributions reveal two, well-differentiated

109 extracted from the images and combined into dwell time distributions that are fitted by kinetic func

110 exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hu

111 simulation (SMIS) tool to give the expected dwell-time distributions and relative populations of eac

112 bility to use a single kinetic scheme to fit dwell-time distributions arising from a variety of exper

113 This efficient method can be used to study dwell-time distributions for a broad class of molecular

114 Analysis of single-molecule dwell-time distributions for each state reveals that for

115 ing boundary method allows global fitting of dwell-time distributions for enzymes subject to differen

116 Statistical analysis of dwell-time distributions from single molecule trajectori

117 e able to use a single kinetic scheme to fit dwell-time distributions observed under different ligand

118 ed the absorbing boundary method to simulate dwell-time distributions of complex kinetic schemes, whi

119 ed absorbing boundary method to experimental dwell-time distributions of single-headed myosin V, and

120 s regular, producing narrow and well-behaved dwell-time distributions that fit a simple drift-diffusi

121 Fitting dwell-time distributions with sums of exponentials is wi

122 The method provides the expected dwell-time distributions, average transition rates, and

123 Dwell-time distributions, waiting-time distributions, an

124 ental observables such as protein number and dwell-time distributions.

125 leads in young patients (>40-year estimated dwell time) driven by high aggregate anticipated risk of

126 We quantified the protein mobility and dwell times during normal replication and following repl

127 ion regression analysis demonstrated that if dwell time exceeded 7 months, the risk of standard techn

128 The optimal dwell time for 40-80 nm particles, limiting both incompl

129 an alpha-hemolysin nanopore, we measured the dwell time for complexes of DNA with the Klenow fragment

130 is negatively correlated with the respective dwell time for different SH2 domains and the dwell time

131 Mean dwell times for pMHC:TCR molecular binding of 5 and 54 s

132 ay discriminate among ligands with different dwell times for receptor binding through a mechanism cal

133 The analysis of run lengths and dwell times for the two-motor complex, which has only on

134 tation rates sometimes unmatched the readout dwell times for transient signal acquisition.

135 ) or nonergodic with a broad distribution of dwell times for traps (continuous-time random walk).

136 inating between undocking and fusion events, dwell times for vesicle fusion after vesicle docking to

137 the number of cytoplasmic MTs and prolonged dwelling times for MTs after reaching the hyphal apex.

138 the cycling double-ring system, and thus of "dwell time" for the folding protein in the cis cavity, p

139 We modeled codon-specific ribosome dwell times from ribosome profiling, considering codon p

140 , patient position during the procedure, and dwell time had no statistically significant relation wit

141 distribution functions of the CW and the CCW dwell times have been measured for different CW biases.

142 le inferior vena cava filters with prolonged dwell times; however, there is no precise definition of

143 icy was performed to assess the impact on ED dwell time, ICU and hospital lengths of stay, complicati

144 receptor to an open state and increases its dwell time in an intrinsically occurring closed conforma

145 in reductions in neutrophil recruitment and dwell time in glomerular capillaries and in reactive oxy

146 The dwell time in one of these orientations was significantl

147 t of receptor triggering reliant only on TCR dwell time in phosphatase-depleted cell contacts constra

148 , we show that BDNF prolonged the average MT dwell time in spines and that this effect was dependent

149 ccounting for long pulses (comparable to the dwell time in t(1)) and short rotation periods.

150 he intrinsic pumping rates but increased the dwell time in the active pumping state.

151 lly incorrect structures produced during the dwell time in the cis cavity.

152 rfere with DNA gate dynamics and shorten the dwell time in the closed state.

153 ected by a mechanism that involves prolonged dwell time in the DZ where selected cells undergo accele

154 ect to symmetrical 1 M KCl, while the duplex dwell time in the nanopore remained acceptable for pulse

155 ism for RNAP II pausing in which a prolonged dwell time in the pre-translocated state increases the l

156 We propose a "dwell time in the target zone" model to explain the effe

157 indicated that adolescents showing increased dwell time in, and persistence of, a frontoinsular-defau

158 ceptor and its cofactors affect each other's dwell times in an asymmetric manner.

159 closed state of the DNA gate and to measure dwell times in each state.

160 oach brought on by the advent of microsecond dwell times in single particle ICP-MS allows for the det

161 , yielding insights into the distribution of dwell times in the paired complex and the propensity for

162 repeated and stochastic manner, and average dwell times in the respective microenvironments are dete

163 faster than previously reported, with state dwell-times in the 50 ms range, and report the kinetics

164 The median device dwell time (in d) differed across cannulation sites (p <

165 sitors and scan sampling showed substantial 'dwell times' in the Centre by common zoo standards and t

166 direction (P < .0001), while perforation and dwell time increased risk of a complicated retrieval by

167 Average nanopore dwell time increased without saturating as a function of

168 tics show even stronger dependence, with the dwell time increasing about 20-fold.

169 as a sigmoidal relationship to the crossover dwell time, indicating a strong bias for longer-lived cr

170 are expressed on CD4(+) T cells, while long dwell times induce negative selection.

171 ignalling, whereas those eliciting prolonged dwell times induce robust signalling.

172 to investigate how cytokine receptor binding dwell-times influence functional selectivity.

173 This has pushed pixel dwell times into the time domain of nanoseconds, resulti

174 This dwell time is 100-fold shorter than previously reported

175 the range of 680 to 695 degrees C (when the dwell time is 48 hours).

176 th the high primary intensity used here, the dwell time is not a parameter as critical as found in pr

177 dwell time for different SH2 domains and the dwell time is positively correlated with the local densi

178 well time calculated by the RIFTA, the total dwell time is shortened by a factor of two and the RMS i

179 is employed to flexibly adapt the calculated dwell time map to any IBF process intervals.

180 We analyzed these dwell time measurements in the framework of a two-state

181 5% versus 68%; P=0.05), and had shorter lead dwell time (median, 3.0 versus 4.0 years; P<0.0001) and

182 the signal passes to second messengers, the dwell time no longer regulates the signal.

183 during reorientation were illustrated using dwell time normalized visual maps.

184 y explain the long and widely distributed LN dwell times observed in vivo.

185 38%-56%; P<0.0001), and emergency department dwell time of </=20 minutes (33%-43%; P<0.0001).

186 nges rapidly at microtubule plus-ends with a dwell time of <1 s, indicating that single EB1 molecules

187 e externalized leads, 0%, 13%, and 26% had a dwell time of <3 years, 3 to 5 years, and >5 years, resp

188 critical as found in previous studies and a dwell time of 1 ms/px is used to minimize dynamic contam

189 A spatial resolution of 4 nm and a pixel dwell time of 20 micros were obtained.

190 etochlor, and 240/238 for metolachlor) and a dwell time of 30 ms were determined as optimized MS para

191 between 5 degrees C and 55 degrees C, with a dwell time of 30 s).

192 namically with the replisome with an average dwell time of 6.5 ms dependent on ATP hydrolysis, indica

193 ate constant of the order of 0.04 s(-1): the dwell time of a given stator in the motor is only approx

194 In reversible adhesion events, the dwell time of cells at the surface before departing was

195 h lower than in noninfected strains, and the dwell time of cryparin within the cell after labeling wa

196 gs to block translocation and to prolong the dwell time of EF-G on the ribosome.

197 is that the S670G point mutation reduces the dwell time of glutamate in its binding site.

198 e in proteostasis whereby Aha1 regulates the dwell time of Hsp90 with client.

199 is more flexible and facile to adapt to the dwell time of ICP-qMS owing to the adjustable throughput

200 the diffusion coefficient and decreases the dwell time of KCC2 at excitatory synapses.

201 Ps and rNTPs diminished the average nanopore dwell time of KF-DNA complexes in a concentration-depend

202 The average nanopore dwell time of KF-DNA complexes increased as a function o

203 ing within the PSD may modulate the synaptic dwell time of many TM proteins important for synaptic fu

204 pathway on lipid bilayers increases membrane dwell time of N-WASP and Arp2/3 complex, consequently in

205 In contrast, the dwell time of replisome-proximal molecules was ~8 s, con

206 We found that the dwell time of SH2 modules within the TIR illumination fi

207 the mean velocity, mean run length, and mean dwell time of the kinesin-1 motors decreased upon increa

208 f DPN to control feature size by varying the dwell time of the tip on the surface, and variation of t

209 counted for entirely by the prolonged thymic dwell time of Tregs.

210 ion, single-molecule studies showed that the dwell time of ubiquitin conjugates at the proteasome was

211 o an applied force of 110 pN, we measure the dwell times of 1647 unfolding events of individual ubiqu

212 The beta1-subunit increased the open dwell times of all three isoforms and decreased the clos

213 verage, activating pMHC ligands exhibit mean dwell times of at least a few seconds when bound to the

214 relations between apparent stoichiometry and dwell times of condensates to being proxies for the inte

215 The dwell times of different macromolecular structural or fu

216 a comprehensive analysis on the intranuclear dwell times of four steroid receptors and a number of kn

217 ntial dwell time distributions, with average dwell times of hundreds of milliseconds.

218 g ATP concentrations lead to both increasing dwell times of individual myosin II filaments and a glob

219 all three isoforms and decreased the closed dwell times of MANG and MDAL but increased the closed dw

220 es of MANG and MDAL but increased the closed dwell times of MSSN.

221 Using the dwell times of Pol II at each nucleosomal position we ex

222 to "limp", i.e., exhibit alternation in the dwell times of successive steps.

223 erpretations of FDAP/FRAP data have revealed dwell times of tau on MTs in the range of several second

224 igher dissociation energies imply longer DNA dwell times of the activator; the activator-bound gene m

225 Different dwell times of the FRET states were found for the distin

226 his analysis, we fit the fluctuations in the dwell times of the packaging motor of the bacteriophage

227 Dwell times of ~2 s were observed for the dispersed gyra

228 tes, through reducing the occurrence and the dwelling time of the long closed states whilst increasin

229 ysis, we have quantitatively measured RAG1/2 dwell time on 12RSS, 23RSS, and non-RSS DNA, confirming

230 ore, a systematic study of the dependence of dwell time on DNA length reveals a single power-law scal

231 This indicates that tau's dwell time on microtubules is sufficiently long to influ

232 gh affinities are achieved by increasing the dwell time on nucleosomes in order to compensate for red

233 but not the control condition, also altered dwell time on socially threatening faces not used in tra

234 Dwell time on socially threatening faces was assessed du

235 rget, but instead function by increasing the dwell time on target RNA.

236 only do the adducts influence the polymerase dwell time on the DNA but also its binding position and

237 nges in retinal bond length alternation, (2) dwell time on the excited state in the I fluorescent sta

238 but not the control condition, also reduced dwell time on threat, which partially mediated clinical

239 We analyze single-protein dwell times on DNA for different flow rates and conclude

240 Finally, measurements of TFP dwell times on surfaces show that tension reinforced the

241 n naive cell correlated with the TCR-p:MHCII dwell time or the amount of p:MHCII.

242 both undamaged and damaged DNA show multiple dwell times over three orders of magnitude: 0.3-0.8, 8.1

243 0.7250), patient position (p = 0.9839), and dwell time (p = 0.9330) had no significant impact on the

244 d a lower number of fixations and normalized dwell time per ROI compared with others, suggesting a mo

245 Deubiquitinases reduce polyubiquitin dwell times preferentially on clients that dissociate mo

246 We assessed patient age/sex, filter dwell time, procedural technical success, the use of adv

247 Agonists inducing short endocytic dwell times produce little or no beta-arrestin signallin

248 Measures included: dwell time (proportion of scan spent in that network sta

249 Based upon dwell time (range = 15-30 s) of the calcium waveform, th

250 wever, this is difficult to reconcile with a dwell time recently measured by single-molecule analysis

251 f the transient fusion pore by measuring its dwell time, relation to vesicular size, flickering and d

252 Our dwell-time resolution of 2.5 mus enables translocation t

253 Statistical analysis of the resolvable dwell times reveals rich kinetic details regarding the d

254 Statistical analysis of the preceding dwell times reveals that multiple ATPs bind during each

255 ts were conducted to investigate the optimal dwell time, safety, and scalability and to determine the

256 ximum likelihood algorithm that extracts the dwell time sequence from noisy data, and estimates state

257 We find that Gal4 dwell time sets the transcriptional burst size.

258 The dwell times showed a broad distribution, but were longer

259 aneous channel opening, with open and closed dwell times similar to those of maximally activated WT G

260 A valid dwell time solution should be non-negative and duplicate

261 The model predicts dwell time statistics, sequences of motor commands and i

262 the results on the general properties of the dwell-time statistics and the mechanism for ultrasensiti

263 dissipative allosteric model that generates dwell-time statistics consistent with the experimental r

264 on a general result on the properties of the dwell-time statistics for all equilibrium models, we sho

265 quilibrium models, we show that the observed dwell-time statistics imply that the flagellar motor swi

266 ficant fraction of molecules (characteristic dwell time tau = 192 +/- 15 s and tau = 98 +/- 15 s for

267 tly to the quality of data, with the optimal dwell time that limits split particle events, particle c

268 the model revealed site- and codon-specific dwell times that differed from those in yeast, as well a

269 CB1R), we identify ligand-specific endocytic dwell times, that is, the time during which receptors ar

270 the need for these cell gases, as at shorter dwell times the proportion of signal attributed to a nan

271 /min AF4 channel flow rate, and 5 ms spICPMS dwell time, the AF4-spICPMS can detect and quantify 40-8

272 elocity in nanotubes that limits the carrier dwell time; the high spin polarization in the manganite

273 predicts the observed differences in antigen dwell-time thresholds used by MHCI- and MHCII-restricted

274 phils and macrophages, yet have a sufficient dwell time to prey on pathogens.

275 between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors fo

276 We then derive a binomial distribution of dwell times to describe the stochastic dynamics of prote

277 exhibits much slower kinetics, extending the dwell times to tens of seconds.

278 companied by significantly increased overall dwell times, tripling for the most committed two thirds

279 ential fits to the distribution of unfolding dwell times under force-clamp.

280 heme in which particles in cages with random dwell times undergo correlated motions owing to interact

281 Selective RPE damage is feasible with dwell times up to 15 micros.

282 concentrations and storage temperatures for dwell times up to 24 h.

283 Dwell time varies with relative stoichiometry of the sig

284 Dwell time was also recorded.

285 ved analysis that identified that the safest dwell time was extended to the first 9 days for centrall

286 Newborns' average dwell time was negatively associated with childhood surg

287 The dwell time was shorter by orders of magnitude than that

288 Logistic regression identified that dwell time was the only risk factor for failure of stand

289 erior tilt angle, degree of perforation, and dwell time were higher for the complicated versus non-co

290 itions such as laser fluence, beam size, and dwell time were optimized for NP analysis to minimize NP

291 ross diurnal time and feeding regimen, codon dwell times were highly stable and conserved in human.

292 Individual dwell times were long enough to discriminate pMHC half-l

293 d the appearance of flickers and reduced the dwell time when astrocytes were mechanically stimulated,

294 Syt1 reduced the dwell time when astrocytes were stimulated either mechan

295 ubclavian catheter placement had the longest dwell time with a median of 16 days (interquartile range

296 is proposed to guarantee the minimized total dwell time with its non-negativity at each dwell point.

297 eptor can induce T-cell motility and shorten dwell times with dendritic cells (DCs).

298 subsets exhibited an increased steady state dwell time within splenic MZ areas.

299 ming, yet still contribute by increasing the dwell time within the SCS and by potentially enhancing T

300 eptors that engage IA(b)-Padi4 with moderate dwell times within a conventional docking orientation ar