ライフサイエンスコーパス: dynamic instability

1 ral fragility, quantified by regional linear dynamic instability).

2 their growth is limited by a size-dependent dynamic instability.

3 ucleation, 2) symmetrical elongation, and 3) dynamic instability.

4 tudy showing that these microtubules display dynamic instability.

5 underlies the ability of Msps to promote MT dynamic instability.

6 tes tubulin GTPase, and promotes microtubule dynamic instability.

7 ting tubulin GTPase and increase microtubule dynamic instability.

8 in the presence of severing and microtubule dynamic instability.

9 microtubule plus ends and thereby suppresses dynamic instability.

10 that interact with microtubules to regulate dynamic instability.

11 ween periods of growth and shrinkage, termed dynamic instability.

12 assembly and disassembly, a behavior called dynamic instability.

13 s-end-directed motor, and the loss of MTs by dynamic instability.

14 of these virus-induced shifts in microtubule dynamic instability.

15 w these transformations may contribute to MT dynamic instability.

16 owth-cone-mediated outgrowth and microtubule dynamic instability.

17 skewed cytoplasmic trajectories and altered dynamic instability.

18 a simple computational model of microtubule dynamic instability.

19 -domain), exhibiting classical properties of dynamic instability.

20 tion, but they have no effect on MT plus end dynamic instability.

21 ion for microtubule assembly, and suppresses dynamic instability.

22 ubulin, using a 2% glycerol buffer to reduce dynamic instability.

23 ading edge of the sheet in which MTs exhibit dynamic instability.

24 osome whereas plus ends are free and display dynamic instability.

25 end on microtubule transport and microtubule dynamic instability.

26 s by generating TuD subunits that then alter dynamic instability.

27 ween the elongation and shortening states of dynamic instability.

28 eeds originating from a self-amplified local dynamic instability.

29 the characteristic self-assembly process of dynamic instability.

30 ion and depolymerization-a behavior known as dynamic instability.

31 depolymerization from their plus ends termed dynamic instability.

32 lattice, and our overall understanding of MT dynamic instability.

33 erlying mechanism of adhesion hysteresis and dynamic instability.

34 a relatively small contribution compared to dynamic instability.

35 romatin and regulation of polar microtubules dynamic instability.

36 due changes in this region alter microtubule dynamic instability.

37 iparallel MTs while the MT plus ends exhibit dynamic instability.

38 ith EB1, a regulator of plus-end microtubule dynamic instability.

39 portant for revealing the mechanism of their dynamic instability.

40 ar how A-lattice seams influence microtubule dynamic instability.

41 cer-causing genes is to regulate microtubule dynamic instability.

42 le of the maturation time for the control of dynamic instability.

43 continuously remodel, a phenomenon known as dynamic instability.

44 o uncover cancer genes affecting microtubule dynamic instability.

45 hich control multiple aspects of microtubule dynamic instability.

46 nor ClipCG12 individually modulated plus-end dynamic instability.

47 lin organization and suppressing microtubule dynamic instability.

48 g periods of growth and shortening, known as dynamic instability.

49 le into filaments that treadmill and exhibit dynamic instability.

50 external forces such as climate can trigger dynamic instabilities.

51 Since the discovery of dynamic instability 20 years ago, no other biological po

52 l division and cell migration by suppressing dynamic instability, a "search and capture" behavior tha

53 Individual microtubules (MTs) exhibit dynamic instability, a behavior in which they cycle betw

54 e tubulin critical concentration or suppress dynamic instability; above these threshold concentration

55 Microtubule dynamic instability allows search and capture of kinetoc

56 MTs undergo dynamic instability, alternating between growth and shor

57 a helical fashion following treadmilling or dynamic instability, although the underlying mechanism i

58 Microtubules in yeast cells exhibit dynamic instability, although they grow and shrink more

59 (1) pathological brain activity representing dynamic instabilities and (2) necessary adjustments of e

60 reased the failing heart's susceptibility to dynamic instabilities and arrhythmias under rapid pacing

61 e of the most divergent of the Alps, display dynamic instability and also treadmill.

62 ifest differing frequencies because of their dynamic instability and are dictated by counteracting ge

63 ranches can occur independent of microtubule dynamic instability and can rely mostly on the transport

64 e sufficient to inhibit plus-end microtubule dynamic instability and cell migration without affecting

65 destabilizes the microtubule and thus powers dynamic instability and chromosome movement.

66 important biological phenomena, microtubule dynamic instability and end tracking.

67 rization revealed that AlfA does not display dynamic instability and is relatively stable in the pres

68 l thermodynamic and kinetic requirements for dynamic instability and its elimination by MTAs have yet

69 his model, we have studied the importance of dynamic instability and microtubule rotational diffusion

70 Dynamic instability and minus-end depolymerization gener

71 rowth rate certainly occurs independently of dynamic instability and probably does not involve hydrol

72 ion yeast, but the relative contributions of dynamic instability and rotational diffusion are not wel

73 rge, low-copy number plasmids, displays both dynamic instability and symmetrical, bidirectional polym

74 discriminate between different states of MT dynamic instability and thereby function differentially

75 of vinflunine and vinorelbine on microtubule dynamic instability and treadmilling and found that thes

76 of effects of vinflunine and vinorelbine on dynamic instability and treadmilling may contribute to t

77 nding the ends of ParM filaments, inhibiting dynamic instability, and acting as a ratchet permitting

78 tubulin structure and biochemistry, displays dynamic instability, and covers experimentally relevant

79 lts show that an isolated GeCH3 layer has no dynamic instability, and is a QSH insulator under reason

80 2 does not play a direct role in microtubule dynamic instability, and little is known about the cellu

81 ng fluid flow, which ultimately dictates the dynamics, instability, and transport properties of visco

82 nge, migration and rearrangement-among other dynamic instabilities-and are prone to dissociation upon

83 rial mini microtubules treadmill and display dynamic instability, another hallmark of eukaryotic micr

84 Because of this local dynamic instability, any initial small random thermal di

85 ore directional instability and kMT plus-end dynamic instability are coupled to oscillations in centr

86 describe mathematically how treadmilling and dynamic instability are mechanistically distinct MT beha

87 larity in the face of constant remodeling by dynamic instability are not known.

88 lts indicate that the effects of stathmin on dynamic instability are strongly but differently attenua

89 Proteins that promote dynamic instability are therefore central to microtubule

90 Current models invoke mechanisms based on dynamic instabilities arising from nonlinear interaction

91 a loss of the two-state behavior typical of dynamic instability as evidenced by the addition of a th

92 In accord with their minimal dynamic instability, assembled HeLa cell microtubules di

93 inus ends can be free and that modulation of dynamic instability at both ends can result in treadmill

94 CLIP-170 cooperatively regulate microtubule dynamic instability at concentrations below which neithe

95 Eribulin does not suppress dynamic instability at microtubule minus ends.

96 Eribulin targets microtubules, suppressing dynamic instability at microtubule plus ends through an

97 ng plus ends, tasidotin enhanced microtubule dynamic instability at minus ends, increasing the shorte

98 Polymerization-biased dynamic instability at one end and slow depolymerization

99 odimer to explain many of the differences in dynamic instability at plus and minus ends.

100 repared from epithelial cells, MTs displayed dynamic instability at plus ends and relative stability

101 (38), on its ability to modulate microtubule dynamic instability at steady-state in vitro.

102 We provide insight into the mechanism of dynamic instability, based on high-resolution cryo-EM st

103 developed buffer conditions that suppressed dynamic instability behavior by approximately 10-fold to

104 excursions of the microtubule plus end, and dynamic instability behavior of both ends during free, i

105 d MCF7 cells and measured the effects on the dynamic instability behavior of individual microtubules

106 It suppressed the dynamic instability behavior of individual microtubules

107 norganic phosphate analogues, suppressed the dynamic instability behavior of individual MTs and, thus

108 ere, we analyzed the effects of SCG10 on the dynamic instability behavior of microtubules in vitro, b

109 However, it strongly suppressed the dynamic instability behavior of the microtubules at thei

110 at microtubule ends that is responsible for dynamic instability behavior.

111 lso alter the ability of Tau to regulate the dynamic instability behaviors of microtubules.

112 ing indicates that stochastic differences in dynamic instability between plus and minus ends are resp

113 , there were no differences in any aspect of dynamic instability between the two beta-tubulin-overexp

114 lar manner to catastrophic depolymerization (dynamic instability) both in vitro and in vivo.

115 during which microtubules nucleate, undergo dynamic instability, bundle, and organize into a bipolar

116 recombinant homogeneous microtubules undergo dynamic instability, but they polymerize slower and have

117 the aramid amphiphile, that overcomes these dynamic instabilities by incorporating a Kevlar-inspired

118 fore ensures that suppression of microtubule dynamic instability by KIF4A is restricted to a specific

119 ents and speculate on how our explanation of dynamic instability can be changed to accommodate them.

120 shows that i), multiple MTs displaying high dynamic instability can drive steady and rapid chromosom

121 their binding to B-tubulin, MTPAs inhibit MT dynamic instability, cell cycle G2/M phase transition an

122 MTs treadmilled rapidly under the suppressed dynamic instability conditions, at a minimum rate of 0.2

123 were present together, the mixture modulated dynamic instability considerably.

124 Microtubule dynamic instability depends on the GTPase activity of th

125 believed to turn over by a mechanism termed dynamic instability: depolymerization and repolymerizati

126 However, this framework does not incorporate dynamic instability (DI), and there is work indicating t

127 Suppression of microtubule (MT) dynamic instability did not interfere with the delivery

128 Suppression of MT dynamic instability, displacement of EB1 from MT ends, o

129 Modeling dynamic instability-driven positioning mechanisms from m

130 or betaIII-tubulin, we analyzed microtubule dynamic instability during interphase by microinjection

131 rminal subunit(s), the MT minus end exhibits dynamic instability even though the terminal beta-tubuli

132 n hypothesized that spatial gradients in kMT dynamic instability facilitate mitotic spindle formation

133 dynamic tubulin-tubulin interactions control dynamic instability has benefitted from visualizing stru

134 es in guanosine triphosphate-(GTP-) mediated dynamic instability has previously been observed to occu

135 le microtubule turnover, likely derived from dynamic instability, has been documented in yeasts, plan

136 netochore, and factors affecting microtubule dynamic instability have been identified.

137 l serine residues of stathmin on microtubule dynamic instability have not been investigated systemati

138 However, previous models for microtubule dynamic instability have not considered such structures

139 cts: whether MAPs cause the rescue events of dynamic instability (i.e., the transitions from shorteni

140 pramolecular peptide nanofibers that display dynamic instability; i.e., they are formed by competing

141 strength is not the key mediator microtubule dynamic instability, implying that GTP acts elsewhere to

142 x keratinocytes and dermal papilla) leads to dynamic instabilities in the population dynamics resulti

143 by leveraging the innate chemical and thermo-dynamic instabilities in the SrTiO3-TiO2 system and non-

144 alue corresponds to the onset of high energy dynamic instabilities in this driven vortex state just a

145 readmilling may occur, but we do not predict dynamic instability in cells.

146 concentrations of nocodazole on microtubule dynamic instability in interphase cells and in vitro wit

147 We also demonstrated a dynamic instability in motion at densities typical of lo

148 etic models that proposed a dampened form of dynamic instability in pure actin where transient loss o

149 ther by constitutively enhancing microtubule dynamic instability in resistant cells or by rendering t

150 Next, we address microtubule dynamic instability in the context of structural informa

151 fies this mutualism as a principal source of dynamic instability in the interaction.

152 Since the discovery of dynamic instability in the mid-1980s, models for spindle

153 ent studies have revealed a pivotal role for dynamic instability in the response to salt stress condi

154 otubule assembly and to regulate microtubule dynamic instability in vitro.

155 g two key parameters of microtubule plus-end dynamic instability in Xenopus egg extract spindles.

156 They undergo a process known as dynamic instability, in which the ends of a microtubule

157 Microtubules self-assemble via "dynamic instability," in which the dynamic plus ends swi

158 plasts containing the centrosome, MTs showed dynamic instability indistinguishable from that in intac

159 essential for productive catalysis with the dynamic instability involved in regulation; these three

160 Dynamic instability is a critical property of microtubul

161 It is unclear whether dynamic instability is an essential feature of all actin

162 Dynamic instability is coupled to the GTPase activity of

163 This dynamic instability is critically important for MT funct

164 Regulation of microtubule dynamic instability is crucial for cellular processes, r

165 Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regu

166 existing theoretical estimates suggest that dynamic instability is efficient enough to allow capture

167 Microtubule (MT) dynamic instability is fundamental to many cell function

168 he most conserved proteins while microtubule dynamic instability is highly temperature sensitive.

169 MT rearward transport persists when MT dynamic instability is inhibited by 100-nM nocodazole bu

170 The growth and shortening of microtubules in dynamic instability is known to be modulated by microtub

171 tabilize microtubules under conditions where dynamic instability is observed and this has been inferr

172 Dynamic instability is promoted by the conserved XMAP215

173 Although microtubule (MT) dynamic instability is thought to depend on the guanine

174 nism based on spatially unbiased microtubule dynamic instability is too slow to account for the exper

175 nderlying mechanism of this property, called dynamic instability, is not fully understood.

176 ion, we found that when microtubules undergo dynamic instability, lateral captures predominate even i

177 ization of MinE over MinD oligomers triggers dynamic instability leading to detachment from the membr

178 in microtubules and suppressing microtubule dynamic instability, leading to mitotic arrest and cell

179 adial arrays centered at the centrosomes and dynamic instability, leading to persistent cycles of pol

180 lly observed images demonstrated that a pure dynamic instability model for kMT dynamics in the yeast

181 Microtubule dynamic instability modifies the landscape over time and

182 ParM is not related to tubulin, so its dynamic instability must have arisen by convergent evolu

183 As an approach toward understanding how dynamic instability occurs at the minus end, we investig

184 f packing efficiency while also depending on dynamic instabilities of the underlying framework topolo

185 ntains Kar9 asymmetry by facilitating proper dynamic instability of astral microtubules (aMTs).

186 Due to dynamic instability of cellular states the cells not kil

187 The dynamic instability of cortical microtubules (MTs) (i.e.

188 by simulating, in three spatial dimensions, dynamic instability of elastic microtubules anchored in

189 cent tubulin and measured the effects on the dynamic instability of individual microtubules.

190 The dynamic instability of microtubules (MTs), which refers

191 re potent anti-tumor agents that repress the dynamic instability of microtubules and arrest cells in

192 tification of a prokaryotic tubulin with the dynamic instability of microtubules and the ability to f

193 we found that cemadotin strongly suppressed dynamic instability of microtubules assembled to steady

194 The dynamic instability of microtubules has long been unders

195 Dynamic instability of microtubules is characterized by

196 Dynamic instability of microtubules is critical for mito

197 ether, these data suggest that a decrease in dynamic instability of microtubules is sufficient to dis

198 esis, we examined the effects of EMAP on the dynamic instability of microtubules nucleated from axone

199 ell metabolism as its energy source, and the dynamic instability of microtubules plays an important r

200 periphery of adenovirus-infected cells, the dynamic instability of microtubules plus ends shifted to

201 This might cause alterations in the dynamic instability of microtubules suggested to contrib

202 provides a comprehensive description of the dynamic instability of microtubules that includes not on

203 tubule-associated protein 2c (rMAP2c) on the dynamic instability of microtubules were examined by dir

204 rotein in primary melanoma could disrupt the dynamic instability of microtubules, inhibit cell divisi

205 light on the coupling between forces and the dynamic instability of microtubules, we focus on the inv

206 Building on previous theoretical work on the dynamic instability of microtubules, we propose here a s

207 -range couplings with a role in blocking the dynamic instability of microtubules.

208 may be related to the GTP cap that produces dynamic instability of microtubules.

209 d and uncapped states, a mild version of the dynamic instability of microtubules.

210 The mechanism may be related to the dynamic instability of microtubules.

211 vents that is mechanistically similar to the dynamic instability of microtubules.

212 in beta-tubulin and thereby account for the dynamic instability of microtubules.

213 lymerizing activity, these kinesins increase dynamic instability of microtubules.

214 factor molecules in stem cell spheroids, the dynamic instability of mitotic microtubules, the immunol

215 eliminate errors in MT organization and that dynamic instability of MT plus ends is a result of cappi

216 and 4R tau might differentially modulate the dynamic instability of MTs in vitro using video microsco

217 Dynamic instability of MTs is thought to be regulated by

218 in with an important role in maintaining the dynamic instability of neuronal microtubules.

219 The dynamic instability of ParM is regulated by adenosine tr

220 ot XKIF2, plays a central role in regulating dynamic instability of plus ends and controls spindle le

221 mechanism in bacteria which is driven by the dynamic instability of polymerizing filaments, which gro

222 tracellular metabolite of tasidotin, altered dynamic instability of purified microtubules in a qualit

223 improve efficacy by taking advantage of the dynamic instability of radioresistance.

224 ation by small actin bundles is limited by a dynamic instability of single actin filaments, and there

225 ns are thought to function by modulating the dynamic instability of spindle microtubules, and in vitr

226 Dynamic instability of such structures beckons control o

227 Assuming that aging results from a dynamic instability of the organism state, we designed a

228 Here we describe a dynamic instability of the surface between impacting mat

229 This dynamic instability of the system introduces a second ci

230 onsistent with antimitotics that inhibit the dynamic instability of tubulin and initiate apoptosis, t

231 Under steady-state conditions, the dynamic instability of unattached ParM filaments provide

232 effects on microtubule polymerization confer dynamic instability on microtubules assembled in cell-fr

233 Suppression of MT dynamic instability or EB1 depletion increased cortactin

234 ike microtubules, may not be able to undergo dynamic instability or to store energy in the polymer fo

235 turally support microtubules, modulate their dynamic instability, or regulate the activity of associa

236 In addition to these changes in dynamic instability, overexpression of beta5-tubulin cau

237 for the observed isotype-specific changes in dynamic instability parameters and tune tubulin's polyme

238 0Glued, both separately and together, on the dynamic instability parameters at plus ends of purified

239 We also found that the dynamic instability parameters from twisted growth mutan

240 f plus and minus end dynamics using measured dynamic instability parameters reproduces our experiment

241 llows us to correlate macroscopic behaviors (dynamic instability parameters) with microscopic structu

242 esults show that within a narrow range of MT dynamic instability parameters, both models can reproduc

243 e differences in their actions on individual dynamic instability parameters, morphologically detectab

244 f the two proteins individually did modulate dynamic instability, perhaps by a combination of effects

245 Dynamic instability, polarity, and spatiotemporal organi

246 rrent two-state GTP cap model of microtubule dynamic instability proposes that a terminal crown of GT

247 ha may play a role in modulating microtubule dynamic instability, providing a mechanism for the modif

248 e centrosome and free plus ends that exhibit dynamic instability, recent observations show that the m

249 bited markedly reduced abilities to regulate dynamic instability relative to wild-type Tau.

250 erlying atomistic mechanistic details of the dynamic instability remains unclear.

251 A full understanding of the mechanism of dynamic instability requires that one distinguish which

252 ortantly, K370 had independent effects on MT dynamic instability, resulting in formation of long MTs

253 The proposal that microtubule dynamic instability results from stabilization of microt

254 SNA1 modulates all parameters of microtubule dynamic instability-slowing down the rates of growth, sh

255 La cell microtubules exhibit remarkably slow dynamic instability, spending most of their time in an a

256 that contributes to its function, including dynamic instability, spontaneous nucleation, and bidirec

257 Microtubules display dynamic instability, switching stochastically between gr

258 The 'plus' ends of microtubules exhibit dynamic instability, switching stochastically from growt

259 activity and were more potent at regulating dynamic instability than their compromised singly pseudo

260 r that this feature of atrial cells leads to dynamic instabilities that may underlie atrial arrhythmi

261 arine-terminating glaciers associated with a dynamic instability that is generally not considered in

262 Here, I review the canonical explanation of dynamic instability that was fleshed out in the years af

263 Although microtubules are known for dynamic instability, the dynamicity is considered to be

264 Dynamic instability, the stochastic switching between gr

265 (MTs) are cytoskeletal polymers that undergo dynamic instability, the stochastic transition between g

266 Dynamic instability-the switching of a two-state polymer

267 ion and depolymerization, i.e. they exhibit "dynamic instability." This behavior is crucial for cell

268 f Cdc14 activity, microtubules maintain high dynamic instability; this correlates with defects in bot

269 number for each pole, exhibited asynchronous dynamic instability throughout the cell cycle, growing a

270 The change in behavior of the plus end from dynamic instability to persistent growth correlated with

271 tely 10-fold to minimize the contribution of dynamic instability to total tubulin-GTP exchange.

272 be read out by dynamic MTs undergoing simple dynamic instability to ultimately break cell symmetry.

273 ntial, as predicted by models of microtubule dynamic instability, to a peaked distribution.

274 and found that the tips of dendrites undergo dynamic instability, transitioning rapidly and stochasti

275 of replacing H(2)O with D(2)O on microtubule dynamic instability, treadmilling, and steady-state GTPa

276 We suppressed dynamic instability using nocodazole, and we observed no

277 uivalent intracellular taxol concentrations, dynamic instability was inhibited similarly in the two c

278 the growth phase in microtubules manifesting dynamic instability was provided by our observation that

279 When its dynamic instability was studied by video-DIC microscopy,

280 wever, in the presence of 150 nm paclitaxel, dynamic instability was suppressed to a significantly le

281 Dynamic instability was very similar in the two cases, d

282 To understand the mechanism of dynamic instability, we determine structures of ParM fil

283 algorithms used by insects to control their dynamic instability, we develop a simulation tool to stu

284 ssible mechanisms responsible for changes in dynamic instability, we examined the effects of 4 nM to

285 jor effects of vinflunine and vinorelbine on dynamic instability were a slowing of the microtubule gr

286 The parameters of microtubule dynamic instability were compared for interphase LLCPK-1

287 in yeast tubulin demonstrates that all alter dynamic instability whereas a subset disrupts the intera

288 se a three-state conformational cap model of dynamic instability, which has three structural states a

289 ton in all eukaryotic cells) depend on their dynamic instability, which is altered by various factors

290 In metaphase, microtubules show high dynamic instability, which is thought to aid the 'search

291 e phragmoplast and that the majority exhibit dynamic instability with higher turnover rates nearer to

292 disassembly and cap dynamics, we generate MT dynamic instability with rates and transition frequencie

293 otubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongati

294 Microtubules undergoing dynamic instability without any stabilization points con