ライフサイエンスコーパス: dynein arm

1 motor units are controlled within the outer dynein arm.

2 fects in ciliary structure, 66% in the outer dynein arm.

3 heavy chain that is a component of the inner dynein arm.

4 ubunit is an integral component of the outer dynein arm.

5 imately 1.0 x 10(-6) dyne (10 pN) per intact dynein arm.

6 d sequence of the 1alpha Dhc of the I1 inner dynein arm.

7 the alpha and beta heavy chains of the outer dynein arm.

8 tubules and the motor domain(s) of the outer dynein arm.

9 ng because of loss of some but not all outer dynein arms.

10 sult in loss of the spermatid axonemal outer dynein arms.

11 other essential for assembling the axonemal dynein arms.

12 ubules occur by cyclic cross-bridging of the dynein arms.

13 a reduction in the number of outer and inner dynein arms.

14 strains had defects in the f class of inner dynein arms.

15 ons are associated with defects in the outer dynein arms.

16 s, particularly involving the inner or outer dynein arms.

17 identify novel partners for inner and outer dynein arms.

18 nger flagella, but the flagella lacked outer dynein arms.

19 signals between the central microtubules and dynein arms.

20 liary dyskinesia caused by the loss of outer dynein arms.

21 the doublet and is linked to different inner dynein arms.

22 it that helps connect the N-DRC to the outer dynein arms.

23 assembly and/or trafficking of the axonemal dynein arms.

24 ant cannot assemble any outer and some inner dynein arms.

25 d defects in the assembly of inner and outer dynein arms.

26 latory signals between the radial spokes and dynein arms.

27 mutants lacking C1d and distinct subsets of dynein arms.

28 ston's organ, the fly's auditory organ, lack dynein arms.

29 sed on sliding doublet microtubules by inner dynein arms.

30 arms, in which forces are generated by inner dynein arms.

31 immotile flaccid cilia that completely lack dynein arms.

32 ein, in between radial spoke 1 and the outer dynein arms.

33 of those strains that fail to assemble outer dynein arms.

34 latory signals between the radial spokes and dynein arms.

35 ely affects CBF through direct influences on dynein arms.

36 ry complex (N-DRC) is proposed to coordinate dynein arm activity and interconnect doublet microtubule

37 ansduction cascade that ultimately regulates dynein arm activity.

38 -radial spoke control pathway that regulates dynein arm activity.

39 2 is an essential subunit of flagellar outer dynein arms allows us to propose a detailed mechanism wh

40 Unlike the Tctex2 homologue within the outer dynein arm, analysis of a Tctex2b-null strain indicates

41 iliary outer dynein arm defects, fewer inner dynein arm and central apparatus defects (P<0.001), and

42 y chain genes: beta heavy chain of the outer dynein arm and heavy chain isotype 1B (DYH1B), by using

43 ally, in the pf13A mutant, which lacks outer dynein arms and inner dynein arm c, the estimates were E

44 onemes from mutants that lack both the outer dynein arms and the MIA complex, I1 dynein failed to ass

45 the chemomechanical energy conversion by the dynein arms and their orchestrated movement in cilia/fla

46 IFT46 has short, paralyzed flagella lacking dynein arms and with central pair defects.

47 tein can be extracted from oda1 (lacks outer dynein arms) and pf17 axonemes with 0.5 M KI, and copuri

48 ls of mammalian epithelia are 9 + 2, possess dynein arms, and are motile.

49 s had markedly reduced HEATR2 levels, absent dynein arms, and loss of ciliary beating.

50 rmal with respect to the 9 + 2 microtubules, dynein arms, and radial spokes but one of the two centra

51 d to generate symmetric waveforms, the outer dynein arms are potential targets of the central pair-ra

52 o cilia and flagella, multi-subunit axonemal dynein arms are thought to be stabilized and pre-assembl

53 own of dnaaf3 in zebrafish likewise disrupts dynein arm assembly and ciliary motility, causing primar

54 Strikingly, multiple dynein arm assembly factors show structural similarities

55 chanisms critical for motile cilia function: dynein arm assembly for C21orf59 and assembly of the nex

56 Of the uncloned ODA genes required for outer dynein arm assembly in Chlamydomonas, ODA5 and ODA10 are

57 hat Pontin and Reptin function to facilitate dynein arm assembly in cytosolic foci enriched with R2TP

58 Dynein arm assembly in smh mutant zebrafish was rescued

59 he cytoplasm of wild-type cells and 11 outer dynein arm assembly mutant strains (oda1-oda11) by Weste

60 down in zebrafish and planaria blocked outer dynein arm assembly, and ccdc65 knockdown altered cilia

61 NAI2, the first appreciated step in axonemal dynein arm assembly.

62 Most are outer dynein arm associated and show that there are multiple c

63 These results identify Ccdc103 as a dynein arm attachment factor that causes primary ciliary

64 is involved in preassembly and stability of dynein arms before they are transported into the cilia.

65 2-1 axonemes exhibited a novel f class inner dynein arm biochemical phenotype; the 138-kD f intermedi

66 ysfunction of both flagellar inner and outer dynein arms but does not require the cytoplasmic isozyme

67 Inner dynein arms, but not outer dynein arms, require the acti

68 ~0.7-mum cilia lacking both inner and outer dynein arms, but with intact doublet microtubules and ce

69 whose cilia demonstrated an absence of inner dynein arms by electron microscopy.

70 re appear to alter the activity of the outer dynein arms by modification of the gamma-dynein heavy ch

71 ant, which lacks outer dynein arms and inner dynein arm c, the estimates were EI = 777 +/- 184 pN.mum

72 e of ATP, the structural conformation of the dynein arms can be clearly resolved by negative contrast

73 The group with absent inner dynein arm, central apparatus defects, and microtubular

74 that mRNAs encoding interacting HCs of outer dynein arms colocalize in cytosolic foci, along with nas

75 sient distal localisation of outer and inner dynein arm complexes (ODAs and IDAs) are consistent with

76 Motility is powered by dynein arm complexes that are assembled in the cytoplasm

77 is found in both the cell body and the inner dynein arm complexes within flagella [3, 4].

78 r, whereas the expression levels of multiple dynein arm components remain unchanged or become elevate

79 ather appear to result from defects in outer dynein arm components.

80 C21orf59 caused loss of both outer and inner dynein arm components.

81 ogs with presence of genes encoding axonemal dynein arm components.

82 In isolated axonemes with a normal dynein arm composition, TTLL6 deficiency did not affect

83 The rescue of inner dynein arms containing p28 in ida4-wild-type dikaryons p

84 Rescue of inner dynein arms containing p28 in ida4fla10-fla10 dikaryons

85 The Chlamydomonas outer dynein arm contains three distinct heavy chains (alpha,

86 and height z-scores than the isolated outer dynein arm defect (n = 55) group.

87 rowth indices compared with those with outer dynein arm defects and DNAH5 mutations, respectively.

88 h situs abnormalities had more ciliary outer dynein arm defects, fewer inner dynein arm and central a

89 rate that animals that completely lack outer dynein arms display a significant decline in beat freque

90 Although the outer dynein arm docking complex is necessary to form arrays o

91 The outer dynein arm-docking complex (ODA-DC) is a microtubule-ass

92 The outer dynein arm-docking complex (ODA-DC) targets the outer dy

93 known subunits of the outer arm or the outer dynein arm-docking complex (ODA-DC), and because genetic

94 This factor, termed the outer dynein arm-docking complex (ODA-DC), previously was show

95 The axoneme-associated inner and outer dynein arms drive sliding of adjacent axoneme microtubul

96 Reptin-Lrrc6/Seahorse complex is involved in dynein arm formation.

97 <0.001), and more mutations in ciliary outer dynein arm genes (DNAI1 and DNAH5; P=0.022).

98 tex2b is required for the stability of inner dynein arm I1 and wild-type axonemal dynein function.

99 a previously undescribed component of inner dynein arm I1.

100 n vivo imaging in Xenopus to show that inner dynein arm (IDA) and outer dynein arm (ODA) subunits are

101 fects (ODA alone; n = 54) and ODA plus inner dynein arm (IDA) defects (ODA + IDA; n = 18) versus subj

102 as well as uniflagellate cells lacking inner dynein arms (ida3) or outer dynein arms (oda2) were stud

103 ects, often caused by dual loss of the inner dynein arms (IDAs) and outer dynein arms (ODAs), which p

104 targeting the assembly of a subset of inner dynein arms (IDAs) to a specific location in the 96 nm r

105 owed that ODA16 is a cofactor which promotes dynein arm import.

106 al I1 dynein (dynein f) is the largest inner dynein arm in cilia and a key regulator of ciliary beati

107 ith 0.6 M NaCl and comigrates with the outer dynein arm in sucrose density gradients.

108 0.6 M NaCl and cofractionates with the outer dynein arm in sucrose density gradients.

109 Formation of flagellar outer dynein arms in Chlamydomonas reinhardtii requires the OD

110 In contrast, the rescue of outer dynein arms in oda2-wild-type dikaryons progressively oc

111 In contrast, rescue of outer dynein arms in oda2fla10-fla10 dikaryons was similar to

112 e have analyzed the rescue of inner or outer dynein arms in quadriflagellate dikaryons by immunofluor

113 onfirmed by EM, which revealed missing outer dynein arms in the respiratory cilia.

114 ong arm result in loss of the axonemal outer dynein arms in the spermatid tail, while three ks-2 alle

115 , but the lack of N-DRC (in pf3; cnk11-6) or dynein arms (in pf13A) significantly reduces interdouble

116 ule sliding in axonemes that also lack outer dynein arms, in which forces are generated by inner dyne

117 heir architecture, including partial loss of dynein arms, incomplete closure of the B-tubule, and occ

118 ly 90% of PCD patients and involve the outer dynein arms, inner dynein arms, or both.

119 for the stable assembly of TCTEX1 and inner dynein arm interacting proteins IC97 and FAP120.

120 ein arm light chain, or IC69(ODA6), an outer dynein arm intermediate chain.

121 or become elevated, the density of axonemal dynein arms is reduced in reptin(hi2394) mutants.

122 The LC2 outer dynein arm light chain of Chlamydomonas reinhardtii is a

123 uorescence microscopy of p28(IDA4), an inner dynein arm light chain, or IC69(ODA6), an outer dynein a

124 ZMYND10 mutations conferred dynein-arm loss seen at the ultrastructural and immunofl

125 he EST for the beta heavy chain of the outer dynein arm mapped to chromosome region 7p15, and the EST

126 isorder frequently caused by non-assembly of dynein arm motors into cilia and flagella axonemes.

127 t, a cargo and an adapter of inner and outer dynein arms moved independently of ARMC2, indicating tha

128 tic phenotypes characteristic of other inner dynein arm mutations.

129 key structural element of the ciliary outer dynein arm (ODA) critical for normal ciliary activity an

130 respiratory pathogens in subjects with outer dynein arm (ODA) defects (ODA alone; n = 54) and ODA plu

131 on six unrelated probands with ciliary outer dynein arm (ODA) defects.

132 ts in multiple genes encoding dyneins, outer dynein arm (ODA) docking complex subunits, and cytoplasm

133 Multisubunit outer dynein arm (ODA) motor complexes, produced and preassemb

134 n reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia.

135 o show that inner dynein arm (IDA) and outer dynein arm (ODA) subunits are partitioned into non-overl

136 elated probands with ciliary outer and inner dynein arm (ODA+IDA) defects.

137 ble Oda5p does not cosediment with the outer dynein arm/ODA-DC in sucrose gradients.

138 ls lacking inner dynein arms (ida3) or outer dynein arms (oda2) were studied.

139 humans showed disruptions of outer and inner dynein arms (ODAs and IDAs, respectively).

140 Outer dynein arms (ODAs) are essential for ciliary motility an

141 Outer dynein arms (ODAs) attach to the doublets at specific in

142 Multiprotein complexes referred to as outer dynein arms (ODAs) develop the main mechanical force to

143 The outer dynein arms (ODAs) of the flagellar axoneme generate for

144 Outer dynein arms (ODAs) require assembly factors to assist th

145 Assembly of outer dynein arms (ODAs) requires multiple steps and involves

146 es, usually as a result of loss of the outer dynein arms (ODAs) that power cilia/flagella beating.

147 ss of the inner dynein arms (IDAs) and outer dynein arms (ODAs), which power cilia and flagella beati

148 mplexes including the force-generating outer dynein arms (ODAs).

149 ryotic cilia and flagella are axonemal outer dynein arms (ODAs).

150 x poise effect is mediated through the outer dynein arms (ODAs).

151 Outer and inner dynein arms on the doublets mediate axoneme motility [1]

152 ial for assembly of the ODA-DC and the outer dynein arm onto the doublet microtubule.

153 nts and involve the outer dynein arms, inner dynein arms, or both.

154 omponent of the central pair, radial spokes, dynein arms, or structures defined by the mbo waveform m

155 evious studies, suggest that flagellar outer-dynein arms preassemble into a complete Mr approximately

156 the top of the gradient, not with 23S outer dynein arm proteins.

157 structures associated with motility such as dynein arms, radial spokes or nexin.

158 he intraflagellar transport system, axonemal dynein arms, radial spokes, the 96-nm ruler, and microtu

159 domonas reinhardtii resulted in absent outer dynein arms, reduced flagellar beat frequency, and decre

160 enotypes that resembled those of known inner dynein arm region mutant strains, but did not have bioch

161 Inner dynein arms, but not outer dynein arms, require the activity of KHP1(FLA10) to reac

162 markably, mutations in either outer or inner dynein arm restore motility to mutants lacking C1d, alth

163 ut) mice, embryonic LRO monocilia lack outer dynein arms resulting in immotile cilia, impaired flow a

164 and the ciliary axonemes of these cells have dynein arms, some cilia remain immotile.

165 late with an approximately 45% loss of outer dynein arm structures.

166 ation between RS2 and the dynein motor inner dynein arm subform c (IDAc), providing a molecular basis

167 Transport of the inner dynein arm subunit p28(IDA4) in Chlamydomonas flagella r

168 We tested Chlamydomonas outer-dynein arm subunit stability and assembly in the cytopla

169 e into a complete Mr approximately 2 x 10(6) dynein arm that resides in a cytoplasmic precursor pool

170 tility requires the assembly of multisubunit dynein arms that drive ciliary bending.

171 , the demonstration of oscillatory forces in dynein arms, the determination of the force-velocity rel

172 incorporates discrete representations of the dynein arms, the passive elastic structure of the axonem

173 sely associated structures such as the inner dynein arms, the radial spokes, and the calmodulin- and

174 complex distorter, Tctex2, within the outer dynein arm, these results support the hypothesis that tr

175 ealed that LC7b interacts with LC3, an outer dynein arm thioredoxin; DC2, an outer arm docking comple

176 -associated structure that targets the outer dynein arm to its binding site on the flagellar axoneme.

177 m-docking complex (ODA-DC) targets the outer dynein arm to its correct binding site on the flagellar

178 ot in cilia, which suggests a role in either dynein arm transport or assembly.

179 lpha-tubulin or p28, a component of an inner dynein arm, which suggests specificity with respect to t

180 aining axonemes composed of microtubules and dynein arms, which provide ATP-driven motility.

181 dividuals in six families with reduced outer dynein arms who carried mutations in CCDC103.

182 ecules involved in active transport of inner dynein arms within flagella we searched for polypeptides

183 e 17S complex transports precursors of inner dynein arms within flagella.

184 the cytoplasmic matrix more frequently than dynein arms within the axoneme.