ライフサイエンスコーパス: dysregulate

1 neurological disorders in which dopamine is dysregulated.

2 ng synaptic pruning, which is detrimental if dysregulated.

3 c alcohol exposure and protracted withdrawal dysregulate 5-HT signaling in the CeA.

4 DHT dysregulates a number of genes enriched for syndromic ca

5 Mice deficient in Fgl2 had dysregulated Ab responses at steady-state and upon immun

6 If the balance between IL-18 and IL-18BP is dysregulated, abnormal levels of free bioactive IL-18 ar

7 therein of BRCA1 PARsylation results in the dysregulated accumulation in these foci of BRCA1 complex

8 in I/R injury in the heart and triggered by dysregulated accumulation of autophagosomes due to upreg

9 Elucidating mechanisms associated with dysregulated activation of specific receptors may identi

10 d event during adaptive immune response, but dysregulated activation of this signaling pathway can le

11 lammation is anemia, which may be related to dysregulated activity of hematopoietic stem and progenit

12 al load, uncontrolled inflammatory response, dysregulated adaptive immunity, coagulation abnormalitie

13 r cell proliferation and differentiation, is dysregulated after ZIKV infection.

14 imer's disease (AD), but whether and how tau dysregulates AHN in AD remain poorly understood.

15 Cancer cells are dysregulated and addicted to continuous supply and metab

16 -inflammatory cytokine signaling pathways as dysregulated, and this was further substantiated by dete

17 remature infants, a disease characterized by dysregulated angiogenesis and impaired vascular and alve

18 tors, CB1 and CB2, show compromised PDZ with dysregulated angiogenic factors, resulting in the retent

19 Steroidogenic T cells dysregulate anti-tumor immunity, and inhibition of the s

20 Dysregulated autophagy contributes to the pathogenesis o

21 europsychiatric diseases are associated with dysregulated basal ganglia direct-pathway activity.

22 se) to assess the effects of the compound in dysregulated behaviors within the transgenic models.

23 teric modulator, ABM300, to ameliorate these dysregulated behaviors.

24 y we found 47 metabolites were significantly dysregulated between HC and the premutation groups (PM).

25 ate to the gut inflammation/permeability and dysregulated bile acid metabolism observed in opioid-exp

26 abnormal axial skeleton segmentation due to dysregulated biogenesis of notochord vacuoles and notoch

27 In sum, IGFs are dysregulated both before and after the clinical diagnosi

28 Biochemical analyses revealed dysregulated brain mTOR and GSK3beta signaling, consiste

29 lls during lysine limitation when growth was dysregulated, but not during glucose limitation when gro

30 specific transcriptional programs, which are dysregulated by multiple mechanisms, including genomic a

31 LnCeVar-Hallmark identifies dysregulated cancer hallmarks of variation-ceRNA events.

32 The importance of dysregulated CD86 expression in Tet2- and Tet3-deficient

33 ist for nonresponders, because the etiology, dysregulated cell types, and signaling pathways are unkn

34 es an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathoge

35 he hypothesis that subacute exposure to DiNP dysregulates cellular, endocrine, and immunological aspe

36 Dysregulated cholesterol homeostasis promotes the pathol

37 Dysregulated cholesterol metabolism is implicated in a n

38 s reveal four distinct AM sub-clusters and a dysregulated cluster-specific pathway in the HDAC3-defic

39 ated damage and pathogenesis associated with dysregulated coagulation.

40 The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneur

41 ate a host of biological processes, and when dysregulated, contribute to disease.

42 pathogenesis of these diseases is related to dysregulated cytokine activity.

43 Dysregulated cytokine expression by T cells plays a pivo

44 singly recognized as disease entities, where dysregulated cytokines contribute substantially to tissu

45 ications for psychiatric disorders involving dysregulated dopamine signaling.

46 in to uncover how innate immune signaling is dysregulated downstream of TBK1/IKKepsilon in a subset o

47 The identified effector genes and the dysregulated downstream pathways provide hints of possib

48 m cells in the gastrointestinal tract and is dysregulated during carcinogenesis.

49 cally active cholinergic interneurons become dysregulated during chronic L-DOPA administration and pa

50 el the structural and functional alterations dysregulated during depression.

51 he activities of many signaling pathways are dysregulated during the progression of neurodegenerative

52 pen early in the secretory pathway are often dysregulated during tumorigenesis.

53 The recognition that dysregulated dynein-mediated transport of nephrin in R21

54 Dysregulated effector binding due to conformational chan

55 vailing models of trauma intrusions focus on dysregulated emotional processes, we hypothesize that a

56 Dysregulated endocannabinoid signaling was linked to inf

57 duction of reactive oxygen species caused by dysregulated endothelial nitric-oxide synthase (eNOS) ac

58 Dysregulated endothelial permeability contributes to man

59 y analyses revealed that the deletion of ALX dysregulated energy metabolism driving toward age-relate

60 loss, aberrant protein phosphorylation, and dysregulated energy metabolism.

61 n ichthyosis-like phenotype characterized by dysregulated epidermal de novo lipid synthesis, altered

62 ronized activation in the healthy heart, the dysregulated excess in this pathway underscores asynchro

63 g to decreased WNT signaling and concomitant dysregulated expression of relevant genes.

64 Figla deficiency dysregulates expression of meiosis-related genes (e.g. S

65 Given the role of dysregulated expressions of cytoskeletal and cytoskeleto

66 onnective tissue pathologies associated with dysregulated extracellular matrix homeostasis.

67 on Parkinson's disease mechanisms have shown dysregulated extracellular transport of alpha-synuclein

68 me proliferator-activated receptor alpha and dysregulated fatty acid metabolism as potential therapeu

69 Dysregulated fear conditioned responses have been associ

70 y response to fungal cell walls, likely by a dysregulated feed-forward loop involving amplified neutr

71 that the commensal microbiome is frequently dysregulated following allo-SCT and that this dysbiosis

72 ionship with nicotine dependence severity is dysregulated following chronic nicotine administration-i

73 on and endogenous transposable elements were dysregulated following MIA, potentially connecting MIA t

74 ected the increased CRTH2 expression and its dysregulated functions.

75 The most highly dysregulated gene ADCYAP1 (encoding PACAP) was associate

76 near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differe

77 of schizotypy and prior histological data on dysregulated gene expression in schizophrenia.

78 provides a mechanistic understanding of the dysregulated gene transcription patterns in SCZ and crea

79 es and to successfully extract significantly dysregulated gene-gene interactions from the data.

80 Significantly dysregulated genes and pathways were determined, and tho

81 ory network analysis showed that many of the dysregulated genes are targeted by multiple transcriptio

82 Intriguingly, 22 of the dysregulated genes encoded known NDD genes, suggesting U

83 We detected hundreds of dysregulated genes in Mef2c-Het cortex, including signif

84 We discovered that the significantly dysregulated genes in the context of immunosuppression a

85 blasts highlighted the overrepresentation of dysregulated genes involved in ECM organization, or bein

86 show a detailed analysis of the most highly dysregulated genes on chromosome 18 and those genome-wid

87 nally, we found three subnetworks of jointly dysregulated genes within the functional gene network wh

88 We identified 521 significantly dysregulated genes, including 61 transcription factors i

89 that Sox2 targeted a large number of ethanol-dysregulated genes.

90 IL4RA was among the top 3 central dysregulated genes.

91 compared their interactions with the ethanol-dysregulated genes.

92 xposure may increase AD risk in offspring by dysregulating genes associated with AD neuropathology an

93 tic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism associated wit

94 tion, and 4) prevent and reverse obesity and dysregulated glucose homeostasis in multiple mouse model

95 ecline in retinal pyruvate levels coupled to dysregulated glucose metabolism prior to detectable opti

96 hways, metabolite sinks and bottlenecks, and dysregulated glucose storage in patients with AH.

97 Dysregulated hematopoiesis occurs in several chronic inf

98 Further, RNA-seq analysis identified dysregulated HIF-1alpha target genes that are relevant t

99 iological evidence indicates the presence of dysregulated homeostatic biological pathways in depresse

100 lets may drive lung injury and contribute to dysregulated host defense in CF lung disease.

101 Dysregulated host immune response in the lung is a key f

102 is a life-threatening syndrome defined as a dysregulated host response to infection and is character

103 fe-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading ca

104 fe-threatening organ dysfunction caused by a dysregulated host response to infection.

105 atients in intensive care worldwide due to a dysregulated host response to infection.

106 sed by SARS-CoV-2 is largely the result of a dysregulated host response, followed by damage to alveol

107 defective Bcl-6(+) T(FH) cell generation and dysregulated humoral immune induction early in COVID-19

108 that TREX1 D18N catalytic deficiency causes dysregulated IFN-I signaling and autoimmunity in mice.

109 te function is, at least in part, related to dysregulated IkappaKalpha/beta activation, and that Ikap

110 Dysregulated IL-11 signaling has been implicated in seve

111 Since the connection of dysregulated IL-17 and psoriasis pathogenesis turned out

112 tment of sepsis, a syndrome resulting from a dysregulated immune response and inappropriate activatio

113 protection or induces pathogenesis through a dysregulated immune response remains unclear.

114 Sepsis is characterized by a dysregulated immune response, metabolic derangements and

115 re cases of SARS-CoV-2 are associated with a dysregulated immune response.

116 Exacerbated inflammation and dysregulated immune responses involving T and myeloid ce

117 Dysregulated immune responses may lead to antibodies aga

118 ctor T-bet have been described in normal and dysregulated immune responses.

119 known to be associated with inflammation and dysregulated immune responses.

120 Although corticosteroids dampen the dysregulated immune system and sometimes are prescribed

121 Clinical features of dysregulated immunity are recorded with a standardised q

122 biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic infla

123 These results suggest dysregulated immunoregulation is associated with poor pr

124 Dysregulated immunothrombosis in severe acute respirator

125 molecules that broadly correct gene networks dysregulated in a human induced pluripotent stem cell (i

126 e show that ROCK2 activity is constitutively dysregulated in ABC-DLBCL but not in GCB-DLBCL and BL.

127 onstrate that approximately 74% of the genes dysregulated in acute lesions remain or are further dysr

128 hanges to effector cells, which are commonly dysregulated in autoimmune diseases.

129 amework to understand how these networks are dysregulated in autoimmune or inflammatory disease.

130 alized proresolving mediator resolvin E1 was dysregulated in calcified regions and acted as a calcifi

131 ly sustain transcriptional programs commonly dysregulated in cancer patients.

132 the endothelin axis genes are methylated and dysregulated in cancer tissue.

133 opment and differentiation and is frequently dysregulated in cancer(1).

134 entral to metazoan development and routinely dysregulated in cancer.

135 ll-positioned nucleosomes and are frequently dysregulated in cancer.

136 cell identity and fate determination, often dysregulated in cancer.

137 he angiotensin-converting enzyme 2 (ACE2) is dysregulated in cardiovascular disease, and this enzyme

138 ronic lesions, whereas only 34% of the genes dysregulated in chronic lesions are altered already in t

139 lated in acute lesions remain or are further dysregulated in chronic lesions, whereas only 34% of the

140 e data indicate that GA-associated genes are dysregulated in diabetes and identify putative markers o

141 gulator of cell growth and metabolism and is dysregulated in diabetes.

142 d to maintain normal cell physiology and are dysregulated in disease.

143 on (FAO) is a key bioenergetic pathway often dysregulated in diseases.

144 ximately half of the detected microRNAs were dysregulated in each epilepsy model.

145 ppreciated that transcriptional pathways are dysregulated in failing hearts, only recently has the id

146 ve physiology and host defence, and is often dysregulated in gastrointestinal disorders(1).

147 ctive quality control mechanisms that can be dysregulated in HIV infection, and the use of methamphet

148 n protein coding genes, several of which are dysregulated in human cancer.

149 Mapping the gene-regulatory networks dysregulated in human disease would allow the design of

150 r various physiological processes and can be dysregulated in human disease.

151 cal for normal growth and development and is dysregulated in human disorders such as benign overgrowt

152 ich were used to identify candidate pathways dysregulated in kidneys destined to form cysts.

153 lying complex biological mechanisms that are dysregulated in many diseases.

154 The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with DNA meth

155 in modulating c-MYC, an oncogene frequently dysregulated in MM.

156 ermore, pause release factors are frequently dysregulated in MS brain tissue.

157 nt in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contri

158 and DNMT3A physiologically, which is likely dysregulated in NAFLD.

159 (PERK-P) signaling-a pathway that is widely dysregulated in neurodegenerative diseases-generates a d

160 tment approach targets a pathway shown to be dysregulated in oral cancer patients, using gene therapy

161 inhibits cell motility and is believed to be dysregulated in pancreatic ductal adenocarcinomas.

162 aim of this study was to identify key miRNAs dysregulated in pancreatic islets during T1D progression

163 e human brain, APOE and NFAT are selectively dysregulated in pericytes of APOE4 carriers, and inhibit

164 Gene networks dysregulated in PMD included inflammatory response, earl

165 PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreas

166 ress and inflammatory factors reported to be dysregulated in ROP were similarly impaired in the lungs

167 factor receptor (c-MET) signaling pathway is dysregulated in several malignancies, including gastric

168 ticularly the locus coeruleus (LC), which is dysregulated in stress-related disorders and activated b

169 to SEM cell transition, and RA signaling was dysregulated in symptomatic human atherosclerosis.

170 Of all DEGs in SC, 12.6% were also dysregulated in the cerebellum.

171 tformin optimally reverts diabetogenic genes dysregulated in the context of immunosuppression.

172 mammalian neurons, and SMAD2 was found to be dysregulated in the nervous systems of ALS patients.

173 rum, suggesting that vitamin D metabolism is dysregulated in these conditions.

174 eptor (Igf1R)-associated gene expression was dysregulated in TrkC-KO mouse glomeruli.

175 tional, differentiated cell states are often dysregulated in tumor development.

176 ial to precisely adjust BDNF levels that are dysregulated in various neurological disorders.

177 keletal muscle hyperthermia in response to a dysregulated increase in myoplasmic calcium.

178 the main therapeutic approaches to alleviate dysregulated inflammation has been to target the activit

179 nflammation (inflammaging) and virus-induced dysregulated inflammation in causing age-related severe

180 including vascular dysfunction, thrombosis, dysregulated inflammation, and respiratory complications

181 te and chronic conditions that are driven by dysregulated inflammation, such as sepsis, and raise the

182 .e., hemophagocytosis) and contribute to the dysregulated inflammation-driven pathology.

183 crucial for host defense but may also drive dysregulated inflammation.

184 epair is highly inflammatory and initiates a dysregulated inflammatory process causing visceral adhes

185 ute infection and the putative etiology is a dysregulated inflammatory response to SARS-CoV-2 infecti

186 agonist, docosahexaenoic acid, rectifies the dysregulated inhibition in vitro as well as acoustic sta

187 s been suggested that RVVC might be due to a dysregulated innate immune response.

188 This highlights that dysregulated innate immune responses of the nasal mucosa

189 with antibody titers, reduced T and B cells, dysregulated innate immunity, neutrophil mobilization to

190 For FGbeta(3) cells, dysregulated integrin beta(3)-KRAS signaling drives tumo

191 otype in C3(hu/hu) mice may originate from a dysregulated interaction of human C3 protein with multip

192 cological inhibition of FAAH bidirectionally dysregulates intracellular, but not circulating, N-acyl

193 tional markers and treatment targets whereas dysregulated intrinsic communication of the striato-amyg

194 pregnancy diabetes, especially when severely dysregulated, is associated with an increased risk of co

195 y mapping global phosphorylation profiles to dysregulated kinases and pathways.

196 y into disc membranes, a process which, when dysregulated, likely gives rise to the visual defects ob

197 Strong evidence suggests that dysregulated lipid metabolism involving dysfunction of t

198 therapeutic interventions for diseases where dysregulated lipid metabolism is the underlying cause.

199 In liver diseases that arise from dysregulated lipid metabolism, proliferation is diminish

200 How ZIKV dysregulates lipid networks to allow this, and consequen

201 The dysregulated lipolysis may contribute to LD accumulation

202 The dysregulated lipolysis may contribute to LD accumulation

203 However, dysregulated LLPS can also facilitate aberrant phase tra

204 This attenuates troponin phosphorylation and dysregulates local sarcomeric microdomains in DCM iPSC-C

205 PA is caused by dysregulated localization of the enzyme aldosterone synt

206 Previous investigations have suggested that dysregulated localized and systemic inflammation contrib

207 However, a dysregulated macrophage response can be damaging to the

208 This suggests targeting dysregulated macrophage responses might be a therapeutic

209 regulatory T (Treg)-cell development, while dysregulated MALT1 activity can lead to lymphoma.

210 , and other psychotic disorders have similar dysregulated mechanisms of dopamine synthesis, which sup

211 and progression of diseases associated with dysregulated metabolic processes.

212 Dysregulated metabolism contributes to cancer initiation

213 t chronic LCMV infection of the GIT leads to dysregulated microbial composition, a cascade of metabol

214 Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad

215 Previously, we identified a dysregulated miR-486/DOCK3 signaling cascade in dystroph

216 Delineating the molecular mechanism of dysregulated miRNA network, we focused on identification

217 wth compared with RGED), we found 1 strongly dysregulated miRNA, hsa-miR-145-5p (P < 8.01E-05).

218 work analysis pinpointed several SE-specific dysregulated miRNAs (miR-200c-3p, miR-25-3p, and miR-302

219 DC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR-367-3p, miR-519d-3p, and miR-96

220 Bioinformatic analysis highlighted that dysregulated miRNAs target synaptic plasticity and dopam

221 These findings point to dysregulated mitochondrial metabolism as a potential roo

222 hibitor 1-methyl-4-phenylpyridinium (MPP(+)) dysregulates mitochondrial fission-fusion, mitophagy, an

223 ergy metabolism and ribosome biogenesis were dysregulated more in physiologically relevant conditions

224 However, dysregulated mucosal trafficking of PMNs and associated

225 henotype of DMD-afflicted skeletal muscle by dysregulating muscle stem cells involved in muscle bioge

226 ty and alcohol use behavior, potentially via dysregulated myelination.

227 Additional studies of this ethanol dysregulated network may identify therapeutic targets th

228 ivation plays crucial roles in immunity, and dysregulated neutrophil responses can lead to pathology

229 lished, yet the cellular mechanisms by which dysregulated Nod2 causes uveitis remain unknown.

230 Dysregulated Notch signaling has also been implicated in

231 t may cause irreversible tissue damage under dysregulated or acute exposure conditions.

232 When the activity of the iCP is dysregulated or highly expressed, it can lead to unwante

233 that steroid resistance was associated with dysregulated p57Kip2 expression.

234 Understanding the origin and consequences of dysregulated PAD enzyme activity and immune responses ag

235 e HDMR formulation to identify significantly dysregulated pairwise interactions.

236 ta identified cell proliferation as the most dysregulated pathway, with 15 of 241 DEGs related to cel

237 by the inflammatory trigger correlated with dysregulated pathways in IBD patients.

238 These dysregulated pathways represent potential targets for th

239 nalysis points to epigenetic and neuroimmune dysregulated pathways, in agreement with previous report

240 convergent symptomatology, suggesting common dysregulated pathways.

241 The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and curre

242 Because almost all GBM tumors have dysregulated phosphoinositide signaling as part of that

243 Dysregulated platelet functions contribute to the develo

244 To test if increased ODC activity and dysregulated polyamine metabolism contribute to the neur

245 ing followed by functional validation of key dysregulated processes.

246 activatable zymography probes (AZP) detected dysregulated protease activity in human prostate cancer

247 esults in dopaminergic neurodegeneration via dysregulated protein translation, although how alteratio

248 y expressed genes (367 vs. 3; P < 0.001) and dysregulated proteins (64 vs. 0; P < 0.001).

249 Collectively, our data provide evidence that dysregulated Pten in microglia has an etiological role i

250 previoulsy reported that systemic endotoxin dysregulates pulmonary angiogenesis resulting in alveola

251 Nevertheless, how dysregulated PV networks affect the neural activity dyna

252 To better understand how the mutation dysregulates RAC2 function, we evaluated the structure a

253 As several lines of evidence have implicated dysregulated rat sarcoma signaling in the pathogenesis o

254 As some cancer-associated mutations dysregulate rather than inactivate SWI/SNF remodelers, o

255 e-specific interactions and the landscape of dysregulated receptor-ligand crosstalk in cancer, includ

256 disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epi

257 e: Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the pathogenesis o

258 SAEC had a significantly dysregulated repair process postinjury, despite having a

259 Chronic airway injury and dysregulated repair programs are evident in airway epith

260 ve capacity as well as markers of injury and dysregulated repair were also assessed.

261 Dysregulated responses in immunity, such as at the stage

262 involvement of this circuit in conditions of dysregulated reward.

263 ew knowledge about secondary consequences of dysregulated RiBi and protein synthesis, including prote

264 Dysregulated RNP granules drive neuromuscular degenerati

265 Thus, dysregulated ROCK2 activity contributes to the aberrant

266 leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels.

267 ic cells (cDC1s) are typically thought to be dysregulated secondarily to invasive cancer.

268 Exposure to social stress and dysregulated serotonergic neurotransmission have both be

269 the process of degeneration is dynamic, that dysregulated signaling pathways change over time and can

270 e hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs.

271 TOR signaling, rapalogs induce cytoxicity by dysregulating spliceosome function via repression of TRI

272 eak social support is itself often linked to dysregulated stress responses.

273 is review identifies consistent evidence for dysregulated subcortical dopamine function in people at

274 These cells have mitochondria that are iron-dysregulated, suggesting disruption of a putative vacuol

275 aling pathways, the biotypes were oppositely dysregulated, suggesting that the biotypes were not simp

276 rthermore, the trajectory from embryonically dysregulated synaptic and cell cycle genes to disrupted

277 It has long been known that dysregulated synthesis of O-linked (threonine or serine)

278 ymphoid tissue (iBALT) likely contributed to dysregulated T cell homing and impaired lung immunity.

279 ity with intense autoantibody production and dysregulated T follicular helper and B cell responses.

280 g to Nav1.5 and Kir6.2 ankyrin binding sites dysregulate targeting of both Na(+) and K(ATP) channels

281 Subsequently, we determined 288 and 664 dysregulated TF-miRNA-gene FFLs in SE and NSE, respectiv

282 Dysregulated Th17 cell differentiation is associated wit

283 signaling, indicating that the viral protein dysregulates the HP.

284 cted apoptosis and cell-cycle checkpoints by dysregulating the expression of apoptosis regulators suc

285 e important sites of EBOV infection and that dysregulating the function of these vital organs contrib

286 mote transformation of cells into tumours by dysregulating the signalling pathways that are involved

287 However, if this GRN is dysregulated, the cell may enter into a disease state su

288 of PKI and its subsequent repression of PKA dysregulates these signaling pathways, resulting in incr

289 of IL-6-deficient asthmatic mice resulted in dysregulated tight junction proteins and increased lung

290 entified all potential genomic targets of 25 dysregulated transcription factors and compared their in

291 3K27ac and H3K9ac affect disease pathways by dysregulating transcription- and chromatin-gene feedback

292 t is a feature of carcinogenesis and propose dysregulated translation as an important new source of t

293 This study reveals a link between dysregulated translation control and Ca(2+) homeostasis

294 ctive ribosomal products, relate this to the dysregulated translation that is a feature of carcinogen

295 ecific elimination of CG methylation did not dysregulate transposons or genes.

296 ecayed in non-lymphoid tissues and expressed dysregulated Trm-specific markers.

297 l stem/progenitor cells, and its activity is dysregulated under conditions of obesity.

298 eukocyte adhesion, platelet aggregation, and dysregulated vasodilation.

299 e, peptidoglycan synthesis becomes spatially dysregulated, which causes cells to grow so large that c

300 neurons, show that disease-related genes are dysregulated with aging, and identify differences betwee