ライフサイエンスコーパス: dysregulated

1 neurological disorders in which dopamine is dysregulated.

2 ng synaptic pruning, which is detrimental if dysregulated.

3 Mice deficient in Fgl2 had dysregulated Ab responses at steady-state and upon immun

4 If the balance between IL-18 and IL-18BP is dysregulated, abnormal levels of free bioactive IL-18 ar

5 therein of BRCA1 PARsylation results in the dysregulated accumulation in these foci of BRCA1 complex

6 in I/R injury in the heart and triggered by dysregulated accumulation of autophagosomes due to upreg

7 Elucidating mechanisms associated with dysregulated activation of specific receptors may identi

8 d event during adaptive immune response, but dysregulated activation of this signaling pathway can le

9 lammation is anemia, which may be related to dysregulated activity of hematopoietic stem and progenit

10 al load, uncontrolled inflammatory response, dysregulated adaptive immunity, coagulation abnormalitie

11 r cell proliferation and differentiation, is dysregulated after ZIKV infection.

12 Cancer cells are dysregulated and addicted to continuous supply and metab

13 Together, these results identify shared, dysregulated, and functionally active microRNAs during t

14 -inflammatory cytokine signaling pathways as dysregulated, and this was further substantiated by dete

15 remature infants, a disease characterized by dysregulated angiogenesis and impaired vascular and alve

16 tors, CB1 and CB2, show compromised PDZ with dysregulated angiogenic factors, resulting in the retent

17 Dysregulated autophagy contributes to the pathogenesis o

18 europsychiatric diseases are associated with dysregulated basal ganglia direct-pathway activity.

19 se) to assess the effects of the compound in dysregulated behaviors within the transgenic models.

20 teric modulator, ABM300, to ameliorate these dysregulated behaviors.

21 y we found 47 metabolites were significantly dysregulated between HC and the premutation groups (PM).

22 ate to the gut inflammation/permeability and dysregulated bile acid metabolism observed in opioid-exp

23 abnormal axial skeleton segmentation due to dysregulated biogenesis of notochord vacuoles and notoch

24 In sum, IGFs are dysregulated both before and after the clinical diagnosi

25 Biochemical analyses revealed dysregulated brain mTOR and GSK3beta signaling, consiste

26 lls during lysine limitation when growth was dysregulated, but not during glucose limitation when gro

27 specific transcriptional programs, which are dysregulated by multiple mechanisms, including genomic a

28 LnCeVar-Hallmark identifies dysregulated cancer hallmarks of variation-ceRNA events.

29 The importance of dysregulated CD86 expression in Tet2- and Tet3-deficient

30 ist for nonresponders, because the etiology, dysregulated cell types, and signaling pathways are unkn

31 es an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathoge

32 Dysregulated cholesterol homeostasis promotes the pathol

33 Dysregulated cholesterol metabolism is implicated in a n

34 s reveal four distinct AM sub-clusters and a dysregulated cluster-specific pathway in the HDAC3-defic

35 ated damage and pathogenesis associated with dysregulated coagulation.

36 Secretomic analysis and ELISA uncovered dysregulated collagen degradation regulators (induced PA

37 The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneur

38 ate a host of biological processes, and when dysregulated, contribute to disease.

39 pathogenesis of these diseases is related to dysregulated cytokine activity.

40 Dysregulated cytokine expression by T cells plays a pivo

41 genes, and blood EG scores were derived from dysregulated cytokine/chemokine levels.

42 singly recognized as disease entities, where dysregulated cytokines contribute substantially to tissu

43 ications for psychiatric disorders involving dysregulated dopamine signaling.

44 in to uncover how innate immune signaling is dysregulated downstream of TBK1/IKKepsilon in a subset o

45 The identified effector genes and the dysregulated downstream pathways provide hints of possib

46 m cells in the gastrointestinal tract and is dysregulated during carcinogenesis.

47 cally active cholinergic interneurons become dysregulated during chronic L-DOPA administration and pa

48 el the structural and functional alterations dysregulated during depression.

49 he activities of many signaling pathways are dysregulated during the progression of neurodegenerative

50 pen early in the secretory pathway are often dysregulated during tumorigenesis.

51 The recognition that dysregulated dynein-mediated transport of nephrin in R21

52 Dysregulated effector binding due to conformational chan

53 vailing models of trauma intrusions focus on dysregulated emotional processes, we hypothesize that a

54 Dysregulated endocannabinoid signaling was linked to inf

55 duction of reactive oxygen species caused by dysregulated endothelial nitric-oxide synthase (eNOS) ac

56 Dysregulated endothelial permeability contributes to man

57 y analyses revealed that the deletion of ALX dysregulated energy metabolism driving toward age-relate

58 loss, aberrant protein phosphorylation, and dysregulated energy metabolism.

59 n ichthyosis-like phenotype characterized by dysregulated epidermal de novo lipid synthesis, altered

60 ronized activation in the healthy heart, the dysregulated excess in this pathway underscores asynchro

61 g to decreased WNT signaling and concomitant dysregulated expression of relevant genes.

62 Given the role of dysregulated expressions of cytoskeletal and cytoskeleto

63 onnective tissue pathologies associated with dysregulated extracellular matrix homeostasis.

64 on Parkinson's disease mechanisms have shown dysregulated extracellular transport of alpha-synuclein

65 me proliferator-activated receptor alpha and dysregulated fatty acid metabolism as potential therapeu

66 Dysregulated fear conditioned responses have been associ

67 y response to fungal cell walls, likely by a dysregulated feed-forward loop involving amplified neutr

68 that the commensal microbiome is frequently dysregulated following allo-SCT and that this dysbiosis

69 ionship with nicotine dependence severity is dysregulated following chronic nicotine administration-i

70 on and endogenous transposable elements were dysregulated following MIA, potentially connecting MIA t

71 ected the increased CRTH2 expression and its dysregulated functions.

72 The most highly dysregulated gene ADCYAP1 (encoding PACAP) was associate

73 near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differe

74 of schizotypy and prior histological data on dysregulated gene expression in schizophrenia.

75 provides a mechanistic understanding of the dysregulated gene transcription patterns in SCZ and crea

76 es and to successfully extract significantly dysregulated gene-gene interactions from the data.

77 Significantly dysregulated genes and pathways were determined, and tho

78 ory network analysis showed that many of the dysregulated genes are targeted by multiple transcriptio

79 Intriguingly, 22 of the dysregulated genes encoded known NDD genes, suggesting U

80 We detected hundreds of dysregulated genes in Mef2c-Het cortex, including signif

81 We discovered that the significantly dysregulated genes in the context of immunosuppression a

82 blasts highlighted the overrepresentation of dysregulated genes involved in ECM organization, or bein

83 show a detailed analysis of the most highly dysregulated genes on chromosome 18 and those genome-wid

84 nally, we found three subnetworks of jointly dysregulated genes within the functional gene network wh

85 ere derived from the expression of 18 highly dysregulated genes, and blood EG scores were derived fro

86 We identified 521 significantly dysregulated genes, including 61 transcription factors i

87 that Sox2 targeted a large number of ethanol-dysregulated genes.

88 IL4RA was among the top 3 central dysregulated genes.

89 compared their interactions with the ethanol-dysregulated genes.

90 tic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism associated wit

91 tion, and 4) prevent and reverse obesity and dysregulated glucose homeostasis in multiple mouse model

92 Increased HKDC1 expression may contribute to dysregulated glucose metabolism and represents a novel b

93 ecline in retinal pyruvate levels coupled to dysregulated glucose metabolism prior to detectable opti

94 hways, metabolite sinks and bottlenecks, and dysregulated glucose storage in patients with AH.

95 Dysregulated hematopoiesis occurs in several chronic inf

96 ioactive lipid mediators (BLM), as well as a dysregulated hepatic lipid gene expression profile.

97 Further, RNA-seq analysis identified dysregulated HIF-1alpha target genes that are relevant t

98 Dysregulated Hippo pathway and YAP/TAZ-TEAD activity is

99 iological evidence indicates the presence of dysregulated homeostatic biological pathways in depresse

100 lets may drive lung injury and contribute to dysregulated host defense in CF lung disease.

101 Dysregulated host immune response in the lung is a key f

102 is a life-threatening syndrome defined as a dysregulated host response to infection and is character

103 fe-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading ca

104 fe-threatening organ dysfunction caused by a dysregulated host response to infection.

105 atients in intensive care worldwide due to a dysregulated host response to infection.

106 sed by SARS-CoV-2 is largely the result of a dysregulated host response, followed by damage to alveol

107 defective Bcl-6(+) T(FH) cell generation and dysregulated humoral immune induction early in COVID-19

108 that TREX1 D18N catalytic deficiency causes dysregulated IFN-I signaling and autoimmunity in mice.

109 te function is, at least in part, related to dysregulated IkappaKalpha/beta activation, and that Ikap

110 Dysregulated IL-11 signaling has been implicated in seve

111 Since the connection of dysregulated IL-17 and psoriasis pathogenesis turned out

112 tment of sepsis, a syndrome resulting from a dysregulated immune response and inappropriate activatio

113 protection or induces pathogenesis through a dysregulated immune response remains unclear.

114 Sepsis is characterized by a dysregulated immune response, metabolic derangements and

115 re cases of SARS-CoV-2 are associated with a dysregulated immune response.

116 Dysregulated immune responses have been reported to occu

117 Exacerbated inflammation and dysregulated immune responses involving T and myeloid ce

118 Dysregulated immune responses may lead to antibodies aga

119 ctor T-bet have been described in normal and dysregulated immune responses.

120 known to be associated with inflammation and dysregulated immune responses.

121 Although corticosteroids dampen the dysregulated immune system and sometimes are prescribed

122 Clinical features of dysregulated immunity are recorded with a standardised q

123 biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic infla

124 These results suggest dysregulated immunoregulation is associated with poor pr

125 Dysregulated immunothrombosis in severe acute respirator

126 microtubule-associated protein that becomes dysregulated in a group of neurodegenerative diseases ca

127 molecules that broadly correct gene networks dysregulated in a human induced pluripotent stem cell (i

128 e show that ROCK2 activity is constitutively dysregulated in ABC-DLBCL but not in GCB-DLBCL and BL.

129 onstrate that approximately 74% of the genes dysregulated in acute lesions remain or are further dysr

130 ranscriptional signatures were substantially dysregulated in astrocytes.

131 hanges to effector cells, which are commonly dysregulated in autoimmune diseases.

132 amework to understand how these networks are dysregulated in autoimmune or inflammatory disease.

133 alized proresolving mediator resolvin E1 was dysregulated in calcified regions and acted as a calcifi

134 ly sustain transcriptional programs commonly dysregulated in cancer patients.

135 the endothelin axis genes are methylated and dysregulated in cancer tissue.

136 opment and differentiation and is frequently dysregulated in cancer(1).

137 entral to metazoan development and routinely dysregulated in cancer.

138 ll-positioned nucleosomes and are frequently dysregulated in cancer.

139 cell identity and fate determination, often dysregulated in cancer.

140 tatic cell turnover in the epithelium but is dysregulated in cancer.

141 he angiotensin-converting enzyme 2 (ACE2) is dysregulated in cardiovascular disease, and this enzyme

142 ronic lesions, whereas only 34% of the genes dysregulated in chronic lesions are altered already in t

143 lated in acute lesions remain or are further dysregulated in chronic lesions, whereas only 34% of the

144 The innate immune system is dysregulated in depression; however, less is known about

145 e data indicate that GA-associated genes are dysregulated in diabetes and identify putative markers o

146 gulator of cell growth and metabolism and is dysregulated in diabetes.

147 he regulatory pathways that control them are dysregulated in disease, highlighting their importance f

148 d to maintain normal cell physiology and are dysregulated in disease.

149 on (FAO) is a key bioenergetic pathway often dysregulated in diseases.

150 ximately half of the detected microRNAs were dysregulated in each epilepsy model.

151 ppreciated that transcriptional pathways are dysregulated in failing hearts, only recently has the id

152 ve physiology and host defence, and is often dysregulated in gastrointestinal disorders(1).

153 ctive quality control mechanisms that can be dysregulated in HIV infection, and the use of methamphet

154 n protein coding genes, several of which are dysregulated in human cancer.

155 Mapping the gene-regulatory networks dysregulated in human disease would allow the design of

156 r various physiological processes and can be dysregulated in human disease.

157 cal for normal growth and development and is dysregulated in human disorders such as benign overgrowt

158 ate immune response against pathogens and is dysregulated in inflammatory disorders.

159 ich were used to identify candidate pathways dysregulated in kidneys destined to form cysts.

160 lying complex biological mechanisms that are dysregulated in many diseases.

161 The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with DNA meth

162 in modulating c-MYC, an oncogene frequently dysregulated in MM.

163 ermore, pause release factors are frequently dysregulated in MS brain tissue.

164 nt in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contri

165 and DNMT3A physiologically, which is likely dysregulated in NAFLD.

166 (PERK-P) signaling-a pathway that is widely dysregulated in neurodegenerative diseases-generates a d

167 tment approach targets a pathway shown to be dysregulated in oral cancer patients, using gene therapy

168 inhibits cell motility and is believed to be dysregulated in pancreatic ductal adenocarcinomas.

169 aim of this study was to identify key miRNAs dysregulated in pancreatic islets during T1D progression

170 e human brain, APOE and NFAT are selectively dysregulated in pericytes of APOE4 carriers, and inhibit

171 Gene networks dysregulated in PMD included inflammatory response, earl

172 PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreas

173 ress and inflammatory factors reported to be dysregulated in ROP were similarly impaired in the lungs

174 factor receptor (c-MET) signaling pathway is dysregulated in several malignancies, including gastric

175 ticularly the locus coeruleus (LC), which is dysregulated in stress-related disorders and activated b

176 to SEM cell transition, and RA signaling was dysregulated in symptomatic human atherosclerosis.

177 Understanding how glycosylation is dysregulated in the brain will further our understanding

178 Of all DEGs in SC, 12.6% were also dysregulated in the cerebellum.

179 tformin optimally reverts diabetogenic genes dysregulated in the context of immunosuppression.

180 alyses revealed that more than 250 genes are dysregulated in the DeltavtlR strain, and importantly, V

181 mammalian neurons, and SMAD2 was found to be dysregulated in the nervous systems of ALS patients.

182 rum, suggesting that vitamin D metabolism is dysregulated in these conditions.

183 eptor (Igf1R)-associated gene expression was dysregulated in TrkC-KO mouse glomeruli.

184 tional, differentiated cell states are often dysregulated in tumor development.

185 ial to precisely adjust BDNF levels that are dysregulated in various neurological disorders.

186 keletal muscle hyperthermia in response to a dysregulated increase in myoplasmic calcium.

187 the main therapeutic approaches to alleviate dysregulated inflammation has been to target the activit

188 nflammation (inflammaging) and virus-induced dysregulated inflammation in causing age-related severe

189 including vascular dysfunction, thrombosis, dysregulated inflammation, and respiratory complications

190 te and chronic conditions that are driven by dysregulated inflammation, such as sepsis, and raise the

191 .e., hemophagocytosis) and contribute to the dysregulated inflammation-driven pathology.

192 crucial for host defense but may also drive dysregulated inflammation.

193 epair is highly inflammatory and initiates a dysregulated inflammatory process causing visceral adhes

194 ute infection and the putative etiology is a dysregulated inflammatory response to SARS-CoV-2 infecti

195 agonist, docosahexaenoic acid, rectifies the dysregulated inhibition in vitro as well as acoustic sta

196 s been suggested that RVVC might be due to a dysregulated innate immune response.

197 This highlights that dysregulated innate immune responses of the nasal mucosa

198 with antibody titers, reduced T and B cells, dysregulated innate immunity, neutrophil mobilization to

199 For FGbeta(3) cells, dysregulated integrin beta(3)-KRAS signaling drives tumo

200 otype in C3(hu/hu) mice may originate from a dysregulated interaction of human C3 protein with multip

201 tional markers and treatment targets whereas dysregulated intrinsic communication of the striato-amyg

202 pregnancy diabetes, especially when severely dysregulated, is associated with an increased risk of co

203 y mapping global phosphorylation profiles to dysregulated kinases and pathways.

204 y into disc membranes, a process which, when dysregulated, likely gives rise to the visual defects ob

205 Strong evidence suggests that dysregulated lipid metabolism involving dysfunction of t

206 therapeutic interventions for diseases where dysregulated lipid metabolism is the underlying cause.

207 In liver diseases that arise from dysregulated lipid metabolism, proliferation is diminish

208 The dysregulated lipolysis may contribute to LD accumulation

209 The dysregulated lipolysis may contribute to LD accumulation

210 However, dysregulated LLPS can also facilitate aberrant phase tra

211 PA is caused by dysregulated localization of the enzyme aldosterone synt

212 Previous investigations have suggested that dysregulated localized and systemic inflammation contrib

213 However, a dysregulated macrophage response can be damaging to the

214 This suggests targeting dysregulated macrophage responses might be a therapeutic

215 regulatory T (Treg)-cell development, while dysregulated MALT1 activity can lead to lymphoma.

216 , and other psychotic disorders have similar dysregulated mechanisms of dopamine synthesis, which sup

217 and progression of diseases associated with dysregulated metabolic processes.

218 Dysregulated metabolism contributes to cancer initiation

219 complex dynamics in the context of normal or dysregulated metabolism.

220 t chronic LCMV infection of the GIT leads to dysregulated microbial composition, a cascade of metabol

221 Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad

222 Previously, we identified a dysregulated miR-486/DOCK3 signaling cascade in dystroph

223 Delineating the molecular mechanism of dysregulated miRNA network, we focused on identification

224 wth compared with RGED), we found 1 strongly dysregulated miRNA, hsa-miR-145-5p (P < 8.01E-05).

225 work analysis pinpointed several SE-specific dysregulated miRNAs (miR-200c-3p, miR-25-3p, and miR-302

226 DC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR-367-3p, miR-519d-3p, and miR-96

227 Bioinformatic analysis highlighted that dysregulated miRNAs target synaptic plasticity and dopam

228 These findings point to dysregulated mitochondrial metabolism as a potential roo

229 ergy metabolism and ribosome biogenesis were dysregulated more in physiologically relevant conditions

230 However, dysregulated mucosal trafficking of PMNs and associated

231 ty and alcohol use behavior, potentially via dysregulated myelination.

232 Additional studies of this ethanol dysregulated network may identify therapeutic targets th

233 ivation plays crucial roles in immunity, and dysregulated neutrophil responses can lead to pathology

234 lished, yet the cellular mechanisms by which dysregulated Nod2 causes uveitis remain unknown.

235 Dysregulated norepinephrine (NE) neurotransmission is as

236 Dysregulated Notch signaling has also been implicated in

237 t may cause irreversible tissue damage under dysregulated or acute exposure conditions.

238 When the activity of the iCP is dysregulated or highly expressed, it can lead to unwante

239 that steroid resistance was associated with dysregulated p57Kip2 expression.

240 Understanding the origin and consequences of dysregulated PAD enzyme activity and immune responses ag

241 e HDMR formulation to identify significantly dysregulated pairwise interactions.

242 ta identified cell proliferation as the most dysregulated pathway, with 15 of 241 DEGs related to cel

243 Our study has identified dysregulated pathways in HI skin that are feasible thera

244 by the inflammatory trigger correlated with dysregulated pathways in IBD patients.

245 These dysregulated pathways represent potential targets for th

246 nalysis points to epigenetic and neuroimmune dysregulated pathways, in agreement with previous report

247 convergent symptomatology, suggesting common dysregulated pathways.

248 The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and curre

249 Because almost all GBM tumors have dysregulated phosphoinositide signaling as part of that

250 Dysregulated platelet functions contribute to the develo

251 To test if increased ODC activity and dysregulated polyamine metabolism contribute to the neur

252 ights into the molecular mechanisms that are dysregulated prior to and following the onset of type 2

253 ing followed by functional validation of key dysregulated processes.

254 activatable zymography probes (AZP) detected dysregulated protease activity in human prostate cancer

255 esults in dopaminergic neurodegeneration via dysregulated protein translation, although how alteratio

256 y expressed genes (367 vs. 3; P < 0.001) and dysregulated proteins (64 vs. 0; P < 0.001).

257 Collectively, our data provide evidence that dysregulated Pten in microglia has an etiological role i

258 Nevertheless, how dysregulated PV networks affect the neural activity dyna

259 As several lines of evidence have implicated dysregulated rat sarcoma signaling in the pathogenesis o

260 e-specific interactions and the landscape of dysregulated receptor-ligand crosstalk in cancer, includ

261 disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epi

262 lly evaluate and argue that this is due to a dysregulated renin-angiotensin system (RAS).

263 e: Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the pathogenesis o

264 SAEC had a significantly dysregulated repair process postinjury, despite having a

265 Chronic airway injury and dysregulated repair programs are evident in airway epith

266 ve capacity as well as markers of injury and dysregulated repair were also assessed.

267 Dysregulated responses in immunity, such as at the stage

268 involvement of this circuit in conditions of dysregulated reward.

269 ew knowledge about secondary consequences of dysregulated RiBi and protein synthesis, including prote

270 Psychiatric diseases characterized by dysregulated risky decision making are differentially re

271 Dysregulated RNP granules drive neuromuscular degenerati

272 Our results link dysregulated RNP granules to myocardial cellular pathobi

273 Thus, dysregulated ROCK2 activity contributes to the aberrant

274 leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels.

275 ic cells (cDC1s) are typically thought to be dysregulated secondarily to invasive cancer.

276 Exposure to social stress and dysregulated serotonergic neurotransmission have both be

277 the process of degeneration is dynamic, that dysregulated signaling pathways change over time and can

278 es establish aberrant AS landscape caused by dysregulated SRGs as a hallmark of PCa aggressiveness an

279 eak social support is itself often linked to dysregulated stress responses.

280 is review identifies consistent evidence for dysregulated subcortical dopamine function in people at

281 These cells have mitochondria that are iron-dysregulated, suggesting disruption of a putative vacuol

282 aling pathways, the biotypes were oppositely dysregulated, suggesting that the biotypes were not simp

283 rthermore, the trajectory from embryonically dysregulated synaptic and cell cycle genes to disrupted

284 It has long been known that dysregulated synthesis of O-linked (threonine or serine)

285 ymphoid tissue (iBALT) likely contributed to dysregulated T cell homing and impaired lung immunity.

286 ity with intense autoantibody production and dysregulated T follicular helper and B cell responses.

287 Subsequently, we determined 288 and 664 dysregulated TF-miRNA-gene FFLs in SE and NSE, respectiv

288 Dysregulated Th17 cell differentiation is associated wit

289 However, if this GRN is dysregulated, the cell may enter into a disease state su

290 of IL-6-deficient asthmatic mice resulted in dysregulated tight junction proteins and increased lung

291 entified all potential genomic targets of 25 dysregulated transcription factors and compared their in

292 t is a feature of carcinogenesis and propose dysregulated translation as an important new source of t

293 This study reveals a link between dysregulated translation control and Ca(2+) homeostasis

294 ctive ribosomal products, relate this to the dysregulated translation that is a feature of carcinogen

295 ecayed in non-lymphoid tissues and expressed dysregulated Trm-specific markers.

296 l stem/progenitor cells, and its activity is dysregulated under conditions of obesity.

297 rk identifies and creates a visualization of dysregulated variation-ceRNA networks.

298 eukocyte adhesion, platelet aggregation, and dysregulated vasodilation.

299 e, peptidoglycan synthesis becomes spatially dysregulated, which causes cells to grow so large that c

300 neurons, show that disease-related genes are dysregulated with aging, and identify differences betwee