ライフサイエンスコーパス: dysregulation

1 ge-associated mobility decline and metabolic dysregulation.

2 tes are associated with cancer-specific gene dysregulation.

3 before progressing to more widespread immune dysregulation.

4 2, implicated in diabetes mellitus and lipid dysregulation.

5 circuitry as a convergence hub for emotional dysregulation.

6 lls and clinical complications due to immune dysregulation.

7 rough testosterone to hippocampus to emotion dysregulation.

8 ationship between metabolic and inflammatory dysregulation.

9 novel stress, cells suffered nutrient-growth dysregulation.

10 round of chronic immunosuppression or immune dysregulation.

11 everity of infections, and an overall immune dysregulation.

12 dysfunction, microbial dysbiosis, and immune dysregulation.

13 echanisms of TMEJ and the consequence of its dysregulation.

14 , cutaneous immune responses, and complement dysregulation.

15 eatment of conditions associated with NAD(+) dysregulation.

16 whether mindfulness training mitigated this dysregulation.

17 lterations in energetics associated with p53 dysregulation.

18 involving mainly non-emotional or emotional dysregulation.

19 nfections, hypogammaglobulinemia, and immune dysregulation.

20 c risk in RA and the wider context of immune dysregulation.

21 drive the tumor's characteristic epigenetic dysregulation.

22 vaccination is impaired as a result of cDC1 dysregulation.

23 eks or more promotes pro-inflammatory immune dysregulation, a risk factor for a range of chronic dise

24 es is crucial for normal development and its dysregulation accounts for several human disorders.

25 vergent molecular subtype of ASD with shared dysregulation across both the epigenome and transcriptom

26 a specially developed immune deficiency and dysregulation activity score, reflecting the sum and sev

27 Immune deficiency and dysregulation activity scores were significantly lower i

28 Finally, we show that MMP-13 dysregulation also underlies paclitaxel-induced peripher

29 -immuno-affective framework of how emotional dysregulation and alcohol-related microbiome dysbiosis c

30 Mechanisms of transcriptional dysregulation and cortical maldevelopment are reviewed,

31 HL) risk, but the effects of allergic immune dysregulation and corticosteroids are poorly understood.

32 neffective hematopoiesis and often include a dysregulation and dysfunction of the immune system.

33 s and is a reasonable measure of homeostatic dysregulation and frailty.

34 s is a rare syndrome characterized by immune dysregulation and hyperinflammation.

35 y-adrenal (HPA) axis, leading to progressive dysregulation and increased cortisol exposure.

36 recombination and ideas on how the resulting dysregulation and inhibition offer opportunities for imp

37 further examine caveolae-mediated tensional dysregulation and its functional consequences in oncogen

38 f Ang II relative to Ang (1-7) is termed RAS dysregulation and leads to cellular signals, which promo

39 ur data suggest a causal link between Ca(2+) dysregulation and primary, nonapoptotic degeneration of

40 d the functional role of KDM5B in epigenetic dysregulation and prostate cancer progression in culture

41 eproductive age is associated with metabolic dysregulation and region of residence.

42 a nonredundant role for IFN-lambda in immune dysregulation and tissue inflammation in a model of TLR7

43 e severe side effects associated with immune dysregulation and, in particular, loss of Treg cells.

44 the gut microbiome, inflammation, metabolic dysregulation, and impaired insulin signalling.

45 at rheumatological manifestations and immune dysregulation are relatively common in GATA2 deficiency.

46 Multiple observations implicate T-cell dysregulation as a central event in the pathogenesis of

47 together, our data point to immunothrombotic dysregulation as a key marker of disease severity in COV

48 Converging evidence implicates redox dysregulation as a pathological mechanism driving the em

49 Our study suggests BCCIP dysregulation as a risk factor for HCC and offers a nove

50 udies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under therapy.

51 tool for exploring epigenetic regulation and dysregulation at the molecular level.

52 chosocial stress, characterised by an immune dysregulation at the transcriptomic, molecular and cellu

53 in vivo model of Toll-like receptor (TLR) 9 dysregulation, based on bypassing the compartmentalized

54 class I cytokine receptor activation and its dysregulation by individual mutations.

55 opment and cellular differentiation, and its dysregulation can cause neuropsychiatric diseases and in

56 elopment and tissue homeostasis, whereas its dysregulation can lead to tumorigenesis.

57 obiome balance in steady-state and how their dysregulation can trigger and promote inflammatory skin

58 the miR-183 cluster, and the miR-183 cluster dysregulation causes certain defects in the differentiat

59 We find that the severity of splicing dysregulation correlates with disease progression and es

60 these studies suggest that an underlying SPM dysregulation could be contributing to SS progression.

61 n and long-term cellular memory, whereas its dysregulation could underlie multiple brain disorders an

62 with anxiety disorders, with disruptive mood dysregulation disorder, with ADHD, or without psychopath

63 only reported manifestation of immune system dysregulation during spaceflight.

64 hat included modification of transcriptional dysregulation elicited by the Htt(Q111) allele, likely v

65 th studies on stress-induced endocannabinoid dysregulation focusing on cerebral changes that are temp

66 elective IL-2 signaling and prevented immune dysregulation following treatment with the inhibitory an

67 viduals display metabolic imbalances, immune dysregulation, gastrointestinal dysfunction, and altered

68 Cardiac autonomic dysregulation has been implicated in the comorbidity of

69 Calcium (Ca(2+) ) dysregulation has been linked to neuronal cell death, in

70 Immune dysregulation has been noted consistently in individuals

71 trointestinal cancer in which WNT signalling dysregulation has been previously reported.

72 ncy in psoriasis with relevance to stem cell dysregulation has not been previously reported.

73 biased approach to SARS-CoV-2-induced immune dysregulation has not been undertaken so far.

74 ntal and luminal factors, and mucosal immune dysregulation, have been suggested to contribute to UC p

75 ies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic

76 ia signaling pathway, resulting in metabolic dysregulation, heightened angiogenesis, intratumoral het

77 (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28).

78 Dysregulation, impairment or inadvertent activation of c

79 present an exploratory trial to study immune dysregulation in a cohort of students who were exposed t

80 A dysregulation in arachidonic acid metabolism is thought

81 es insight into the cellular basis of immune dysregulation in bacterial sepsis.

82 t whether AD pathogenesis is associated with dysregulation in brain transmethylation and polyamine pa

83 le new insights into the biology of protease dysregulation in cancer and accelerate the development o

84 ovides new biological insights into protease dysregulation in cancer and guides the design of conditi

85 In fact, VSG corrected hepatic triglyceride dysregulation in CD36KO mice, and circulating triglyceri

86 underscore the risk of post-transcriptional dysregulation in co-occurring neurodevelopmental disorde

87 Dysregulation in cortisol, a stress hormone that is the

88 Dysregulation in FA processing and storage causes toxic

89 stic splicing machinery-associated molecular dysregulation in glioblastomas, which could potentially

90 studying cell type-specific gene expression dysregulation in HD pathogenesis and reveal that the act

91 h implications for targeting transcriptional dysregulation in HD.

92 ay be a new approach to ameliorate metabolic dysregulation in heart failure.

93 Type I IFN signaling caused tight junction dysregulation in IECs, promoted gut microbiome shifts an

94 nstrate non-allergen-specific immune network dysregulation in individuals long before clinical asthma

95 ve reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks.

96 biology that were paralleled by bioenergetic dysregulation in midlife aging female brain.

97 ovide the first evidence for critical period dysregulation in NF1 and suggest that treatments aimed a

98 homeostasis in the lean state and metabolic dysregulation in obesity.

99 oligodendrocyte maturation and that HIFalpha dysregulation in OPCs but not oligodendrocytes disturbed

100 On the other hand, identifying ACE2 dysregulation in patients with comorbidities may offer i

101 eeded to determine the mechanisms of mucosal dysregulation in patients with inflammatory bowel diseas

102 alteration of ENaC-alpha causes aldosterone dysregulation in patients, highlighting that the FURIN s

103 ween mitochondrial dysfunction and lysosomal dysregulation in PD pathogenesis.

104 y cause of monogenic human SRNS due to actin dysregulation in podocytes.

105 vealed a potential role of metalloproteinase dysregulation in proliferative, premalignant Hi-Myc pros

106 usibly manifested by complex transcriptional dysregulation in the brain, involving networks of co-exp

107 Increasing evidence implicates immune dysregulation in the development of neurological disorde

108 arget for therapeutic intervention given its dysregulation in the disease.

109 A dysregulation in the IL-23/IL-17 axis can lead to inflam

110 TNF-alpha mediated dysregulation in the plasticity of monocytes/macrophages

111 Preclinical studies suggest epigenetic dysregulation, including altered DNA methylation, promot

112 ith increased cell death and transcriptional dysregulation indicative of an inflammatory response and

113 These data demonstrate that BRD4 dysregulation is a critical driver for RTT etiology and

114 Context fear memory dysregulation is a hallmark symptom of several neuropsyc

115 Metabolic dysregulation is a known hallmark of cancer progression,

116 icity are poorly delineated, transcriptional dysregulation is a likely contributor.

117 s, data indicate that CVID-associated immune dysregulation is a T(H)1-mediated inflammatory process d

118 ation and cell-cycle progression, and kinase dysregulation is associated with numerous disease phenot

119 ial essential for lysosomal function and its dysregulation is associated with the development of Park

120 IL-6 transcriptional dysregulation is commonly seen in patients with autoimmu

121 f their specific exposure and complex immune dysregulation is controversial.

122 In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendr

123 The synaptic calcium dysregulation is due to a loss of dendritic inhibition v

124 Its dysregulation is implicated in muscle wasting diseases.

125 T(FH) cell regulation and dysregulation is involved in a range of diseases.

126 Brain zinc dysregulation is linked to many neurological disorders.

127 w levels of TLR7, which may explain why TLR9 dysregulation is particularly consequential early in lif

128 However, whether this trait circuit dysregulation is predispositional to or resultant from n

129 Severe RAS dysregulation is present in CKD dictated by high chymase

130 Ca(2+) dysregulation is thought to cause rod and cone photorece

131 system integrity: Levine Method, homeostatic dysregulation, Klemera-Doubal method biological age, and

132 ic disease that is associated with metabolic dysregulation leading to atherosclerosis in chickens.

133 Its dysregulation leads to pathophysiological inflammatory p

134 Lipid dysregulation manifests during disease; however, it is u

135 geneity by illustrating that such biological dysregulations map more consistently to atypical behavio

136 In this context, dopamine dysregulation may be transdiagnostic of the pathophysiol

137 Vascular dysregulation may contribute to disc hemorrhage formatio

138 n and our current understanding of how their dysregulation may contribute to gliomagenesis.

139 the Th1 immune response, suggesting that p73 dysregulation may contribute to susceptibility to autoim

140 rols liver cell lineage commitment and whose dysregulation may play a role in biliary cancer.

141 We found that the greatest dysregulation occurred in deep layer excitatory neurons

142 In vitro VDR knockdown induces myogenic dysregulation occurring through impaired differentiation

143 itive layer III neurons revealed significant dysregulation of a mosaic of genes in MCI and AD that we

144 in specific subtypes reflected preferential dysregulation of additional pathways, such as induction

145 Our study presents a strategy to follow the dysregulation of APOBEC3A in tumors, providing opportuni

146 nthesis of 15-Oxo-ETE, may contribute to the dysregulation of arachidonic acid metabolism via the 15-

147 Dysregulation of autophagy is associated with several oc

148 between KO/KD and KO, there was significant dysregulation of BA transporters and BA detoxification/s

149 from health to disease are characterized by dysregulation of biological networks under the influence

150 Further investigation showed that the dysregulation of BLM is associated with poor overall sur

151 capable of preventing long-term, THC-induced dysregulation of both PFC and VTA DAergic activity state

152 ) and Akt signaling pathways, and normalized dysregulation of both PFC and VTA DAergic activity, demo

153 pts both signaling and transport, leading to dysregulation of both the Has and Phu uptake systems.

154 ase hereditary ferritinopathy (HF), in which dysregulation of brain iron homeostasis is the primary c

155 Combinatorial experiments revealed that dysregulation of calcineurin-nuclear factor of activated

156 Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with sev

157 Dysregulation of Cdk1 is an early driver of cyst cell pr

158 , Gdown1-deficient hepatocytes show a severe dysregulation of cell cycle progression, with incomplete

159 potently degrade XPB does not lead to global dysregulation of cellular mRNA expression.

160 Dysregulation of cellular ribose uptake can be indicativ

161 activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflamm

162 LZTR1-mediated dysregulation of CHMP1B ubiquitination triggers endosoma

163 lcarnitine oxidation capacities, implicating dysregulation of CoA-dependent intermediary metabolism r

164 A proinflammatory dysregulation of cytokine release is associated with var

165 HC-induced pathologic alterations, including dysregulation of DAergic activity states, loss of PFC GA

166 programs or signaling pathways resulting in dysregulation of downstream processes such as proliferat

167 Specifically, we emphasize examples of dysregulation of each level of epigenetic control though

168 gs provide evidence for genetically mediated dysregulation of early neuronal connectivity in cerebral

169 bosome profiling (Ribo-seq) we find specific dysregulation of endoplasmic reticulum (ER)-targeted mRN

170 ion in anorexia nervosa (AN), a hypothalamic dysregulation of energy and glucose homeostasis has been

171 Thus, widespread epigenetic dysregulation of enhancers in PD neurons may, in part, b

172 ndlin3 causes high microglial contractility, dysregulation of ERK signaling, excessive TGFbeta1 expre

173 of neurodegeneration ensues from homeostatic dysregulation of excitability and have tested this hypot

174 VDD induced dysregulation of gene networks associated with growth ho

175 , TWAS-based enrichment analysis highlighted dysregulation of gene sets for, among others, neuronal a

176 many acrylamide neurotoxic effects, like the dysregulation of genes related to microtubules, presynap

177 I that underlie signaling defects, including dysregulation of genes within the endosomal-lysosomal an

178 other neurological disorders associated with dysregulation of GLAST/GLT-1.

179 This reduction in eIF2 activity results in dysregulation of global and gene-specific protein synthe

180 rders is complex, but involves bidirectional dysregulation of gut-brain interaction (via the gut-brai

181 Dysregulation of habit formation has been recently propo

182 Mutation, malfunction, and dysregulation of HATs are associated with a wide range o

183 cretion is often regarded as an early cue of dysregulation of homeostasis due to diseases or infectio

184 Dysregulation of homeostatic and hedonic brain nuclei ca

185 ignaling to generate ICWs that amplified the dysregulation of host cells and altered gastrointestinal

186 repression is a crucial question, given the dysregulation of HSF1 target genes in both cancer and ne

187 Dysregulation of hydrogen sulfide (H(2)S) by inhibition

188 ndent phosphorylation of Na(V)1.5 results in dysregulation of I(Na) with proarrhythmic activity that

189 ogress, we observe statistically significant dysregulation of IFN-gamma, IL-1RA, IL-6, IL-10, IL-19,

190 The dysregulation of IL-23 pathways and bile acid pathways m

191 endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of

192 Dysregulation of inhibition can lead to neuropsychiatric

193 y degeneration was associated with selective dysregulation of ion channel transcripts and altered Pur

194 ate that type I interferons (IFNs-I) promote dysregulation of iron homeostasis in macrophages upon in

195 ypothesized to derive from the within-system dysregulation of key neurochemical circuits that mediate

196 Our results suggest dysregulation of kynurenine metabolism associated with a

197 Dysregulation of lipogenesis therefore has the potential

198 in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets.

199 Dysregulation of LXR pathways have been identified in ma

200 Dysregulation of macrophage phenotypes is a major driver

201 The dysregulation of matrix metalloproteinase-9 (MMP-9) has

202 In this report, we identified dysregulation of members of the Dlk1-Dio3 miRNA cluster

203 n of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein m

204 Dysregulation of miRNA expression has been implicated in

205 Recent evidence suggests that dysregulation of mitochondrial calcium homeostasis is al

206 Although dysregulation of mitochondrial dynamics has been linked

207 Dysregulation of MOF activity occurs in multiple cancers

208 The role of dysregulation of mRNA alternative splicing (AS) in the d

209 ning cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in

210 rticularly of the glomerular capillary knot, dysregulation of nephrin and collagen IV, and ultrastruc

211 A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role

212 components, suggesting tumors arise from the dysregulation of normal development.

213 Dysregulation of PARP activity in these processes can pr

214 cardiovascular disease, potentially through dysregulation of physiological responses to negative str

215 d FGR, with relevance to human disease since dysregulation of placental Htra1 and placental oxidative

216 t to contribute to neuropathology by causing dysregulation of plasticity.

217 ational landscape and has a common origin in dysregulation of PRH.

218 Finally, expression dysregulation of proinflammatory cytokines in the serum,

219 Here, we investigate the dysregulation of rRNA synthesis in CS.

220 ral metabolic disease models have shown that dysregulation of sarcoplasmic reticulum Ca(2+) ATPase (S

221 Dysregulation of signaling pathways is correlated with A

222 k has resulted in a paradigm shift away from dysregulation of single neurotransmitter systems in depr

223 in the study of ASD frequently recapitulate dysregulation of sleep and biological (diurnal, circadia

224 ellite instable (MSI) cell lines reveals the dysregulation of specific protein complexes associated w

225 Dysregulation of SPOP-mediated proteolysis might be invo

226 We discovered highly sensitive dysregulation of TBX5-dependent pathways-including linea

227 increased DNA damage and apoptosis caused by dysregulation of TDP-43 localization and formation of cy

228 ompared with healthy donors, suggesting that dysregulation of the AHR/CYP1A1 axis may play a role in

229 The G(s)alpha mutation results in dysregulation of the cAMP signaling cascade, leading to

230 Dysregulation of the cGAS-STING pathway is responsible f

231 Dysregulation of the DNA/RNA-binding protein FUS causes

232 Dysregulation of the E/I ratio is associated with numero

233 We review evidence for dysregulation of the endogenous opioid system as a mecha

234 Dysregulation of the glutamatergic system and its recept

235 Loss of KDM5A also resulted in dysregulation of the hippocampal transcriptome.

236 s well as human subjects have shown that the dysregulation of the immune system in autoimmune disease

237 une-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) sy

238 Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in b

239 compromise in CSE/H(2)S pathway is linked to dysregulation of the mitochondrial bioenergetics and oxi

240 The dysregulation of the molecular mechanisms underlying the

241 ressive disorder, originate in part from the dysregulation of the Netrin-1/DCC pathway by a mechanism

242 Dysregulation of the PI3K/Akt/mTOR pathway has become a

243 g, and CD4 T-cell apoptosis or depletion via dysregulation of the PI3K/ATM pathways.

244 of differentially expressed genes identified dysregulation of the pre-mRNA splicing pathway, accompan

245 Our findings indicate that the dysregulation of the RalA pathway has an important impac

246 We conclude that dysregulation of the retromer complex system is an early

247 One plausible mechanism is dysregulation of the reward system, a common feature of

248 MAGP-1 gene inactivation are consistent with dysregulation of the transforming growth factor beta (TG

249 cific mutations in SEC61A1 cause SCN through dysregulation of the UPR.

250 R5(+) stem cells to gastric cancer following dysregulation of the WNT pathway-a frequent event in gas

251 Dysregulation of the Wnt/beta-catenin signaling pathway

252 es a dynamic response of HSCs to stress, and dysregulation of these adaptive-response mechanisms unde

253 regulating HSC behaviour with the functional dysregulation of these mechanisms in myeloid leukaemia a

254 uire further investigation, as reversing the dysregulation of these processes in NDD-CKD may provide

255 Mutations or dysregulation of these proteins are associated with many

256 ) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes

257 Dysregulation of this homeostasis is implicated in tumor

258 anization as a multiphase condensate and how dysregulation of this organization could provide insight

259 Dysregulation of this protein plays a pivotal role in th

260 presentative molecule and highlights how the dysregulation of this system can lead to several immune

261 R signaling exacerbated the TGF-beta-induced dysregulation of tight junction proteins, E-cadherin and

262 analysis and ATAC-seq revealed a significant dysregulation of transcripts involved in DNA repair, chr

263 filing and RNA sequencing to investigate the dysregulation of translation in the mouse brain cortex.

264 Dysregulation of translation initiation factor 4E (eIF4E

265 In this study, we observed broad dysregulation of transmethylation and polyamine synthesi

266 Dysregulation of TrkB signaling is implicated in neurode

267 wth inhibition at high levels of defense and dysregulation of Trp biosynthesis.

268 ations in fusA1 can lead to highly selective dysregulation of virulence gene expression.

269 receptor, and its role of the regulation and dysregulation of water excretion in the kidney.

270 gulatory interaction between IL-10 and PGE2, dysregulation of which may drive aberrant Mphi activatio

271 Chronic stress causes dysregulations of mood and energy homeostasis, but the n

272 e was no molecular evidence of either clonal dysregulation or transgene silencing.

273 However, the mechanism underlying this dysregulation, particularly in human cells, remains poor

274 Immune-dysregulation, polyendocrinopathy, enteropathy, X-linked

275 underlying mechanism(s) of rotavirus-induced dysregulation remains unclear.

276 Immune dysregulation seen in STAT3 LOF patients suggests a susc

277 lopmental disorders resulting from histamine dysregulation.SIGNIFICANCE STATEMENT Monogenic causes of

278 ary antibody deficiency, 9 (9.6%) had immune dysregulation syndrome, 6 (6.4%) a phagocyte defect, 7 (

279 ential early in life, while symptoms of TLR7 dysregulation take longer to manifest.

280 aberrant innate immune signaling, complement dysregulation, Th2 skewing, and increased secretion of M

281 Glutamatergic system dysregulation that is observed in AUD is a likely substr

282 ous disease characterized by transcriptional dysregulation that results in a block in differentiation

283 ads to a shared signature of transcriptional dysregulation that underlies these phenotypes.

284 Thus, CHD1 loss results in chromatin dysregulation, thereby establishing a state of transcrip

285 le strategy to broadly attenuate sympathetic dysregulation, thereby improving cardiovascular regulati

286 cases not due to genetic defects, suggesting dysregulation through alternative mechanisms.

287 support a mechanism linking heterochromatin dysregulation to cerebellar circuit dysfunction and beha

288 inding and -activating (GBA) motif and whose dysregulation underlies human diseases, including cancer

289 LPA/S1P pathway as a novel mode of metabolic dysregulation upon TSC2 loss, highlighting critical role

290 This review describes how immunometabolic dysregulations vary as a function of depression heteroge

291 ic expression that drives multi-organ immune dysregulation via kinase dependent and independent mecha

292 This dysregulation was rescued by treatment with Clostridiale

293 ings reveal a direct, underlying role of NAD dysregulation when telomeres are short and underscore it

294 ession of the nervous system due to integrin dysregulation, which causes locomotor defects in the ani

295 Lesional AD skin shows a NK-cell dysregulation, which despite clinical improvement under

296 fraction of the patients suffer from immune dysregulation, which leads to increased morbidity and mo

297 rophages affect systemic immunopathology and dysregulation, which likely leads to fatal outcomes.

298 enes (DEGs) highlighted oligodendrocyte (OL) dysregulation, which we confirmed in two additional mous

299 nly modest physiological and transcriptional dysregulation, with derepressed target gene enrichment l

300 ed appetite exhibited marked immunometabolic dysregulation, with higher insulin, insulin resistance,