ライフサイエンスコーパス: early

1 attributed to events that took place in the early 1990s, consciousness studies today are a continuat

2 oratory counterparts were first noted in the early 20(th) century and led some researchers to later q

3 n essential tool to study gene function when early ablation or overexpression can cause developmental

4 while residents gain breeding benefits from early access to resources.

5 Additionally, Alix is an early acting endosomal factor involved in HIV-1 budding

6 rized by the emergence of myofibroblasts and early activation of pro-fibrotic signaling pathways befo

7 Immunopattern II early active lesions contain 64% more iron (95% confiden

8 the identification of unique biomarkers for early AD.

9 SIRT3 rapidly increases SOD2 activity as an early adaptation to cellular detachment, which is follow

10 n vitro transporter inhibition assays in the early ADME profiling space in drug discovery.

11 Approximately one third of patients require early admission after LT.

12 We evaluated outcomes among survivors of early-adolescent and young adult cancer (aged 15-20 year

13 cause-specific mortality among survivors of early-adolescent and young adult cancer.

14 examined trajectories across adolescence and early adulthood for 2 major dietary patterns and their a

15 activity of proteostasis-related pathways in early adulthood.

16 the induction of NK cell effector functions early after Ad26.ZEBOV, MVA-BN-Filo vaccination and prov

17 increased mortality and acute kidney injury early after transcatheter aortic valve replacement and i

18 is a circadian pattern in the occurrence of early afterdepolarizations (EADs), which are abnormal de

19 present with severe disease at a relatively early age and most (67%) have slow-to-moderate progressi

20 We tested whether (1) small group size, (2) early age of allocation to a group decreases aggression

21 In summary, plasma p-tau217 increases during early Alzheimer's disease and can be used to monitor dis

22 277 (51%) of 544 patients commenced therapy early and 267 (49%) commenced therapy late.

23 es in response to COVID-19 were sufficiently early and assiduous to avert a public health crisis - fo

24 The ability to detect disease early and deliver precision therapy would be transformat

25 Although both early and late viral transcripts contain m(6)A, depletio

26 However, the study was stopped early and likely was underpowered to find a statisticall

27 This study compared early and long-term outcomes of PCI versus CABG in patie

28 in vitro and in silico approach, we turn to early and lower vertebrates and ask two fundamental ques

29 t)-D(apexpost) difference were higher in the early and mild KC groups compared to the control group (

30 However, the early and nonadopter changes in implantation rates were

31 after adjustment for age and sex, driven by early and noncardiovascular death.

32 nclusion This multicenter study demonstrated early and progressive involvement of upper extremity mus

33 -induced signaling cascades are altered when early and recycling endosomes are disrupted by the expre

34 that ILM macrophage cells appear to play an early and regionally specific role of nerve fiber layer

35 erphosphorylation of NM hTau was observed as early as 4 weeks of age, and transgene suppression for t

36 mestic chicken in northern China, perhaps as early as 8,000 years ago.

37 imers discernible in the lattices we predict early assembly intermediates, and indeed we observe such

38 We find aberrant activation of early B cell factor 1 (EBF1) to promote transformation o

39 We conclude that early blockade of the IL-1 receptor is therapeutic in ac

40 Ibises (Eudocimus albus) to MeHg also caused early breeding failure and a ~20% reduction in breeding

41 fy Padi2 as a potential intermediary between early calcium signaling and subsequent tissue regenerati

42 common, and more patients were diagnosed at early cancer stage.

43 The early cancer-immune interaction sculpts intratumor heter

44 Clinically relevant precursors and early cancers were too small to be detected.Keywords: Ge

45 Early case detection, contact screening, and chemoprophy

46 ed with interferon type I and III responses, early CD4(+) and CD8(+) T cell activation, and counterre

47 same visit (i.e., concurrently) and whether early changes in irritability with antidepressant treatm

48 These results suggest a novel mechanism of early childhood asthma and demonstrates the importance o

49 Early childhood deprivation is associated with higher ra

50 Early childhood development (ECD) programmes can help ad

51 nt of autoantibodies against (pro)insulin in early childhood.

52 While this notion is supported by early clinical evidence, the mutation frequencies of the

53 we found that increased plasma IFN-gamma in early clinical sepsis was associated with the later deve

54 Our work provides a mechanism for how early clonal dynamics imprint the hierarchy of T cell cl

55 Species composition is also contingent on early community states, not only because of differences

56 S action that, through the disruption of the early coordinated non-lytic cell death response, ultimat

57 response prompted us to examine the role of early corticosteroid therapy in patients with moderate t

58 Early cultures maintain the clonal heterogeneity seen in

59 on free adducts were higher in patients with early decline in GFR, compared to those with stable GFR.

60 VG results permitted early deescalation for methicillin-susceptible Staphyloc

61 ective cure and disease management relies on early detection and removal of infected trees.

62 ion formation introduces complexity for both early detection and the study of metastasis in preclinic

63 he use of sensitive screening modalities for early detection of lung cancer might result in the disco

64 of automated, open-source algorithms for the early detection of sepsis from clinical data.

65 k prediction, risk-stratified prevention and early detection strategies, and their implementation.

66 supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in

67 ior portion of the right CB may underlie the early development of the preterm behavioral phenotype.

68 and central nervous system, strongest during early development, and decreasing postnatally.

69 l and functional network connectivity during early development.

70 ortant for genetic counseling and subsequent early diagnosis and initiation of proper therapy.

71 iew, we discuss how machine learning can aid early diagnosis and interpretation of medical images as

72 detecting T-cell activation would allow for early diagnosis and possibly more effective management o

73 hich demonstrated the great potential in the early diagnosis and postoperative monitoring of breast c

74 ounger and black PLWH highlight the need for early diagnosis and treatment of HIV infection.

75 s to prevent their occurrence and facilitate early diagnosis and treatment.

76 reatment of AKI due to the lack of efficient early diagnosis is an important cause of its high mortal

77 Early diagnosis of an infection based on antibody detect

78 in the AN population through prevention and early diagnosis.

79 rs, intercepted in the blood, could serve as early diagnostic markers.

80 cer biology as well as to the development of early diagnostics and personalized therapies.

81 e accessible within pre-existing TADs during early differentiation.

82 evelopment (ECD) programmes can help address early disadvantages for the 43% of children younger than

83 Early discrimination of patients with ischemic stroke (I

84 made in cancer therapeutics and treatments, early disease detection and diagnosis remains critical t

85 titer convalescent plasma is efficacious in early-disease patients.

86 ans, and gene flow into Neanderthals from an early dispersing group of humans out of Africa.

87 Chytrids are early-diverging fungi that share features with animals t

88 Although not yet widely implemented, early drain removal after distal pancreatectomy is assoc

89 its benefit following pancreatoduodenectomy, early drain removal after DP has yet to be explored.

90 port for a possible mechanistic link between early driver mutations in RAS and KIT and the widespread

91 SPRINT was terminated early due to benefit observed in the primary outcome (co

92 nsorimotor network, also tend to be affected early during premanifest stages.

93 ategy for identification of durable response early during the course of treatment and could improve p

94 r subspecies O. nivara and thus was acquired early during the evolution of rapid cycling trait in ric

95 nd no aura from posterior insula features of early dystonia, early tonic motor features, and sensorim

96 refore, dust was a critical component of the early Earth system, and should always be considered when

97 cious nuclear translocation of NRDE-3 in the early embryo.

98 will generate an integrated understanding of early embryogenesis and new strategies for therapeutic i

99 lesterol and steroid hormone metabolism with early embryonic cell movements.

100 d by a failure of neural tube closure during early embryonic development.

101 hinitis involve a combination of genetic and early environmental exposures, whereas late transient rh

102 redisposition and increased vulnerability to early environmental insults.

103 structed from proxy data for anywhere on the early Eocene Earth, and these data therefore suggest tha

104 odes punctuated the background warmth of the early Eocene, likely linked to eruptive phases of the No

105 cell wall protein is required to promote the early epithelial transmigration of human neutrophils int

106 of transcriptional co-repressor ETO2 during early erythropoiesis and hemoglobin switching is unclear

107 ulation of the retromer complex system is an early event in the development of the AD-like pathology

108 While early experience with moving stimuli is necessary for th

109 In this early feasibility study of the BEC for intermediate-risk

110 rom a single introduction in late January or early February 2020, which subsequently spread locally b

111 o 1.2%]), and favorable clinical response at early follow-up was 61.0% and 55.8%, respectively (diffe

112 blished, and this may be because of the very early formation of a reservoir of latently infected cell

113 the absence of endochondral ossification in early fossil gnathostomes appear to lend support to this

114 In particular, the MCPyV early gene downregulated the expression of the tumor sup

115 Babies with GACI are diagnosed early, generally soon after birth and in some cases befo

116 The early-generated, largely transient neurons of the subpla

117 For the diagnosis of early glaucoma, both macular and optic disc scans should

118 n studies have shed light on the genetics of early growth and its links with later-life health outcom

119 We conclude that early healing after orthopaedic trauma must be allowed p

120 The aim of this study was to examine if early health status changes were associated with long-te

121 listic forecasts of disease incidences, this early health warning system is found to be a useful tool

122 y provides temporal and spatial clues of the early history of the Hawaiian plume for future plate rec

123 that these responses play a role in driving early HIV-1 viral evolution.IMPORTANCE HIV-1 has excepti

124 (4) advection at the studied site during the Early Holocene and the Younger-Dryas - post-Bolling.

125 , but while plant diversity recovered in the early Holocene, animal diversity did not.

126 granzyme B and IFN-gamma occurred within the early hours after reactivation and correlated with local

127 wing endothelial Nck1 and IRAK-1 staining in early human atherosclerosis, and demonstrating that dist

128 s (hESC) to investigate the effect of PCE on early human brain development.

129 ed anterior insula manifestations, including early hypermotor signs, early recovery, and no aura from

130 aucity of protective vaccines as well as the early identification of individuals with the highest ris

131 Early impairments to neurovascular coupling have been pr

132 lts in rapid changes in metabolic parameters early in direct-acting antiviral (DAA) therapy.

133 ation of the vertebral column is established early in embryogenesis, when pairs of somites are rhythm

134 in or gentamicin is effective when initiated early in illness but can have serious side effects.

135 g that language is distributed symmetrically early in life.

136 w song-generating circuits may be influenced early in song learning by a cortical region (NIf) at the

137 he results of this investigation, especially early in the course of treatment.

138 d precipitation during the fall spawning and early incubation period and increased with above-average

139 HO-1 and/or carbon monoxide correlated with early induction of the long-chain acyl-CoA synthetase 1

140 ve parenting (RP) intervention, initiated in early infancy, prevented the use of nonresponsive, contr

141 veloping a cognitively flexible brain during early infancy.

142 In 70 CF patients with early infections, 14 shared strains infected 29 (41%) pa

143 learn from high-achieving centers to promote early initiation of prenatal care among medically vulner

144 racked over their complete development, from early instar larvae to adult death.

145 These findings highlight the need for early interventions for dementia prevention to mitigate

146 ibody detection might lead to less invasive, early interventions.

147 munity transmission of SARS-CoV2 in Wuhan in early January 2020.

148 urvived the embryonic period but perished in early juvenile life.

149 he current study, we examined the effects of early ketamine exposure on brain structure and function.

150 tor 2 (ROBO2) plays an important role during early kidney development.

151 Colostrum and early lactation milk samples were collected from 285 mot

152 rafish mimicked the patients' phenotype with early lethality, defects in neurogenesis and cardiac dil

153 eased prevalence of ADHD in association with early life exposure to PFOS and PFOA.

154 This limitation has led to models of early life in which the first cells used simpler types o

155 le stressors on immune system development in early life stage fishes.

156 is finding suggests that maternal effects on early life survival such as maternal age may act through

157 is a time-limiting step for research on the early life-history stages of corals.

158 to develop oral tolerance to food antigen in early life.

159 ul in randomized trials, but the quantity of early-life gluten exposure has been a major focus of pre

160 We identified developmental trajectories of early-life microbiome composition, as well as predominan

161 ne the role of leptin in the associations of early-life nutrition and adult cardiometabolic outcomes.

162 neuroimmune network hypothesis suggests that early-life stress initiates a positive feedback loop bet

163 The cellular complexity and scale of the early liver have constrained analyses examining its emer

164 oved rate of seropositivity in patients with early Lyme infection.

165 d by a rapid simple assay, proved a valuable early marker of severity in ABP with clear advantages fo

166 hat we consume highly digestible foods, wean early, mature slowly, and exhibit high lifelong investme

167 We analyze reported cases, between March and early May 2020, in five (urban and rural) counties in th

168 Early menarche was not associated with increased risk of

169 isk factors, such as premature menopause and early menarche, with risk of AAA in a large, ethnically

170 Fulvestrant treatment induced a similar early metabolic response for both WT-ER and Y537S-ER tum

171 the effect of maternal heat exposure during early-mid gestation, when pig placentae grow heavily, on

172 PCs is reexpression of viral major immediate early (MIE) genes.

173 ILD events were more common among those with early/mild ILA at enrollment (63.3% vs. 6.1%; P < 0.0001

174 thesis decreases by approximately 50% during early mitosis and increases back to G2 levels during cyt

175 All publications supported implementation of early mobilization.

176 tional cpRNFL thickness for the diagnosis of early/moderate glaucoma, whereas cpRNFL thickness remain

177 es in the highest IOP PRS quintile showed an early morning IOP increase of 4.3 mmHg (95% confidence i

178 In a large cohort of 302 volunteers, early morning vaccination resulted in a superior cytokin

179 Early mycorrhizal colonization was reduced in mlo mutant

180 665 to 0.695, and discriminate patients with early neoplasia from patients without BE with AuROC valu

181 An important question in early neural development is the origin of stochastic nuc

182 Increasing evidence indicates that early neural measures implicated in anxiety and anxious

183 MS is associated with brain structure during early neurodevelopment remains unclear.

184 d suspended sediments to construct extensive Early Noachian highlands.

185 ) were classified into one or more subtypes: early onset (EO), lethal, and/or clinically significant.

186 antigens, including those who have exhibited early onset or accelerated cardiac allograft vasculopath

187 d flies lacking functional autophagy develop early onset progressive neurodegeneration.

188 The incidence of early-onset colorectal cancer (CRC), which occurs in ind

189 argest net reclassification improvements for early-onset coronary heart disease, atrial fibrillation

190 nts with diabetes, who are at higher risk of early-onset CRC than the general population.

191 All patients had neonatal/early-onset diabetes, severe microcephaly, and epilepsy.

192 BS-specific antibodies protect newborns from early-onset disease, yet their impact on GI colonization

193 <5 years old; lesional and nonlesional) with early-onset moderate-to-severe AD (<=6 months) and 17 he

194 and mutations in Parkin are a major cause of early-onset Parkinson's disease (PD).

195 Notably, the early-onset tumor formation observed in p53(5KR/5KR) and

196 Culture-proven aspiration pneumonia and early-onset ventilator-associated pneumonia occurred in

197 erate by direct interaction with each during early oocyte development and share downstream gene targe

198 indicate laminin-111 protein therapy either early or late in the disease process could serve as an e

199 investigated whether this integration occurs early or late in the process of perception.

200 behavior among amniotes and may indicate an early origin of brain lateralization.

201 r super-spreading events occurred during the early outbreak phase, as has been observed for other eme

202 t themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immun

203 A and mTOR, are currently being evaluated in early phase clinical trials in children with high-risk M

204 fector cell population most prominent in the early phase of acute viral and bacterial infections and

205 el environment presented during a vulnerable early phase of consolidation.

206 raveling cases represented a priority in the early phase of the epidemic.

207 reased levels of uncleaved C99 in the ER, an early phenotype of the disease, upregulates the formatio

208 We conclude that, in early plants, H3K27me3 played an essential role in heter

209 gnificant marginal bone loss occurred in the early post-diagnosis period of peri-implantitis, which c

210 Thus, in cortically-induced blindness, the early post-stroke period appears characterized by gradua

211 arbor of pyramidal neurons collected across early postnatal development in visual cortex of mice of

212 ) mouse and investigated the consequences of early postnatal inactivation of Kif11 in vascular endoth

213 ISG profile of RdRP mice is mostly triggered early postnatally, is maintained through adulthood, and

214 mplications described in the literature, are early postoperative complications.

215 Early-postpartum cows were metabolically deficient with

216 owering of ACR risk, particularly during the early posttransplant period.

217 he cingulum bundle may be a hallmark for the early prediction of Alzheimer's disease and a predictor

218 The strongest early predictors (within 5 years of presentation) of sec

219 ation predict the overall risk of developing early preeclampsia and indicate distinct subtypes of pat

220 Immune cells play a central role in early pregnancy establishment in cattle.

221 The diagnosis of an early pregnancy loss is relatively straightforward, alth

222 w strategies for therapeutic intervention in early pregnancy loss.

223 of implantation, plays a crucial role during early pregnancy.

224 ggest that this tumor suppressor can promote early premalignant epidermal lesion formation.

225 postmortem brain studies have indicated that early prenatal development may be altered in autism.

226 observed that CD11c(+) APCs are critical for early priming of CD8 T cells against the immunodominant

227 estations, including early hypermotor signs, early recovery, and no aura from posterior insula featur

228 detailed studies regarding isoform-specific early regulatory functions of the dynamins are lacking.

229 ience is critical for the alignment of these early representations.

230 rhinitis may relate to maternal factors and early respiratory infections independent of atopy.

231 Early rituximab intensification during R-CHOP-14 does no

232 Prevention of early RSV will require passive protection via maternal i

233 s there is no unambiguous evidence that this early scorpion was terrestrial, this evidence suggests t

234 Specifically, we identified the role of an early-season national show in the propagation and spatia

235 Translation of these mRNAs occurs during early seed germination, even before the requirement of t

236 h ambient temperature are coordinated during early seedling development in Arabidopsis A shoot signal

237 ignificant antitumor effect, indicating that early, self-activating expression of anti-PD-L1-gamma1 c

238 iases depend on sensory experience during an early sensitive period.

239 Early sensitization is ~50% higher in children with atop

240 e dysfunction, and grey matter atrophy is an early sign of potential future cognitive decline.

241 eous (C-type) asteroids(1) are relics of the early Solar System that have preserved primitive materia

242 ells are able to regulate osteoclasts at the early stage of rapid palatal expansion and further facil

243 , these data provide compelling evidence for early stage TRM fate decisions and the existence of comm

244 Furthermore, patients with early-stage breast cancer who experienced cardiovascular

245 Men with early-stage disease should not be treated with bone-modi

246 ved chemical proteomic strategy to track the early-stage entry of ZIKV into host cells.

247 atients distributed in 82 normal corneas, 40 early-stage keratoconus and 83 established keratoconus.

248 We diagnose early-stage LA with sensitivity~70-90% and specificity~9

249 expectedly, when overexpressing MMP14 in the early-stage obese adipose tissue, the transgenic mice sh

250 Patients with early-stage PD (duration <3 years) who were not taking d

251 urbance of cognitive ability observed in the early stages of Alzheimer's disease (AD).

252 amin also plays a regulatory role during the early stages of CME; however, detailed studies regarding

253 During the early stages of cytokinesis, FtsZ protofilaments form a

254 virus-host interaction occurring during the early stages of HIV infection.

255 Identifying early stages of hypersensitivity pneumonitis (HP) is ham

256 rotubules soon after virus entry and promote early stages of infection.

257 forms repulsive molecular brushes during the early stages of mitosis(8), but during mitotic exit the

258 e FSHD Lymphoblast score correlates with the early stages of muscle inflammation identified by histol

259 and of lipid rafts by Nef may contribute to early stages of neurodegeneration and pathogenesis in HA

260 r transfer chain and stop sever outbreaks in early stages of their appearance.

261 e (AD) is poorly understood, particularly at early stages preceding neurodegeneration.

262 predict the risk of RA and identify cases in early stages to prevent or alter disease progression via

263 Here we address that question by trapping an early state of pore formation for the CDC intermedilysin

264 ed to only binders to the target protein, in early steps of lead compound development, and this proce

265 most potent derivatives, 22 and 30, inhibit early steps of the replicative cycles of HIV-1 and EV-A7

266 recognising these predictors may help inform early stroke versus d-sICH prevention strategies.

267 Early structured physiotherapy involved mobilisation tec

268 Early studies suggested differential polarization of ATM

269 Early studies suggested that Fe(III) complexes cannot co

270 e, and the MRD-positive patients experienced early subsequent relapse.

271 us ~ switchgrass ~ native grasses ~ poplar > early successional >= restored prairie; direct climate b

272 ad an aIRR of 1.22 (95% CI, .93-1.60) during early suppression and 2.09 (95% CI, 1.18-3.70) during lo

273 Among patients with chronic pancreatitis, early surgery compared with an endoscopy-first approach

274 understanding of the mechanisms by which the early synergism between antibody-mediated toxin neutrali

275 Missouri is no exception, with increases in early syphilis (ES), congenital syphilis, and PWID, espe

276 Early T1 shortening showed high diagnostic performance (

277 weeks), and 1.47 (95% CI: 1.30 to 1.65) for early-term (37 to 38 weeks), compared with full-term (39

278 eatment and a reduced sample size due to the early termination of the study.

279 rauma-induced coagulopathy (TIC), to support early therapeutic decision-making.

280 showed similar growth kinetics; however, at early time points, HVT-DeltavNr-13 showed 1.3- to 1.7-fo

281 posterior insula features of early dystonia, early tonic motor features, and sensorimotor aura.

282 ratively transactivates the BoHV-1 immediate early transcription unit 1 (IEtu1) promoter that drives

283 Risk factors for early transient rhinitis involve a combination of geneti

284 For the early-treated cohort (83 HIV-1 adult patients treated wi

285 The mainstay of early treatment for SCI for all cases was blood pressure

286 he proportion of patients gaining 15 or more Early Treatment of Diabetic Retinopathy Study (ETDRS) le

287 ninferior to intravenous antibiotics for the early treatment of KLA.

288 her they influence heavy drinking during the early treatment phase.

289 rudent to prevent a substantial shift toward early vaccination.

290 The VERDICT (Very Early Versus Deferred Invasive Evaluation Using Computer

291 a novel role for MondoA in the regulation of early vertebrate development, connecting glucose, choles

292 itigates the CD8 T cell response, preventing early viral clearance and immunopathology associated wit

293 rs have been shown to evoke responses in the early visual cortex despite the lack of direct receptive

294 res, we have a poor understanding of how the early visual system contributes to figure-ground process

295 ode natural sounds from activity patterns in early "visual" areas of congenitally blind individuals w

296 Both TACTs were well tolerated, although early vomiting (within 1 h) was more frequent after dihy

297 he current technology as a powerful tool for early warning and detection of low pathogen concentratio

298 Results: Each radioligand gave high early whole-brain uptake of radioactivity, followed by a

299 ith confirmed NSTEACS randomized 1:1 to very early (within 12 h) or standard (48 to 72 h) invasive co

300 Here, we observed toxicity in early Xenopus laevis embryos when using such a conventio