ライフサイエンスコーパス: early embryonic

1 However, unlike early embryonic ablations, the growth plates of these mi

2 We recently reported that in the early embryonic absence of N-Myc (using Pax2-Cre), hair

3 er tritiated thymidine ([(3)H]dT, or TdR) at early embryonic ages were killed at different intervals

4 demonstrate the importance of investigating early embryonic alterations toward understanding the pat

5 DNA glycosylase (TDG) play crucial roles in early embryonic and germ cell development by mediating D

6 that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development.

7 e identified roles for GDF6 orthologs during early embryonic and neural crest development, but have n

8 oduce human NT-ESCs have failed secondary to early embryonic arrest of SCNT embryos.

9 cytes, highly abnormal Ca(2+) transients and early embryonic arrest.

10 dentify a genetic network that reinforces an early embryonic bias in auxin distribution to create a l

11 esenchyme exerts a considerable influence on early embryonic brain development and its disruption con

12 nurenine metabolism plays a critical role in early, embryonic brain development, although fewer effec

13 osphatases during progression throughout the early embryonic cell cycle and shed new light on potenti

14 phosphorylation is restricted throughout the early embryonic cell cycle, not just during M-phase, and

15 ses AurA(Thr-295) phosphorylation during the early embryonic cell cycle.

16 machinery before segregation, explaining why early embryonic cell cycles are so error-prone.

17 opic geminin slows down, but neither arrests early embryonic cell cycles nor affects endogenous gemin

18 on the chiral twist that takes place during early embryonic cell divisions.

19 e loss of AURKB, to support both meiotic and early embryonic cell divisions.

20 ings provide an example of the regulation of early embryonic cell fates by direct competition for a s

21 ans display embryonic reproducibility: Their early embryonic cell lineages are considered invariant a

22 lesterol and steroid hormone metabolism with early embryonic cell movements.

23 To define the early embryonic cell population that responds to Mesp1,

24 onstrate that the two daughter cells of many early embryonic cell-doubling events contribute asymmetr

25 Using early embryonic cells to determine the functional relati

26 During the short interphase of early embryonic cells, AL are rapidly delivered into the

27 RVK can induce viral restriction pathways in early embryonic cells.

28 y-breaking processes observed in oocytes and early embryonic cells.

29 e anterior cerebellar neuroepithelium in the early embryonic cerebellum was expanded and that granule

30 Differential conditional deletion of Sp2 in early embryonic cerebral cortical progenitors, and perin

31 findings reveal the diverse conformations of early embryonic chromosomes and uncover a previously una

32 Early embryonic chromosomes organized into an unconventi

33 n in the nematode Ascaris suum occurs during early embryonic cleavages and leads to the loss of germl

34 1 in the peripheral nervous system, using an early embryonic conditional knock-out model in which the

35 These early embryonic CSF1R(+)CD19(+) ProB cells also express

36 is from the yolk sac and enter the CNS quite early (embryonic day 9.5-10 in mice).

37 ruption of the ppm1f gene in mice results in early embryonic death at day E10.5.

38 Those succumbing to early embryonic death had markedly deformed vasculature

39 velopment is severely impaired, resulting in early embryonic death.

40 ection causes arrest before gastrulation and early embryonic death.

41 In early stage reduced implantation sites, early embryonic deaths, abortions, and necro-haemorrhagi

42 Early embryonic deletion of just the Swi/Snf Brg1 ATPase

43 ryonic stem (ES) cell line that emulates the early embryonic demethylation and remethylation waves.

44 of PRC2 components have been complicated by early embryonic dependence on PRC2 activity and the part

45 Our results demonstrate that early embryonic depletion of LAP1 does not impair myogen

46 emature burst of granule neurogenesis during early embryonic development accompanied by increased cel

47 Loss of HDAC3 in early embryonic development affects AM development start

48 ated the expression of specific miRNA during early embryonic development and between in vivo (IVO) an

49 understanding energetics of morphogenesis in early embryonic development and cancer-cell metastasis a

50 ne-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis dur

51 ome data set of bovine oocyte maturation and early embryonic development and detailed insight into th

52 DNA replication is crucial during C. elegans early embryonic development and further provide a novel

53 tor1 was expressed ubiquitously during early embryonic development and in multiple adult tissue

54 ning embryonic stem cell pluripotency during early embryonic development and it is required for gener

55 anslation, establishes its essential role in early embryonic development and mESC homeostasis, and of

56 minimum, fully substantiate L1 mosaicism in early embryonic development and neural cells, including

57 ctors are essential for diverse processes in early embryonic development and organogenesis.

58 basic activity of kcnh1 that is crucial for early embryonic development and patterning.

59 ental step toward understanding the bases of early embryonic development and pluripotency.

60 tion of mature oocytes capable of undergoing early embryonic development and successful pregnancy.

61 highly efficient splicing during Drosophila early embryonic development and suggest in highly prolif

62 ls, Set1A has been shown to be essential for early embryonic development and the maintenance of embry

63 fects in differentiation in vitro and impair early embryonic development as p150 deletion.

64 We analysed TSS usage during zebrafish early embryonic development at high resolution using cap

65 monocilia of the left-right organizer during early embryonic development can lead to laterality defec

66 Early embryonic development features rapid nuclear DNA r

67 acterizing Dicer and miRNA expression during early embryonic development from IVO and IVF sources are

68 st pronounced for gene regulatory domains of early embryonic development genes, housekeeping genes, a

69 Our understanding of reproduction and early embryonic development has directly enabled our man

70 esses and multi-lineage specification during early embryonic development have also been uncovered.

71 that the cell-cycle timing asynchrony of the early embryonic development in C. elegans is determined

72 e that extracellular zinc similarly disrupts early embryonic development in eggs from diverse phyla,

73 machinery, and that Donson is essential for early embryonic development in mice as well, suggesting

74 isruption of a CSN gene causes arrest during early embryonic development in mice.

75 It is essential for differentiation and early embryonic development in mice.

76 polarized epithelial monolayer necessary for early embryonic development in rodents.

77 ar morphogenetic movements that occur during early embryonic development in the frog Xenopus laevis.

78 n, we performed a transcriptomic analysis of early embryonic development in the spider Parasteatoda t

79 Early embryonic development in zebrafish is characterize

80 Early embryonic development is characterized by rapid cl

81 In most metazoans, early embryonic development is characterized by rapid mi

82 Early embryonic development is driven exclusively by mat

83 Early embryonic development may be a particularly suscep

84 However, early embryonic development occurs in the absence of tra

85 maintenance of embryonic stem (ES) cells and early embryonic development of the mouse.

86 d the effects of low frequency vibrations on early embryonic development of two aquatic species, Xeno

87 ors are characterized with the activation of early embryonic development pathways, whereas less aggre

88 resistant breast cancer cells, reflecting an early embryonic development process.

89 wever, their roles in cell fate decisions in early embryonic development remain poorly understood.

90 cluding SOX9, SF1, SOX8, AMH and DMRT1 in an early embryonic development stage at E34 in the XY(DSD)

91 s involved in cell fate specification during early embryonic development through regulating mRNAs inv

92 tors, including Wnt proteins, operate during early embryonic development to induce the NC cell fate.

93 Spinal neurons arise during early embryonic development with the establishment of sp

94 otent stem cells recapitulates the stages of early embryonic development(1-6).

95 l responsible for organizing activity during early embryonic development, and is necessary for bilate

96 esults reveal essential roles for Cubilin in early embryonic development, and suggest that in additio

97 Almost all Armc5 knockout mice died during early embryonic development, around 6.5 and 8.5 days.

98 During early embryonic development, atRA is synthesized from al

99 tional modification plays a critical role in early embryonic development, but its functions in C&E mo

100 Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechani

101 for telomere protection specifically during early embryonic development, cells exiting pluripotency

102 as started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell di

103 Application of SoptSC to early embryonic development, epidermal regeneration, and

104 Thus, during early embryonic development, NT-4 produced in the gangli

105 During early embryonic development, one of the two X chromosome

106 During early embryonic development, pHSCs migrate into the feta

107 d protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotenc

108 gene expression gradually strengthens during early embryonic development, reaching its peak at the po

109 During early embryonic development, roots of the model plant Ar

110 transport and local translation required for early embryonic development, synaptic plasticity, and lo

111 ism, pluripotency and differentiation during early embryonic development, the functional relationship

112 y of cannabinoid and alcohol exposure during early embryonic development, this study establishes a no

113 To further investigate the role of Zic3 in early embryonic development, we utilized two model syste

114 d by a failure of neural tube closure during early embryonic development.

115 it paternally acquired phenotypes by shaping early embryonic development.

116 throughout Drosophila oocyte maturation and early embryonic development.

117 in ovarian functions, oocytes, ovulation and early embryonic development.

118 with a bias against truncating mutations in early embryonic development.

119 ipto-1/FRL-1/Cryptic family, is critical for early embryonic development.

120 lls (mESCs) is a valuable in vitro model for early embryonic development.

121 reach and fertilise the oocyte, and aberrant early embryonic development.

122 stence of similar regulations in vivo during early embryonic development.

123 ork underlies cell fate specification during early embryonic development.

124 xretpos(L)) being transcribed solely during early embryonic development.

125 ritical for setting up pluripotent states in early embryonic development.

126 ription and changes to the cell cycle during early embryonic development.

127 stalling promotes repeat instability during early embryonic development.

128 ghly expressed in the CNS, especially during early embryonic development.

129 se, a unique "chanzyme," required for proper early embryonic development.

130 highlights the importance of TF activity in early embryonic development.

131 s cell fate with compartmentalisation during early embryonic development.

132 tional programs critical for angiogenesis in early embryonic development.

133 ally expressed and widely distributed during early embryonic development.

134 est whether Hif-1alpha also was required for early embryonic development.

135 blish a concentration gradient in Drosophila early embryonic development.

136 ad mutations in Atm (Atm(KD/KD)) died during early embryonic development.

137 required for inner cell mass survival during early embryonic development.

138 basal levels display oscillations throughout early embryonic development.

139 implications for cell fate decisions during early embryonic development.

140 tion in heterochromatin during oogenesis and early embryonic development.

141 lly redundant in ES cell differentiation and early embryonic development.

142 germ line, but it is required maternally for early embryonic development.

143 caused by a somatic mutation arising during early embryonic development.

144 gulated basement membrane remodelling during early embryonic development.

145 insertion events in either gametogenesis or early embryonic development.

146 tivated by maternal factors, allowing normal early embryonic development.

147 e study of metabolic processes in oocyte and early embryonic development.

148 that unlike ARPP19, ENSA is not required for early embryonic development.

149 ne expression that may model key features of early embryonic development.

150 n changes occur in carcinogenesis as well as early embryonic development.

151 ry structures and large chromatin domains in early embryonic development.

152 chanisms regulating X chromosome activity in early embryonic development.

153 t marsupials also have a placenta to mediate early embryonic development.

154 n parental genomes contribute differently to early embryonic development.

155 fects of sexing on bovine sperm function and early embryonic development.

156 critical for normal cilium formation during early embryonic development.

157 hat Nv-TLR also has an essential role during early embryonic development.

158 Abundant cell death marks early embryonic development.

159 d specificity for five Drosophila TFs during early embryonic development: Bicoid, Caudal, Giant, Hunc

160 Laminin-gamma1 is required for early embryonic development; however, the need for lamin

161 Malpighian tubules is not established during early embryonic development; instead, pluripotent progen

162 ale resource to further our understanding of early embryonic developmental disorders.

163 the degree to which the networks regulating early embryonic differentiation are conserved.

164 genitor cells is distinct from that found in early embryonic divisions and is more similar to that of

165 e a small RNA-Argonaute pathway that ensures early embryonic divisions in C. elegans by employing cat

166 romosome segregation during gametogenesis or early embryonic divisions.

167 es affect anaphase timing differently in the early embryonic divisions.

168 fy genes that affect NPC distribution during early embryonic divisions.

169 6 hpf (shield stage) leads to impacts on the early embryonic DNA methylome; and (3) TDCIPP-induced im

170 onstitute a plausible causal pathway linking early embryonic environment, epigenetic alteration, and

171 In the single-layered epithelium of the early embryonic epidermis, winner progenitors kill and s

172 ial for embryo production, cell division and early embryonic events are frequently reused later in em

173 focused on identifying compounds that affect early embryonic events in Caenorhabditis elegans We iden

174 ng either prior or post spermatogenic, i.e., early embryonic events.

175 Nix exhibits persistent M linkage and early embryonic expression, two characteristics required

176 okadaic acid (OA) or fostriecin into Xenopus early embryonic extract revealed that phosphatase activi

177 es the reprogramming process and reactivates early embryonic genes.

178 nd together facilitate the remodeling of the early embryonic genome.

179 Pregestational diabetes retards early embryonic growth.

180 ike progenitors that faithfully recapitulate early embryonic haematopoiesis.

181 o decipher the molecular pathways that drive early embryonic haematopoiesis.

182 ies define the ETS expression profile in the early embryonic heart and identify an ETS-dependent enha

183 In contrast, we propose here that, in the early embryonic heart tube, the signaling mechanism coor

184 Wnt signaling controls early embryonic hematopoiesis and dysregulated beta-cate

185 acity originate and differentiate within the early embryonic kidney by hemovasculogenesis (the concom

186 e required to understand the extent to which early embryonic landscapes are conserved.

187 Mice with mWh knockout are early embryonic lethal and display DNA damage.

188 d that monoallelic expression of CDK1(AF) is early embryonic lethal in mice and induces S phase arres

189 mutants were identified as null mutants with early embryonic lethal phenotypes that could be rescued

190 Smg1 homozygous KO mice were early embryonic lethal, but Smg1 heterozygous mice showe

191 ygous null for the alpha2(V) gene Col5a2 are early embryonic lethal, whereas haploinsufficiency cause

192 ad a normal lifespan, while homozygotes were early embryonic lethal.

193 sium homeostasis but additionally results in early embryonic lethality and neural tube closure defect

194 To avoid early embryonic lethality and study NFP function in late

195 inactivation of Atm and H2ax in mice causes early embryonic lethality associated with substantial ce

196 Absence of ALK5 leads to early embryonic lethality because of severe defects in v

197 reased TRPM7 expression, indicating that the early embryonic lethality caused by loss of hepatocystin

198 emonstrated in EPCR knockout mice which show early embryonic lethality due to placental thrombosis.

199 The finding of early embryonic lethality in a Tonsl(-/-) murine model a

200 ecause germ line deletion of Flcn results in early embryonic lethality in animal models.

201 1) is expressed by osteoblast-lineage cells; early embryonic lethality in Bag-1 null mice, however, h

202 RBP with a putative role in splicing, causes early embryonic lethality in mice and that its loss in P

203 mice, both D2899A and Q2740P mutations cause early embryonic lethality in mice, without displaying do

204 y, elevated p53 transcriptional activity and early embryonic lethality in mice.

205 d transcriptional elongation rate results in early embryonic lethality in mice.

206 ment, alteration of which may be involved in early embryonic lethality in mice.

207 normal cell cycle progression and results in early embryonic lethality in vertebrates.

208 In contrast to the early embryonic lethality of Atm(KD/KD) mice, AtmR3016H

209 In contrast to the early embryonic lethality of H2AX(-/-)XLF(-/-) mice, 53B

210 o play a role in patterning blood formation, early embryonic lethality of mice lacking Hh signaling p

211 Early embryonic lethality of the mouse knockout challeng

212 tes are perinatal lethal, in contrast to the early embryonic lethality previously reported for Rnaseh

213 ould lead to degradation of type I collagen, early embryonic lethality, and the scarcity of reported

214 Whereas complete loss of Spartan causes early embryonic lethality, hypomorphic mice with low amo

215 Although NIR deficiency in mice leads to early embryonic lethality, lymphoid-restricted deletion

216 While TDP-43 knockout mice show early embryonic lethality, post-natal conditional knocko

217 Deletion of CDK2AP1 leads to early embryonic lethality, potentially through altered d

218 oliferate, whereas deletion from mice causes early embryonic lethality, raising the question of wheth

219 utive Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality, whereas conditional Ssb1/Ssb2

220 n of the TRP channel TRPM7, which results in early embryonic lethality.

221 ound that loss of functional Zbtb24 leads to early embryonic lethality.

222 blindness, and, in mice, manifests with very early embryonic lethality.

223 and show that Slc52a3 deficiency results in early embryonic lethality.

224 demonstrated that deletion of Ada3 leads to early embryonic lethality.

225 H3.3 leads to developmental retardation and early embryonic lethality.

226 t the postimplantation stage, which leads to early embryonic lethality.

227 oviding a molecular explanation for htt(-/-) early embryonic lethality.

228 disease (HD), while htt(-/-) mutants display early embryonic lethality.

229 P1 receptor agonist to pregnant dams rescued early embryonic lethality.

230 g leads to complex developmental defects and early embryonic lethality.

231 ells, and germ-line deletion of Palb2 led to early embryonic lethality.

232 plasia and poorly developed OFT resulting in early embryonic lethality.

233 specific loss-of-function of YY1 resulted in early embryonic lethality.

234 hat Rdh10 loss-of-function mutations lead to early embryonic lethality.

235 uding exocytosis and cytokinesis, leading to early embryonic lethality.

236 letal and cardiac muscle defects, leading to early embryonic lethality.

237 trap knockout of Specc1l in mouse results in early embryonic lethality.

238 , since total body deletion in mice leads to early embryonic lethality.

239 knockout of both paralogs in mice results in early embryonic lethality.

240 ited formation of abnormal actin bundles and early embryonic lethality.

241 o E19, increased thereafter, and rose to the early embryonic level in the adult cornea.

242 lopment of the neocortex in p73 KO mice from early embryonic life into advanced age (25 months).

243 erentiation and further our understanding of early embryonic lineage segregation.

244 iate neural crest specification from various early embryonic lineages in Xenopus and chicken embryos

245 mice lacking NLRP2 are subfertile because of early embryonic loss and the production of fewer offspri

246 development, we specifically deleted Pten in early embryonic lung mesenchyme in mice.

247 nize in vitro, but whether they can recreate early embryonic morphogenesis is unclear.

248 ome profiling demonstrates that, in general, early embryonic mRNAs are not stored for subsequent tran

249 ls isolated from these tumors that formed in early embryonic murine retinas were characterized.

250 normal blood from 241 adults to identify 163 early embryonic mutations.

251 onnexin (Cx) 45 is strongly expressed in the early embryonic myocardium.

252 that pathological processes taking place in early embryonic neurodevelopment might be responsible fo

253 the IgLON family, neurotrimin and NEGR1, in early embryonic neurons was sufficient to confer sensiti

254 ntracellular viral sensing pathways (RIG-I), early embryonic, nonrenal lineage genes and increased ce

255 Recent findings suggest AMs are of early embryonic or fetal origin.

256 d7 were all broadly expressed throughout the early embryonic pancreatic epithelium.

257 Early embryonic patterning events are strikingly precise

258 f broad developmental regulators followed by early embryonic patterning genes and culminating in the

259 y of work aimed at understanding the role of early embryonic patterning genes in organizing adult res

260 and its sexually derived endosperm regulate early embryonic patterning in flowering plants.

261 The involvement of these protrusions in early embryonic patterning is suggested by the discoveri

262 During the early embryonic period, neuroblasts generate the primary

263 Early embryonic piwi-1+ cells are molecularly and functi

264 Imprinted genes have been implicated in early embryonic, placental, and neonatal development and

265 amily provides insight into the evolution of early embryonic potency.

266 , we show that snMacs do not derive from the early embryonic precursors colonizing the CNS, but origi

267 This study reveals an early embryonic regional specification of postnatal neur

268 H3 in the sperm genome is maintained during early embryonic replication.

269 morphogenesis in the epithelial tissue of an early embryonic salivary gland at a local scale using an

270 Early embryonic signalling may be necessary to guarantee

271 in early human embryos, our understanding of early embryonic somatic mutations is very limited.

272 he epithelium of the tongue primordium at an early embryonic stage, acquire epithelial cell phenotype

273 , whereas POLR3G knockout mice die at a very early embryonic stage, POLR3GL knockout mice complete em

274 opulations exhibit immature properties of an early embryonic stage, raising concerns about their abil

275 aboral (O-Ab) axis first develops during the early embryonic stage.

276 invade the mammalian spinal cord (SC) at an early embryonic stage.

277 t, but its boundary to the embryonic body at early embryonic stages and the fate of cells constitutin

278 dantly to regulate the generation of RGCs at early embryonic stages as well as the survival of RGCs a

279 stological analysis of BMPER(-/-) embryos at early embryonic stages demonstrates that commencement of

280 nalling in the distal limb primes the ZRS at early embryonic stages maintaining a poised, but inactiv

281 ociated with the calyceal processes from the early embryonic stages of outer segment growth onwards.

282 nt sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages.

283 into the extraembryonic blood vessel at the early embryonic stages when endogenous PGCs migrate thro

284 At early embryonic stages, high Ctbp2 levels sustain Notch

285 les (CRMs) than the coactivator p300, during early embryonic stages.

286 and mixed ancestry of these brain regions at early embryonic stages.

287 er, about the possible actions of NGF during early embryonic stages.

288 and TrkA(+)/TrkC(+) double positive cells at early embryonic stages.

289 cial role in microglial establishment during early embryonic stages.

290 However, comparative studies focusing on early/embryonic stages during insect development are lim

291 The core subunit SMARCB1 is required for early embryonic survival, and mutations can give rise to

292 yclin A2 loss lead to increased apoptosis at early embryonic time points but not at post-natal time p

293 oteinase 9 (MMP9) is expressed in teeth from early embryonic to adult stage.

294 transgenic reporting methods to analyze the early embryonic transcription factor T-box gene 4 (TBX4)

295 We report that DUX4, an early embryonic transcription factor that is normally si

296 l, paternal and zygotic contributions to the early embryonic transcriptome, we sequenced the transcri

297 In zebrafish, twist was expressed in early embryonic vasculature where it promoted angiogenes

298 s reminiscent of local activation of Toll in early embryonic ventral hypoderm, consistent with the hy

299 ed that ISL1 within SAN is a requirement for early embryonic viability.

300 Using four stages of early embryonic zebrafish development, we map nucleosome