ライフサイエンスコーパス: early event

1 h signaling in the hair matrix is a critical early event.

2 of basal forebrain cholinergic neurons is an early event.

3 is a V600E substitution in BRAF, which is an early event.

4 nt, micro-metastatic dissemination may be an early event.

5 -1 mouse cardiomyocytes to investigate these early events.

6 e-1-specific substrate to allow study of the early events.

7 for declining treatment assignment and other early events.

8 us on protease activation pathways and other early events.

9 In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft fun

10 lthough there is a good understanding of the early events after birth that lead to the rapid increase

11 Hras(G12V) knock-in allele to elucidate the early events after Hras activation, and to evaluate the

12 ction factors in primary cells or during the early events after SIV infection and suggest that the le

13 amyloid-beta peptide (Abeta) in brain is an early event and hallmark of Alzheimer's disease (AD).

14 amyloid-beta (Abeta) peptide in brain is an early event and hallmark pathology of Alzheimer's diseas

15 We hypothesized that MC activation is an early event and now find by histology that exocytosis of

16 Axon degeneration is an early event and pathological in neurodegenerative condit

17 he expression level of specific miRNAs is an early event and plays a functional role in the pathogene

18 c proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas

19 study HIV-1, but only limited information on early events and immune responses is available to date.

20 Secondary outcomes were early events and major adverse cardiac and cerebrovascul

21 onship between NK and CD4 cells, we analyzed early events and selective depletion of T regulatory cel

22 r alterations in EGFR and CDKN2A/B/p14ARF as early events, and aberrations in PDGFRA and PTEN as late

23 g comparison of risk of DCGF associated with early events (AR, DGF, baseline serum Cr >2.0 mg/dL) to

24 These early events are associated with impairment of parasite

25 These early events are driven by the epithelial MyD88-signalin

26 Subtle modifications in such early events are likely to have major impacts in later m

27 We identify a putative target for early events as a TRPM channel.

28 Inactivation of HR appears to be an early event, as 62.5% of tumours showed a LOH pattern su

29 iously responded to immunochemotherapy is an early event associated with a poor outcome that may dese

30 To investigate early events associated with antigen exposure, we first

31 ology and glutamatergic synaptic loss may be early events associated with cognitive impairment, we co

32 raction and highlight the modulation of this early event by the DNA sequence.

33 neural stem cell (eNSC) model to understand early events contributing to sexually dimorphic brain de

34 These results suggest that thrombin supports early events coupled to inflammation-mediated tumorigene

35 RUNX1 mutations can be early events, creating preleukemic stem cells that expan

36 0 days, neither clinical characteristics nor early events distinguished those who subsequently did or

37 for defects in mitochondrial function is an early event during adaptation and that up-regulation of

38 lomerase expression in senescent cells is an early event during cancer progression in humans.

39 e checkpoint that can lead to polyploidy, an early event during cervical carcinogenesis that predispo

40 An early event during homology-dependent repair is resectio

41 that myelin phagocytosis by astrocytes is an early event during lesion formation and leads to astrogl

42 Early events during dengue virus (DENV) infection remain

43 stomata and apoplast are the most important early events during plant-bacteria interactions.

44 Early events during retroviral infection play a critical

45 mass controls are similarly coordinated with early events during the differentiation of pluripotent s

46 asensitive HIV-1 quantification to delineate early events during the eclipse, burst, and chronic phas

47 lignant lesions suggests that they represent early events during tumor progression and additional alt

48 already in 2005, but an in-depth analysis of early events during virus infection had not been perform

49 To investigate the early events following acquisition of this mutation in m

50 olved in plant embryogenesis, especially the early events following fertilization are largely unknown

51 s of plant biologist for many years, yet the early events following water uptake, during which metabo

52 efore, place PARP-1 activation as a critical early event for DNA DSB repair activation and regulation

53 itial steps in Pfr signaling are unclear, an early event for the phyB isoform after photoconversion i

54 ATG induction was associated with increased early event-free survival, with no difference in long-te

55 generative diseases is commonly viewed as an early event in a continuum that ultimately results in ne

56 Furthermore, EndMT is an early event in a JAK2-V617F knock-in mouse model of prim

57 tical importance of Abeta accumulation as an early event in AD pathogenesis, multiple lines of eviden

58 beta (Abeta) protein has been proposed as an early event in AD pathogenesis.

59 tion of intracellular Abeta42 peptides is an early event in AD progression.

60 nctional alterations in the vacuole, a known early event in aging.

61 (VHL) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell

62 et enriched conformations was proposed as an early event in Alzheimer's Disease (AD).

63 One early event in AMI is the increased cardiac expression o

64 hat altered calcium homeostasis may be a key early event in basal toxicity or narcosis induced by lip

65 ion of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dorm

66 Since the migration of CTCs is an early event in cancer progression, patients who still ha

67 Endothelial dysfunction is an early event in cardiovascular disease and characterized

68 l effectors of ciliary vesicle formation, an early event in ciliogenesis.

69 ell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC) development.

70 increased whole-body protein breakdown is an early event in development of PDAC.

71 Podocyte injury is an early event in diabetic kidney disease and is a hallmark

72 titute the outer layer of capillaries, is an early event in diabetic retinopathy; however, the relati

73 revealing altered RT of the TP63 gene as an early event in disease progression of both HGPS and RTS.

74 glomerular endothelial cells representing an early event in DKD progression, and suggest that cross t

75 ctive oxygen species (ROS) metabolism are an early event in DMD onset and they are tightly linked to

76 r results indicate that HuR activation is an early event in FAP-adenoma but is not present in IBD-dys

77 ns therefore implicate CREBBP mutation as an early event in FL evolution that contributes to immune e

78 so found that peripheral degeneration was an early event in FUS as well as C9ORF72 repeat expansion m

79 pulation and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral

80 IDH mutation is an early event in gliomagenesis and has significant implica

81 assembly suggests that core formation is an early event in granule assembly.

82 ggesting that deficient protein import is an early event in HD.

83 proteins, most notably including AQP2, is an early event in hypokalemia-induced NDI.

84 -dependent helicase unloading as a critical, early event in ICL repair.

85 onfirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potentia

86 Axonal degeneration is a critical, early event in many acute and chronic neurological disor

87 ctivated protein kinase (MAPK) pathway is an early event in many different cancers and a key driver o

88 l distal processes has been identified as an early event in multiple sclerosis (MS) lesion developmen

89 polyploidization and suggest that this is an early event in NAFLD that may contribute to HCC developm

90 ggests that the IER3-dependent pathway is an early event in pancreatic tumorigenesis.

91 Intra-pancreatic activation of trypsin is an early event in pancreatitis.

92 trocytic Dlp1 likely represents a relatively early event in PD pathogenesis.

93 We propose that axonal injury may be an early event in presymptomatic Alzheimer's disease, causi

94 other methods, reveal abnormal TP63 RT as an early event in progeroid disease progression, and sugges

95 on of paraspeckle proteins to nucleoli is an early event in PS-ASO toxicity, followed by nucleolar st

96 that PKCalpha translocation may occur as an early event in radiation-induced bystander responses and

97 ribe ligand-mediated receptor assembly as an early event in receptor signaling and its application to

98 CNS, a process that has been proposed as an early event in several neurodegenerative conditions and

99 An early event in skeletal joint development is the specifi

100 hy the same driver gene change appears as an early event in some cancer types and as a later event, o

101 n samples, to identify NOTCH1 mutation as an early event in squamous cell carcinogenesis.

102 Our data suggest that BBB breakdown is an early event in the aging human brain that begins in the

103 emic inflammation, which can be viewed as an early event in the course of Alzheimer's disease.

104 nent mitochondrial dysfunction as a critical early event in the delayed degeneration of CA1 neurons a

105 mast cell sensory clusters represents a key early event in the development of allergic skin reaction

106 orebrain cholinergic circuitry represents an early event in the development of Alzheimer's disease (A

107 apoptosis induced by oxidative stress is an early event in the development of atherosclerosis.

108 ependent inflammation and fibrosis may be an early event in the development of ccRCC.

109 alterations in NF-kappaB signaling may be an early event in the development of cSCC.

110 of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a

111 ts indicate that Braf mutation is a frequent early event in the development of rat gliomas caused by

112 tumors, implicating RNF20/H2Bub1 loss as an early event in the development of serous ovarian carcino

113 ulation of the retromer complex system is an early event in the development of the AD-like pathology

114 is considered as an important factor and an early event in the etiology of Alzheimer's disease (AD).

115 Atg-16L-positive vesicles represents a very early event in the generation of the phagophore and in t

116 Cap snatching is an early event in the initiation of virus replication in in

117 t of recurrent collateral synapses may be an early event in the initiation process of SE and that TRP

118 e viral life cycle affected revealed that an early event in the life cycle is inhibited.

119 titutes both a genetic hallmark and critical early event in the natural history of follicular lymphom

120 logy points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infecti

121 hypothesize that microglial activation is an early event in the Parkinson's disease (PD) spectrum and

122 Amyloid beta (Abeta) accumulation is an early event in the pathogenesis of Alzheimer's disease (

123 esulting in mitochondrial dysfunction are an early event in the pathogenesis of Alzheimer's disease (

124 a (Abeta)-induced synaptic dysfunction is an early event in the pathogenesis of Alzheimer's disease (

125 tion of amyloid-beta (Abeta) plays a pivotal early event in the pathogenesis of Alzheimer's disease (

126 e hypothesis that SOX2 deregulation is a key early event in the pathogenesis of bronchial dysplasia;

127 a (Abeta)-induced synaptic dysfunction is an early event in the pathogenesis of cognitive deficits in

128 Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy

129 le-negative state appears to be an important early event in the pathogenesis of lymphoproliferation i

130 t that mitochondrial hyperactivity may be an early event in the pathogenesis of PD, and that strategi

131 dothelial cells (MVECs) injury is a critical early event in the pathogenesis of systemic sclerosis (S

132 ant survival mechanism that appears to be an early event in the pathogenesis of the disease.

133 mpairment of mitochondrial respiration is an early event in the pathogenesis, but the exact mechanism

134 er proteins P54nrb and PSF to nucleoli is an early event in the pathway that explains the effects of

135 egulate membrane potential signifying a very early event in the signal transduction.

136 irus protein B12, which otherwise impedes an early event in the viral lifecycle.

137 r to dissipate mitochondrial potential as an early event in their antimalarial action and therefore m

138 nt in retinal vessels near the ON head is an early event in TON and the CXCL10/CXCR3 axis has a criti

139 Hypermethylation may be an early event in tumor development that progress along a c

140 Widely assumed to be an early event in tumor development, this phenomenon plays

141 is common in cancer and often considered an early event in tumorigenesis.

142 and subsequent NK cell activation may be an early event in viral containment and may support inducti

143 and mitochondrial dysfunction are also among early events in AD.

144 on mediates activity-dependent regulation of early events in adult neurogenesis.

145 mpen, whereas circulating monocytes promote, early events in allergic lung inflammation.

146 ocused on improving the understanding of the early events in blood/material interactions with the goa

147 To evaluate early events in C4 evolution, we compared leaf anatomy,

148 That prothrombin is linked to early events in CAC was strongly inferred by the observa

149 iling molecular field dynamics for resolving early events in cancer evolution.

150 t imperative to develop new tools to measure early events in cell death.

151 in spike proteins are key players mediating early events in cell-to-cell fusion, vital for intercell

152 fficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic c

153 cate that the regions of CENP-A required for early events in centromere establishment differ from tho

154 ious regions unique to CENP-A to investigate early events in centromere establishment.

155 e in the neural progenitors is essential for early events in corticogenesis, and help to understand t

156 These findings suggest that early events in DDH cartilage originate at the chondrocy

157 s a general and effective route to study the early events in enzyme-substrate reactions.

158 be compared to the emerging understanding of early events in eukaryotic evolution to generate a coher

159 y (CFM) used to supplement information about early events in fibrillogenesis.

160 aling through alpha(4)beta(7) likely impacts early events in HIV infection.

161 ll line-specific models that demonstrate how early events in IGF1R signaling depend on the protein ab

162 n opportunity to study the clinically silent early events in infection.

163 Here we analyzed the early events in influenza B virus infection and interfer

164 outcomes of ATG5 activity, and shed light on early events in innate immunity that are required to reg

165 dies confirm that cell-based QCMs can detect early events in intrinsic apoptosis and reveal unique ki

166 Conversely, adverse early events in life may have consequences later in life

167 We examined early events in liver and plasma through A5335S, a subst

168 way field has been postulated as a model for early events in lung cancer pathogenesis.

169 cular circadian rhythms that are relevant to early events in lung injury.

170 pithelial tissues principally by influencing early events in malignant transformation.

171 We present a model of the early events in mast cell signaling mediated by Fcepsilo

172 ther, our findings provide new insights into early events in myelopoiesis, whereby Trib1 functions at

173 KRAS mutation and alterations in CDKN2A are early events in pancreatic tumorigenesis.

174 ylation, ubiquitination, or internalization, early events in PKCalpha desensitization.

175 tility of hyperpolarized NMR for quantifying early events in polymerization reactions.

176 g the time that would have been required for early events in primordial chemistry before the advent o

177 errant expression of ERG are the most common early events in prostate cancer and are significantly en

178 the environment and may be representative of early events in protein folding and structure stabilizat

179 assay makes it ideally suited for studies of early events in pure lipid bilayer fusion or fusion assi

180 ng might also help to establish the order of early events in RA.

181 We discuss how the various early events in SL signalling could result in the observ

182 Early events in T cell receptor signaling can distinguis

183 to and exocytosis at the contact region, are early events in TCR-driven, but not chemokine-driven TEM

184 The early events in the aggregation of the intrinsically dis

185 richment in the PrP(C) monomer as one of the early events in the conversion of PrP(C) into PrP(Sc).

186 n the present study, we sought to reveal the early events in the cytosolic sensing of this nucleic ac

187 ation that exerts significant influence over early events in the developing immune response.

188 these mutations may represent characteristic early events in the development of hematologic cancers.

189 nt, but also to provide a unique window into early events in the development of inflammatory arthriti

190 urrent mutations and genomic instability are early events in the disease.

191 Furthermore, little is understood about the early events in the establishment of chronic infection i

192 To identify the early events in the establishment of totipotency, we mon

193 e for hepatic fibrosis; elucidation of these early events in the fibrotic process will provide target

194 unfolding rates and specifically modulating early events in the folding process, stabilizing formati

195 heat stress to investigate specifically the early events in the heat stress and recovery response.

196 We show that LFA-1 and Fas are early events in the LtxA-mediated cell death cascade as

197 provide insight into mechanisms controlling early events in the metastatic process and suggest that

198 ing evolution and metastatic spread are very early events in the natural history of urothelial carcin

199 for disease therapy and tool for unraveling early events in the onset of polyQ diseases.

200 ld of cancerization, providing insights into early events in the pathogenesis of NSCLC that may compr

201 This has been associated with early events in the pathogenesis of several disorders th

202 ng that aberrations in phase transitions are early events in the pathogenesis of several neurodegener

203 In this review, we focus on the early events in the process of fibroblast spreading on f

204 The early events in the retrovirus assembly pathway, particu

205 Although our simulations represent the early events in the self-assembly process of chitosan, w

206 Thus, early events in thymic T cell development and repertoire

207 To study the kinetics of early events in trypanosome division, we employed an "AE

208 found that tandem duplications appear to be early events in tumor evolution, especially in the genes

209 hat EGFR amplification and rearrangement are early events in tumorigenesis and EGFRvIII follows a mod

210 To further investigate early events in vaccine-induced antibody responses again

211 Understanding early events in viral spread can inform antiviral interv

212 ic mutant was used as a tool to observe very early events in viroplasm assembly.

213 coating by the long non-coding RNA XACT are early events in XCI erosion and, therefore, may play a r

214 Known early events include opening of the blood-brain barrier

215 Early events initiating the pathophysiological outcomes

216 Although some of the early events involved in this pathology have been identi

217 However, the early events involving HIV-1 epitope presentation to CD8

218 In lytic infection, an important early event is the colocalization of ICP0 to nuclear dom

219 An early event is the shedding of the outermost fibrous cor

220 We analyzed early events leading to apoptosis of human endothelial c

221 vide evidence that caspase-9 facilitates the early events leading to autophagosome formation; that it

222 sequences play crucial roles in biasing the early events leading to frustration in the folding of Ch

223 unctional integrin-beta1 is required for the early events leading to renal cystogenesis in ADPKD and

224 nism of macrophage-dependent coordination of early events leading to stable tolerance.

225 at the IL-2 receptor activation, among other early events, leads to activation of PKCtheta.

226 enesis the onset of Nrf2 mutations is a very early event, likely essential for the clonal expansion o

227 ecruitment of mannosidase-II vesicles was an early event mediated by focal exocytosis and coincided w

228 ry receptor, EGFR, in CD34(+) HPCs initiates early events necessary for successful latent infection o

229 nisms used by the parasites to carry out the early events necessary for their establishment in the fl

230 tional connectivity (FC) is thought to be an early event occurring in diseases with cerebral amyloido

231 Here, we focused on the early events occurring after the interaction between Wnt

232 y patients with BE and EAC and indicate that early events occurring even in histologically NE cells m

233 These results define early events occurring in an inhalational macaque monkey

234 within 24 h after AS01, suggesting that the early events occurring postinjection were required for t

235 and mouse models with scRNA-seq to elucidate early events occurring with oncogenic KRAS activation.

236 Here, we report that an immediate-early event of Arg-auxotrophic response involves reactiv

237 twork fragmentation was also confirmed as an early event of replicative aging.

238 umour and reveal that clonal expansion is an early event of tumorigenesis.

239 They also suggest that early events of adherens junction assembly involve inter

240 s were a core platform on which the critical early events of autophagosome formation occurred, includ

241 lls and the impact of CD23 expression on the early events of B-cell receptor (BCR) activation using C

242 uggests that Rictor positively regulates the early events of BCR signaling.

243 tion, and functional studies, we uncover the early events of C. elegans brain assembly.

244 These are shown to be early events of catch-up growth that are independent of

245 The early events of cholesterol crystal development were inv

246 bust and faithful experimental system of the early events of epigenetic reprogramming and regulation

247 ve embryonic stem cells and characterize the early events of epigenetic reprogramming during the form

248 erexpression perturbs both nuclear shape and early events of HIV infection.

249 ith an autologous immune system for studying early events of human leukemogenesis and for evaluating

250 ) with autologous immune system for studying early events of human leukemogenesis and testing the eff

251 However, almost no information exists on the early events of human pancreatic specification in the di

252 The early events of IFNgamma-induced tumour ischaemia resemb

253 ing methods, Ritter et al. (2015) define the early events of immunological synapse formation and gran

254 due to the challenges involved in examining early events of infection at the cellular and molecular

255 reaction can lead to systemic shock, but the early events of its development in lung tissues have not

256 that P55 plays no important role during the early events of M. bovis infection.

257 infection and offer important insights into early events of M. tuberculosis infection.

258 proach targeting aeroallergen sensing in the early events of mucosal immunity could have greater bene

259 ellular matrix, has an essential role in the early events of myelination.

260 The molecular interactions governing the early events of osteolytic lesion formation are currentl

261 es, and protein contents associated with the early events of postharvest physiological deterioration

262 a pellucida (ZP) interactions as well as the early events of sperm capacitation, the remodeling of th

263 oited by C. neoformans to interfere with the early events of the afferent responses that support Th1

264 results provide better understanding of the early events of the BR signaling pathway.

265 ndancy and efficiently support the postentry early events of the mammalian-retrovirus replication cyc

266 ults provide a framework for elucidating the early events of the PRV replicative cycle.

267 In this study, we describe the early events of tissue colonization and compartmentaliza

268 uman 48S The structure reveals insights into early events of translation initiation complex assembly,

269 rs a new and unique opportunity to study the early events of tumor invasion, metastasis and drug resp

270 the time patients are diagnosed with cancer, early events of tumorigenesis have already taken place.

271 thin host cells; however, the role of ROS in early events of viral entry and the induction of signali

272 a "closed" to "open" conformation during the early events of virus-cell membrane fusion.

273 results provide significant insight into the early events of XLRS pathophysiology, from phenotype dif

274 between recruited APC and TC may occur as an early event promoting allergic airway inflammation.

275 Pollen-pistil interactions are critical early events regulating pollination and fertilization an

276 , the molecular mechanisms accompanying this early event remain unclear.

277 at the ensuing signaling regulates important early events required for successful infection of CD34(+

278 ishment/clearance research, and transmission/early-event studies.

279 gs highlight a novel role for neutrophils in early events such as angiogenesis and modulation of the

280 ge incipient atherosclerosis is based on the early events taking place at the endothelial level.

281 understanding of the role of Slug in ADM, an early event that can eventually lead to pancreatic cance

282 molecule expression in large arteries is an early event that coincides with diet-induced obesity and

283 immune response during injury is a critical early event that determines whether the outcome of tissu

284 y, endothelial inflammatory activation is an early event that occurs coincident with the development

285 intaining whole-body energy balance might be early events that contribute to weight gain and obesity

286 ow enable structural characterization of the early events that drive phytochrome photoconversion.

287 However, the early events that initiate type 2 immune responses remai

288 Delineating the key early events that lead to the development of broadly neu

289 a better systems level understanding of the early events that occur during the development of OA in

290 Mutations in GNAQ and GNA11 are early events that promote cell proliferation, and these

291 er metastasis dataset, and discovered common early events that promote tumor progression and migratio

292 gs reveal an essential role for Siah2 in the early events that signal undifferentiated progenitor cel

293 illogenesis remains unresolved, particularly early events that trigger the misfolding and assembly of

294 To identify these early events, we have evaluated both phenotypic and gene

295 These early events were concomitant with deregulation of circu

296 These early events were followed by a progressive mitochondria

297 sion identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplific

298 BCL2 translocations and CREBBP mutations are early events, whereas MLL2 and TNFRSF14 mutations probab

299 infection are poorly understood, especially early events which are difficult to follow in vivo.

300 The characterization of these early events, which are similar to those encountered in