ライフサイエンスコーパス: early gene

1 ession of ICP27, a multifunctional immediate-early gene.

2 lue required for inhibition of expression of early genes.

3 ranscription of plasticity-related immediate early genes.

4 ion by targeting the expression of immediate-early genes.

5 ctivation of a subset of viral genes, termed early genes.

6 eactivation requires expression of immediate early genes.

7 IE expression but not the transactivation of early genes.

8 s examined and differed from other immediate early genes.

9 hin the virion, another being the product of early genes.

10 quantifying mRNA levels for other immediate early genes.

11 cRE multiplicity is a general feature of the early genes.

12 t mechanism governs the hormonal response of early genes.

13 ls expressing immediate-early genes (IE) and early genes.

14 lso essential for the transcription of HAdv5 early genes.

15 units on transcriptional activation of HAdv5 early genes.

16 similar to that of protein-coding immediate early genes.

17 enes and a decreased expression of immediate early genes.

18 and, in most cases, expression of immediate early genes.

19 eviously demonstrated that TGFbeta Inducible Early Gene-1 (TIEG1), also known as KLF10, plays importa

20 as transforming growth factor-beta-inducible early gene 2) between the brains of 18 human subjects wi

21 gulates cellular proliferation and immediate early gene activation, CaMKII-mediated signaling to H3 i

22 und dosage-dependent activation of immediate early genes after 1 h.

23 Immediate early gene analysis identified T-types exhibiting prefer

24 0 (ICP0) of HSV-1 is encoded by an immediate early gene and plays a fundamental role during infection

25 esponded to fight outcome included immediate early genes and genes involved in neuroplasticity and ep

26 , activated ERK1/2 is recruited to immediate early genes and phosphorylates INTS11, the catalytic sub

27 Insulin-stimulated expression of immediate early genes and proliferation were also potently reduced

28 functionally deleted for all five immediate-early genes and the 15-kb internal repeat region.

29 ndent recruitment of Integrator at immediate early genes and their enhancers.

30 idespread changes in expression of immediate early genes and their targets, supporting the likely inv

31 vents Cav1.2-mediated induction of immediate early genes and transcription factors, and inactivation

32 r to the stimuli, predominantly at immediate-early genes, and identified specific TF ensembles that c

33 viral entry, normal expression of immediate early genes, and viral DNA replication.

34 nduced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, w

35 tial and transient increase of the immediate early gene apc/ebp mRNA, a prolonged increase in apc/ebp

36 The immediate early gene Arc (also Arg3.1) produces rapid changes in s

37 GCs), many of which upregulate the immediate-early gene Arc after male-male social experience.

38 how that the plasticity-associated immediate-early gene Arc is selectively expressed in IGCs from res

39 Visualization using the immediate early gene Arc revealed sparser and more robust odor rep

40 detection of the expression of the immediate-early gene Arc, used as a marker of neuronal activation.

41 expressing the plasticity-related immediate early gene Arc.

42 and IC based on activation of the immediate early gene Arc; however, we found that infusion of the N

43 endent manner from the loci of the immediate early genes Arc and Fos.

44 nt increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor (Trkb), g

45 The early genes are a key group of ecdysone targets that fun

46 At the molecular level, immediate early genes are among the synaptic plasticity genes that

47 EBV early genes are expressed independently of viral DNA amp

48 Vaccinia virus early genes are transcribed immediately upon infection.

49 sion of NDRG1 was downregulated by the MCPyV early gene, as T antigen knockdown rescued the level of

50 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity, zif268,

51 iated mRNAs were detected for most annotated early genes at 2 h and for most intermediate and late ge

52 A sequences were detected for most annotated early genes at 2 h and for most intermediate and late ge

53 e PCR and NGS revealed the activation of key early genes at 6 h and transition to late gene activatio

54 ELK-1 stimulates the expression of immediate early genes at the onset of the cell cycle and participa

55 lease step as an "accelerator" over specific early gene body regions.

56 coordinate the all-or-nothing expression of early genes, but also over a longer time course integrat

57 OCV RNAs mapped to homologs of orthopoxvirus early genes, but few did so to homologs of intermediate

58 transcription factors, which are products of early genes, but not for late transcription factors.

59 stic insights on the regulation of immediate early genes by anesthesia and hypothermia.

60 ant addiction, blocks induction of immediate early genes by DRD1 stimulation, and prevents DRD1-media

61 did not bind to either of the EBV immediate early genes BZLF1 and BRLF1.

62 ctivating expression of both EBV immediately early genes, BZLF1 and BRLF1.

63 with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activation) was u

64 ed by immunohistochemistry for the immediate-early gene c-Fos and behavioral tracking, which both dem

65 e first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and lateral (VP-l)

66 ht, and enhances expression of the immediate early gene c-fos in the SCN, which is involved in photic

67 otein was under the control of the immediate early gene c-fos promoter as well as time-lapse two-phot

68 s indicated that expression of the immediate-early gene c-fos was aberrantly elevated in the Bdnf(+/-

69 e LS, stress-induced expression of immediate early gene c-fos, and anxiety-related and depression-rel

70 atterns of immunoreactivity of the immediate early gene c-Fos, with a blunted response to the drug in

71 ion of the protein products of the immediate early genes c-fos and arc in new and mature granule neur

72 term changes in activity-dependent immediate early genes c-Fos and Arc/Arg3.1 in auditory and neighbo

73 odulation of the expression of the immediate early genes c-fos and egr-1 upon change in numerousness;

74 produced widespread reductions in immediate-early gene (c-fos) expression in a network of memory-rel

75 al magnetic resonance imaging, and immediate early gene (c-fos) expression to assess the hypoxic vent

76 tive analysis of expression of the immediate early gene cFos and generalized linear mixed-effects mod

77 nditioning drove expression of the immediate early genes cFos and Nr4a2 in the hippocampus, which coi

78 , encoded by genes present at the end of the early gene cluster in their respective phage genomes and

79 ZIC2 localized at immediate early and early gene cluster regions of the KSHV genome and contri

80 markers, retrograde tracings, and immediate early gene colocalizations.

81 Moreover, upregulation of immediate early genes, complement factors, apoptosis, and immune r

82 c signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity.

83 In particular, the MCPyV early gene downregulated the expression of the tumor sup

84 tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC) activation

85 d in decreased expression of viral immediate early genes during infection.

86 Chromatin remodeling of early genes during the inflammatory response in vivo is

87 cial aptazymes into the adenoviral immediate early gene E1A enables small-molecule-triggered, dose-de

88 The adenovirus immediate early gene E1A initiates the program of viral gene trans

89 previously found that one of the Drosophila early genes, E75, harbors multiple functional ecdysone r

90 associated with nuclear translocation of the early gene Egr-1 In conclusion, specific and strictly or

91 We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA), hippocamp

92 P) kinase signaling but not on the immediate early gene EGR-1.

93 fied as a downstream target of the immediate early gene Egr1.

94 Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent proliferation no

95 We showed that the immediate early gene Egr3 has long-term effects on drug-related be

96 activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effectors that ar

97 One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), whic

98 ~85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that they are fu

99 In the presence of ecdysone, early genes exhibit a highly characteristic rapid and po

100 f Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI.

101 e mutant gene is required for LVH or whether early gene expression acts as an immutable inductive tri

102 ination of pups' neural activity using c-Fos early gene expression and (14)C 2-deoxyglucose autoradio

103 howed a lack of activity-triggered immediate early gene expression and altered sensory-related behavi

104 hotoconversion was correlated with immediate early gene expression and higher FRs ex vivo and tracked

105 in the noncoding control region that control early gene expression and miRNA expression before genome

106 ed using brain mapping analyses of immediate-early gene expression and produced a robust silencing of

107 OSMI-1, affects initiation of HSV immediate-early gene expression and viral replication.

108 HCMV pUL97 kinase regulates viral immediate early gene expression by phosphorylation-mediated disrup

109 Early gene expression changes were determined by low-den

110 We report robust and early gene expression changes within these tissues, indi

111 ing-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity.

112 tentials and for establishment of endogenous early gene expression domains in the anterior ectoderm,

113 E1a is important for activating early gene expression from the other viral early transcr

114 impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting that chron

115 nalysis and in situ hybridization assays for early gene expression in the mutant revealed that severa

116 ar analyses of neural activity via immediate early gene expression indicate a functional role for hin

117 seq analysis of neurons divided by Immediate Early Gene expression levels.

118 r ORF30 is required for immediately early or early gene expression or viral DNA replication, but each

119 This study corroborates shared features of early gene expression patterns in the thalamus between X

120 Immediate early gene expression patterns were informative of signa

121 While the early gene expression profile induced by both growth fac

122 nhibition, nor do they specifically activate early gene expression programs upon short exposure to ER

123 Analysis of immediate early gene expression revealed parallel up-regulation in

124 , SND1 depletion leads to inhibition of KSHV early gene expression showing that SND1 is essential for

125 gene expression, acting after initiation of early gene expression to block viral DNA replication and

126 lular resolution through profiling immediate early gene expression using immunostaining and light-she

127 hCMV early gene expression was responsible, as ultraviolet-in

128 endent on progression beyond viral immediate-early gene expression, but not dependent on viral DNA re

129 Nevertheless, this mutant can induce early gene expression, suggesting a possible defect at t

130 rand breaks are crucial to the modulation of early gene expression, which provides a mechanistic link

131 effect on neuronal firing rate or immediate early gene expression.

132 ylation that coordinately regulate immediate early gene expression.

133 litates transcription-factor recruitment and early gene expression.

134 ever, the replication cycle is stopped after early gene expression.

135 preventing core entry into the cytoplasm and early gene expression.

136 osphorylation and the induction of immediate-early gene expression.

137 -1) to limit viral replication and immediate-early gene expression.

138 te receptors and singing-dependent immediate-early gene expression.

139 ne expression but also because it suppresses early gene expression.

140 ntially be involved in the regulation of HPV early gene expression.

141 ontributes to the FAM111A-mediated effect on early gene expression.IMPORTANCE SV40 has served as a po

142 onic acid (JA) signaling plays a key role in early gene-expression changes, well before it leads to d

143 Coexpression of immediate early genes (for example, Egr1, Fos, Dusp1) and inflamma

144 transcripts including the expected immediate early gene Fos and Stk11, a master kinase of the AMP-rel

145 d2 (Per1 and Per2), as well as the immediate-early gene Fos in the SCN, dorsal hippocampus, and olfac

146 was increased and the DA-regulated immediate early gene Fos was upregulated.

147 l detection of the tracers and the immediate early gene Fos.

148 d with increased expression of the immediate early genes Fos and FosB and the NMDA receptor subunit g

149 stream early and late genes, while immediate early genes from other loci remain unaffected.

150 rtalized keratinocytes (NIKs) expressing the early genes from six distinct human polyomaviruses (PyVs

151 We found that activity-dependent immediate early gene H1a is critical for establishing normal OD in

152 One subset of seven early genes had promoters that were transcribed in a sup

153 ovel role of an activity-dependent immediate early gene Homer1a (H1a) in these processes.

154 These changes are driven by the immediate early gene Homer1a and signaling from group I metabotrop

155 stic level, we show that the HSV-1 immediate early gene ICP22 binds the CD80 promoter and that this i

156 all percentage of cells expressing immediate-early genes (IE) and early genes.

157 itine treatment, transfection with immediate early genes (IE), and infection with a recombinant HSV-1

158 Immediate early gene (IEG) activity mapping has been widely used t

159 rum response factor (SRF) mediates immediate early gene (IEG) and cytoskeletal gene expression progra

160 In the cortex, the immediate early gene (IEG) ARC was increased in VNS rats and corre

161 oskeletal-associated protein (Arc) immediate-early gene (IEG) expression and changes in BLA AMPA rece

162 is associated with CB1R-dependent immediate-early gene (IEG) expression and changes in excitatory sy

163 The induction of immediate-early gene (IEG) expression in brain nuclei in response

164 a key player in the regulation of immediate early gene (IEG) expression underlying the consolidation

165 e IL-PFC as evidenced by increased immediate early gene (IEG) expression.

166 e, we found that expression of the immediate early gene (IEG) Homer1a (H1a) and its subsequent intera

167 shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate g

168 Arc, an immediate-early gene (IEG) product involved in dendritic spine dyn

169 otein (APP) and TIAM1, and between immediate early gene (IEG) proteins and the HSA21 protein superoxi

170 Arc is a cellular immediate-early gene (IEG) that functions at excitatory synapses a

171 scription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound phosphorylat

172 Among these immediate early genes (IEG), members of the Early growth response

173 set of genes we identified several Immediate Early Genes (IEG), which were highly expressed in restin

174 We review the "Immediate Early Gene" (IEG) response, the starting point for under

175 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc, and Bdnf

176 ion induces rapid transcription of immediate early genes (IEGs) and longer-term chromatin remodeling

177 ely resemble the dynamics of known immediate-early genes (IEGs) and this enables a comprehensive comp

178 elevation in the expression of the immediate early genes (IEGs) Arc/Arg3.1 and Egr-1 in the lateral a

179 Immediate early genes (IEGs) are activated as a first line of defe

180 Immediate-early genes (IEGs) are rapidly activated after sensory a

181 creases the expression of multiple immediate early genes (IEGs) associated with growth and angiogenes

182 Profound induction of immediate early genes (IEGs) by neural activation is a critical de

183 nd the release of paused RNAPII at immediate early genes (IEGs) following transcriptional activation

184 r (NELF) complex upon induction of immediate early genes (IEGs) in neurons.

185 Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsi

186 tor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens.

187 lternatively, post hoc staining of immediate early genes (IEGs) indicates highly active cells within

188 wn for Egr-2, all of which are the immediate early genes (IEGs) of the Erk1/2 pathway.

189 n induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1.

190 In addition and unlike mammalian immediate early genes (IEGs), fly ARGs do not have short gene leng

191 Here, we used the expression of immediate-early genes (IEGs), protooncogene, c-Fos, and zinc finge

192 sion patterns of JUN, FOS and EGR1 immediate early genes (IEGs), reflected by the presence or absence

193 rmal growth factor (EGF)-inducible immediate early genes (IEGs).

194 ect how Erk activity is decoded by immediate early genes (IEGs).

195 ation of the serum response genes (immediate early genes [IEGs]) FOS, EGR1, and cJUN.

196 ctivation of a learning-associated immediate early gene in rat olfactory cortices is uninterrupted by

197 d in endothelial cells (ECs) as an immediate early gene in response to PH.

198 ed had expression of the EBV major immediate-early gene in the blood indicative of active EBV lytic i

199 ymerase II and drive expression of immediate-early genes in neurons.

200 iated with decreased expression of immediate early genes in rat GC of both sexes, and with reduced am

201 of YAP/TAZ blocks the induction of immediate early genes in response to mitogenic stimuli.

202 RNA) reduced the expression of HSV immediate-early genes, in addition to reducing viral yields.

203 lation expressing higher levels of immediate early genes indicative of a homeostatic activation.

204 mined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizures (ECS),

205 s a complex phenomenon involved in Immediate-early gene induction in metazoan eukaryotes.

206 ices in DH-compromised animals and immediate early gene induction profiles for amygdala-projecting pr

207 eptor populations up-regulate many immediate early genes involved in growth and differentiation.

208 Arc/Arg3.1, an activity regulated immediate early gene, is essential for learning and memory, synapt

209 eased along with the expression of immediate early genes like c-fos and Egr-1 by the disease mutants.

210 Since most of the EcREs within early gene loci are situated distantly from promoters, w

211 RNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, with the high

212 A whole brain immediate early gene mapping highlighted the dorsolateral bed nucl

213 d memory maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recordings and vira

214 ession of c-Fos and C/EBPbeta, two immediate-early gene markers of neuronal activity.

215 the expression or activity of this immediate-early gene may also contribute to the pathophysiology of

216 ur analysis identifies previously undetected early gene modules expressed long before fate determinat

217 ization of a transiently expressed immediate early gene mRNA by a repeated training trial may therefo

218 The immediate early gene neuronal activity-regulated pentraxin (NARP)

219 The early genes NLRC5, RTP4, and RHOH, which were modulated

220 tic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons.

221 of HSV-1 ICP22, the product of an immediate early gene of HSV-1, to the promoter of CD80.

222 , abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID), was mitig

223 equired for transactivation of the immediate-early genes of herpes simplex virus (HSV).

224 Kruppel-like factor 2 and several immediate early genes of the AP1 and Egr family.

225 rning on expression of both of the immediate early genes of the virus, probably by directly acting up

226 ssion of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involunta

227 m of the predicted promoter of the immediate early gene open reading frame 63 (ORF63).

228 is modulated by expression of the immediate early gene product Arc.

229 tatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic activity

230 The pattern of expression of the immediate early gene product cFos was used to identify key brain r

231 oduction induced expression of the immediate early gene product Fos in trigeminal regions that receiv

232 Colocalization of TH with the immediate early gene product Fos, an indirect marker of neural act

233 Here, we report that the immediately early gene product of gammaHV68, replication transactiva

234 Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown

235 The EBV genome encodes an early gene product, BARF1, which contributes to pathogen

236 on, Homer1a, an activity-dependent immediate early gene product, disrupted the persistent mGluR5 acti

237 Our findings implicate an immediate-early gene product, Egr1, as part of the mechanism media

238 To identify activated neurons, the immediate early gene product, Fos protein, was labeled.

239 d capacity for gene expression restricted to early gene products and is considered a replicative dead

240 Consequently, induction of the immediate early gene products and transcription factors c-Fos and

241 on, representative viral immediate-early and early gene products as well as viral DNA accumulated suf

242 ntly of viral DNA amplification, and several early gene products facilitate DNA amplification.

243 ect autoregulatory activity on virus-encoded early gene products is completely preserved.

244 A number of herpesvirus immediate early gene products play important roles in the regulati

245 ntative viral immediate-early gene products, early gene products, and viral DNA sufficiently but had

246 2 accumulated representative viral immediate-early gene products, early gene products, and viral DNA

247 tively spliced transcript expressed from the early gene region concomitant with an increase in the ab

248 PV types have evolved to recruit CTCF to the early gene region to control the balance and complexity

249 1/2 activation, growth factor-like immediate early gene regulation and EGR1 protein expression.

250 Therefore, understanding of immediate early gene regulation might add insights into viral path

251 Using immediate early gene reporter mice, active cells expressing cfos w

252 Immediate early genes, represented by AP-1 complex, are rapidly in

253 Several early gene responses were correlated with HAI titer, ind

254 ar nucleus, and we used lesion and immediate-early gene studies to test our working hypothesis that t

255 show that after UV-C irradiation, immediate early genes such as activating transcription factor 3 (A

256 ef2, as well as activity-regulated immediate-early genes, such as fos and jun.

257 hat was post-binding but took place prior to early gene synthesis for both PR772 and HAdV-2.

258 of Arc (also known as Arg3.1), an immediate-early gene that is required for long-term memory.

259 CCN1 is a product of an immediate-early gene that is transcriptionally induced in ECs in r

260 Arc is an immediate early gene that is unique among neuronal mRNAs because i

261 ton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying

262 ding Arc, also known as Arg3.1, an immediate early gene that plays a significant role in memory conso

263 ity causes the rapid expression of immediate early genes that are crucial for experience-driven chang

264 rsally at active genes, except for immediate early genes that are strongly induced before Myc.

265 seizure activity and induction of immediate early genes that control hippocampal excitability.

266 oth known to be activity-dependent immediate early genes that respond to stimuli in the brain.

267 The FGFR immediate early genes that were identified include those encoding

268 Multiple isoforms encoded by early genes then coordinate the activation of a larger g

269 e disease, recent clinical trials as well as early gene therapy trials have evaluated the use of sial

270 echanism underlying the distinct response of early genes to ecdysone.

271 ed on the cellular distribution of immediate early genes to examine the effect of LC activation and i

272 he emphasis of gene expression switches from early genes to late genes in a highly regulated manner.

273 differentiation trigger, induces a subset of early genes to mirror the sustained, bistable dynamics o

274 ly proteins is important for efficient viral early gene transcription and for changes in expression o

275 e I (NPH I) is an essential component of the early gene transcription complex.

276 The first was regulation of early gene transcription in lambda, the study of which b

277 STATEMENT How does the pattern of immediate early gene transcription in the brain relate to the stor

278 Therefore, the initiation of early gene transcription is attenuated following DNA rep

279 dy, we show that ivermectin inhibits HAdV-C5 early gene transcription, early and late protein express

280 in herpes simplex virus 1 (HSV-1) immediate early gene transcription, our findings suggest that EBV

281 Glycolysis is necessary for early gene transcription, while glutaminolysis is necess

282 h the roles of these proteins in intravirion early gene transcription.

283 (MAPK) phosphorylation to regulate immediate early gene transcription.

284 ption, while glutaminolysis is necessary for early gene translation but not transcription.

285 onine import, leading to decreased immediate-early gene translation without significant toxicity.

286 LC, the transcription of the viral immediate early genes UL122 and UL123 and of the delayed early gen

287 rly genes UL122 and UL123 and of the delayed early gene UL50 is substantially lower than that in mLC.

288 ppocampus, whereas upregulation of immediate early genes was observed in both dorsal and ventral hipp

289 For each early gene we detected chromatin loops that juxtapose th

290 After CO2 asphyxiation, several immediate early genes were expressed at lower levels in Abcc5(-/-)

291 a robust expression of a panel of immediate early genes, which included the Nr4a subfamily of nuclea

292 Nur77 is an immediate early gene whose expression is rapidly upregulated by TC

293 he expression of c-Fos, a neuronal immediate early gene with key roles in synaptic plasticity, brain

294 uced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused polymerases,

295 duce partially overlapping sets of immediate early genes without sustaining the response.

296 (as the expression pattern of the immediate early gene ZENK) during sleep in juvenile zebra finch ma

297 Thus, altered expression of the immediate early gene Zif268 may contribute to lower levels of GAD6

298 rons that depends on the inducible immediate early gene zif268, processes that are critical for their

299 g and in situ hybridization of the immediate early gene zif268, respectively.

300 of newborn neurons, the inducible immediate early gene zif268/egr1.