ライフサイエンスコーパス: early-stage

1 Cy5.5-CTLs at targeted tumor tissues in the early stage.

2 eptor-independent manner at least during the early stage.

3 defects in embryo pattern formation from the early stage.

4 uires surveillance to detect epidemics at an early stage.

5 y to diagnose and treat these diseases at an early stage.

6 onsidered a biomarker for dengue fever in an early stage.

7 es aimed at blocking viral infection at very early stages.

8 ches that can identify tumor-positive LNs in early stages.

9 ry atresia is difficult to detect during its early stages.

10 bidity and mortality and rarely diagnosed in early stages.

11 resence of the sensitizing nAChRs, linked to early-stage Abeta-induced neurotoxicity, which may repre

12 wship program to enhance the competencies of early-stage AF basic, clinical, and population health re

13 or the in vivo portion, 3 male patients with early-stage ALS (59.3 +/- 7.2 y old) and 6 healthy volun

14 tion group of 710 patients, 619 of whom with early stage and 91 with late stage colorectal cancers.

15 ients enables detection of lung cancer at an early stage and can reduce the risk of dying from lung c

16 y valuable and complements the diagnosis for early stage and seronegative RA.

17 requencies for known HCC drivers compared to early stages and identifies predictive biomarkers of res

18 eed to develop robust methods to access both early-stage and late-stage organoboron intermediates ame

19 An early-stage and timely diagnosis of SCD can help in the

20 iagnosed by screening were more likely to be early-staged and treated by surgery than those diagnosed

21 ent and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventin

22 reviously, we described REAF (RNA-associated early-stage antiviral factor; RPRD2), a constitutively e

23 n biological events such as cell metabolism, early stage apoptosis, and cell differentiation.

24 Simple diagnostic tools in early stages are strongly required to monitor and preven

25 ide concentration during symbiosis, from the early stage, avoiding the plant's defense response, to n

26 Therefore, it is essential to identify early-stage biomarkers in those at risk for AD and age-r

27 SM-164 is a promising therapeutic agent for early stage bone and lung metastasis from triple-negativ

28 aoperative radiotherapy (IORT) in women with early stage breast cancer outside of a clinical trial, a

29 tive single-agent denosumab in premenopausal early-stage breast cancer patients from the Phase-II D-B

30 ible patients were postmenopausal women with early-stage breast cancer taking an AI for > 30 days wit

31 Furthermore, patients with early-stage breast cancer who experienced cardiovascular

32 tasis or disease recurrence in patients with early-stage breast cancer, in this study, denosumab did

33 local radiotherapy after primary surgery for early-stage breast cancer.

34 cating high fraction of distant diffusion in early stages but the dominance of local diffusion in lat

35 ls correlated with non-mucinous histology in early stage cancers but not with other clinicopathologic

36 ts with CD: 116 biologic-naive patients with early-stage CD (validation cohort 1) and 195 biologic-ex

37 open radical hysterectomy for patients with early stage cervical cancer.

38 observed, 473; EAR, 18.2) for advanced- and early-stage cHL, respectively, compared with the general

39 ates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizi

40 2RA therapy is, therefore, being explored in early-stage clinical trials.

41 rrelates with strain fitness and that enable early-stage colonizers to survive during introduction of

42 ciated with longer survival in patients with early stage colorectal cancer, especially longer disease

43 e SlBBXs were found to be upregulated in the early stages, controlled by the proper chloroplast diffe

44 is essential for terminal differentiation of early stage DCTs into mature DCTs, and impairment of the

45 unveil the impact of SEI inhomogeneities on early-stage defect formation in Si electrodes.

46 Buried under the SEI, these early-stage defects are inaccessible by most surface-pro

47 of the EGFR to the apical side of the FCs at early stages depended on the TGFalpha-like ligand Gurken

48 The early stage detection technology is desired to improve t

49 hway may serve a function in vivo and during early-stage development of PEL.

50 t in the immunocompetent SKH1 mouse model of early stage diabetes.

51 widely studied as circulating biomarkers for early stage diagnosis of several diseases.

52 This sensor paves a way to detect early-stage diagnosis of prostate cancer rapidly in the

53 residual disease following treatment and for early-stage diagnosis.

54 Better outcomes for patients with early stage diffuse large B-cell lymphoma and follicular

55 ntigens, which can be given to patients with early stage disease after the completion of neoadjuvant

56 Early stage disease pseudotime samples are enriched for

57 s impact on tumor recurrence, especially in "early stage disease" (PDAC <=20 mm, R0/N0 PDAC).

58 Most patients present with early-stage disease at the initial diagnosis.

59 Men with early-stage disease should not be treated with bone-modi

60 ghlights potential epigenetic strategies for early-stage disease treatment.

61 erentiation of distal tubule precursors into early stage distal convoluted tubules (DCTs) during neph

62 affolds that are likely to be of interest to early-stage drug discovery programs.

63 in research attention in target space at an early stage during the drug discovery process.

64 exposure to a single microRNA, expressed at early stages during normal development, improves the dif

65 mains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickn

66 DNA methylation regulation in germ lines and early stage embryos.

67 he flow-cell, enabling the identification of early-stage embryos (2-cell to morula stage).

68 ved chemical proteomic strategy to track the early-stage entry of ZIKV into host cells.

69 However, grazing impacts on early stages, especially under the context of a rapidly

70 CofActor holds promise for the tracking of early stage events in neurodegeneration and for investig

71 These tools can be useful for investigating early stage events in neurodegenerative diseases in both

72 e after risk-adapted first-line treatment of early-stage, favorable, classic Hodgkin lymphoma (ES-HL)

73 Regarding early-stage FECD, average En-DMT of central zones achiev

74 In early stages, fluid accumulation occurs owing to a net g

75 e to an expanded form of holistic care at an early stage for patients with serious illnesses and thei

76 investigating MoA and pharmacokinetics at an early stage for phenotypically active series.

77 reater than that of healthy controls at this early stage, further studies are required to clarify whe

78 rmation, because ectopic adaxial activity at early stages gives radialized leaves and no traps.

79 Early stage HCC gradually increased from 2004-2007 to 20

80 escribe the current therapeutic landscape of early stage HER2-positive breast cancer, focusing on str

81 nical Trials NCT00769470), participants with early-stage HER2-positive breast cancer (N = 128) were r

82 ed prognostic score identifies patients with early-stage, HER2-positive breast cancer who might be ca

83 Beginning at early stages, human Alzheimer's disease (AD) brains mani

84 sical activity and sedentary behaviour at an early stage in life.

85 te electron transfer and catalysis at a very early stage in the origin of metabolism.

86 while O(2) nanobubbles can be detected at an early stage in the oxygen evolution reaction (OER), the

87 The epidemic is at an early stage in the state, and there is high compliance w

88 mitation to the use of biologic agents at an early stage in their development, although regulatory gu

89 e production, and intracellular migration of early-stage inflammatory elements.

90 ur experimental approach represents a useful early-stage integrated risk/benefit method that, when TT

91 With a focus on the transition of early stage investigators to research independence, we o

92 possible solutions for funding and retaining early-stage investigators in research that supports the

93 atients distributed in 82 normal corneas, 40 early-stage keratoconus and 83 established keratoconus.

94 observed when comparing normal corneas with early-stage keratoconus/ in variables of the vertical as

95 bolites and relevant pathways to distinguish early-stage LA from controls (p < 0.05).

96 We diagnose early-stage LA with sensitivity~70-90% and specificity~9

97 arning of serum metabolic patterns to detect early-stage LA.

98 rogen oxide radicals (HO(x) = OH + HO(2)) in early stage (<3 h) wildfire plume evolution.

99 dy revealed substantial heterogeneity within early-stage LUAD harboring EGFR mutations, implicating c

100 cell-derived lung epithelial cells to model early-stage lung adenocarcinoma.

101 (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched contr

102 uish normal epithelial progenitor cells from early-stage lung cancer, facilitating the search for tar

103 e show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to trea

104 , or at least induces functional dormancy at early stages, malignant PCs eventually evade immune elim

105 In the early stages, MaR1 treatment decreased the number of pro

106 he isolation process relative to that of the early stage materials, which likely obfuscated previous

107 that >=80% ARG1-expressing MDSCs were mainly early-stage MDSCs (HLA-DR(-)CD33(+)CD14(-)CD15(-)MDSCs).

108 (-)CD33(-)CD11b(-)CD14(-)CD15(-)MDSCs), >15% early-stage MDSCs and >40% monocytic MDSCs (HLA-DR(-)CD1

109 tor of apoptosis proteins (IAPs), eliminated early-stage metastases and reduced progression of advanc

110 We also demonstrate that at this early stage, motile cilia ensure the proper formation of

111 " could be used as a prognostic biomarker in early-stage MS, to track disease progression or stratify

112 Early stage MSCs showed active inter-state conversions i

113 Early-stage mycosis fungoides (MF) has been associated w

114 long-term course of 471 patients with NLPHL (early stages, n = 251; intermediate stages, n = 76; adva

115 gh-resolution images of rigorously confirmed early-stage neoplasia in BE and nondysplastic BE, derive

116 y findings, scoring of images that contained early-stage neoplasia in data sets 2-5 were delineated i

117 Suppression of early-stage neuronal death by AAV-YAPdeltaC reduces the

118 Transplantation of early-stage neurons to the injured cord may reconstruct

119 Patients with early-stage NLPHL other than stage IA and intermediate-s

120 ostic (18)F-FDG PET/CT radiomic signature in early-stage non-small cell lung cancer patients treated

121 nodal disease correlates with recurrence in early stage NSCLC.

122 cell repertoire analysis in a cohort of 236 early-stage NSCLC patients.

123 expectedly, when overexpressing MMP14 in the early-stage obese adipose tissue, the transgenic mice sh

124 hat rosettes reproducibly transition from an early stage of 2-dimensional (2D) growth to a later stag

125 lays a primary role in memory decline in the early stage of AD.

126 e endothelial dysfunction, but their role in early stage of atherosclerosis and on vascular smooth mu

127 show that Urd inhibits transcription at the early stage of closed complex formation by blocking inte

128 hat administration of IFN-alpha2b during the early stage of COVID-19 could induce favorable clinical

129 ized division, but the process arrests at an early stage of daughter cell growth.

130 ne was highly expressed in osteoblasts at an early stage of differentiation.

131 In the early stage of discovering such transformations, most ef

132 rediction have become essential tasks in the early stage of drug discovery.

133 completely attached graft and operated in an early stage of FECD may show the lowest endothelial cell

134 ing the development of biliary sludge in the early stage of gallstone formation.

135 ition from the control stage (benign) to the early stage of hepatocellular carcinoma on an eight-stag

136 uces a stronger inflammatory response at the early stage of infection, and displays reduced intestina

137 At this early stage of infection, skin infected with the Deltafa

138 mis, inhibiting M. oryzae penetration at the early stage of infection.

139 morphine and naloxone, were used during the early stage of NSC differentiation, increased neurogenes

140 rs Solomon and Viroflay, respectively, at an early stage of pathogen establishment (48 hours post ino

141 ells are able to regulate osteoclasts at the early stage of rapid palatal expansion and further facil

142 t number was downregulated at the end of the early stage of rapid palatal expansion.

143 ata identified Id1/2 as driver regulators of early stage of reprogramming.

144 ed Abca4(-/-) mouse strain only reflects the early stage of STGD1 since it is devoid of retinal degen

145 nd ELKS-1 undergo phase separation during an early stage of synapse development, and later mature int

146 compliance with social distancing during the early stage of the coronavirus disease 2019 (COVID-19) p

147 ading events played an important role in the early stage of the COVID-19 outbreak.

148 ion of lung abnormalities, especially in the early stage of the disease.

149 perspreading events played a key role in the early stage of the outbreak, i.e., a small number of inf

150 both techniques are capable of recording the early stage of uniaxial flow behaviour of the irradiated

151 to the development of synaptic damage in the early stages of AD.SIGNIFICANCE STATEMENT Soluble amyloi

152 urbance of cognitive ability observed in the early stages of Alzheimer's disease (AD).

153 estigating the link between SCD and the very early stages of Alzheimer's disease and other neurodegen

154 lopment of instruments to record PROs in the early stages of AMD have the potential to produce inexpe

155 dpoint in future intervention trials for the early stages of AMD to improve their feasibility substan

156 intense public health control efforts in the early stages of an emerging epidemic.

157 propose that phylogenetic insights from the early stages of an outbreak should heed all of the avail

158 lease death-propagating complexes during the early stages of apoptosis.

159 tify gene regulatory networks functioning at early stages of brain development.

160 e cells during glandular development and the early stages of breast cancer.

161 an adjuvant treatment for select patients at early stages of breast cancer.

162 tead, they may destabilize the genome in the early stages of cancer development.

163 tory roles played by dynamin isoforms during early stages of CME.

164 amin also plays a regulatory role during the early stages of CME; however, detailed studies regarding

165 During the early stages of cytokinesis, FtsZ protofilaments form a

166 The vasculature has a critical role during early stages of development and regeneration events, and

167 counters intermittent water stress either at early stages of development or flowering stage or both.

168 om already established drug classes, most in early stages of development, and few are sponsored by la

169 g levels of inhibition will need to start at early stages of development.SIGNIFICANCE STATEMENT Neuro

170 poral changes in retinal vasculature at very early stages of diabetes using fundus images from precli

171 OD1(G93A) mouse, FRZB was upregulated in the early stages of disease (between 40 and 60 days) until e

172 factor levels were significantly reduced at early stages of disease in SMA mice.

173 a is the most malignant brain cancer but the early stages of disease progression remain elusive.

174 RIC, when administered in the early stages of disease progression, decreases intestina

175 nabled visualization of T-cell activation at early stages of disease, prior to overt clinical symptom

176 EVs are present in circulation at relatively early stages of disease, providing potential opportuniti

177 ly diverse species that are typically in the early stages of domestication.

178 be scaled up to assess compound efficacy at early stages of drug development or in personalized medi

179 Place cell firing rate increases in early stages of exploration of novel environments but re

180 parasites that share a common pathway in the early stages of fly colonization but apparently use diff

181 contrast to lipid structures reported during early stages of fungal growth in nutrient-rich media, va

182 The results are consistent with the early stages of GA biosynthesis within the root occurrin

183 formation acting as a metabolic sink during early stages of grain development and the high carotenoi

184 virus-host interaction occurring during the early stages of HIV infection.

185 We therefore reconstituted and imaged the early stages of HIV-1 replication in a cell-free system.

186 me of the key processes occurring during the early stages of hydrotropic response.

187 Identifying early stages of hypersensitivity pneumonitis (HP) is ham

188 es nucleation of Gag-Gag interactions at the early stages of immature viral particle assembly in a p6

189 deposition is unlikely to be achieved at the early stages of implementing NH(3) emission abatement.

190 lease from intracellular vesicles during the early stages of infection and identifying intracellular

191 med a transcriptomic analysis focused on the early stages of infection and using transgenic lines der

192 rs of COVID-19 rapidly and accurately in the early stages of infection, based on reviewing the resear

193 in barrier (BBB), and infects the CNS in the early stages of infection.

194 rotubules soon after virus entry and promote early stages of infection.

195 t between newts was very high (>90%) even at early stages of infection.

196 nd tracking proteins (+TIPs) in facilitating early stages of infection.

197 cells positioned to respond to pathogens at early stages of infection.

198 AD is not a major virulence mechanism during early stages of inflammatory arthritis.

199 through preventative monitoring programs at early stages of invasion far outweigh the long-term cost

200 morphology compatible with the diagnosis of early stages of keratoconus.

201 ates that it overlaps significantly with the early stages of l-histidine biosynthesis.

202 The early stages of leukaemogenic transformation are typical

203 ritical role within the human body, from the early stages of life (i.e., embryonic development) to li

204 function independent of p53 to regulate the early stages of metastasis.

205 of DGCR8 in interacting with RNA during the early stages of miRNA processing.

206 forms repulsive molecular brushes during the early stages of mitosis(8), but during mitotic exit the

207 expanded our analysis to scRNA-seq data from early stages of mouse embryogenesis.

208 elates with the grey matter damage since the early stages of multiple sclerosis (MS), but whether the

209 e FSHD Lymphoblast score correlates with the early stages of muscle inflammation identified by histol

210 and of lipid rafts by Nef may contribute to early stages of neurodegeneration and pathogenesis in HA

211 alogous to the oxidative events surfacing at early stages of neurodegenerative diseases.

212 urons and plays an important role during the early stages of neuronal development.

213 (KrasG12D; Pdx-1cre, KC), which mirrors the early stages of pancreatic cancer development.

214 acity of many developed countries during the early stages of pandemics.

215 tected in early-adolescent ASD, (b) occur at early stages of perceptual processing, (c) can possibly

216 entary, mutually-stabilizing interactions at early stages of polypeptide and nucleic acid co-existenc

217 est interventions that could be taken in the early stages of postdoctoral training to prevent this at

218 ue remodelling and maternal tolerance during early stages of pregnancy.

219 r other radiology departments who are in the early stages of preparation and management.

220 ions in the epiblast of chick embryos in the early stages of primitive streak formation.

221 coordinating septal cell wall synthesis, the early stages of protofilament formation and subsequent a

222 -associated traits may be favored during the early stages of range expansion, and also the rate of re

223 ters, including the bICP0 E promoter, during early stages of reactivation from latency.

224 ng protection of implanted allografts during early stages of reperfusion while patient is hemodynamic

225 oints from developing retina as well as four early stages of retinal organoid differentiation.

226 into the complex roles of +TIPs in mediating early stages of retroviral infection, and reveal diverge

227 ead to saturation of neural responses at the early stages of stimulus encoding.

228 gnatures of genome erosion characteristic of early stages of symbiosis, with the Howardula symbiont's

229 By engineering mice lacking NLK in early stages of T cell development, we set out to charac

230 ption factors repress the Ealpha enhancer at early stages of T cell differentiation, while their deco

231 To understand the early stages of the amyloid assembly process, we have us

232 tation of the presented technologies even at early stages of the biopharmaceutical development platfo

233 tes to massive cuticle deposition during the early stages of the cell expansion period by incorporati

234 The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an

235 In the early stages of the disease, most patients experience mi

236 nts may have normal radiological findings at early stages of the disease.

237 dule were elevated in cerebrospinal fluid in early stages of the disease.

238 ct the progression of CCA, especially in the early stages of the disease.

239 ests moderate, stereotyped remodeling in the early stages of the human disease and represents a promi

240 cterize translational regulation of mRNAs at early stages of the nitrogen-fixing symbiosis establishe

241 In the early stages of the outbreak of coronavirus disease 2019

242 iences of these health-care providers in the early stages of the outbreak.

243 AF ablation should be performed at early stages of the patient's heart failure symptoms.

244 ejection grades were on average lower in the early stages of the posttransplant period (<postoperativ

245 resulting in lower interaction energy in the early stages of the reaction path and in a later transit

246 onse is triggered upon injury and during the early stages of the regeneration process.

247 , we demonstrated the roles of HVT vNr-13 in early stages of the viral replication cycle, mitochondri

248 s, offering an excellent alternative for the early stages of the winemaking process and in the juice

249 r transfer chain and stop sever outbreaks in early stages of their appearance.

250 hat predict these distances are still in the early stages of their development.

251 ild protection against biliary injury in the early stages of treatment, it comes at the expense of he

252 estigate the roles of matrix biomechanics on early stages of vasculogenesis by using hydrogels with t

253 ndocardial and neural crest cells during the early stages of VIC development.

254 ven the key role of the ACE2 receptor in the early stages of viral entry, we show that loss of RAB7A

255 ric form that is hypothesized to promote the early stages of viral replication.

256 The representation of faces in early stages of visual processing depends on retino-cent

257 ion channels by arousal state occurs at very early stages of visual processing, before the informatio

258 Here, we show that during the early stages of WBR in Botrylloides diegensis, prolifera

259 quiring infection from someone in the acute (early) stage of infection increases the risk of multiple

260 c alternative splicing isoform biomarkers at early-stage of cancer.

261 a potential biomarker for the development of early-stage, pan-cancer blood tests.

262 A screening program to find early-stage pancreatic cancer is needed but has been cha

263 t identified a vulnerable high-risk group of early stage patients associated with poor outcomes.

264 istinguished the clinical characteristics of early stage patients with EGFR mutations.

265 yet underexplored coregulator in aggressive early stage PCa.

266 Patients with early-stage PD (duration <3 years) who were not taking d

267 hose with low delta tumors (< 40 HU) in both early stage PDAC (13.5 months vs 23.3 months; hazard rat

268 erization of linear polarization dynamics in early-stage plasma emission from laser-induced breakdown

269 e (AD) is poorly understood, particularly at early stages preceding neurodegeneration.

270 ely collected cohort in Taiwan, representing early stage, predominantly female, non-smoking lung aden

271 two stages of the HAZV replication cycle: an early stage prior to and including gene expression and a

272 Among men with early-stage prostate cancer managed with active surveill

273 ion and accelerated periodontal repair at an early stage, providing good prospects for the further de

274 onset and monitor disease progression during early stages, raising the possibility of personalized ey

275 ne photoreceptor production is restricted to early stages remains unclear.

276 inactivation screens to a cellular model of early-stage SCLC.

277 validates the effectiveness of transplanting early-stage serotonergic neurons into the spinal cord fo

278 ings demonstrate that nlr-1/CASPR acts as an early stage signal for gap junction formation through an

279 The role of PNI is particularly relevant in early stages, supporting the hypothesis that invasion of

280 An early stage (tens of seconds) in which individual protei

281 network centrality measures to assess, at an early stage, the likelihood of the long-term positive ec

282 In patients with early-stage TNBC, neoadjuvant treatment with atezolizuma

283 orted EFS/OS results by pCR in patients with early-stage TNBC.

284 yclophosphamide as neoadjuvant treatment for early-stage TNBC.

285 esenting a promising DNA-based biomarker for early-stage TNBC.

286 utcomes of new interventions is needed at an early stage to improve outcomes.

287 predict the risk of RA and identify cases in early stages to prevent or alter disease progression via

288 We assessed 100 patients with early-stage to mid-stage PD, and 37 age-matched controls

289 , these data provide compelling evidence for early stage TRM fate decisions and the existence of comm

290 highly sensitive assay capable of detecting early-stage tumors.

291 Our approach leverages the fact that at early stages, tumors recruit hematopoietic stem/progenit

292 1 (ODC1), are affected by DNA methylation in early stage UC.

293 on and guest competition processes at a very early stage under nonequilibrium conditions.

294 ent were recently reported for patients with early-stage unfavorable cHL treated in the German Hodgki

295 ts with "residual schizophrenia", in whom an early stage with positive psychotic symptoms has progres

296 nsplanted HSCs in myeloablated recipients at early stage, with implications for clinical applications

297 our method can predict exposure response at early stage (within 24 h) and the informative gene sets

298 field deployable diagnosis of dengue at the early stage (within 5 days of the onset of symptoms).

299 ient with aceruloplasminaemia detected in an early stage (without clinical symptoms of damage to the

300 eal dystrophy was classified clinically into early-stage (without edema) and late-stage (with edema)