ライフサイエンスコーパス: ecdysone

1 iation when treated with the steroid hormone ecdysone.

2 ying the distinct response of early genes to ecdysone.

3 pal molt orchestrated by the steroid hormone ecdysone.

4 generation controlled by the steroid hormone ecdysone.

5 ocalized growth-perturbation are mediated by ecdysone.

6 nce or absence, respectively, of the hormone ecdysone.

7 duration of secretion of the steroid hormone ecdysone.

8 promotes the release of the steroid hormone ecdysone.

9 activity likely involves the inactivation of ecdysone.

10 al that are regulated by the steroid hormone ecdysone.

11 through the secretion of the steroid hormone ecdysone.

12 pathways that are regulated in MB neurons by ecdysone.

13 premature amplification when incubated with ecdysone.

14 competent to respond to the systemic hormone ecdysone.

15 architectural proteins upon stimulation with ecdysone.

16 nitiate metamorphosis through the release of ecdysone.

17 d developmental defects due to deficiency of ecdysone.

18 roduction and release of the molting steroid ecdysone.

19 uptake of the primary insect steroid hormone ecdysone [2].

20 ction between the steroid hormone 20-hydroxy-ecdysone (20E) transferred by males during copulation an

21 regulated by sexually transferred 20-hydroxy-ecdysone (20E), a steroid hormone that is produced by th

22 d ETH receptor genes is in turn dependent on ecdysone (20E).

23 Here, we show 20-Hydroxy-Ecdysone (20HE)-signaling controlling organ homeostasis

24 The physiological substrate ecdysone 22-phosphate was modeled in a hydrophobic cavit

25 s) often associated with decreased levels of ecdysone - a steroid hormone that regulates developmenta

26 regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and

27 neration is initiated by the steroid hormone ecdysone, acting through a nuclear receptor complex comp

28 Recent new advances in our understanding of ecdysone action have relied heavily on the application o

29 romoters and multiple distant EcREs prior to ecdysone activation.

30 Ecdysone also induces transcription of the II/9A genes.

31 Treatment with the ecdysone analog ponasterone-A induced tightly regulated

32 or DHR78 is regulated by the steroid hormone ecdysone and is required for growth and viability during

33 The steroid hormone ecdysone and its receptor (EcR) play critical roles in o

34 he interaction with insect hormones, such as ecdysone and juvenile hormone.

35 lear receptors and their effector molecules, ecdysone and NO.

36 duct whose mutations impair the synthesis of Ecdysone and produce cell-autonomous survival defects, b

37 The surge of 20-OH ecdysone and/or ponasterone A initiates the molting proc

38 gulated by two hormones, 20-hydroxyecdysone (ecdysone) and juvenile hormone.

39 s of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination o

40 nd results in the accumulation of unreleased ecdysone, and the knockdown of calcium-mediated vesicle

41 e with juvenoids resulted in deregulation of ecdysone- and farnesoid-regulated genes, accordingly wit

42 role of JH in regulating growth rate via the ecdysone- and insulin-signaling pathways.

43 Instead, ecdysone appears to regulate the growth of imaginal disc

44 y disrupts production of the steroid hormone ecdysone at the time of pupariation not by destruction o

45 on These results indicate the requirement of ecdysone binding to the EcR:RXR:MfR complex to regulate

46 e focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing o

47 While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting Fo

48 ng in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight.

49 Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to cr

50 scriptional levels, respectively, to control ecdysone biosynthetic enzyme expression.

51 y and is rate limiting for the expression of ecdysone biosynthetic genes.

52 ticipate as stage-specific components of the ecdysone biosynthetic machinery.

53 t between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during develo

54 In the absense of ecdysone, both ecdysone receptor subunits localize to th

55 l peptide production, so the inactivation of ecdysone by glycosylation results in a failure of host l

56 ession by E75A is triggered by a decrease in ecdysone concentration and by direct repression of the E

57 In Drosophila, the steroid hormone ecdysone controls developmental transitions, thereby reg

58 Like other hormones, ecdysone controls gene expression through a nuclear rece

59 Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognit

60 In Drosophila and other insects, ecdysone coordinates developmental transitions, includin

61 e show that hypomorphic gt mutations lead to ecdysone deficiency and developmental delay by affecting

62 To identify ecdysone-dependent gene expression changes in MB gamma n

63 e production in the beetle and up-regulating ecdysone-dependent gene expression.

64 Although ecdysone-dependent growth of the female gut augments fec

65 eurons degenerate during metamorphosis in an ecdysone-dependent manner.

66 While the general mechanism of ecdysone-dependent transcription is well characterized,

67 hanism at work in salivary glands during the ecdysone-dependent transition from larvae to pupae.

68 regulate lipid storage and that an excess of ecdysone disrupts the whole process, probably by trigger

69 ects, in which pulses of the steroid hormone ecdysone drive the wholesale transformation of the larva

70 o the rapid and powerful response of E75A to ecdysone during Drosophila development.

71 r protein that is required for production of ecdysone during Drosophila larval development.

72 d), encoding the monooxygenase that converts ecdysone (E) to the more active 20-hydroxyecdysone (20E)

73 In the presence of ecdysone, early genes exhibit a highly characteristic ra

74 ow that components of the steroid-responsive ecdysone (Ec) pathway modulate Hippo transcriptional eff

75 Although it is clear that ecdysone elicits distinct transcriptional responses with

76 [3], our finding raised the question of how ecdysone enters the CNS through the BBB to exert its div

77 Drosophila BBB that EcI is indispensable for ecdysone entry into the CNS to facilitate brain developm

78 e CNS requires EcI in the BBB to incorporate ecdysone from the culture medium.

79 Thus, ecdysone functions at two levels to support reproduction

80 We show that the steroid hormone ecdysone functions in Drosophila to control lipid metabo

81 Ecdysone has two distinct functions: At low concentratio

82 identify the bithorax-complex genes and the ecdysone hormone as critical factors in these difference

83 ng regulation and chromatin accessibility of ecdysone hormone regulated genes, revealing that SNR1 fu

84 coordinating gene expression in response to ecdysone hormone signaling at critical points during dev

85 Cmi is required for the activation of ecdysone hormone targets and plays a critical role in de

86 nsporting polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake

87 demonstrate that the molting steroid hormone ecdysone in adult Drosophila is critical to the evolutio

88 However, the functions of ecdysone in adult physiology remain largely elusive.

89 boule expression is downregulated by ecdysone in MB neurons at the onset of pruning, and forc

90 cdysone pathway, we investigated the role of ecdysone in the development of the adult-specific neuron

91 These results implicate ecdysone in the regulation of DNA amplification in Sciar

92 s present at both enhancers and promoters of ecdysone-induced Drosophila genes, where it phosphorylat

93 We found the hormone-responsive Ecdysone-induced genes (Eig) were strongly misregulated

94 these proteins at enhancers and promoters of ecdysone-induced genes results in the establishment of t

95 r supported that hypoxia leads to growth and ecdysone-induced molting.

96 In addition, ecdysone-induced overexpression of HO-1 in cells led to

97 a circadian function for a nuclear receptor, ecdysone-induced protein 75 (Eip75/E75), which we identi

98 blocking cell death, allowing for subsequent ecdysone-induced reaper and head involution defective de

99 Finally, we show that the ecdysone-induced transcription factor E93 controls tempo

100 that this shift is controlled in part by the ecdysone-induced transcription factor E93.

101 s that stress response genes are induced and ecdysone-induced transcription factors are severely repr

102 nd act on nearby midgut progenitors inducing Ecdysone-induced-protein-75B (Eip75B).

103 n and contain sequences sufficient to confer ecdysone inducibility to a reporter gene.

104 Using an ecdysone-inducible expression system in mammalian dopami

105 98 in mediating enhancer-promoter looping at ecdysone-inducible genes.

106 Induction of SYK in an ecdysone-inducible mammalian expression system results i

107 Injection of ecdysone into pre-amplification stage larvae induces amp

108 We propose that ecdysone is able to consolidate memories possibly by rec

109 The regulation of organ growth by ecdysone is evolutionarily conserved in hemimetabolous i

110 As ecdysone is first secreted into the hemolymph before rea

111 played little sleep rebound, suggesting that ecdysone is involved in homeostatic sleep regulation.

112 of other organs in the body, indicating that ecdysone is limiting for their growth, and disrupts the

113 la, endocrine release of the steroid hormone ecdysone is mediated through a regulated vesicular traff

114 Although ecdysone is present throughout life in both males and fe

115 EcR is involved in gene activation when ecdysone is present, and gene repression in its absence.

116 Here we show that the hormone ecdysone is required to down-regulate Chinmo/Imp and act

117 The steroid hormone ecdysone is the central regulator of insect developmenta

118 Ecdysone is the major steroid hormone in insects and pla

119 In insects, ecdysone is the major steroid hormone, and it is well ch

120 retion to be hyperactivated independently of ecdysone levels in SCs, permitting more rapid replenishm

121 Finally, endogenous ecdysone levels increased after sleep deprivation, and m

122 anscription factor expression in response to ecdysone, making it unclear which ecdysone-responsive ge

123 cell death triggered by the steroid hormone ecdysone, making room for their developing adult counter

124 research suggested that the steroid hormone ecdysone may play a role in this polyphenism.

125 ry in cells that have previously experienced ecdysone, mediated by Nup98-dependent enhancer-promoter

126 ecdysone signaling within the CNS and blocks ecdysone-mediated neuronal events during development.

127 In this study we demonstrate that ecdysone-mediated signaling in the adult is intimately i

128 lianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodel

129 h genes known to be regulated in response to ecdysone or EcR.

130 Experimental injections of ecdysone or its analog resulted in a decreased productio

131 ere consistent with a down-regulation of the ecdysone pathway being involved in the production of win

132 The ecdysone pathway was among the first experimental system

133 eurons in the CNS is highly dependent on the ecdysone pathway, we investigated the role of ecdysone i

134 Broad Complex (BRC) is a highly conserved, ecdysone-pathway gene essential for metamorphosis in Dro

135 mponents of the insulin/insulin-like/Tor and ecdysone pathways in the control of organ growth.

136 neurite remodeling following the late-larval ecdysone peak.

137 In response to ecdysone, ph mutant neurons are transformed into cells w

138 ere, we present the crystal structure of the ecdysone phosphate phosphatase (EPPase) phosphoglycerate

139 are therefore consistent with the idea that ecdysone plays a causative role in the regulation of the

140 Normally, ecdysone positively regulates both molting and antimicro

141 However, the mechanism by which gt regulates ecdysone production has remained elusive.

142 I larvae promote beetle pupation by inducing ecdysone production in the beetle and up-regulating ecdy

143 g gland, we conclude that gt likely controls ecdysone production indirectly by contributing the pepti

144 Null mutants rescued to adults by restoring ecdysone production mimic human NPC patients with progre

145 , we block the molt by genetically dampening ecdysone production, creating an experimental paradigm i

146 Here we show that ecdysone promotes the growth of imaginal discs in mid-th

147 transcriptional responses to the late larval ecdysone pulse delays the onset of the subsequent prepup

148 delays the onset of the subsequent prepupal ecdysone pulse, resulting in a significantly longer prep

149 s in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for

150 is determined by the length of time between ecdysone pulses.

151 tain an ABC transporter that functions as an ecdysone pump to fill vesicles.

152 We have developed a Choristoneura fumiferana ecdysone receptor (CfEcR)-based two-hybrid gene switch t

153 ts conserved heterodimeric nuclear receptor: Ecdysone Receptor (EcR) and Ultraspiracle (USP)/Retinoid

154 ulation of Notch signaling and activation of ecdysone receptor (EcR) are required for the E/A switch

155 On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containi

156 Finally, we show that Ecdysone receptor (EcR) functions autonomously both for

157 ogous to the acetylcholinesterase (AChE) and ecdysone receptor (EcR) genes of B. tabaci, resulted in

158 The ecdysone receptor (EcR) has been used to develop gene sw

159 In addition, disruption of the Ecdysone receptor (EcR) in mature follicle cells mimicke

160 BMP signalling appears to regulate ecdysone receptor (EcR) levels via one or more mechanism

161 erexpressing a dominant negative form of the Ecdysone receptor (EcR) or its heterodimeric partner ult

162 receptor coactivator (SRC) and GATAa but not ecdysone receptor (EcR) or its partner, ultraspiracle (U

163 In addition, knocking down the Ecdysone receptor (EcR) selectively in the discs also pr

164 n Orthodenticle (Otd) acts together with the ecdysone receptor (EcR) to directly repress the expressi

165 ng this tool, we show that signaling via the Ecdysone Receptor (EcR), a known regulator of developmen

166 eroids induce and direct molting through the ecdysone receptor (EcR), a nuclear hormone receptor with

167 One insect NR, ecdysone receptor (EcR), functions as a receptor for the

168 B) defects and Df(4)dCORL larvae are lacking Ecdysone Receptor (EcR-B1) expression in MB neurons.

169 we identify a role for the B1 isoform of the ecdysone receptor (EcR-B1) in this process.

170 s using a dominant-negative construct of the ecdysone receptor (EcR-DN).

171 The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or re

172 ents represent in vivo binding sites for the ecdysone receptor and are necessary for hormone-mediated

173 ushroom body (MB), are decommissioned by the ecdysone receptor and mediator complex, causing them to

174 ne-tolerant protein) and ecdysteroid action (ecdysone receptor and ultraspiracle) suggest that these

175 interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdyso

176 They showed premature ecdysone receptor B1 (EcR-B1) in the photoreceptors and

177 pression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, sugg

178 x composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to regulate gene expression in MB

179 that Ash2 functions together with Trr as an ecdysone receptor coactivator.

180 These results indicate that the ecdysone receptor complex influences the fine-tuning of

181 cohesin cleavage, long before any decline in ecdysone receptor could be detected at this locus.

182 C1(-/-) clones exhibit reduced levels of the ecdysone receptor EcR-B1, a key regulator of axon prunin

183 one receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increase

184 reases recruitment of FISC to the functional ecdysone receptor in a 20E-dependent manner.

185 hemical evidence for the central role of the ecdysone receptor in his model.

186 E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering t

187 The ecdysone receptor is also expressed in central clock cel

188 We find that ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomous

189 DNA amplification in Sciara and suggest the ecdysone receptor may be the elusive amplification facto

190 taFtz-F1 facilitates loading of FISC and the ecdysone receptor on the target promoters, leading to en

191 med human hepatocyte line cell HH4 using the ecdysone receptor regulatory system.

192 In the absense of ecdysone, both ecdysone receptor subunits localize to the cytoplasm, an

193 ild-type and mutant MB neurons in which EcR (ecdysone receptor) activity is genetically blocked, and

194 ne 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptor

195 ssion after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation bet

196 ke 20-hydroxyecdysone (natural ligand of the ecdysone receptor, EcR), methyl farnesoate, pyrirproxyfe

197 Second, global signaling via the ecdysone receptor, EcR, establishes a female metabolic s

198 betaFtz-F1 and a p160/SRC coactivator of the ecdysone receptor, FISC, is crucial for the stage-specif

199 , a component of the canonical heterodimeric ecdysone receptor, to induce malaria parasite killing re

200 ins interact with each other as well as with ecdysone receptor, ultraspiracle, and methoprene-toleran

201 ns of ecdysone signal transduction involving ecdysone receptor-B (EcR-B) isoforms suppressed vCrz dea

202 Myoglianin, Baboon, and Ecdysone Receptor-B1 are also required for neuromuscular

203 axon pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon pruning.

204 f these neurons, however, are independent of ecdysone receptor-B2 regulation.

205 ific isoform of the steroid hormone receptor ecdysone receptor-B2, for which functions have thus far

206 abscisic acid (ABA) biosynthesis, using the ecdysone receptor-based plant gene switch system and the

207 eracts with Ultraspiracle (Usp), part of the ecdysone receptor.

208 the EcR subunit of the heterodimeric EcR-USP ecdysone receptor.

209 e that it is efficiently bound by the Sciara ecdysone receptor.

210 the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormon

211 inds to the nuclear hormone receptor complex Ecdysone Receptor/Ultraspiracle, and is recruited to the

212 r analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the nuclear receptor ftz-f1

213 and conditional overexpression of wild-type ecdysone receptors in the adult mushroom bodies resulted

214 Third, mutants for nuclear ecdysone receptors showed reduced sleep, and conditional

215 Sequential pulses of the steroid hormone ecdysone regulate the major developmental transitions in

216 Four of these are ecdysone-regulated enhancers, which possess hormone-resp

217 80 facilitates transcriptional repression of ecdysone-regulated genes during prepupal development.

218 Notch-regulated Hey1 gene and at Drosophila ecdysone-regulated genes.

219 tion of apoptosis and autophagy genes during ecdysone-regulated programmed cell death of Drosophila s

220 Ecdysone regulates biological responses by directly init

221 Ecdysone regulation allows females to assess the demands

222 nes from the carbohydrate metabolism and the ecdysone regulatory pathway.

223 Here, we analyzed ecdysone-related gene expression patterns and found that

224 ogy: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tiss

225 We report the presence of a putative ecdysone response element directly adjacent to the origi

226 arly genes, E75, harbors multiple functional ecdysone response elements (EcREs).

227 tabase, we then identified a set of putative ecdysone response elements (EcREs).

228 the immature stage by suppressing E93 (early ecdysone response gene) in N4.

229 ross the genome, including at many canonical ecdysone response genes.

230 protein recruitment are regulated during the ecdysone response.

231 set of genes, including those mediating the ecdysone response.

232 kr-h1, and SRC is required for expression of ecdysone-response genes.

233 insulator proteins during the heat-shock and ecdysone responses.

234 s and is required for activation of the E75A ecdysone-responsive and hsp70 heat-shock genes.

235 ng discs caused precocious expression of the ecdysone-responsive gene broad.

236 esponse to ecdysone, making it unclear which ecdysone-responsive genes are direct EcR targets.

237 l visualization of transcription at selected ecdysone-responsive genes reveals that puffing at Eip74E

238 metamorphosis due to a lack of activation of ecdysone-responsive genes.

239 e species, which stimulate the high level of ecdysone secretion that induces a molt.

240 der low-nutrition conditions, TOR suppresses ecdysone secretion--which otherwise terminates larval de

241 variation in both the duration and level of ecdysone secretion.

242 ess each other's expression and that a local Ecdysone signal is required to shift the balance in favo

243 he shrimp may be explained by an intensified ecdysone signal pathway through gene expansion and posit

244 ther Ecdysone synthesis or the expression of Ecdysone signal transducers or targets in the cyst cells

245 Genetic and transgenic disruptions of ecdysone signal transduction involving ecdysone receptor

246 tion, is attributed to Notch downregulation, ecdysone signaling activation and upregulation of the zi

247 20E levels are lower in males than females, ecdysone signaling acts through distinct cell types and

248 c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite prunin

249 These results suggest that activated ecdysone signaling determines precise developmental timi

250 sleep deprivation, and mutants defective for ecdysone signaling displayed little sleep rebound, sugge

251 Ecdysone signaling downregulates miR-965 at the onset of

252 sor and changes in juvenile hormone (JH) and ecdysone signaling during the reprogramming of social be

253 e, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs

254 We also found that mutants in which ecdysone signaling is reduced were defective in LTM, and

255 cRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regu

256 EcR-B2 in the CySC lineage, indicating that ecdysone signaling supports stem cell viability primaril

257 lting hormone ecdysone, we hypothesized that ecdysone signaling switches the larva to a nutrition-ind

258 We find that ecdysone signaling through Ecdysone receptor isoform B1

259 Conversely, interfering with ecdysone signaling using an ecdysone receptor antagonist

260 Further analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the n

261 BBB, and EcI knockdown in the BBB suppresses ecdysone signaling within the CNS and blocks ecdysone-me

262 We therefore predicted that reduced ecdysone signaling would result in more winged offspring

263 In contrast, GSCs non-autonomously require ecdysone signaling.

264 (c) feedback regulation and coordination of ecdysone signaling.

265 unding member of a new pathway downstream of ecdysone signaling.

266 ltransferase (UGT) that negatively regulates ecdysone signaling.

267 clear growth in virgin males is dependent on ecdysone, some of which is synthesised in SCs.

268 ttributable to loss of cholesterol-dependent ecdysone steroid hormone production.

269 ors following a pulse of the steroid hormone ecdysone such that different times in wing development c

270 maginal discs from larvae with reduced or no ecdysone synthesis are smaller than wild type due to sma

271 Second, mutants for ecdysone synthesis displayed the "short-sleep phenotype,

272 Discs from larvae with reduced ecdysone synthesis have elevated levels of Thor, while m

273 s) and for proper storage of cholesterol and ecdysone synthesis in ring glands.

274 ppears to be mediated, at least in part, via ecdysone synthesis in the prothoracic gland.

275 In spi mutant animals, reducing either Ecdysone synthesis or the expression of Ecdysone signal

276 and secreted normally in larvae with reduced ecdysone synthesis, and upstream components of insulin/i

277 The early genes are a key group of ecdysone targets that function at the top of the signali

278 in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent check

279 Growth is stopped by the pulse of ecdysone that initiates the metamorphic molt.

280 roxyecdysone (20E), the active metabolite of ecdysone that is induced by environmental stimuli in adu

281 h is controlled by two hormones, insulin and ecdysone, that act synergistically by controlling cell g

282 s locus is controlled by the steroid hormone ecdysone, the master regulator of insect development.

283 d by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer o

284 ell-autonomous manner by the steroid hormone ecdysone, through changes in expression of critical pro-

285 ne giant (gt) have long been known to affect ecdysone titers resulting in developmental delay and the

286 Further, feeding ecdysone to larvae eliminates the effects of critical we

287 Application of ecdysone to larvae with growth-perturbed wing discs resc

288 poral requirement for nos correlates with an ecdysone-triggered switch in sensitivity to apoptotic st

289 he onset of metamorphosis have identified an ecdysone-triggered transcriptional cascade that consists

290 The molting hormone ecdysone triggers chromatin changes via histone modifica

291 A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary gla

292 The steroid hormone ecdysone triggers the rapid and massive destruction of l

293 ulates the production of the molting hormone ecdysone via an incompletely defined signaling pathway.

294 Ecdysone was implicated in this suppression by a reducti

295 Because the PGs produce the molting hormone ecdysone, we hypothesized that ecdysone signaling switch

296 f mixtures with fenarimol, testosterone, and ecdysone were antagonistic, mixtures of juvenoids showed

297 limited by the ranges of Dpp and Wg, and by ecdysone, which regulates the cellular response to their

298 aries of the fly produce the steroid hormone ecdysone, which stimulates the division and expansion of

299 n the receptor for the developmental steroid ecdysone, whose concentration is reported to reflect soc

300 Co-exposures of ecdysone with juvenoids resulted in deregulation of ecdy