ライフサイエンスコーパス: ecdysone receptor

1 ther nuclear receptors, including the insect ecdysone receptor.

2 sone but that of its actions mediated by the ecdysone receptor.

3 eracts with Ultraspiracle (Usp), part of the ecdysone receptor.

4 the EcR subunit of the heterodimeric EcR-USP ecdysone receptor.

5 e that it is efficiently bound by the Sciara ecdysone receptor.

6 also enhance dominant-negative mutations in ecdysone receptor.

7 n of p75(NTR) is inducibly controlled by the ecdysone receptor.

8 ement (E/GRE) enhancer for binding activated ecdysone receptors.

9 a 3.8-fold increase in TPMT activity in the ecdysone receptor 293 embryonic kidney cell line, we dem

10 r analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the nuclear receptor ftz-f1

11 ne 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptor

12 y the steroid hormone 20-OH ecdysone via the ecdysone receptor, a member of the nuclear receptor supe

13 this event, we cloned and characterized the ecdysone receptor (AaEcR) and the nuclear receptor Ultra

14 Mutation of the ecdysone receptor abolishes their induction.

15 servations indicate that usp is required for ecdysone receptor activity in vivo, demonstrate that the

16 x (Hsp90 and Hsc70) are required in vivo for ecdysone receptor activity, and that EcR is the primary

17 ild-type and mutant MB neurons in which EcR (ecdysone receptor) activity is genetically blocked, and

18 ents represent in vivo binding sites for the ecdysone receptor and are necessary for hormone-mediated

19 ushroom body (MB), are decommissioned by the ecdysone receptor and mediator complex, causing them to

20 reporter of transcriptional activity of the Ecdysone Receptor and of the Z1 isoform of the Broad Com

21 rogen receptor ligand binding domains or one ecdysone receptor and one retinoid X receptor ligand bin

22 ty is then terminated by the steroid hormone ecdysone receptor and the Sox transcription factor Dicha

23 d binding domains of the Heliothis virescens ecdysone receptor and the transactivation domain of the

24 ough a heterodimeric receptor comprising the Ecdysone Receptor and the Ultraspiracle proteins.

25 ne-tolerant protein) and ecdysteroid action (ecdysone receptor and ultraspiracle) suggest that these

26 adult behavioural maturation in honey bees; ecdysone receptor and ultraspiracle.

27 The EcR ecdysone receptor, and the BR-C, E74 and E75 early regul

28 interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdyso

29 ns of ecdysone signal transduction involving ecdysone receptor-B (EcR-B) isoforms suppressed vCrz dea

30 When the ecdysone receptor B1 (EcR-B1) and Ultraspiracle 1 (USP-1

31 They showed premature ecdysone receptor B1 (EcR-B1) in the photoreceptors and

32 pression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, sugg

33 Interestingly, expression of the ecdysone receptor B1 isoform (EcR-B1) is reduced in acti

34 x composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to regulate gene expression in MB

35 Myoglianin, Baboon, and Ecdysone Receptor-B1 are also required for neuromuscular

36 axon pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon pruning.

37 f these neurons, however, are independent of ecdysone receptor-B2 regulation.

38 ific isoform of the steroid hormone receptor ecdysone receptor-B2, for which functions have thus far

39 abscisic acid (ABA) biosynthesis, using the ecdysone receptor-based plant gene switch system and the

40 Our studies of the Bombyx mori ecdysone receptor (BE) revealed that, unlike the Drosoph

41 Transgenic mice expressing the modified ecdysone receptor can activate an integrated ecdysone re

42 traspiracle (USP), the two components of the ecdysone receptor, causes precocious differentiation of

43 We have developed a Choristoneura fumiferana ecdysone receptor (CfEcR)-based two-hybrid gene switch t

44 that Ash2 functions together with Trr as an ecdysone receptor coactivator.

45 tion directly regulated by the heterodimeric ecdysone receptor complex composed of ecdysone receptor

46 These results indicate that the ecdysone receptor complex influences the fine-tuning of

47 The ecdysone receptor complex is present in both tissues at

48 orphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone

49 Thus, in addition to the ecdysone receptor complex, region-specific factors gover

50 we show that rpr is induced directly by the ecdysone-receptor complex through an essential response

51 A similar block was observed when ecdysone receptor-containing RKO cells were infected wit

52 cohesin cleavage, long before any decline in ecdysone receptor could be detected at this locus.

53 led that, unlike the Drosophila melanogaster ecdysone receptor (DE), treatment of BE with the ecdyson

54 ssion after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation bet

55 C1(-/-) clones exhibit reduced levels of the ecdysone receptor EcR-B1, a key regulator of axon prunin

56 ecdysteroid levels induce expression of the ecdysone receptor (EcR) and ETH gene in Inka cells and e

57 und in Drosophila adults and report that the ecdysone receptor (EcR) and its direct downstream NHR Ei

58 imeric ecdysone receptor complex composed of ecdysone receptor (EcR) and ultraspiracle (USP) via ecdy

59 sone consists of two nuclear receptors (NRs) ecdysone receptor (EcR) and ultraspiracle (USP), USP bei

60 ysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP).

61 a a heterodimeric receptor consisting of the ecdysone receptor (EcR) and ultraspiracle (USP).

62 ts conserved heterodimeric nuclear receptor: Ecdysone Receptor (EcR) and Ultraspiracle (USP)/Retinoid

63 ulation of Notch signaling and activation of ecdysone receptor (EcR) are required for the E/A switch

64 On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containi

65 yonic kidney cells (293) that express a TBX2-ecdysone receptor (EcR) chimeric protein.

66 Finally, we show that Ecdysone receptor (EcR) functions autonomously both for

67 ogous to the acetylcholinesterase (AChE) and ecdysone receptor (EcR) genes of B. tabaci, resulted in

68 The ecdysone receptor (EcR) has been used to develop gene sw

69 In addition, disruption of the Ecdysone receptor (EcR) in mature follicle cells mimicke

70 oids acting through multiple isoforms of the ecdysone receptor (EcR) initiate molting and metamorphos

71 Surprisingly, although the ecdysone receptor (EcR) is essential for pruning in all

72 In Drosophila, expression of specific ecdysone receptor (EcR) isoforms has been correlated wit

73 Further, knockdown of the ecdysone receptor (EcR) led to a decrease in overall AaC

74 BMP signalling appears to regulate ecdysone receptor (EcR) levels via one or more mechanism

75 erexpressing a dominant negative form of the Ecdysone receptor (EcR) or its heterodimeric partner ult

76 receptor coactivator (SRC) and GATAa but not ecdysone receptor (EcR) or its partner, ultraspiracle (U

77 Loss of function of either the ecdysone receptor (EcR) or Ultraspiracle (USP), the two

78 In addition, knocking down the Ecdysone receptor (EcR) selectively in the discs also pr

79 n Orthodenticle (Otd) acts together with the ecdysone receptor (EcR) to directly repress the expressi

80 ltraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex tha

81 l patterning of the A and B1 isoforms of the ecdysone receptor (EcR) within muscle DEO1 corresponds w

82 ng this tool, we show that signaling via the Ecdysone Receptor (EcR), a known regulator of developmen

83 The ecdysone receptor (EcR), a member of the nuclear recepto

84 eroids induce and direct molting through the ecdysone receptor (EcR), a nuclear hormone receptor with

85 Two Zld target genes, qkr58E-2 and Ecdysone receptor (EcR), are upregulated in chinmo-mutan

86 One insect NR, ecdysone receptor (EcR), functions as a receptor for the

87 notion that USP forms a heterodimer with the ecdysone receptor (EcR), we found that the EcR-B1 isofor

88 ugh a ligand-activated nuclear receptor, the ecdysone receptor (EcR), which plays critical roles in i

89 To develop an ecdysone receptor (EcR)-based inducible gene regulation

90 We report that the ecdysone receptor (EcR)-mediated 20-hydroxyecdysone (20E

91 d indirect transcriptional repression by the ecdysone receptor (EcR).

92 The Drosophila ecdysone receptor (EcR)/ultraspiracle (USP) heterodimer

93 B) defects and Df(4)dCORL larvae are lacking Ecdysone Receptor (EcR-B1) expression in MB neurons.

94 we identify a role for the B1 isoform of the ecdysone receptor (EcR-B1) in this process.

95 s using a dominant-negative construct of the ecdysone receptor (EcR-DN).

96 The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or re

97 ke 20-hydroxyecdysone (natural ligand of the ecdysone receptor, EcR), methyl farnesoate, pyrirproxyfe

98 clear receptor heterodimer consisting of the ecdysone receptor, EcR, and the Drosophila RXR receptor,

99 Second, global signaling via the ecdysone receptor, EcR, establishes a female metabolic s

100 Although Ecdysone receptor-encoded nuclear receptor isoforms are

101 s that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and res

102 rby canine kidney (MDCK) cells and inducible ecdysone receptor-expressing (EcR)-CHO cells.

103 attenuated in beta FTZ-F1 mutants, although ecdysone receptor expression is unaffected.

104 betaFtz-F1 and a p160/SRC coactivator of the ecdysone receptor, FISC, is crucial for the stage-specif

105 We show that mutations in the EcR ecdysone receptor gene and crooked legs (crol), an ecdys

106 Expression of dsRNA corresponding to the EcR ecdysone receptor gene generated defects in larval molti

107 nown ecdysteroid receptors, we show that the Ecdysone receptor gene is not required for furrow functi

108 one receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increase

109 Loss of ecdysone receptor has previously been shown to reduce no

110 reases recruitment of FISC to the functional ecdysone receptor in a 20E-dependent manner.

111 augmented transcriptional activation by the ecdysone receptor in cultured cells.

112 hemical evidence for the central role of the ecdysone receptor in his model.

113 E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering t

114 TAI protein colocalized with the ecdysone receptor in vivo and augmented transcriptional

115 and conditional overexpression of wild-type ecdysone receptors in the adult mushroom bodies resulted

116 The ecdysone receptor is also expressed in central clock cel

117 We show that the EcR-USP ecdysone receptor is first activated in the extraembryon

118 ronal remodeling and suggest that functional ecdysone receptor is necessary for some, but not all, re

119 We find that ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomous

120 tors that differ according to which of three ecdysone receptor isoforms encoded by the EcR gene (EcR-

121 insect steroid hormone ecdysone to distinct ecdysone receptor isoforms induces different metamorphic

122 sponsive genes, including those encoding the ecdysone receptor itself, a downstream transcription fac

123 DNA amplification in Sciara and suggest the ecdysone receptor may be the elusive amplification facto

124 r expression is neither dependent on the EcR ecdysone receptor nor inducible by ecdysone in cultured

125 taFtz-F1 facilitates loading of FISC and the ecdysone receptor on the target promoters, leading to en

126 med human hepatocyte line cell HH4 using the ecdysone receptor regulatory system.

127 vitro studies have demonstrated that the EcR ecdysone receptor requires an RXR heterodimer partner fo

128 ng region was found to contain four putative ecdysone receptor response elements (EcREs) and a monome

129 Third, mutants for nuclear ecdysone receptors showed reduced sleep, and conditional

130 In the absense of ecdysone, both ecdysone receptor subunits localize to the cytoplasm, an

131 of both the E/GRE hairpin of the adapter and ecdysone receptors, suggesting it was due to an intrinsi

132 cells by the stable expression of a modified ecdysone receptor that regulates an optimized ecdysone r

133 , a component of the canonical heterodimeric ecdysone receptor, to induce malaria parasite killing re

134 ins interact with each other as well as with ecdysone receptor, ultraspiracle, and methoprene-toleran

135 the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormon

136 inds to the nuclear hormone receptor complex Ecdysone Receptor/Ultraspiracle, and is recruited to the

137 Transgenes encoding RXRalpha and a chimeric ecdysone receptor under control of a modified MMTV-LTR,

138 ased on a heterodimer composed of a modified ecdysone receptor (VgEcR) and the retinoid X receptor (R