ライフサイエンスコーパス: ecdysteroid

1 ing before E75B, coincident with the rise of ecdysteroid.

2 s in insects and plants that have endogenous ecdysteroids.

3 espectively, two tissues known to synthesize ecdysteroids.

4 tial neuroprotective effect of nonconjugated ecdysteroids.

5 Here, we identify the signal as ecdysteroids.

6 nces in the sensitivity or responsiveness to ecdysteroids.

7 ts is regulated by juvenile hormone (JH) and ecdysteroids.

8 important roles in cross-talk between JH and ecdysteroids.

9 compounds include organic acids, hematin, or ecdysteroids.

10 the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evo

11 Two key hormones, juvenile hormone (JH) and ecdysteroids (20-hydroxyecdysone, 20E, is the most activ

12 gered hormonally by the prepupal peak of the ecdysteroid, 20-hydroxyecdysone (20-HE).

13 cessfully obtained and used to identify four ecdysteroids: 20-hydroxyecdysone-3-O-beta-D-glycopyranos

14 t not B. bassiana, has apparently evolved an ecdysteroid-22-oxidase (MrE22O) that inactivate ecdysone

15 We identify a male-specific oxidized ecdysteroid, 3-dehydro-20E (3D20E), which safeguards pat

16 With the evolution of metamorphosis, ecdysteroids acquired a metamorphic function that exploi

17 Ecdysteroids acting through multiple isoforms of the ecd

18 in both JH (methoprene-tolerant protein) and ecdysteroid action (ecdysone receptor and ultraspiracle)

19 JH directs ecdysteroid action, controlling Kr-h1 expression which i

20 c morphogenesis and does so independently of ecdysteroid action.

21 steroids through a sophisticated network of ecdysteroid-activating/inactivating enzymes.

22 orphosis reflect what would be predicted for ecdysteroid activation of the EcR/USP heterodimer.

23 field-use rates, a neurotoxic effect of the ecdysteroid agonist RH-5849 is observed that involves bl

24 Researchers have developed nonsteroidal ecdysteroid agonists for EcR that disrupt molting and ca

25 molting is known to be regulated largely by ecdysteroids and crustacean hyperglycemic hormone (CHH)

26 tasks, from the synthesis and degradation of ecdysteroids and juvenile hormones to the metabolism of

27 The EcR binds to ecdysteroids and regulates transcription of genes that c

28 timately linked to two hormonal systems, the ecdysteroids and the juvenile hormones (JH), which funct

29 horacic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhyd

30 correlated with changes in the titers of the ecdysteroids, and these events could be prevented by app

31 Ecdysteroids are multifunctional hormones in male and fe

32 MF and the ecdysteroids are respectively synthesised under the nega

33 However, little is known about the action of ecdysteroids at the level of gene transcription and regu

34 evidence for negative feedback regulation of ecdysteroids at the site of moult-inhibiting hormone (MI

35 gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the con

36 Ecdysteroid biosynthesis and its hormonal regulation are

37 zonin (Crz)-producing neurons regulate basal ecdysteroid biosynthesis by affecting PTTH neurons.

38 This review summarizes the evidence for ecdysteroid biosynthesis by gonads and its metabolism in

39 25 hydroxylase and has an essential role in ecdysteroid biosynthesis during insect development.

40 )-producing neurons stimulate peak levels of ecdysteroid biosynthesis for maturation [3].

41 st that the Crz-PTTH neuronal axis modulates ecdysteroid biosynthesis in response to octopamine, unco

42 , designated Cyp306a1, that is essential for ecdysteroid biosynthesis in the PGs of the silkworm Bomb

43 physiological properties of the enzymes for ecdysteroid biosynthesis, most of the molecular identiti

44 h npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the av

45 ts that the embryonic epidermis is a site of ecdysteroid biosynthesis.

46 ar how PTTH signaling is regulated for basal ecdysteroid biosynthesis.

47 t the ring gland and regulates expression of ecdysteroid biosynthetic genes.

48 ifferentiative and maturational responses to ecdysteroids by requiring tonic exposure to the hormone

49 on and off repeatedly simply by shifting the ecdysteroid concentration to above or below this thresho

50 sis of a standard of 20-hydroxyecdysone- and ecdysteroid-containing plant extracts.

51 Ecdysteroid control of proliferation is distinguished fr

52 urs throughout such animals, suggesting that ecdysteroids control development of other tissues in a m

53 The insect steroid hormone, ecdysteroid, coordinates growth and maturation, represen

54 Subsequent ecdysteroid decline is required for peptide release, whi

55 In contrast to the ecdysteroid-deficient, larval-lethal phenotype of npc1a

56 ping Drosophila eye is an early metamorphic, ecdysteroid-dependent event.

57 ptic lobe development to be divided into two ecdysteroid-dependent phases.

58 ows two different developmental responses to ecdysteroids depending on the concentration to which it

59 Pulses of ecdysteroids direct Drosophila through its life cycle by

60 tor E74 is one of the early genes induced by ecdysteroids during metamorphosis of Drosophila melanoga

61 ithin the optic lobe anlagen is dependent on ecdysteroids during metamorphosis of the moth Manduca se

62 Genetic analysis shows that DIOMs secrete ecdysteroids during mTOR-mediated muscle remodeling.

63 dysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes (E74, E75, and Broad)

64 t partially overlapping binding cavities for ecdysteroid (ECD) and diacylhydrazine (DAH) ligands, pro

65 ted from enhanced growth rate and a delay in ecdysteroid elevation during the mid-third instar larval

66 ponasterone A), identified through screening ecdysteroids from local plants, demonstrated sustained r

67 The in vitro secretion of ecdysteroids from the prothoracic glands of last instar

68 Here, we examine a putative ecdysteroid glycosyltransferase, Hba_07292 (Hb-ugt-1), w

69 amorphosis, a pulse of circulating steroids, ecdysteroids, governs the dramatic remodeling of larval

70 e fifth instar (after the commitment peak of ecdysteroids) had little effect on proliferation.

71 e gene regulation properties of one of these ecdysteroids have been examined in cell culture and in n

72 Fifty-eight ecdysteroids, herbal analogues of the insect molting hor

73 The ecdysteroid hormone 20-hydroxyecdysone (20E), transferre

74 emonstrates that molting is regulated by the ecdysteroid hormone in the tardigrade Hypsibius exemplar

75 By removing the source of ecdysteroid hormone through ligation, and by subsequent

76 ods and considers the apparent uniqueness of ecdysteroid hormones in arthropods, given the predominan

77 The functional receptor for insect ecdysteroid hormones is a heterodimer consisting of two

78 od meal and stimulate the ovaries to secrete ecdysteroid hormones, which modulate yolk protein synthe

79 this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR.

80 integument of ticks are sources of secreted ecdysteroids in adults, as in earlier stages, but the ti

81 The role of ecdysteroids in modulating exoskeletal growth during the

82 nal) instar when the epidermis is exposed to ecdysteroids in the absence of juvenile hormone (JH) and

83 mplicating this tissue as a source of active ecdysteroids in the early embryo.

84 To better understand the role of ecdysteroids in the molt regulation, the full-length cDN

85 ttle is known about the relative activity of ecdysteroids in various arthropods.

86 o the changes in the levels of hemolymphatic ecdysteroids indicates that these tissues may have diffe

87 The ecdysteroids induce and direct molting through the ecdys

88 We propose that ecdysteroid-induced E75A expression defines a feed-forwa

89 The homolog of the ecdysteroid-induced transcription factor E75A in Drosoph

90 5A, E75B, and E75C, encoded by the E75 early ecdysteroid-inducible gene.

91 Ecdysteroids initiate molting and metamorphosis in insec

92 are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some enviro

93 re viable and fertile with relatively normal ecdysteroid level.

94 Prior to behavioral onset, rising ecdysteroid levels induce expression of the ecdysone rec

95 proliferating and later degenerate with high ecdysteroids levels.

96 Ecdysteroids mediate a wide variety of developmental and

97 in regulating the cyclicity of vitellogenic ecdysteroid-mediated signaling through heterodimerizatio

98 Ecdysteroid metabolism occurs in several tissues of adul

99 eveloping epidermis when there is a surge of ecdysteroid midway through embryogenesis.

100 lateral cells of the ring gland that produce ecdysteroid molting hormone (EC).

101 eptor (EcR), functions as a receptor for the ecdysteroid molting hormones of insects.

102 urs at a characteristic concentration of the ecdysteroid molting hormones that regulate metamorphosis

103 Synthesis of ecdysteroids (molting hormones) by crustacean Y-organs i

104 The prepupal peak of ecdysteroids (molting hormones) triggers the regression

105 d by a combination of neuropeptide hormones, ecdysteroids (moulting hormones) and the isoprenoid, met

106 We use cultured tissues to show that ecdysteroids must be maintained above a sharp threshold

107 TTH signaling indicated that basal levels of ecdysteroid negatively affect systemic growth prior to m

108 When exposed to low levels of ecdysteroid, NO production is stimulated and proliferati

109 ulture experiments indicate that the peak of ecdysteroids occurring at pupariation is required for th

110 Our results show the effect of ecdysteroids on MDR cancer cells for the first time.

111 signaling pathway, and the juvenile hormone/ecdysteroid pathway.

112 gulated CYP307A1 in the juvenile hormone and ecdysteroid pathways, respectively, were linked to accel

113 r cascade', which translates features of the ecdysteroid peak into the different phases of the molt.

114 result from some cells 'misinterpreting' the ecdysteroid peaks that drive metamorphosis.

115 The results suggest that both neurons and ecdysteroids play an important regulatory role in adult

116 100-400 microg on column) but also the major ecdysteroids present in crude extracts of Silene otites,

117 ease in intracellular free Ca(2+) stimulates ecdysteroid production by crustacean molting glands (Y-o

118 dently stimulated yolk uptake by oocytes and ecdysteroid production by the ovaries at lower concentra

119 In contrast, ecdysteroids promote metamorphosis by inducing the E93 t

120 In contrast, free ecdysteroids protected both cell lines from tBHP-induced

121 Ecdysteroid pulses trigger the major developmental trans

122 responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner

123 consisting of two nuclear hormone receptors, ecdysteroid receptor (EcR) and the retinoid X receptor h

124 traspiracle (USP), the obligatory functional ecdysteroid receptor (EcR) partner.

125 erived from the Drosophila melanogaster (Dm) ecdysteroid receptor (EcR)- and retinoid X receptor (RXR

126 s an obligatory dimerization partner for the ecdysteroid receptor (EcR).

127 yecdysone (20E) are dually controlled by the ecdysteroid receptor (EcR/USP) and products of ecdystero

128 ow that a transcriptional coactivator of the ecdysteroid receptor complex, FISC, acts as a functional

129 operative interaction between AaE74B and the ecdysteroid receptor is required for high-level expressi

130 secticidal activity via interaction with the ecdysteroid receptor proteins.

131 AaE74B and the ecdysteroid receptor synergistically enhanced 20E-induce

132 AHR38 also disrupts binding of ecdysteroid receptor to ecdysone response elements.

133 h is an obligatory partner in the functional ecdysteroid receptor, exists at the state-of-arrest as a

134 DHR78, which encodes another candidate ecdysteroid receptor, is also not required.

135 pendent activation of a reporter gene by the ecdysteroid receptor.

136 nuclear receptor isoforms are the only known ecdysteroid receptors, we show that the Ecdysone recepto

137 Ecdysteroids regulate a wide variety of cellular process

138 Ecdysteroids regulate many key developmental events in a

139 n the ecdysone biosynthetic pathway and that ecdysteroids regulate many late embryonic morphogenetic

140 Ecdysteroids regulate the remodeling of the dorsal exter

141 DHR78 protein is bound to many ecdysteroid-regulated puff loci, suggesting that DHR78 d

142 receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies.

143 n rather than binding competition for the Vg ecdysteroid response element accounts for the inhibition

144 idermal growth factor signaling pathways, an ecdysteroid-response gene, cabut, and an ubiquitin-speci

145 Our results provide novel evidence for an ecdysteroid responsive gene in a crustacean that has man

146 This paper reports the cloning of an ecdysteroid responsive gene, HHR3, a potential Manduca s

147 the question of whether a similar cascade of ecdysteroid responsive genes exist in other members of A

148 Although EcR.USP-A recognizes the same ecdysteroid-responsive elements, EcR.USP-B binds them wi

149 lude that EcR/USP activation by the systemic ecdysteroid signal may be spatially restricted in vivo.

150 However, whether ecdysteroid signaling can bypass transcriptional hierarc

151 gene mediates the transcriptional output of ecdysteroid signaling in Drosophila myoblast fusion, a c

152 Ecdysteroid signaling in insects is transduced by a hete

153 monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic

154 Furthermore, we showed that ecdysteroid signaling is essential for the proper activa

155 In this study, we demonstrated that ecdysteroid signaling is operating in mature follicle ce

156 We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Dro

157 sis, providing a new tool for characterizing ecdysteroid signaling pathways during development.

158 Although ecdysteroid signaling regulates multiple steps in oogene

159 pamycin (TOR) pathways, juvenile hormone and ecdysteroid signaling, and epigenetic regulation.

160 llicle cells in late stages of oogenesis via ecdysteroid signaling.

161 However, at pupariation, ecdysteroid signalling stimulates Ab expression, which c

162 Eight ecdysteroid-squalene conjugates were semi-synthesized an

163 Initially, moderate levels of ecdysteroid stimulate proliferation.

164 f NO repression though, but also requires an ecdysteroid stimulatory pathway.

165 ervous systems (CNS) cultured with low or no ecdysteroids survive and continue to divide, whereas the

166 mol and testosterone (reported inhibitors of ecdysteroid synthesis and an EcR antagonist, respectivel

167 th decreased expression of genes involved in ecdysteroid synthesis and signaling.

168 mic hormone (CHH), which not only influences ecdysteroid synthesis but also water uptake during moult

169 ined hyperglycemia in vivo and repression of ecdysteroid synthesis in vitro.

170 stacean hyperglycaemic hormone (CHH) repress ecdysteroid synthesis of the target tissue (Y-organ) onl

171 nd cellular level by bioassay (inhibition of ecdysteroid synthesis), radioligand (receptor) binding a

172 molting to adulthood due to a deficiency in ecdysteroid synthesis.

173 lt-inhibiting hormone (MIH), which represses ecdysteroid synthesis; crustacean hyperglycaemic hormone

174 Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone

175 lowed by betaFTZ-F1 mRNA expression when the ecdysteroid titer becomes low.

176 tly during the larval and pupal molts as the ecdysteroid titer begins to decline and again just befor

177 low levels and in the adult molt just as the ecdysteroid titer begins to decline.

178 sion patterns are correlated with changes in ecdysteroid titer during development.

179 ward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring pr

180 In contrast, E75A mutants have a reduced ecdysteroid titer during larval development, resulting i

181 s transiently at the onset of the decline of ecdysteroid titer followed by betaFTZ-F1 mRNA expression

182 e in the larval and the pupal molts when the ecdysteroid titer has declined to low levels and in the

183 A and MHR3, whose mRNAs are induced when the ecdysteroid titer increases, the expression of MHR4 mRNA

184 s observed at the end of the instar when the ecdysteroid titer is high.

185 is seen in mid-third instar larvae when the ecdysteroid titer is low, and strong widespread activati

186 ng the development of the adult wings as the ecdysteroid titer is rising, and this increase was preve

187 s from a failure to induce the large rise in ecdysteroid titer that triggers metamorphosis.

188 were not well correlated with the hemolymph ecdysteroid titer, developmental expression and phosphor

189 nic stages, corresponding to a period of low ecdysteroid titer, while USP-B mRNA exhibits its highest

190 , about the time of the premolt peaks in the ecdysteroid titer.

191 vitellogenic period, correlating with a high ecdysteroid titer.

192 rrelated with PTTH release and the hemolymph ecdysteroid titer.

193 nearly disappears in mid-vitellogenesis when ecdysteroid titers are high.

194 uring pre- and postvitellogenic periods when ecdysteroid titers are low.

195 he spook (spo) locus result in low embryonic ecdysteroid titers, severe late embryonic morphological

196 d by interactions between rising and falling ecdysteroid titers, the pattern of expression of EcR iso

197 s the overgrowth and is a consequence of low ecdysteroid titers.

198 ds to the period of the moult cycle when the ecdysteroid titre is high.

199 reach a peak prior to that of the haemolymph ecdysteroid titre, supporting a role for the enzyme in d

200 ured primordia simply by adjusting levels of ecdysteroid to be above or below a critical threshold co

201 nile hormone, which acts in conjunction with ecdysteroids to control gene expression in insects.

202 n that it does not involve direct binding of ecdysteroids to either DHR38 or USP.

203 In insects, the principal steroid hormones, ecdysteroids, trigger the expression of thousands of gen

204 ring the third larval instar with defects in ecdysteroid-triggered developmental responses.

205 The ecdysteroids unequivocally identified in these extracts

206 , we have analyzed the activities of various ecdysteroids using gel mobility shift assays and transfe

207 nvolvement of hormone signaling by measuring ecdysteroids, which increase following cocaine exposure,

208 anoconjugates of naturally derived antitumor ecdysteroids, which were designed to interfere with oxid

209 The observed bioactivity and composition of ecdysteroids will contribute to the future development o

210 gism or antagonism was observed by combining ecdysteroids with doxorubicin, and specific structure-ac

211 l-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals.