ライフサイエンスコーパス: echovirus

1 elated enteroviruses, such as poliovirus and echovirus.

2 mode reported previously for DAF binding to echoviruses.

3 ain dynamics of pathogens such as dengue and echoviruses.

4 uses and coxsackieviruses type B and 94% for echoviruses.

5 85% for coxsackieviruses type B, and 94% for echoviruses.

6 B, and six serotypes of commonly circulating echoviruses.

7 tegrin with antibodies or the human pathogen echovirus 1 (EV1) causes redistribution of alpha2 integr

8 We have examined the mechanism by which echovirus 1 (EV1) enters polarized intestinal epithelial

9 Following analysis in echovirus 1 and collagen binding assays, chimeras with s

10 synthesized and conjugated to enteroviruses echovirus 1 and coxsackievirus B3.

11 Asn(289) had not been implicated in previous echovirus 1 binding studies.

12 Echovirus 1 binding was lost in a chimera containing the

13 ified Asn(289) as playing a critical role in echovirus 1 binding.

14 Binding sites for both collagen and echovirus 1 have been mapped to the I domain within the

15 an also bind to large ligands, such as human echovirus 1.

16 ctions with collagen and is the receptor for echovirus 1.

17 dition, the alpha(2) integrin I domain binds echovirus 1; the alpha(1) I domain does not.

18 oxsackievirus A9; coxsackieviruses B1 to B6; echoviruses 1 to 7, 9, 11 to 21, 24 to 27, and 29 to 33;

19 e, we evaluated the inactivation kinetics of echovirus 11 (E11) by free chlorine, ultraviolet (UV) ir

20 mental conditions, we experimentally adapted echovirus 11 (E11) to four climate regimes.

21 Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (

22 nfection by diverse enteroviruses, including echovirus 11 (E11), coxsackievirus B (CVB), and enterovi

23 tes, that infection by a DAF-using strain of echovirus 11 (EV11) is dependent upon cholesterol and an

24 By comparison of the binding affinity for echovirus 11 of various fragments of decay-accelerating

25 The interaction between echovirus 11 strain 207 (EV11-207) and decay-acceleratin

26 f the bacteriophage T4 and the enteric virus echovirus 11 when exposed to the filter feeders Tetrahym

27 affinity and kinetics of the interaction of echovirus 11 with its cellular receptor decay-accelerati

28 f infection of polarized epithelial cells by echovirus 11, DAF binding appears be a key determinant i

29 ative IRES element from the Travis strain of echovirus 12 (ECV12), a wild-type, relatively nonvirulen

30 r enteric single-stranded RNA viruses (e.g., Echovirus 12, feline calicivirus) but degraded much fast

31 Here, we report a case of echovirus 18-associated severe systemic infection and ac

32 The HPeVs (including the former echoviruses 22 and 23, now HPeV type 1 (HPeV1) and HPeV2

33 ribe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old bo

34 rovirus A71 and D68, human rhinovirus C, and echoviruses 29 as prototype pathogens of this virus fami

35 mers permit specific RT-PCR amplification of echovirus 30 (E30) sequences by targeting sites that enc

36 ypes were identified (n = 11 605 cases) with echovirus 30 (E30), coxsackievirus A6 (CVA6), EV-D68, E9

37 ruses, and 384 (82%) of 467 individuals with echovirus 30 infection with available clinical data had

38 Echovirus 30 was the second most frequently detected ent

39 on of the recombinant virus was derived from echovirus 6, with the carboxy-terminal portion originati

40 The most frequent genotypes, echoviruses 6 and 30, were associated with different vir

41 ficiency (1), and liver failure secondary to echovirus 7 (1).

42 Using the echovirus 7 (E7) model in several cell types, we show th

43 larly mediates antiviral restriction against echovirus 7 (E7) mutants with elevated frequencies of Up

44 s functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and

45 Echovirus 7 (EV7) belongs to the Enterovirus genus withi

46 Using echovirus 7 and poliovirus 1, we confirmed the expressio

47 cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding

48 Echovirus 7 enters polarized Caco-2 intestinal epithelia

49 thways that target CpG and UpAs in HIV-1 and echovirus 7 genomes and restrict their replication have

50 th specific small interfering RNAs inhibited echovirus 7 infection upstream of uncoating but had litt

51 tics by free chlorine were also observed for echovirus 7, 9, and 13, and coxsackievirus A9.

52 y characterised mutants of the picornavirus, echovirus 7, in which these parameters were independentl

53 foundly influence the replication ability of echovirus 7.

54 with those observed for the EV-B serotypes, echovirus 9 (E9), E30, and E11, respectively (1.3 to 9.8

55 us clone 2E11 (Chemicon) with 10 poliovirus, echovirus, and coxsackievirus type A and B stock isolate

56 ologue of the FcRn, the primary receptor for echoviruses, and ablation of type I IFN signaling are re

57 Echoviruses are among the most common worldwide causes o

58 IMPORTANCE Echoviruses are among the most common worldwide causes o

59 Echoviruses are amongst the most common causative agents

60 intestinal organoids, uORF protein-knockout echoviruses are attenuated compared to the wild-type at

61 Echoviruses are enteroviruses that belong to Picornaviri

62 rential roles of type I and type III IFNs in echovirus-associated neuronal disease and defines the sp

63 s cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a

64 an enterovirus species B, which contains the echoviruses, coxsackie B viruses, coxsackievirus A9, and

65 962 isolates revealed 53 NPEV types in which echovirus (E) 6 (7.6%), E14 (7.6%), E11 (7.4%), coxsacki

66 Many serotypes of echovirus (EV) and Coxsackie B virus (CBV) bind human de

67 Echoviruses have been implicated in multiple human disea

68 EV-Bs) (e.g., coxsackie B viruses [CVBs] and echoviruses) have been implicated as environmental facto

69 nal cord, reported identification of a novel echovirus in 15 of 17 French subjects with ALS and only

70 Here, we establish a neonatal mouse model of echovirus-induced aseptic meningitis and show that expre

71 insights into the host factors that control echovirus-induced meningitis and a model that could be u

72 I IFN signaling are required to recapitulate echovirus-induced meningitis and clinical disease.

73 ouse model that recapitulates key aspects of echovirus-induced meningitis.

74 The mechanisms by which echoviruses infect the brain are poorly understood, larg

75 d the immunological response of the brain to echovirus infection and identified key cytokines, such a

76 ermissive human and mouse cells sensitive to echovirus infection and that the extracellular domain of

77 xpressing human FcRn are more susceptible to echovirus infection by the enteral route.

78 that a blocking antibody to beta2M inhibits echovirus infection in cell lines and in primary human i

79 model of aseptic meningitis associated with echovirus infections that delineates the differential ro

80 n the enhanced susceptibility of neonates to echovirus infections.

81 inoculation of newborn transgenic mice with echovirus leads to paralysis and wasting.

82 polioviruses, the coxsackieviruses, and the echoviruses of humans, plus a number of enteroviruses of

83 cellular domain of human FcRn directly binds echovirus particles and neutralizes infection.

84 ate antigen 2 transgenic mice as a model for echovirus pathogenesis.

85 vivo models that recapitulate this aspect of echovirus pathogenesis.

86 vivo models that recapitulate this aspect of echovirus pathogenesis.

87 ession of the human homologue of the primary echovirus receptor, the neonatal Fc receptor (FcRn), is

88 Our findings thus identify FcRn as a pan-echovirus receptor, which may explain the enhanced susce

89 ify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor.

90 pressing human FcRn permitted high levels of echovirus replication in the brain, with corresponding c

91 real-time RT-PCR method based on this novel echovirus sequence and used this method and that previou

92 e widely applicable to the identification of echovirus serotypes by PCR.

93 and between adult AGI and enteroviruses when echovirus serotypes predominated.

94 Lastly, we showed that echoviruses specifically replicate in the leptomeninges,

95 om the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary process

96 reas with a greater similarity to particular echoviruses than to CVB1N, suggesting that recombination

97 and a model that could be used to test anti-echovirus therapeutics.

98 cent (3- to 4-week-old) transgenic mice with echovirus type 1 did not lead to paralysis but an acute

99 integrin very late antigen 2, a receptor for echovirus type 1, in transgenic mice conferred susceptib

100 in cells infected with rhinovirus type 16 or echovirus type 1.

101 Echovirus type 12 (EV12), an Enterovirus of the Picornav

102 of the enterovirus isolate identified it as echovirus type 18.

103 for an earlier reconstruction of the related echovirus type 7 bound to DAF, attachment is not within

104 Many echoviruses use decay-accelerating factor (DAF) as their