ライフサイエンスコーパス: ectoderm

1 oid (endoderm), heart (mesoderm), and brain (ectoderm).

2 ely unknown patterning cues expressed by the ectoderm.

3 expressed throughout dorsal and ciliary band ectoderm.

4 dial contractile processes (myonemes) in the ectoderm.

5 ryos permits immunocyte insertion in ventral ectoderm.

6 n of Foxg1 expression in the anterior neural ectoderm.

7 l ectoderm and ciliary band, but not ventral ectoderm.

8 es such as endoderm, mesendoderm, and neural ectoderm.

9 will give rise both to hindgut and to border ectoderm.

10 orsal surface of the somites and contact the ectoderm.

11 ine, which expresses Cre in the head surface ectoderm.

12 ndirectly suppresses Vegf3 expression in the ectoderm.

13 and they never loose contact with the neural ectoderm.

14 in the urethral endoderm and in the surface ectoderm.

15 ovement to the midline is independent of the ectoderm.

16 ventral ectoderm, but signals in the dorsal ectoderm.

17 proto-pituitary with newly evolved placodal ectoderm.

18 he three germ layers: endoderm, mesoderm and ectoderm.

19 f the p63 protein in the embryonic limbs and ectoderm.

20 ry set by the occipital lateral mesoderm and ectoderm.

21 l and anteroposterior regionalisation of the ectoderm.

22 cretory cells in the anteriormost non-neural ectoderm.

23 ntial to plasticity and pattern in the early ectoderm.

24 c absence of BMP activity in the preplacodal ectoderm.

25 blastula embryo into endoderm, mesoderm and ectoderm.

26 blast, which is derived from extra-embryonic ectoderm.

27 ression to the lateral domains of the animal ectoderm.

28 inhibitors are required for formation of the ectoderm.

29 c lateral plate mesoderm (LPM) and overlying ectoderm.

30 of the anterior-posterior and dorsal-ventral ectoderm.

31 ivity, which is specified as the preplacodal ectoderm.

32 paration of the mesoderm, neuroectoderm, and ectoderm.

33 ary band emerge adjacent to the central oral ectoderm.

34 derm actively patterns the adjacent boundary ectoderm.

35 es in periodic patterns is restricted to the ectoderm.

36 inate, at least in part, from the non-neural ectoderm.

37 pagated upon differentiation to mesoderm and ectoderm.

38 omplete medial-lateral axis of the embryonic ectoderm.

39 etinal cells, lens cells, and ocular-surface ectoderm.

40 programs in the epiblast and extraembryonic ectoderm.

41 etrads and rosettes in Fgfr2 mutant limb-bud ectoderm.

42 es of ES cell differentiation into the neuro-ectoderm.

43 f the pharynx, which separates endoderm from ectoderm.

44 o into the early epiblast and extraembryonic ectoderm.

45 rises at the border of neural and non-neural ectoderm.

46 l crest, ocular-surface ectoderm, or surface ectoderm.

47 y from the ventral midline to the neurogenic ectoderm.

48 ills were classically thought to derive from ectoderm [10, 13].

49 h bilaterally separates the oral from aboral ectoderm; (3) the vegetal lateral CB, which bilaterally

50 ereas Univin is bilaterally expressed in the ectoderm adjacent to the anterior skeleton during the re

51 elay in expression of Fgf8 in branchial arch ectoderm and a failure of neural crest cells in the arch

52 nd re-enter ectoderm, distributing in dorsal ectoderm and ciliary band, but not ventral ectoderm.

53 ct of the embryo that separate endoderm from ectoderm and ectoderm from neurogenic apical plate and t

54 gement of the antiviral defenses compromised ectoderm and endoderm formation and dysregulated the dev

55 sh foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi

56 actor Foxi3, which is expressed in branchial ectoderm and endoderm.

57 t in alternate planar cell divisions between ectoderm and endomesoderm.

58 sue-specific functions in patterning surface ectoderm and its appendages by controlling division orie

59 tailed transcriptomic analysis of changes in ectoderm and mesenchyme in Esrp1(-/-) embryos during fac

60 a Gata2 target gene that is required in both ectoderm and mesoderm for primitive hematopoiesis to occ

61 ces along this signaling highway between the ectoderm and mesoderm.

62 For ectoderm and motor neuron differentiation, peptide-modif

63 Notum is expressed in naive ectoderm and neural plate in Xenopus and is required for

64 embryos, we show that affecting Vmem of the ectoderm and no other cell layers is sufficient to cause

65 Foxg1 expression requires LPAR6 within ectoderm and not mesoderm.

66 /2 share expression in periderm, frontonasal ectoderm and oral epithelium.

67 lls and allowed discrimination of non-neural ectoderm and otic lineage cells from off-target populati

68 e embryonic non-neural ectoderm, preplacodal ectoderm and otic vesicle epithelia.

69 We find that collective spreading of the ectoderm and persistent de-epithelialization in the endo

70 calcifying medium between the calicoblastic ectoderm and pre-existing skeleton, separated from the o

71 t cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating em

72 the Wnt signals operating between secreting ectoderm and receiving chondrocytes.

73 w lens vesicle separation from the overlying ectoderm and regulate corneal epithelial proliferation.

74 results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epitheli

75 in lamprey as the LPM is separated from the ectoderm and sequestered to the coelomic linings during

76 The neural ectoderm and surrounding tissues also coordinate prolife

77 The border between the posterior ectoderm and the endoderm is a location where two germ l

78 expressed from E12 posterior to the surface ectoderm, and became widespread from E14.

79 omodeal subdomain emerges inside of the oral ectoderm, and bilateral subdomains defining the lateral

80 er genes of non-neural ectoderm, preplacodal ectoderm, and early otic lineage.

81 F ligand Pyramus is expressed broadly in the ectoderm, and ectopic Pyramus expression disrupted muscl

82 the ability to differentiate down mesoderm, ectoderm, and endoderm lineages, demonstrating pluripote

83 ranscription factor, glia originate from the ectoderm, and hemocytes from the mesoderm.

84 he ectoplacental cone, in the extraembryonic ectoderm, and in trophoblast giant cells in the E6.5 emb

85 ion in the archenteron requires contact with ectoderm, and loss-of-function experiments indicate that

86 g intermediate stages of endoderm, mesoderm, ectoderm, and neural crest (NC) development.

87 uch (pouch 6) has made contact with the skin ectoderm, and only after periderm-like cells have covere

88 aggregation promoting pluripotency loss and ectoderm, and slower aggregation favoring mesoderm and e

89 arly gene expression domains in the anterior ectoderm, and that variants in KCNJ2 disrupt this region

90 cation of the immediately adjacent stripe of ectoderm, and the restriction of the apical neurogenic d

91 chyme, overlying olfactory placode/epidermal ectoderm, and underlying neuroepithelium, as well as the

92 specifies a neural fate in undifferentiated ectoderm; and (2) transformation induces posterior spina

93 have reported their induction from primitive ectoderm (animal cap).

94 e p53 activation in the neural crest, facial ectoderm, anterior heart field, and endothelium induces

95 We find that enhancers in ectoderm are already pre-accessible in embryonic day 6.5

96 patterning the neural crest and preplacodal ectoderm are specified in adjacent domains at the neural

97 rs, expressed in the embryonic limb buds and ectoderm, are disease genes for these conditions.

98 pore, which are fated to become neural plate ectoderm, are polarized and have straight boundaries.

99 between the neuroepithelium and the surface ectoderm, are required for completion of neural tube clo

100 lx4b, which are expressed in the preplacodal ectoderm, are required for the expression of a cell-auto

101 la embryos, and specific signatures for each ectoderm area.

102 il their expression is cleared from the oral ectoderm as an indirect consequence of Nodal signaling.

103 uish differentiated neurons from nonneuronal ectoderm as it does in many other animals, but instead c

104 chimeras from these strains to identify the ectoderm as the target tissue for DAC-2-25.

105 erived ectoplacental cone and extraembryonic ectoderm, as well as in the yolk sac and labyrinth tissu

106 regional expression in ventrolateral surface ectoderm at E10.5, much earlier than previously reported

107 is concentrated in the lateral mesoderm and ectoderm at the neurula stage.

108 ire transdifferentiation across the mesoderm-ectoderm barrier.

109 ately restricted to subregions of the border ectoderm (BE).

110 The formation of the oral ectoderm begins with an oral-aboral redox gradient, whic

111 ferent boundaries: repulsion at the mesoderm-ectoderm border, decreased adhesion at the notochord-pre

112 murfs regulate tissue separation at mesoderm/ectoderm boundaries through antagonistic interactions wi

113 iated band cells and cells from the endoderm/ectoderm boundary that will give rise both to hindgut an

114 ells begin to exit the neural fold/epidermal ectoderm boundary, we examined the cranial mesenchyme, c

115 ch are specific to vertebrates, arise in the ectoderm but can generate cell types that are typically

116 -Eph results in rounded immunocytes entering ectoderm but not adopting a dendritic form.

117 chin embryos, BMP is produced in the ventral ectoderm, but signals in the dorsal ectoderm.

118 a star embryo initially has a pan-neurogenic ectoderm, but the genetic mechanism that directs a subse

119 erature, sweat glands develop from embryonic ectoderm by a poorly defined mechanism.

120 transcription factor that expands the neural ectoderm by down-regulating genes that promote the onset

121 ivated in the ventral midline and neurogenic ectoderm by the Spitz ligand, which is processed by the

122 originate from thickenings in the embryonic ectoderm called cranial sensory placodes.

123 fferent germ layers - endoderm, mesoderm and ectoderm - can spontaneously segregate within a cell agg

124 We find that the endoderm-ectoderm cell fate switch is controlled by the cumulativ

125 We also show that SE cells and neural ectoderm cells possess distinct gene expression patterns

126 ype of adhesive contact between mesoderm and ectoderm cells that shows properties of a cleft-like bou

127 ntegrin beta1 and focal anchorage of surface ectoderm cells to a shared point of fibronectin-rich bas

128 tors is sufficient to reprogramme developing ectoderm cells to mesendoderm.

129 t the blastopore and ectopic constriction of ectoderm cells triggered by the actin-binding protein Sh

130 Surface ectoderm cells undergo proximal junction shortening, est

131 en up from the body cavity into the PMCs and ectoderm cells, where the two labels are predominantly c

132 Mechanistically, TFAP2C primes the surface ectoderm chromatin landscape and induces p63 expression

133 cells from the stomodeal region of the oral ectoderm, ciliated band cells and cells from the endoder

134 We demonstrate that pouch-ectoderm contact and the presence of a periderm-like lay

135 migrate, either surrounding the prospective ectoderm contributing to the embryo proper, or into the

136 work explains how spatial patterning in the ectoderm controls progression of neurogenesis in additio

137 In both normal and adhesion-reduced ectoderm, cortical tension of the free cell surfaces at

138 e a dynamic expression pattern of Shh in the ectoderm covering the frontonasal (FNP) and maxillary (M

139 or endoderm, and that FGF signaling from the ectoderm defines the location and amount of mesoderm.

140 ent stem cells that arise from the embryonic ectoderm, delaminate from the neural tube in early verte

141 but its specification of ventral neurogenic ectoderm demands a relatively high-threshold response to

142 K16 protein) is constitutively expressed in ectoderm-derived appendages and in palmar/plantar epider

143 l potential persists past the time when most ectoderm-derived cells become lineage-restricted.

144 eristic of metaphocytes, recently discovered ectoderm-derived cells.

145 ateral plate mesoderm-derived mesenchyme and ectoderm-derived surface epithelium.

146 erning to develop into several endoderm- and ectoderm-derived tissues, mimicking their in vivo counte

147 search for the downstream targets of YAP in ectoderm-derived tissues.

148 e report that VEGF signaling, acting through ectoderm-derived VEGF3 and its cognate receptor, VEGF re

149 ific deletion of the PRC2 proteins embryonic ectoderm development (EED) (a subunit required for PRC2

150 ed via combinatorial regulation of embryonic ectoderm development (EED) and lysine-specific demethyla

151 current mutations in core subunits embryonic ectoderm development (EED) and suppressor of zeste 12 ho

152 The WD-repeat protein embryonic ectoderm development (EED) is a non-catalytic but an ess

153 var)3-9; E(z); Trithorax] (SET)-7, embryonic ectoderm development (EED), and SU(Z)12 (suppressor of z

154 units, enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 (

155 olycomb group (PcG) proteins CBX7, embryonic ectoderm development (EED), enhancer of zeste homologue

156 which the essential PRC2 subunits embryonic ectoderm development (EED), suppressor of zeste 12 homol

157 ains are suppressed by mutation of embryonic ectoderm development or Su-(var)3-9; E(z); Trithorax (se

158 e report the identification of the embryonic ectoderm development polycomb histone-methylation modula

159 erlap those following knockdown of embryonic ectoderm development, a common cofactor of EZH2 and EZH1

160 Sox5 is required for proper ectoderm development, and deficient embryos display patt

161 Sox9 deletion from the ectoderm did not affect Fgf10 expression in the adjacent

162 pregnant mutant females revealed defects in ectoderm differentiation leading to abnormal foetal deve

163 t not p63, is sufficient to initiate surface ectoderm differentiation, and TFAP2C-initiated progenito

164 we showed that Wnt ligands from the surface ectoderm directly or indirectly elicit a Wnt/beta-cateni

165 Moreover, this mouthless, neurogenic ventral ectoderm displayed a medial-to-lateral organization simi

166 nsition to mesenchyme, migrate, and re-enter ectoderm, distributing in dorsal ectoderm and ciliary ba

167 n into germ layers of endoderm, mesoderm and ectoderm during gastrulation.

168 n and the proper specification of the neural ectoderm during neural induction.

169 ic lineage commitment during gastrulation to ectoderm (early switch) or mesoderm/endoderm (late switc

170 sential roles of Htt in the specification of ectoderm, endoderm and mesoderm, in the specification of

171 axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to drive axis morphogenesis remain l

172 tween different epithelial populations (skin ectoderm, endoderm, and periderm-like cells in zebrafish

173 epithelial cyst with an asymmetric amniotic ectoderm-epiblast pattern that resembles the human amnio

174 st-implantation epiblast and extra-embryonic ectoderm (ExE) by assaying allelic histone modifications

175 between the epiblast and the extraembryonic ectoderm (ExE) of the developing mouse embryo.

176 in early head development and pituitary oral ectoderm exhibit craniofacial defects and pituitary glan

177 for Otx2 deficiency in the pituitary neural ectoderm exhibited altered patterning of gene expression

178 Mutant ectoderm exhibited markedly reduced levels of histone H3

179 ressed Rspo2 inhibited elongation of Xenopus ectoderm explants and Erk1 activation in response to FGF

180 Lack or excess expression of the surface ectoderm-expressed transcription factor Grainyhead-like2

181 mbryos, immunocytes insert preferentially in ectoderm expressing Sp-Efn.

182 lopment, while blocking placodal and surface ectoderm fates.

183 ially synchronous guidance toward non-neural ectoderm, followed by comparatively asynchronous occurre

184 nent analysis on the transcriptomes of these ectoderm fragments primarily identifies embryonic axes a

185 and Delta pathways to distinguish neurogenic ectoderm from endomesoderm.

186 ryo that separate endoderm from ectoderm and ectoderm from neurogenic apical plate and that delineate

187 use along a narrow region that separates the ectoderm from the anterior endoderm and mesoderm.

188 gion between the neural plate and non-neural ectoderm from which multiple cell types, including lens

189 heir clearance explains the dynamics of oral ectoderm gene expression.

190 The sea urchin oral ectoderm gene regulatory network (GRN) model has increas

191 signal activates a unique subcircuit of the ectoderm gene regulatory network, including the transcri

192 ch selectively prevent transcription of oral ectoderm genes until their expression is cleared from th

193 permitted construction of an enhanced animal ectoderm GRN model highlighting the repressive interacti

194 The larval ectoderm has an anterior molecular signature, while most

195 Rather, modulation of Pvr levels in the ectoderm has an impact on PIP3 membrane accumulation, co

196 tivation of the RAF signaling pathway in the ectoderm has effects on specific steps of epidermal diff

197 s (PMCs) and the overlying pattern-dictating ectoderm; however, our understanding of the molecular ba

198 entralized the nervous system to the ventral ectoderm in both hemichordate and sea urchin larvae.

199 t (NC), cranial placode (CP), and non-neural ectoderm in multiple hPSC lines, on different substrates

200 BMP from the ventral ectoderm to the dorsal ectoderm in sea urchin embryos is not understood.

201 ere first recruited to the dorsal non-neural ectoderm in the tunicate-vertebrate ancestor but subsequ

202 f Grhl2 generates a super-epithelial surface ectoderm, in which up-regulation of cell-cell junction p

203 mitotic entry in an artificially contractile ectoderm induced ectopic tissue invaginations.

204 During embryogenesis, the immature ectoderm initially consists of a single layer of undiffe

205 o critical chromatin networks during surface ectoderm initiation and keratinocyte maturation, which a

206 m, via meso-ectodermal, or neural-non-neural ectoderm interactions.

207 trulation and progressively divide embryonic ectoderm into neural and non-neural regions, followed by

208 ting two epithelial cell types, endoderm and ectoderm, into inner and outer layers, respectively.

209 tivation of the same enhancers in the dorsal ectoderm is associated with Polycomb-repressed H3K27me3

210 ow band of ectodermal cells, even though all ectoderm is competent to receive the signal.

211 onstrates that Otx2 expression in the neural ectoderm is important intrinsically for the development

212 During development, the ectoderm is patterned by a combination of BMP and WNT si

213 During vertebrate neurulation, the embryonic ectoderm is patterned into lineage progenitors for neura

214 During early embryogenesis, the ectoderm is rapidly subdivided into neural, neural crest

215 n the centipede, vsx expressing invaginating ectoderm is situated bilaterally adjacent to the medial

216 in mesoderm, or ectopic Snail expression in ectoderm, is sufficient to drive early disassembly of ju

217 tive of lineage, spanning the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithe

218 We further show that amniotic ectoderm-like cells function as a signalling centre to t

219 in (nbeta-catenin) promotes mesendoderm over ectoderm lineages.

220 n of EZH1 or EZH2 fail to differentiate into ectoderm lineages.

221 The pre-placodal ectoderm, marked by the expression of the transcription

222 B markers, which are co-expressed in lateral ectoderm, medial neural plate or posterior-lateral mesod

223 ives of all the three embryonic germ layers: ectoderm, mesoderm and endoderm.

224 strain that expresses nuclear markers in the ectoderm, mesoderm and endoderm/pharynx; and a Morphogen

225 The three germ layers--ectoderm, mesoderm, and endoderm--are affected coordinat

226 astrulation generates three layers of cells (ectoderm, mesoderm, endoderm) from a single sheet, while

227 cells transcriptionally similar to epiblast, ectoderm, mesoderm, endoderm, primordial germ cells, tro

228 We studied the cleft-like ectoderm-mesoderm boundary in Xenopus laevis and zebrafi

229 nuates planar cell polarity signaling at the ectoderm-mesoderm boundary to lower cell adhesion and fa

230 the border of the neural plate and epidermal ectoderm, migrate extensively and differentiate into div

231 neurons originate in placodes in the surface ectoderm, migrating to form ganglia that connect to the

232 ad-like 2 (GRHL2) is expressed in non-neural ectoderm (NNE) and Grhl2 loss results in fully penetrant

233 Surprisingly, the neurogenic ectoderm, not the ventral midline, was found to be the d

234 tic sac-with the embryonic disc and amniotic ectoderm occupying opposite poles-is a vital milestone d

235 The anterior-most ectoderm of ascidian larvae contains the adhesive papill

236 ween the presumptive mesoderm and neurogenic ectoderm of early Drosophila embryos.

237 e and is enriched in the mesoderm and dorsal ectoderm of early gastrulae.

238 pressed in distinct domains in the embryonic ectoderm of Lytechinus variegatus.

239 ting potential) regionalization found in the ectoderm of neurulating embryos, and changes the normal

240 atory state pattern in the pregastrular oral ectoderm of the embryo.

241 xpansion of the Shh expression domain in the ectoderm of the facial primordia.

242 tingly, despite strong expression of Vax1 in ectoderm of the medial nasal processes, the upper lip re

243 mplantation, the epiblast and extraembryonic ectoderm of the mouse embryo become enveloped by a basem

244 The ectoderm of the Xenopus embryo is permeated by a network

245 self-organization of all three germ layers: ectoderm on the outside layer, mesoderm in the middle an

246 derm segmentation is either dependent on the ectoderm, or occurs through an independent mechanism.

247 neuroectoderm, neural crest, ocular-surface ectoderm, or surface ectoderm.

248 expression of an FGF ligand, fgf8/17/18, in ectoderm overlying sites of mesoderm specification withi

249 the development of the epiblast and amniotic ectoderm parts of the conceptus, including lumenogenesis

250 atform is a powerful tool for studying human ectoderm patterning and for improving directed different

251 ral further subdivisions into which the oral ectoderm per se is partitioned.

252 The broad neurogenic potential of the ectoderm persists throughout much of gastrulation.

253 ages including the lens placode and the oral ectoderm (pituitary precursor) cells.

254 Ciona intestinalis exhibits a proto-placodal ectoderm (PPE) that requires inhibition of bone morphoge

255 ommon pool of progenitors in the preplacodal ectoderm (PPE).

256 hat represent the mouse embryonic non-neural ectoderm, preplacodal ectoderm and otic vesicle epitheli

257 cal expression of marker genes of non-neural ectoderm, preplacodal ectoderm, and early otic lineage.

258 The calicoblastic ectoderm produces extracellular matrix (ECM) proteins, s

259 ose a subset of the TFAP2C-initiated surface ectoderm program.

260 We showed that the surface ectoderm region that includes the lens placode expressed

261 maps, including all spatially expressed oral ectoderm regulatory genes, were established.

262 Wnt11r and Wnt4a from the head mesoderm and ectoderm, respectively, play distinct roles in the segme

263 code to define positional information of any ectoderm sample along the anterior-posterior and dorsal-

264 Surface ectoderm (SE) cells give rise to structures including th

265 pigenomes of cell types derived from surface ectoderm (SE), including keratinocytes and breast lumina

266 strular sea urchin embryo surrounds the oral ectoderm, separating it from adjacent embryonic territor

267 Grhl2 null surface ectoderm shows a shift from epithelial to neuroepithelia

268 ting cultures first expressed the non-neural ectoderm specific transcriptional factors TFAP2A, GATA2,

269 erior skeleton, but does not perturb general ectoderm specification or development.

270 ntained and, in fact, essential during early ectoderm specification.

271 onent in the regulation of Hoxc genes in the ectoderm, suggesting that these two enhancers may have e

272 ting biomechanical properties of the surface ectoderm that are essential for spinal neurulation.

273 ll as the neural crest, arise from a zone of ectoderm that borders the neural plate.

274 ctive event of the mesoderm on the overlying ectoderm that generates a neural plate that, after rolli

275 from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle.

276 headed by the occipital lateral mesoderm and ectoderm that split into two streams.

277 driven by the occipital lateral mesoderm and ectoderm, that ensure cell transport and organ assembly

278 somites, pharyngeal pouches, the preplacodal ectoderm (the common precursor region of many cranial se

279 We show that in Xenopus early ectoderm, the Prickle3/Vangl2 complex was polarized to a

280 regulatory genes in the central animal oral ectoderm thereby confining their expression to the later

281 of the embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-ind

282 suppresses genes within the PMCs and in the ectoderm to impact PMC patterning and skeletogenesis.

283 The transport of BMP from the ventral ectoderm to the dorsal ectoderm in sea urchin embryos is

284 at activation of BRAF in the embryonic mouse ectoderm triggers both craniofacial and skin defects, in

285 importance of the non-neural and preplacodal ectoderm, two critical precursors during inner ear devel

286 s that determine gap sizes and shapes in the ectoderm, using a general model of interstitial gap mech

287 ectopic endodermal cells in the presumptive ectoderm via targeted sox32 induction.

288 rmation suggested derivation from neuralized ectoderm, via meso-ectodermal, or neural-non-neural ecto

289 tain spatial information, dorsal and ventral ectoderm was subdivided along the anterior-posterior and

290 The lack of FGF signaling from the neural ectoderm was sufficient to impair anterior lobe growth,

291 he dorsal neuroepithelium, or in the surface ectoderm, we show that these protrusions originate from

292 and stalk, which normally arise from neural ectoderm, were extremely hypoplastic.

293 o-opted to be transcribed in the distal limb ectoderm, where it is activated following the rule of te

294 ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb a

295 e attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure.

296 -mediated separation of this tissue from the ectoderm, which can be rescued by the coincident inhibit

297 nto the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.

298 While morphogenesis of the dorsal ectoderm, which lies directly above the Drosophila dorsa

299 corneal epithelium is descended from surface ectoderm, while the iris and collagen-rich stroma of the

300 Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling