ライフサイエンスコーパス: ectodomain

1 rane protein with nine LRRs in its predicted ectodomain.

2 K in the E2 endodomain or E1-T317I in the E1 ectodomain.

3 the endodermis reveals a large spiral-shaped ectodomain.

4 linked together by a shortened water-soluble ectodomain.

5 in the central vestibule region of the large ectodomain.

6 his structure is inhibited by the unliganded ectodomain.

7 y S37a in the TSHR-TMD construct lacking the ectodomain.

8 ctron microscopy structure of the complete S ectodomain.

9 g regions in the apical part of the receptor ectodomain.

10 tic release of the transmembrane TNF (tmTNF) ectodomain.

11 complete 61 domains of the full-length LRP1 ectodomain.

12 n reshape the antigenic structure of the Env ectodomain.

13 sis at the cell surface to release a soluble ectodomain.

14 these structures span the entire gamma-Pcdh ectodomain.

15 r the Pd-enhancing function mediated by a Pd ectodomain.

16 how that IDA is sensed directly by the HAESA ectodomain.

17 ing that dimerization occurs through CDCP1's ectodomain.

18 structure of the prefusion form of the HeV F ectodomain.

19 (Lotus) exopolysaccharide receptor 3 (EPR3) ectodomain.

20 tioning as decoy receptors, contain only the ectodomain.

21 ry effect of PSGL-1 required its full-length ectodomain.

22 ion models of the monomeric protocadherin-15 ectodomain.

23 esults revealed that HSP47 binds to the DDR2 ectodomain.

24 igand binding pocket formed between two TLR2 ectodomains.

25 rry an agonistic sequence within their large ectodomains.

26 rface for proper assembly and display of the ectodomains.

27 s of PlxnA (PlxnA1, PlxnA2, and PlxnA4) full ectodomains.

28 d assays have relied on soluble glycoprotein ectodomains.

29 herin, all directly interact with E-cadherin ectodomains.

30 Although LRP6 ectodomain 1 (E1) is known to interact with SOST, severa

31 for unusual antibodies that contain a LAIR1 ectodomain(2-4) or as ligands for LILRB1(5).

32 cts of NAM S37a on: 1) chimeras with swapped ectodomain, 2) stepwise N-terminal truncations, 3) disti

33 ving their substrate's extracellular domain (ectodomain), a process known as shedding.

34 n contrast to the relatively well-understood ectodomain, a predictive mechanistic understanding of th

35 Interestingly, the ectodomain, a region that carries the functional domain

36 GE exists as a membrane glycoprotein with an ectodomain, a transmembrane helix, and a short carboxyl-

37 ce, diffusion trapping mediated by the NF186 ectodomain aberrantly persists into adulthood, whereas t

38 er structural analyses suggest that all CNTN ectodomains adopt a bent conformation and might lie para

39 d report the crystal structure of the CedV G ectodomain alone and in complex with ephrin-B1 or ephrin

40 nducing proteolytic cleavage of the receptor ectodomain, an event that requires ligand to be endocyto

41 mergence of mutant viruses that lack the N11 ectodomain and acquired mutations in H18.

42 reveal that a direct interaction between NCT ectodomain and APP(C99) influences the stability of GSEC

43 r-to-alanine (CCTA) mutants within the UL148 ectodomain and compared them to wild-type UL148, both in

44 dynamic coupling across the TMD between the ectodomain and CT.

45 is switch, we compared accumulation of NF186 ectodomain and cytoplasmic domain constructs in WT versu

46 , we engineer a pre-fusion-stabilized hMPV F ectodomain and determine its crystal structure to 2.6 A

47 chains selectively bind to the purified DR5 ectodomain and induce its oligomerization.

48 interactions between the entire alphavbeta8 ectodomain and its intact natural ligand, L-TGF-beta, as

49 rface-exposed residues within the human DSG1 ectodomain and LJM17.

50 make inferences about the connection between ectodomain and membrane-proximal external region (MPER)

51 negative-stained electron micrographs of the ectodomain and multidomain constructs, we have determine

52 SEZ6 interacted with GluK2 through its ectodomain and promoted post-endoplasmic reticulum trans

53 ns of N-glycosylation within the recombinant ectodomain and S1 subunit of the SARS-CoV-2 spike protei

54 ual glycans on the modification sites of the ectodomain and subunit proteins.

55 that block the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.

56 rocess depends on the length of the extended ectodomain and the tethered agonist of the receptor, but

57 ructural insights into the interface between ectodomain and transmembrane domain in the TSHR, as well

58 e substitutions at every residue of the gp41 ectodomain, and 362 space-filling residue substitutions

59 methionine- and histidine-rich metal-binding ectodomain, and it exhibits reduced Cu(+) transport acti

60 t with receptors ANXUR1 and ANXUR2 via their ectodomains, and both sets of receptors bind RALF4 and R

61 We studied the relationship among anti-spike ectodomain (anti-ECD), anti-receptor-binding domain (ant

62 s ligand specificities are affected by their ectodomain architectures.

63 processed proforms on cell bodies, and their ectodomains are shed by metalloproteinases in response t

64 Thus these dimeric rsFcgammaR ectodomains are validated, defined probes that should pr

65 studies on glioma implicate the neuroligin-3 ectodomain as a mitogen.

66 ations suggested that more flexible cadherin ectodomains at lower Ca(2+) concentration alternated bet

67 Together, we establish an engineered GPCR-ectodomain-based mimicry principle that differentiates b

68 The LRP6 ectodomain binds Wnt proteins, as well as Wnt inhibitors

69 ntibody RmcB treatment, and recombinant hCAR ectodomain blocked ReCV replication in LLC-MK2 cells.

70 and regulated by shedding of the substrate's ectodomain by alpha- or beta-secretase.

71 ceded by shedding of most of the substrate's ectodomain by alpha- or beta-secretases.

72 DAR activity is required for shedding of its ectodomain by metalloproteinases.

73 As with the isolated ectodomain, c13C6 bound to the glycan cap, whereas c2G4

74 A that is bound by the polymeric Ig-receptor ectodomain, called secretory component (SC).

75 ally diverse and multimodal protocadherin-15 ectodomain can act as a stiff or soft gating spring.

76 Surprisingly, proteolytic removal of the DR5 ectodomain can fully activate downstream signaling in th

77 While loss of Tie2 ectodomain can suppress Angpt1 signalling locally in the

78 GAIN cleaved PC1 and PPC cleaved fibrocystin ectodomains can be released under non-reducing condition

79 C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2

80 ion or TNF-alpha led to Tie1 inactivation by ectodomain cleavage and promoted the Tie2 antagonist act

81 metalloproteinase) proteases are involved in ectodomain cleavage of transmembrane proteins, and ADAM1

82 we identified the exact MMP14-mediated Tie2 ectodomain cleavage sites and could show that pharmacolo

83 This receptor can undergo regulated ectodomain cleavage that releases the ligand-binding dom

84 oclusters that are dynamically regulated via ectodomain cleavage.

85 a direct and rate-limiting step in the Ctr1 ectodomain cleavage.

86 beta1 legs, activate, and stabilize extended ectodomain conformations.

87 d on this analysis, we developed two soluble ectodomain constructs for the SARS-CoV-2 S-protein, in w

88 Plasma antibody binding to a variety of gp41 ectodomain-containing antigens was associated with incre

89 The Mxra8 ectodomain contains two strand-swapped Ig-like domains o

90 Here, we show that oligomeric receptor ectodomains coupled to concatenated units of the light-g

91 l structure of the human calcitonin receptor ectodomain (CTR ECD) in complex with a truncated analogu

92 by GP, VP40, and BST2 together requires the ectodomain cysteines needed for BST2 dimerization, the p

93 Our model describes E1-E2 ectodomain dimerization interfaces, provides a structura

94 complex of cadherin 23 and protocadherin 15 ectodomain dimers, connect each stereocilium to the tip

95 crystal structure of the intact human Robo2 ectodomain (domains D1-8).

96 The HIV gp41 ectodomain (e-gp41) is an attractive target for the deve

97 conformation of the recombinant soluble IRR ectodomain (ectoIRR) at neutral and alkaline pH.

98 the role in pH sensing of two regions of the ectodomain enriched in acidic residues: the acidic pocke

99 screened peptide libraries derived from the ectodomain for agonistic activity on the receptors.

100 The mean substitution rate of the G ectodomain for the Kilifi data set was estimated at 3.58

101 like model of the short NC gp41 in which the ectodomain forms a partially folded hairpin that places

102 surface NgR1 by MT3-MMP generates a soluble ectodomain fragment that accelerates the formation of ex

103 Here we report crystal structures of ectodomain fragments comprising cell-cell recognition re

104 evealing trans-homodimers, and of C-terminal ectodomain fragments from gamma-Pcdhs gammaA4 and gammaB

105 the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the mo

106 roteins were replaced with the corresponding ectodomains from avian paramyxovirus serotype 3 (APMV-3)

107 Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 sh

108 Biophysical studies showed that Pcdh ectodomains from gammaB-subfamily isoforms formed cis di

109 hemical binding studies with purified LjLYS6 ectodomains further showed that at least six GlcNAc moie

110 (SOS) to covalently link the gp120 and gp41 ectodomain (gp41(ECTO)) subunits and a point substitutio

111 al structure of FSH bound to the entire FSHR ectodomain has been instrumental in more clearly definin

112 ides that interact with the insulin receptor ectodomain have been discovered by phage display and rep

113 partial crystal structures of the E1 and E2 ectodomains have been determined.

114 rect binding of soluble recombinant receptor ectodomains have been successful, but genome-scale scree

115 20), structures of full-length protocadherin ectodomains have not been determined, and how these two

116 , we provide the molecular basis of the CD71 ectodomain-human ferritin interaction by determining the

117 This work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory sep

118 Insulin binding stabilizes the receptor ectodomain in a T-shaped conformation wherein the membra

119 we solved a crystal structure of the HCV E2 ectodomain in complex with AR3X, a bNAb with an unusuall

120 lution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutraliz

121 llowed by the appearance of the soluble GPVI ectodomain in the plasma.

122 s involved in cell binding and implicate the ectodomain in this role.

123 ement of full-length clustered protocadherin ectodomains in single-isoform self-recognition complexes

124 ient cleavage of substrates retaining longer ectodomains, indicating that nicastrin actively excludes

125 or PirB-myelin-associated glycoprotein (MAG) ectodomain interactions.

126 eases the precision with which transmembrane ectodomain interactors can be identified.

127 uited for catalysis when its remaining short ectodomain interacts with the nicastrin component of gam

128 ial cells induces shedding of the P-selectin ectodomain into the circulation.

129 Interestingly, the SORLA ectodomain is cleaved into a soluble form, sSORLA, which

130 t of gamma-secretase, we find that substrate ectodomain is entirely dispensable for cleavage.

131 The receiver ectodomain is not required, but phosphorylation in trans

132 Our results indicate that extension of the ectodomain is possible without separating the legs or ex

133 ER are observed, providing evidence that the ectodomain is sufficiently collapsed to bring the N- and

134 Proteolytic shedding of the ectodomain is thought to redirect activated T-cells from

135 lture and, in contrast to a stabilized spike ectodomain, is tolerant of exposure to temperatures as h

136 The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine cand

137 amino terminus of influenza A virus matrix 2 ectodomain (M2e) is highly conserved among influenza sub

138 TSPN6 also inhibits the shedding of the SDC4 ectodomain, mimicking the effects of matrix metalloprote

139 ad to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD) ) on the vessels.

140 20.6 gp140 trimer, the soluble and uncleaved ectodomain of (gp160)3, retains many antigenic propertie

141 The transmembrane and ectodomain of A34 are sufficient for interaction with B5

142 ransfection assay, residues 80 to 130 of the ectodomain of A34 were determined to be sufficient for i

143 nteraction and define the domains within the ectodomain of AAVR that facilitate this interaction.

144 se (PKD) repeat domain (PKD2) present in the ectodomain of AAVR.

145 Soluble klotho (sKlotho), the shed ectodomain of alpha-klotho, protects the heart by down-r

146 Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2

147 r domain of Axl at the interface of the Ig-1 ectodomain of Axl and the Lg-1 of Gas6.

148 The N-terminal ectodomain of BTNL2 has a significantly reduced surface

149 The N-terminal ectodomain of BTNL2, which was able to inhibit T cell fu

150 e effects were mirrored by expression of the ectodomain of cancer-associated mucin MUC1.

151 Our data show that the ectodomain of CLEC14A regulates sprouting angiogenesis a

152 ally required detection range of the soluble ectodomain of EGFR (sEGFR).

153 Expression of GM-CSF and the ectodomain of FcgammaIIIA receptor led to approximately

154 he ectodomain of gH/gL binds directly to the ectodomain of gD when (i) gD is captured by certain anti

155 d surface plasmon resonance to show that the ectodomain of gH/gL binds directly to the ectodomain of

156 consists of just 3 B cell epitopes from the ectodomain of glycoproteins L and H that are highly flex

157 showed distant homology between GP38 and the ectodomain of Gn (a structural glycoprotein in CCHFV), s

158 served binding site that we localized to the ectodomain of gp41.

159 ural homology modeling, we now show that the ectodomain of HAP2 orthologs from Tetrahymena thermophil

160 ARP) as a secreted ligand that recognizes an ectodomain of human erythrocyte anion-exchanger, band 3/

161 crystal structure of the trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody

162 LLG1 interacts with the ectodomain of LET1/2 and mediates LET1/2 transport to th

163 nctional and translational evidence that the ectodomain of membrane-bound ephrin-B2 is shed from fibr

164 ss this discrepancy, we expressed the entire ectodomain of mouse P-selectin as a monomer (sP-selectin

165 In this study, the membrane-distal ectodomain of murine BTNL2 was expressed in bacteria as

166 nctions, the short isoform MADD-4B binds the ectodomain of neuroligin NLG-1, itself a postsynaptic or

167 Introduction of the shed ectodomain of NgR1 is sufficient to accelerate excitator

168 ration of RAGE ligands or the ligand-binding ectodomain of RAGE.

169 o, 3,4-DCQAME can interact with F(ecto), the ectodomain of RSV fusion (F) protein.

170 Palpha is a ligand of Mac-1: (a) recombinant ectodomain of SIRPalpha supports adhesion of Mac-1-expre

171 We found that the ectodomain of ST2 undergoes slower conformational relaxa

172 valent complex between FVIIa and the soluble ectodomain of TF (sTF) was engineered by introduction of

173 erties are also recapitulated by the soluble ectodomain of TF (sTF).

174 Soluble klotho, the shed ectodomain of the antiaging membrane protein alpha-kloth

175 order to propose an in silico model for the ectodomain of the E1E2 heterodimer.

176 codons represented at most positions in the ectodomain of the E2 gene.

177 The uncleaved ectodomain of the envelope protein, called gp140, has al

178 viruses had amino acid substitutions in the ectodomain of the F protein that confer enhanced fusion

179 fragmentary, structures to model a complete ectodomain of the major glycoprotein E2 from three strai

180 tinic receptors in vitro, as did full length ectodomain of the rabies virus glycoprotein.

181 ia ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby

182 been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein.

183 The large TSH-bound ectodomain of the thyrotropin receptor (TSHR) activates

184 s, a single-amino-acid change (T568I) in the ectodomain of the TM subunit was sufficient to confer Vp

185 n extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the re

186 The functional ~310 kDa ectodomain of VAR2CSA is a multidomain protein that requ

187 HIV-1 gp140 trimers-the uncleaved ectodomains of (gp160)3-from a few selected viral isolat

188 e, ligand-independent complexes with the LRR ectodomains of BAK1-INTERACTING RECEPTOR-LIKE KINASE3 (B

189 Furthermore, LLG2 and LLG3 interact with ectodomains of both BUPSs and ANXURs, and this interacti

190 Furthermore, we showed that soluble ectodomains of both type I and type III NRG1 significant

191 Whether the ectodomains of cytokine receptors at the membrane exhibi

192 ased on a mesogenic NDV strain, in which the ectodomains of envelope glycoproteins were replaced with

193 TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPbeta1, CR3)

194 cles with geometries tailored to present the ectodomains of influenza, HIV, and RSV viral glycoprotei

195 dentical mutations on structurally conserved ectodomains of osteoprotegerin (OPG) and decoy receptor

196 1) chimeric receptor modules built with the ectodomains of pMHCII assemble with CD3 signaling module

197 t also facilitates cleavage of HS-containing ectodomains of syndecan-1, thereby further enhancing HSV

198 Here we determine atomic structures of the ectodomains of the 57-kDa spike protein VP5 from two rel

199 oteases, the intracellular caspases, and the ectodomains of the sheddases, ADAMs 10 and 17.

200 The ectodomains of the three proteins bind cooperatively.

201 and topological similarities present in the ectodomains of TNFRSF members, our findings provide mech

202 8 types of vertebrate TLRs showed that their ectodomains possessed three types of architectures: a si

203 Although the structure of the gB ectodomain postfusion conformation has been determined,

204 of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence and absence

205 an MF59-like squalene-based adjuvant, the gB ectodomain protein (lacking AD-3) with squalene adjuvant

206 igin-1 present in the adult brain as soluble ectodomain proteins.

207 The TLR8-ectodomain:(R)-7 complex confirmed TLR8 binding and a di

208 e report crystal structures of Sdk1 and Sdk2 ectodomain regions, revealing similar homodimers mediate

209 gular arrangement is followed throughout the ectodomain, resulting in an extended zigzag conformation

210 The crystal structure of the CD300lf ectodomain reveals a potential ligand-binding cleft comp

211 The 2.3-A crystal structure of the LjLYS6 ectodomain reveals three LysM betaalphaalphabeta motifs

212 tro selection against recombinant human TfR1 ectodomain (rh-TfR1-ECD) followed by in vivo selection i

213 cells, reduces secretion of the soluble APP ectodomain (sAPPalpha), even though the total plasma mem

214 cture of the entire dimeric insulin receptor ectodomain saturated with four insulin molecules.

215 ro binding assay for MIF-1/MIF-2 to the CD74 ectodomain (sCD74) indicated that 4-CPPC inhibits MIF-2-

216 cleaved, resulting in secretion of its large ectodomain (sec49K).

217 osa, where proteolytic cleavage releases the ectodomain (secretory component [SC]) as an integral com

218 lia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component

219 se structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-

220 ecretase selectively recognizes and recruits ectodomain-shed substrates for catalysis remains unclear

221 aRIII extracellular mutant that has enhanced ectodomain shedding ("super shedding (SS)"-TbetaRIII-SS)

222 leavage assays and demonstrated by increased ectodomain shedding activity.

223 egulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavag

224 d murine IL-23R as novel targets for protein ectodomain shedding by ADAM10 and ADAM17.

225 ral signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptor

226 Ectodomain shedding by the metalloprotease ADAM10 and ly

227 both the transient thrombocytopenia and GPVI ectodomain shedding depend on the Fc portion of the anti

228 atrix metalloprotease (MMP)-14-mediated Tie2 ectodomain shedding has recently been recognized as a po

229 xns with postsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presy

230 We used this assay to show that ectodomain shedding in EVs is continuous and is mediated

231 s' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired.

232 Ectodomain shedding of both human and mouse RAGE was dep

233 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloprote

234 Ectodomain shedding of glycoprotein (GP) Ibalpha is thou

235 ases ADAM10 and ADAM17 can produce sgp130 by ectodomain shedding of gp130, even though this mechanism

236 ly, IL-3 decreases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregula

237 eolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins.

238 Here we observed that ectodomain shedding of RAGE is critical for its role in

239 hat following TNF-converting enzyme-mediated ectodomain shedding of TNF type I receptor (TNFR1), the

240 or matrix, and mouse plasma, indicating that ectodomain shedding of VLDLR occurs endogenously.

241 share the same subcellular distribution and ectodomain shedding properties.

242 nd transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina co

243 TbetaRIII also undergoes ectodomain shedding to release a soluble form (sTbetaRII

244 a transmembrane protein involved in protein ectodomain shedding, cell adhesion and signalling.

245 AGE splice variant 4), which is resistant to ectodomain shedding, inhibited RAGE ligand dependent cel

246 immunodepletion predominantly occurs through ectodomain shedding, which is accompanied by a transient

247 C-terminal fragments (Nrxn-CTF) generated by ectodomain shedding.

248 ar regulation of Wnt signaling through VLDLR ectodomain shedding.

249 le is known about the mechanisms that govern ectodomain shedding.

250 ary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of t

251 tures of the PirB ectodomain; the first full ectodomain structure for a LILR family member, at 3.3-4.

252 cis-dimerization mutations to the C-terminal ectodomain structures.

253 the S1 subunit compared with published spike ectodomain structures.

254 Though gB ectodomain subunit vaccination eliminated targeting of e

255 , regulation could be conferred to a foreign ectodomain, suggesting a common higher-order structure.

256 Understanding the reasons why gp41 ectodomain-targeting antibodies are associated with tran

257 we show that clustered protocadherin gammaB6 ectodomains tethered to liposomes spontaneously assemble

258 racking to measure the diffusion of cadherin ectodomains tethered to supported lipid bilayers at vary

259 hort carboxyl-terminal tail, or as a soluble ectodomain that acts as a decoy receptor (sRAGE).

260 ctions are mediated by both the secreted APP ectodomain that acts as a neurotrophic factor and full-l

261 age event in the juxtamembrane region of the ectodomain that generated a dominant-negative form of TL

262 as the TSHR has a uniquely large N-terminal ectodomain that includes the hormone binding site and an

263 However, in acute endotoxemia, the Tie1 ectodomain that is responsible for interaction with Tie2

264 wo structurally-distinct regions of the BST2 ectodomain that play divergent roles during ILT7 activat

265 ra8 encodes a 15-amino acid insertion in its ectodomain that prevents Mxra8 binding to CHIKV.

266 sogenic membrane proteins with tall (>10 nm) ectodomains that undergo conformational changes to bring

267 rt that a viral fusogen with a short (<2 nm) ectodomain, the reptilian orthoreovirus p14, accomplishe

268 A disulfide-stabilized, trimeric Env ectodomain-the "SOSIP" construct-has many of the relevan

269 re, we report crystal structures of the PirB ectodomain; the first full ectodomain structure for a LI

270 mall-angle X-ray scattering with purified E2 ectodomain; this data was consistent with our MD experim

271 have hindered structural studies of the full ectodomain, thus preventing a molecular understanding of

272 ECL were guided by our refined model of the ectodomain/TMD interface and indicate an interaction wit

273 The ectodomain/TMD interface consists of a converging helix,

274 the TMD, we conclude that S37a binds at the ectodomain/TMD interface, between the converging helix,

275 ramolecular course of TSHR activation at the ectodomain/TMD interface, including the delocalization o

276 ed and that direct coupling of the fusogenic ectodomain to branched actin assembly is sufficient to d

277 n receptor (CAR) T cells, expressing the CD4 ectodomain to confer specificity for the HIV envelope, t

278 e, and crystallography of the ligand-binding ectodomain to establish receptor homology models.

279 86 is initially targeted/accumulates via its ectodomain to forming PNS (hemi)nodes by diffusion trapp

280 as likely accomplished by the binding of Mt2 ectodomain to Hjv and Hfe.

281 Here, we show that CD81 relies on its ectodomain to traffic CD19 to the cell surface.

282 oned M protein at the boundaries between the ectodomain, transmembrane domains, or endodomain.

283 binders in complex with the SARS-CoV-2 spike ectodomain trimer with all three RBDs bound are nearly i

284 corresponding to the prefusion SARS-CoV-2 S ectodomain trimer, covalently stabilized by a disulfide

285 mined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design

286 r-packaging signal, and (iii) secreted pre-F ectodomain trimer.

287 B protein and mRNA-LNP groups, though not in ectodomain-vaccinated rabbits.

288 Whether beta1 integrin ectodomains visit conformational states similarly to bet

289 A genuine ligand of RET receptor ectodomain was identified, which acts as an agonist.

290 bstitution (D122N) in the IgV-core of the gD ectodomain was impaired on nectin-1-bearing cells.

291 tic drug cisplatin via direct binding to the ectodomain, we demonstrate that the combination of cispl

292 d with recombinant Dsg1, Dsc1, Dsg3, or Dsc3 ectodomains were developed.

293 RD2 (A1CRD2) confers structural integrity of ectodomain where aromatic sidechain deletion increases t

294 ular basis of noncysteine mutations in TNFR1 ectodomain where loss of an aromatic moiety in cysteine-

295 protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) a

296 ion is mediated by a soluble form of NRX-1's ectodomain, which is released from the post-synaptic mem

297 cture of Diprovocim in a complex with a TLR2 ectodomain, which revealed, unexpectedly, two Diprovocim

298 cture of the clustered protocadherin gammaB4 ectodomain, which reveals a zipper-like lattice that is

299 re the X-ray crystal structure of the ADAM10 ectodomain, which, together with biochemical and cellula

300 T efficacy, combining an inhibitory receptor ectodomain with a costimulatory endodomain to convert ne