ライフサイエンスコーパス: ectodomain shedding

1 le is known about the mechanisms that govern ectodomain shedding.

2 xtracellular domain of Klotho is secreted by ectodomain shedding.

3 ed new light on the unexpected complexity of ectodomain shedding.

4 hr(735), which is required for TACE-mediated ectodomain shedding.

5 novel trans-subunit mechanism for regulating ectodomain shedding.

6 sPmel17 is released by regulated proteolytic ectodomain shedding.

7 ntly down-regulated from the cell surface by ectodomain shedding.

8 ein interactions instead of membrane protein ectodomain shedding.

9 oject was to determine the mechanism of Sdc1 ectodomain shedding.

10 uster at an early stage and elicits nectin-1 ectodomain shedding.

11 C-terminal fragments (Nrxn-CTF) generated by ectodomain shedding.

12 ls with exogenous MMP-9 catalyzed E-cadherin ectodomain shedding.

13 lustering on proteinase-catalyzed E-cadherin ectodomain shedding.

14 of the receptor is rapidly down-regulated by ectodomain shedding.

15 l surface can be cleaved in a process termed ectodomain shedding.

16 proteinase-mediated, phorbol ester-inducible ectodomain shedding.

17 can completely block PMA-induced syndecan-1 ectodomain shedding.

18 not capable of defining the requirements of ectodomain shedding.

19 induces EGFR transactivation through HB-EGF ectodomain shedding.

20 heart development, neurogenesis, and protein ectodomain shedding.

21 cell surface by autocatalytic processing and ectodomain shedding.

22 es that MT1-MMP is regulated by a process of ectodomain shedding.

23 from membrane-spanning receptor isoforms by ectodomain shedding.

24 plasma membrane in a process termed protein ectodomain shedding.

25 nderstood how PMA activates TACE and induces ectodomain shedding.

26 ar regulation of Wnt signaling through VLDLR ectodomain shedding.

27 long been known as a potent agent to enhance ectodomain shedding.

28 at nitric oxide (NO) activates TACE-mediated ectodomain shedding.

29 state 13-acetate, a known inducer of protein ectodomain shedding.

30 ransmembrane domains are key determinants of ectodomain shedding.

31 beta-APP rendered betaglycan susceptible to ectodomain shedding.

32 ze that activated neutrophils lose SIRL-1 by ectodomain shedding.

33 rtilin TMD, modulating its susceptibility to ectodomain shedding.

34 tion) might represent a general principle in ectodomain shedding.

35 plasmic domain and did not require TbetaRIII ectodomain shedding.

36 der role of site-specific O-glycosylation in ectodomain shedding.

37 RTC2.2 itself is a target for P2X7-triggered ectodomain shedding.

38 omain in regulating ADAM10-dependent protein ectodomain shedding.

39 eogenin and allowing this protease to induce ectodomain shedding.

40 NFRI) from the surface of senescent cells by ectodomain shedding.

41 nly generated by ADAM10- and ADAM17-mediated ectodomain shedding.

42 unction of coiled coils in the regulation of ectodomain shedding.

43 CERK1 undergoes ectodomain shedding, a well-known process in animal cell

44 We found that after ectodomain shedding, ACE2 is targeted for intramembrane

45 phosphorylation and metalloprotease-mediated ectodomain shedding, activating phosphoinositide-3-kinas

46 leavage assays and demonstrated by increased ectodomain shedding activity.

47 identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for deli

48 Surface ectodomain shedding affects numerous biological processe

49 embrane proteins are sequentially cleaved by ectodomain-shedding alpha-secretases and the gamma-secre

50 Sortilin is modified by ectodomain shedding, although the biological implication

51 hown to involve: 1) metalloprotease-mediated ectodomain shedding and gamma-secretase-mediated intrame

52 of different activities involved in protein ectodomain shedding and has implications for the functio

53 at ROS production is involved in PMA-induced ectodomain shedding and implicate a role for ROS in othe

54 dergoes sequential proteolytic processing by ectodomain shedding and intramembrane proteolysis.

55 This is a process referred to as ectodomain shedding and is implicated in the process of

56 kinase C regulated, metalloprotease-mediated ectodomain shedding and is the substrate for gamma-secre

57 omal protein that is released by proteolytic ectodomain shedding and might be a useful and specific h

58 ared to inhibit tumor invasion by undergoing ectodomain shedding and producing soluble TbetaRIII, whi

59 n a membrane-proximal region that results in ectodomain shedding and retention of a 6-kDa transmembra

60 egulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavag

61 reover, we reveal that ADAM17-mediated TNFR1 ectodomain shedding and subsequent processing by the gam

62 reover, we reveal that ADAM17-mediated TNFR1 ectodomain shedding and subsequent processing by the y-s

63 ribe Tim-3 as novel target for ADAM-mediated ectodomain shedding and suggest a role of Tim-3 shedding

64 ous H2O2 mimicked PMA-induced enhancement of ectodomain shedding, and H2O2-induced shedding was block

65 dulates HGF/c-Met activity by inducing c-Met ectodomain shedding, and HGF/c-Met transactivates EGFR,

66 is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block prote

67 sduction pathways to TPA-stimulated TNFalpha ectodomain shedding are mediated by TACE, a transmembran

68 nduces cleavage of the NRR, leading to Notch ectodomain shedding as the first step of signal transduc

69 Ectodomain shedding at the cell surface is a major mecha

70 s to demonstrate that sPmel17 is released by ectodomain shedding at the juxtamembrane and/or intramem

71 eavage site is utilized for basal syndecan-1 ectodomain shedding both in vitro from NMuMG and CHO cel

72 altered beta-amyloid precursor protein (APP) ectodomain shedding but was a result of an enhanced degr

73 invariant cytoplasmic Tyr residues abrogates ectodomain shedding, but not because it is Tyr phosphory

74 d murine IL-23R as novel targets for protein ectodomain shedding by ADAM10 and ADAM17.

75 Protein ectodomain shedding by ADAM17 (a disintegrin and metallo

76 ral signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptor

77 Nectin-1 is known to undergo ectodomain shedding by alpha-secretase and subsequent pr

78 moting bacterial pathogenesis, activation of ectodomain shedding by alpha-toxin and beta-toxin may be

79 Blocking HB-EGF ectodomain shedding by inhibition of matrix metalloprote

80 In situ, CD200 underwent ectodomain shedding by metalloproteinases MMP3 and MMP11

81 and function in vivo, regulation of syndecan ectodomain shedding by physiological mediators indicates

82 rise during tube expansion, Piopio undergoes ectodomain shedding by the Matriptase homolog Notopleura

83 Ectodomain shedding by the metalloprotease ADAM10 and ly

84 uggests that aberrant regulation of sortilin ectodomain shedding can contribute to amyloid-beta patho

85 a transmembrane protein involved in protein ectodomain shedding, cell adhesion and signalling.

86 ha signaling through this inability of TNFR1 ectodomain shedding contributes to chronic low-grade inf

87 unclear, we aimed to unravel how much TNFR1 ectodomain shedding controls the development of nonalcoh

88 activity, we sought to identify the cause of ectodomain shedding deficiencies in two mutated CHO subl

89 both the transient thrombocytopenia and GPVI ectodomain shedding depend on the Fc portion of the anti

90 , coiled coils can also act as regulators of ectodomain shedding depending on the biological context.

91 Ligand-induced ectodomain shedding eliminates size-dependent segregatio

92 Ectodomain shedding (ES) is a post-translational protein

93 bout the biological significance of neuronal ectodomain shedding (ES).

94 essing of various transmembrane proteins via ectodomain shedding followed by an intramembrane cleavag

95 ng of single pass transmembrane proteins via ectodomain shedding followed by intramembrane proteolysi

96 Here we found that beta2 undergoes ectodomain shedding followed by presenilin (PS)-dependen

97 The functionality of ADAM10 ectodomain shedding for podocyte development and injury

98 a 55% decrease in constitutive collagen XVII ectodomain shedding from Adam9(-/-) keratinocytes, and (

99 in SARS-CoV-2 infection by catalyzing ACE-2 ectodomain shedding from the airway epithelia.

100 sport to the cell surface but do not inhibit ectodomain shedding from the cell surface.

101 that a secreted form of GPNMB is released by ectodomain shedding from the largely Golgi-modified form

102 Ectodomain shedding has emerged as an important regulato

103 atrix metalloprotease (MMP)-14-mediated Tie2 ectodomain shedding has recently been recognized as a po

104 data demonstrate that CD93 is susceptible to ectodomain shedding, identify multiple stimuli that trig

105 rthermore, both PMA and H2O2 failed to cause ectodomain shedding in a cell line that lacks TACE activ

106 ptible to phorbol dibutyrate-induced protein ectodomain shedding in a time- and dose-dependent manner

107 xns with postsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presy

108 hrough endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, attenuating le

109 We used this assay to show that ectodomain shedding in EVs is continuous and is mediated

110 ell death control and is the first report of ectodomain shedding in plants.

111 ic events and biological significance of the ectodomain shedding in the PTK7 function, we used highly

112 ent and emphasizes the importance of protein ectodomain shedding in vivo.

113 d ADAM10 and ADAM17 are Robo4 sheddases, and ectodomain shedding, including negative regulation by it

114 AGE splice variant 4), which is resistant to ectodomain shedding, inhibited RAGE ligand dependent cel

115 GF receptor activation through TACE-mediated ectodomain shedding intimately links inflammation and ca

116 ence of a common system for membrane protein ectodomain shedding involving one or several proteolytic

117 Protein ectodomain shedding is a critical regulator of many memb

118 Ectodomain shedding is a proteolytic mechanism by which

119 Although regulated ectodomain shedding is a well known process that affects

120 erminal fragment (CTF) of TREM2 generated by ectodomain shedding is cleaved by gamma-secretase.

121 Ectodomain shedding is crucial for receptor signaling an

122 One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase

123 s' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired.

124 iding at the injury site and that pro-HB-EGF ectodomain shedding is necessary for retina regeneration

125 TNFR1 ectodomain shedding is not an essential feedback mechani

126 TACE-mediated ectodomain shedding is regulated, and the cytoplasmic do

127 However, little is known about how syndecan ectodomain shedding is regulated.To elucidate the mechan

128 Although the physiological relevance of ectodomain shedding is well recognized, little is known

129 Ectodomain shedding may activate or inactivate a substra

130 ADAMs-mediated ectodomain shedding may have a role in gastric carcinoge

131 ignaling in Drosophila and C. elegans via an ectodomain shedding mechanism that depends on a metallop

132 ability through stimulation of the host cell ectodomain shedding mechanism.

133 ransferase (GalNAc-T) isoforms to coregulate ectodomain shedding mediated by the A Disintegrin And Me

134 different cancer entities released B7-H6 by ectodomain shedding mediated by the cell surface proteas

135 rocessing of glycosidases and uncovered that ectodomain shedding might be common for a diverse range

136 Because regulation of this ectodomain shedding might be critical in the generation

137 tion of L-selectin and better understand how ectodomain shedding might contribute to TEM.

138 Ectodomain shedding occurs in the immediate extracellula

139 lpha converting enzyme (TACE; ADAM17) in the ectodomain shedding of ACE and APP from human SH-SY5Y ce

140 r the involvement of ADAM17 in the regulated ectodomain shedding of ACE2.

141 (ADAM10) is such a protease known to mediate ectodomain shedding of adhesion molecules, among others.

142 Ectodomain shedding of both human and mouse RAGE was dep

143 e on epithelial cell surfaces is followed by ectodomain shedding of both matriptase and its Kunitz-ty

144 soluble leptin receptor may be derived from ectodomain shedding of both receptor isoforms in vivo.

145 We conclude that ADAM8 could contribute to ectodomain shedding of CD23 and may thus be a potential

146 ADAM15, and MDC-L, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE recept

147 Ectodomain shedding of cell surface membrane-anchoring p

148 Ectodomain shedding of cell surface proteins is an impor

149 cell and cell-matrix interactions as well as ectodomain shedding of cell surface receptors and ligand

150 i-inflammatory signaling events by promoting ectodomain shedding of cytokine precursors and cytokine

151 availability and signaling by inhibiting the ectodomain shedding of cytokines and their receptors.

152 at collagen binding induces ADAM10-dependent ectodomain shedding of DDR1.

153 0, a transmembrane metalloprotease mediating ectodomain shedding of diverse membrane proteins, was re

154 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloprote

155 metalloproteinases, which are activators of ectodomain shedding of EGFR ligands, also blocked TPA-in

156 soluble Robo4 is the product of constitutive ectodomain shedding of endothelial cell surface Robo4 by

157 ys, the overexpression of ADAM9 enhanced the ectodomain shedding of EphB4, Tie-2, Flk-1, CD40, VCAM,

158 Ectodomain shedding of epidermal growth factor receptor

159 Our studies show that constitutive ectodomain shedding of full-length ErbB4 yields the appr

160 Ectodomain shedding of glycoprotein (GP) Ibalpha is thou

161 Ligand-induced ectodomain shedding of glycoprotein VI (GPVI) is a metal

162 ases ADAM10 and ADAM17 can produce sgp130 by ectodomain shedding of gp130, even though this mechanism

163 ng carcinoma showed decreased expression and ectodomain shedding of HB-EGF and reduced incidence of c

164 motes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha.

165 cer conditioned medium on the expression and ectodomain shedding of HB-EGF by TNFalpha-converting enz

166 Constitutive and stimulated ectodomain shedding of HB-EGF is comparable in embryonic

167 ubsequent ERK1/2 phosphorylation result from ectodomain shedding of HBEGF through PKC-dependent activ

168 growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth f

169 a indicate that bacterial pathogens activate ectodomain shedding of host cell surface molecules to en

170 Several microbial pathogens stimulate the ectodomain shedding of host cell surface proteins to pro

171 Here, ectodomain shedding of human and murine IL-23R was ident

172 ADAM10-mediated ectodomain shedding of injury-related cadherins drives p

173 cytoplasmic domain of L-selectin to regulate ectodomain shedding of L-selectin on the other side of t

174 tin in the cell to modulate the function and ectodomain shedding of l-selectin.

175 The ectodomain shedding of ligand can be stimulated by Notch

176 suggesting that sup-17 and adm-4 may mediate ectodomain shedding of LIN-12 and/or GLP-1.

177 ginine 4442 as key amino acids important for ectodomain shedding of LRP1B.

178 Proteolytic ectodomain shedding of membrane proteins is a fundamenta

179 ly, IL-3 decreases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregula

180 rin alpha) is a key enzyme implicated in the ectodomain shedding of membrane-anchored heparin-binding

181 eolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins.

182 gh initiation of an autocrine loop requiring ectodomain shedding of membrane-bound RANKL in prostate

183 yristate 13-acetate and ionomycin stimulated ectodomain shedding of meprin beta and meprin A.

184 This induces ectodomain shedding of metalloprotease-sensitive cell su

185 Furthermore we demonstrate that the ectodomain shedding of MT1-MMP can serve as a mechanism

186 vation of the MMP2 proenzyme (pro-MMP2), the ectodomain shedding of MT1-MMP, and the collagenolysis a

187 ated a first proteolytic event, resulting in ectodomain shedding of nectin-1alpha.

188 ntramembraneous proteolysis of p75(NTR), and ectodomain shedding of Nogo receptor, correlated with a

189 M10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Not

190 Because ectodomain shedding of p75NTR releases a soluble ectodom

191 udy, we evaluated the activities involved in ectodomain shedding of p75NTR, a neurotrophin receptor w

192 e-bound metalloproteinase is responsible for ectodomain shedding of pathologically significant substr

193 Here we observed that ectodomain shedding of RAGE is critical for its role in

194 se (ADAM) 17, a metalloenzyme that catalyzes ectodomain shedding of receptor tyrosine kinase ligands.

195 metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical

196 Here we show that activity-dependent ectodomain shedding of signal regulatory protein-alpha (

197 Thus, ectodomain shedding of SIRPalpha is an activity-dependen

198 talloproteinase (MT1-MMP) expression and the ectodomain shedding of soluble (s)CD44.

199 ne of the main proteases responsible for the ectodomain shedding of surface proteins.

200 inosa and Staphylococcus aureus activate the ectodomain shedding of syndecan-1 and that syndecan-1 sh

201 The ectodomain shedding of syndecan-1, a major cell surface

202 with the ability of beta-toxin to stimulate ectodomain shedding of syndecan-1, a major heparan sulfa

203 t several major bacterial pathogens activate ectodomain shedding of syndecan-1, the major heparan sul

204 ta-toxin, but not alpha-toxin, also enhanced ectodomain shedding of syndecan-4 and heparin-binding ep

205 Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta resp

206 organisms, for example, through proteolytic ectodomain shedding of the adhesion-mediating cell surfa

207 In this study, we investigated the ectodomain shedding of the betacellulin precursor (pro-B

208 Pseudomonas virulence, including stimulating ectodomain shedding of the cell surface heparan sulphate

209 , we offer evidence of a mechanism involving ectodomain shedding of the EGFR ligands amphiregulin (AR

210 aling-dependent manner, leading to increased ectodomain shedding of the epidermal growth factor (EGF)

211 We also show conserved ectodomain shedding of the human TGFbeta type III recept

212 ivation either by increasing ADAM17-mediated ectodomain shedding of the Notch receptor or by modifica

213 lin regulates in an "inside-out" fashion the ectodomain shedding of the receptor.

214 This catalytic activity requires prior ectodomain shedding of the substrate and can cleave liga

215 acterized the activities involved in protein ectodomain shedding of the tumor necrosis factor family

216 suggested susceptibility gene for ccRCC and ectodomain shedding of this molecule may be a predictive

217 d rapid exocytosis of the TIE ligand ANGPT2, ectodomain shedding of TIE1 by disintegrin and metallopr

218 ha to its mature form and is involved in the ectodomain shedding of TNF receptors.

219 hat following TNF-converting enzyme-mediated ectodomain shedding of TNF type I receptor (TNFR1), the

220 on vectors for human and mouse TACE restored ectodomain shedding of TNF-alpha and TGF-alpha, suggesti

221 Inflammatory stimuli activate ectodomain shedding of TNF-alpha, L-selectin, and other

222 ; ADAM17) is known to have a key role in the ectodomain shedding of TNFalpha in several cell types.

223 TNFalpha and more than a 6-fold increase in ectodomain shedding of TNFalpha into the serum of PKCeps

224 Ectodomain shedding of transmembrane precursor proteins

225 Ectodomain shedding of transmembrane proteins may be reg

226 bilayer and that anionic lipids may modulate ectodomain shedding of transmembrane receptors.

227 lization, myoblast fusion, neurogenesis, and ectodomain shedding of tumor necrosis factor (TNF)-alpha

228 Ectodomain shedding of tumor necrosis factor receptor 1

229 e amino-terminal stubs that are generated by ectodomain shedding of type I transmembrane proteins.

230 or matrix, and mouse plasma, indicating that ectodomain shedding of VLDLR occurs endogenously.

231 loprotease, activity, distinguishing it from ectodomain "shedding" of other membrane receptors, which

232 for further studies examining the impact of ectodomain shedding on platelet function.

233 We propose that sVEGFR-1 produced via ectodomain shedding plays a prominent role in the VEGF r

234 gest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regul

235 orylated c-Met expression and elevated c-Met ectodomain shedding postliver IRI.

236 n molecules, and NO may be involved in other ectodomain shedding processes.

237 share the same subcellular distribution and ectodomain shedding properties.

238 VLDLRII displayed a higher ectodomain shedding rate and a more potent inhibitory ef

239 but not VLDLRII, determined the differential ectodomain shedding rates.

240 These studies suggest that ectodomain shedding regulates the pericellular and extra

241 However, TbetaRIII can also undergo ectodomain shedding, releasing soluble TbetaRIII, which

242 er of PM proteins, delivery to lysosomes and ectodomain shedding represent distinct parallel mechanis

243 t the level of expression, protease-mediated ectodomain shedding represents an alternative means of r

244 ed form of LIN-12 that mimics the product of ectodomain shedding rescues this fertility defect, sugge

245 Interestingly, abrogating ectodomain shedding resulted in a loss of the ability of

246 integrin and metalloprotease (ADAM)-mediated ectodomain shedding resulting in a soluble form of Tim-3

247 tion of VEGFR-1 and render it susceptible to ectodomain shedding, resulting in the generation of sVEG

248 Functionally, ADAM10-related ectodomain shedding results in cleavage of the cell-adhe

249 h impaired (DeltaShed-TbetaRIII) or enhanced ectodomain shedding (SS-TbetaRIII).

250 The calmodulin (CaM) hypothesis of ectodomain shedding stipulates that CaM, an intracellula

251 d that Cys(600) was absolutely essential for ectodomain shedding, suggesting that Cys(600), similar t

252 ic epitope harbors the cleavage site for its ectodomain shedding, suggesting that proteolysis has an

253 aRIII extracellular mutant that has enhanced ectodomain shedding ("super shedding (SS)"-TbetaRIII-SS)

254 Induction of HB-EGF expression and ectodomain shedding synergistically led to robust epider

255 that bre-5 functions prior to ligand-induced ectodomain shedding that activates LIN-12 for signal tra

256 ts a novel regulatory mechanism for sortilin ectodomain shedding that is regulated in a neuron-specif

257 ases have also been implicated in E-cadherin ectodomain shedding, the current study was undertaken to

258 Protein ectodomain shedding, the proteolytic release of the extr

259 y accepted model of calmodulin regulation of ectodomain shedding, the R152E/L153E mutation in the GPI

260 n metalloproteases plays important roles in "ectodomain shedding," the process by which biologically

261 nd transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina co

262 th membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate a shed soluble form (sol

263 TbetaRIII also undergoes ectodomain shedding to release a soluble form (sTbetaRII

264 smembrane precursors and undergo proteolytic ectodomain shedding to release a soluble mature growth f

265 the prognostic value of ALCAM by visualizing ectodomain shedding using a dual stain that detects both

266 odulator of sortilin function, promoting its ectodomain shedding via ADAM10.

267 stablish that S. aureus activates syndecan-1 ectodomain shedding via its two virulence factors, alpha

268 d by integrin aggregation, integrin-mediated ectodomain shedding was inhibited by a MMP-9 function bl

269 R-CTF accumulation, demonstrating that prior ectodomain shedding was prerequisite for PS/gamma-secret

270 itiating cell surface protein CD200, through ectodomain shedding, was responsible for the near absenc

271 immunodepletion predominantly occurs through ectodomain shedding, which is accompanied by a transient

272 This resulted in a substantial increase of ectodomain shedding, which was not mediated by disintegr

273 knockdown of ROCK2 with siRNA decreased LR11 ectodomain shedding while simultaneously increasing intr

274 avage in the extracellular domain results in ectodomain shedding while the cytoplasmic domain remains

275 s revealed non-redundant roles of BACE1/2 in ectodomain shedding with BACE1 regulating a broader and

276 y cleaved from the plasma membrane (known as ectodomain shedding), with little knowledge of the timin

277 nges, we identified critical determinants of ectodomain shedding within the stalk region of the IL-23