ライフサイエンスコーパス: ectoenzyme

1 t not ART2.2, as a GPI-anchored cell surface ectoenzyme.

2 f 1321N1 cells, suggesting involvement of an ectoenzyme.

3 idases are a particularly important class of ectoenzymes.

4 glycosylphosphatidylinositol (GPI)-anchored ectoenzymes.

5 Ectoenzyme activities displayed by living worms suggest

6 also tested the hypothesis that endothelial ectoenzyme activity is an earlier indicator of lung inju

7 These findings indicate that BP-1 ectoenzyme activity is not essential for normal B and T

8 mbrane protein ANK and generation of ePPi by ectoenzyme activity, continue to be supported and better

9 ffects of monocytes on endothelial cell (EC) ectoenzyme activity.

10 ors, 1,25(OH)2D3 rapidly induced CD38 Ag and ectoenzyme activity.

11 ADP-ribose (cADPR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38.

12 zation process include the integral membrane ectoenzymes alkaline phosphatase (ALPase) and nucleotide

13 Inhibition of the multifunction ectoenzyme/amino acid transporter gamma-glutamyltranspep

14 f total cysteine transport), multifunctional ectoenzyme/amino acid transporter gamma-glutamyltranspep

15 DP-ribosyl cyclase family and possesses both ectoenzyme and receptor functions.

16 CD38 is an ectoenzyme and receptor with key physiological roles.

17 CD157/BST-1 behaves both as an ectoenzyme and signaling receptor and is an important re

18 Newly synthesized canalicular ectoenzymes and a cell adhesion molecule (cCAM105) have

19 In this review, we focus on CD39 and CD73 ectoenzymes and encompass aspects of the biochemistry of

20 e of ATP, which is converted to adenosine by ectoenzymes and subsequently activates neuronal adenosin

21 ellular pyrophosphate is likely generated by ectoenzymes and/or is a consequence of transport of intr

22 complement regulatory proteins, cell surface ectoenzymes, and growth factor receptors.

23 either by soluble enzymes or membrane-bound ectoenzymes, and uptake or clearance are two such proces

24 s indicate that, whereas the Ap(n)A-cleaving ectoenzyme appears to be located mainly in the oocyte, e

25 Ectoenzymes are differentially localized in cartilage an

26 Quiescent EC express the ectoenzyme ATP-diphosphohydrolase (ATPDase; an apyrase),

27 eral step in the homing cascade in which the ectoenzyme ATX facilitates the entry of lymphocytes into

28 membrane protein that acts as a bifunctional ectoenzyme, catalyzing the synthesis of cyclic ADP-ribos

29 The ectoenzyme CD38 catalyzes the production of cyclic ADP-r

30 The functionally pleiotropic ectoenzyme CD38 is a glycohydrolase widely expressed on

31 mAbs directed against the ectoenzyme CD38 will induce B cell proliferation in norm

32 NMN is a substrate of both ectoenzymes CD38 and CD73, with generation of NAM and NR

33 verted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into ade

34 The ectoenzyme CD39 on the plasmalemma of endothelial cells

35 The ectoenzyme CD39 suppresses thrombosis and inflammation b

36 rgistic effect through downmodulation of the ectoenzyme CD39, which converts ATP to ADP/AMP, and an i

37 the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to

38 viously, we found that mice deficient in the ectoenzyme CD73, which generates adenosine in the extrac

39 8+ short-lived effector cells, while it's co-ectoenzyme, CD73, is found on memory precursor effector

40 ls that lack the expression of ATP degrading ectoenzyme cluster of differentiation (CD) 39.

41 vated levels of NAD+ catabolites produced by ectoenzyme cluster of differentiation 38 (CD38) that hav

42 xpressed ADP-ribosyltransferase 2 (ART2) are ectoenzymes competing for NAD substrate.

43 atory microenvironment, suggesting that this ectoenzyme could be involved in the generation of defici

44 Ectoenzymes detected on these cells were recently shown

45 l membrane gelatinase that is related to the ectoenzyme dipeptidyl peptidase IV.

46 y express a unique combination of functional ectoenzymes, driving the production of adenosine (ADO) v

47 tigated the role of the adenosine-generating ectoenzyme, ecto-5'-nucleotidase (CD73), in regulating i

48 asis, including the pyrophosphate-generating ectoenzyme Enpp1.

49 Ectoenzymes expressed on the surface of vascular cells a

50 Expression of the ectoenzyme gamma-glutamyl transpeptidase (GGT) is regula

51 The ectoenzyme, gamma-glutamyl transpeptidase (GGT, EC ) cle

52 sine 5'-diphosphate (ADP)-ribosyltransferase ectoenzyme gene family.

53 These ectoenzymes generate pericellular adenosine from extrace

54 The ecto-5'-nucleotidase CD73, an ectoenzyme highly expressed in cancer, is suggested to r

55 To study the structure of this ectoenzyme, human CD39 was modified by directed mutation

56 odon and encodes an active GGT heterodimeric ectoenzyme identical to constitutive GGT cDNA but transl

57 nowledge of the functions of nucleotides and ectoenzymes in the cartilage extracellular matrix.

58 ked by a VIP antagonist and augmented by the ectoenzyme inhibitor, phosphoramidon.

59 O production, as confirmed by using specific ectoenzyme inhibitors.

60 idylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been i

61 appears to be located mainly in the oocyte, ectoenzymes involved in the dephosphorylation of mononuc

62 ypothesis is that NAD(+) and ATP, along with ectoenzymes involved in their metabolism, play a signifi

63 The ectoenzyme is activated by Ca(2+) and Mg(2+), reaches ma

64 However, the involvement of ADO-producing ectoenzymes is less apparent in this context.

65 metabolizing ATP or NAD(+), some purinergic ectoenzymes metabolize other inflammatory modulators, no

66 regulatory cells" through ADO produced by an ectoenzymes network, with a pivotal role of CD38.

67 les, particularly with overexpression of the ectoenzyme NT5E (encoding CD73), which could counterbala

68 Deficient generation of ePPi by the ectoenzyme nucleoside triphosphate pyrophosphohydrolase

69 e nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide pyrophosphate phosphodiesterase (E

70 the nonsynonymous K121Q polymorphism in the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

71 Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

72 We have reported previously that the ectoenzyme of membrane type matrix metalloproteinase 5 (

73 These data show that GGT, a regulated ectoenzyme on T cells, controls the rate of nitric oxide

74 ters of the enzyme reaction catalyzed by the ectoenzyme pantetheinase are KM,C/alpha = 4.4 +/- 1.1 mM

75 components include alkaline phosphatase, the ectoenzyme PC-1, and osteopontin.

76 more complex understanding of the ank gene, ectoenzyme PC-1, and the transglutaminase enzyme family

77 ch as the inorganic pyrophosphate-generating ectoenzyme PC-1/nucleotide pyrophosphatase phosphodieste

78 The two ectoenzymes presented opposite airway distributions, ect

79 nucleotides are metabolized by a variety of ectoenzymes, producing free phosphate (Pi) or pyrophosph

80 CD73, an ectoenzyme responsible for adenosine production, is ofte

81 Human CD38 is a multifunctional ectoenzyme responsible for catalyzing the conversions fr

82 hain antibody that selectively inhibits CD38 ectoenzyme resulted in NAD(+) boosting that was associat

83 with a specific monoclonal antibody to this ectoenzyme revealed high expression in liver with lesser

84 veloped to integrate nucleotide release, the ectoenzymes supporting the dephosphorylation of ATP into

85 Human CD38 is an ectoenzyme that can use NAD(+) to synthesize two calcium

86 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphat

87 gamma-Glutamyl transpeptidase (GGT) is an ectoenzyme that catalyzes the first step in the cleavage

88 entified BP-1 as glutamyl aminopeptidase, an ectoenzyme that catalyzes the hydrolysis of acidic amino

89 ydrolase 1 (ENTPD1) (also known as CD39), an ectoenzyme that catalyzes the rate-limiting step in conv

90 It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis o

91 sphate diphosphohydrolase 2 (E-NTPDase2), an ectoenzyme that converts ATP to ADP, caused ectopic eye-

92 Recent evidence suggests that CD38, an ectoenzyme that converts NAD(+) to cyclic ADP-ribose (cA

93 ooth muscle and the upregulation of NEP, the ectoenzyme that degrades BNP, in the vascular wall in at

94 Mice lacking CD38, an ectoenzyme that generates the calcium-mobilizing metabol

95 phohydrolase (NTPDase or CD39) is a vascular ectoenzyme that hydrolyses ATP and ADP; however, this ac

96 PD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to

97 CD38 is an ectoenzyme that mediates the release of brain OT.

98 ransmembrane glycoprotein, is a bifunctional ectoenzyme that participates in signal transduction path

99 stromal antigen 1 (Bst1) in Paneth cells-an ectoenzyme that produces the paracrine factor cyclic ADP

100 We previously found that CD38, an ectoenzyme that regulates the production of NAD(+), is u

101 nment plays an important role, including the ectoenzyme that triggers blood clotting, the plasma seri

102 Although the existence of ectoenzymes that metabolize extracellular nucleotides is

103 understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, E

104 lls that expresses CD73 as well as CD39, two ectoenzymes that together catalyze the extracellular dep

105 an Neprilysin, functions as a transmembrane "ectoenzyme" that cleaves neuropeptides that regulate e.g

106 iological function(s) of this novel class of ectoenzyme we generated mice carrying a null mutation in

107 The basic properties of this ectoenzyme were investigated using as substrates di-(1,N

108 This ectoenzyme, which is also present on bone marrow-derived

109 alpha protein suggests a transmembrane-bound ectoenzyme, which, in addition to the phosphodiesterase-