ライフサイエンスコーパス: effector

1 he presence of a saturating concentration of effector.

2 avirulent strain of Pst that carries AvrRpt2 effector.

3 n mortalin substrate and cell survival/death effector.

4 emains unclear which contain transcriptional effectors.

5 lectively assist the export of a subclass of effectors.

6 ignaling pathways that regulate these immune effectors.

7 ing little resemblance to recently activated effectors.

8 LAVATA3/EMBRYO SURROUNDING REGION-like (CLE) effectors.

9 h selective antibodies against Sec-delivered effector 1 (SDE1), a secreted protein biomarker, for the

10 tching and contributes to the induction of B effector 2 (Be2) cells.

11 ing protein 1 (RREB1), a RAS transcriptional effector(20,21), as a key partner of TGF-beta-activated

12 sion of the integrated stress response (ISR) effector activating transcription factor 4 (Atf4) and in

13 and this allows us to estimate the range of effector activation.

14 or RNA quality, which may impair analysis of effector activities of these cells.

15 Effectors alter host metabolism and immunity for the ben

16 to reveal substantial heterogeneity in both effector and immature populations.

17 strains are identical in sequence across all effector and regulatory genes but differ in duplication

18 correlating with the presence of functional effector and regulatory T-cell subsets with diverse T-ce

19 formation on the interaction between the end effector and the remote environment.

20 d by a combination of gastric and intestinal effectors and (ii) chlamydial colonization in small inte

21 ger proteins, transcriptional activator-like effectors and clustered regularly interspaced short pali

22 a resource of 600 human proteins containing effectors and demonstrate a scalable strategy for assign

23 clear expression of Hippo signalling pathway effectors and restricted expression of TE-associated fac

24 Ns) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers.

25 for how the Dot/Icm T4CP complex recognizes effectors, and highlights the multiple substrate-binding

26 ructural features, association with distinct effectors, and presence or absence of the ring nuclease

27 ofiles and likely function, some H. sacchari effectors are adapted to monocots.

28 Both nuclear effectors are secreted via the biotrophic interfacial co

29 mains in host cell invasion and for the Tarp effector as a bona fide C. trachomatis virulence factor.

30 How does the brain control an effector as complex and versatile as the hand?

31 p locus which encodes putative secreted ETT2 effectors as well as eilA, a gene encoding a putative tr

32 ISPR-Cas systems, which use a single-protein effector, as well as other types of bacterial and eukary

33 ne secretion and in vivo gene expression for effectors associated with inflammation, vascularization,

34 Ras activates its effectors at the membrane.

35 autophagy is enhanced and inhibited by these effectors, autophagy likely has different functions thro

36 Low-valency antigens induced smaller effector B cell responses, with preferential recruitment

37 n of immunity-associated genes by binding on effector binding elements in rice.

38 Our findings differentiate effector binding from biological function, which has ram

39 TPase-activating protein (GAP) activity, and effector binding of RAC2(E62K) Our findings indicate the

40 in a chemical interaction network that links effector binding to distal regions of the fold that supp

41 nvestigated whether the E62K mutation alters effector binding, as activated RAC2 binds effectors to t

42 s4B homodimerization and the beta-surface in effector binding.

43 : (i) beta-interface, mapped to Switch I and effector-binding regions, (ii) alpha-interface at the al

44 Using dual effectors capable of re-writing enhancer-associated chro

45 Inhibition of the inflammasome effector caspase-1 or IL-1beta pathway attenuated platel

46 "silent coupling" scenario, the presence of effector causes a change in the DeltaH associated with s

47 Effector CD8(+) T cells are important mediators of adapt

48 oreover, adoptive transfer of virus-specific effector CD8(+) T cells or immunization with a vaccine t

49 n with a vaccine that induces virus-specific effector CD8(+) T cells prior to infection enhanced the

50 esponses by directly or indirectly excluding effector CD8+ T cells from the tumor microenvironment.

51 virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus p

52 ent class ( e.g., IgE) could engender potent effector cell activation, and unleash previously untappe

53 ncluding a Blimp1(hi)Id3(lo) tissue-resident effector cell population most prominent in the early pha

54 e memory population or are instead a remnant effector cell population that failed to undergo initial

55 to carry out ADCP in settings of high target/effector cell ratios, such as those seen in patients wit

56 The anti-IgE autoantibodies prevented effector cell sensitization, reduced total IgE serum lev

57 re with the binding and interaction with the effector cell.

58 se and that these T cells (termed long-lived effector cells [LLEC]) display robust protective functio

59 his mouse strain, suggesting either that the effector cells are present in greater numbers within dys

60 T cells can have features of both naive and effector cells has forced the field to struggle with sev

61 ciated with proliferation of recipient CD8 T effector cells in the periphery and liver, increased ser

62 ncode processing enzymes in CD16a-expressing effector cells is sufficient to affect N-glycan composit

63 Platelets are chief effector cells of hemostasis and pathological thrombosis

64 ucleated cells are continuously monitored by effector cells of the immune system, which police the pe

65 poised to quickly develop into regulatory or effector cells, depending on the needs of the host.

66 naive T cells to differentiate into various effector cells, determining immune responses such as all

67 results in enhanced differentiation towards effector cells, glycolysis and apoptosis.

68 ial activity of the host immune response via effector cells, like macrophages and neutrophils.

69 4 T cells undergo transcriptional changes to effector cells, which are commonly dysregulated in autoi

70 inflammation through FcepsilonRI on allergic effector cells, while IgE-ICs were noninflammatory becau

71 ls, monocytes, neutrophil trafficking, and T effector cells.

72 ctors must recognize cognate Ag at a defined effector checkpoint to become memory cells.

73 oblem in the mammalian immune system, namely effector choice among CD4+ T helper (Th) cells.

74 ing unrestricted activation of intracellular effectors, compartmentalized signaling of cyclic nucleot

75 he type I-C system employs a minimal Cascade effector complex, which encodes only three unique subuni

76 ent interactions with PTIP and RIF1/shieldin effector complexes.

77 aradox intimates Tfh cells as key pathologic effectors, consistent with an observed Tfh signature in

78 The prevalence of GEF/effector coupling in nature suggests a possible universa

79 rol ligand binding, receptor activation, and effector coupling.

80 y triggering sustained immune activation and effector cytokine production.

81 l strength is able to regulate CD8(+) T cell effector cytokine R production independent of TCR Ag aff

82 ionally modular, consisting of an N-terminal effector domain (NTD) and a C-terminal regulatory domain

83 may aid future work on the function of this effector during Legionella pathogenesis.

84 f found in over 6000 putative TMD-containing effectors encoded predominantly by 15 genera of Proteoba

85 eptor-specific chaperone that stabilizes the effector enzyme of phototransduction, cGMP phosphodieste

86 The discovery that one bacterial effector evolved to target ATG16L1's engagement in intra

87 ceptor 5 (DR5) and its downstream regulators/effectors FLIP, Caspase-8, and FADD had particularly poo

88 ur findings identify an additional tuft cell effector function and suggest context-specific regulatio

89 l mechanisms for LXA(4) regulation of T cell effector function and trafficking.

90 cific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cell

91 NK cells activated with TEPP-46 had reduced effector function due to TEPP-46-induced increases in ox

92 ently showed that MP cells exert innate-like effector function during host defense, but whether MP CD

93 al control of CD8 T cell differentiation and effector function following T cell activation has been e

94 STING scaffold enabled a switch from direct effector function to regulation of antiviral transcripti

95 e in FcgammaR engagement and subsequent ADCC effector function, as they contain a decrease in afucosy

96 T cell effector function, migration and glycolytic responses we

97 l expression and processing, enhancing TCR-T effector function, trafficking, expansion, persistence,

98 instructing recruited cells to elicit their effector function, was, at least in part, dependent on f

99 Concurrent administration of a neutralizing/effector function-positive bNAb via the airway and syste

100 ind to HLA-E and block inhibition of NK cell effector function.

101 1BBL axis enhanced costimulatory signals and effector functions among APC and autologous TILs.

102 hagy uncouples T-cell proliferation from its effector functions and offers a potential new strategy t

103 masome composition, assembly and activation, effector functions and role in infection and inflammator

104 lay between MAIT cell-mediated antibacterial effector functions and the humoral immune response.

105 Evidence abounds that effector functions are important in controlling infectio

106 en together, these data demonstrate that IgA effector functions depend on subclass and glycosylation,

107 ariant natural killer T (iNKT) cells acquire effector functions during development by mechanisms that

108 study demonstrates the induction of NK cell effector functions early after Ad26.ZEBOV, MVA-BN-Filo v

109 In this study, Fc-mediated effector functions have been quantified in vivo relative

110 factor signaling, metabolic dependence, and effector functions in vitro.

111 Given the unique effector functions of macrophages and their capacity to

112 is modulated by IL-4, and IL-3 regulates the effector functions of Th2 cells.

113 Differentiation stage and immune-effector functions of the underlying tumor cell are insu

114 cells and also examined the role of IL-3 in effector functions of these cells.

115 However, its effects on stimulating antibody effector functions, including NK cell activation, monocy

116 he human iG1 mAb, termed Avidimabs, retained effector functions, paving the way for the proinflammato

117 hrough Fc gamma receptor (FcgammaR)-mediated effector functions, which should affect the kinetics of

118 conventionally utilized for proinflammatory effector functions.

119 invariant gammadelta T cells with programmed effector functions.

120 c pathways as a key part of how they promote effector functions.

121 l for T cell activation, differentiation and effector functions.

122 ect K. pneumoniae against neutrophil-related effector functions.

123 as through the recruitment of innate immune effector functions.

124 ognized for its influence on Ig turnover and effector functions.

125 to CD8(+) T cells, thereby paralyzing their effector functions.

126 checkpoint inhibitor anti-PD-L1-gamma1 as an effector gene.

127 guanine nucleotide exchange factors (GEF) to effectors, generating a positive feedback of GTPase acti

128 It stimulated effector generation, long-lived CD4 memory generation, a

129 7, Slamf6, Xcl1) whereas SNP-SC enriched for effector genes (Gzmb, Klrg1, Cx3cr1).

130 The identified effector genes and the dysregulated downstream pathways

131 The main effector genes for producing penicillin G (pcbAB, pcbC a

132 l regulatory network model for AF defined by effector genes in Genome-wide association studies loci.

133 at correlated with upregulation of antiviral effector genes.

134 RORgammat activity and expression of type 3 effector genes.

135 Thus, we have identified how the Toxoplasma effector GRA15 affects cell-autonomous immunity in human

136 is not simply a switch, but rather generates effector gradients where importins alpha and beta gradua

137 Based on differing numbers of TMDs, effectors group into two distinct classes that both requ

138 Although many apoplastic and cytoplasmic effectors have been reported, nuclear effectors have not

139 lasmic effectors have been reported, nuclear effectors have not been well characterized in fungal pat

140 as strongly associated with the abundance of effector HLA-DR(+)CD8(+) T cells.

141 hand motor imagery when acting with another effector (i.e., foot).

142 oproteomics data among key and emerging GPVI effectors (ie, FcRgamma, Syk, PLCgamma2, PKCdelta, DAPP1

143 foci, and 3) production of anti-inflammatory effectors IL-10 and thioredoxin 1.

144 mic immunotherapy led to the infiltration of effector immune cells into the lungs, in situ immunizati

145 hondrial abundance, type I IFN signaling and effector immunity.

146 hancer-binding factor 1 (LEF1), a downstream effector in the canonical Wnt signaling pathway.

147 contributes to the upregulation of antiviral effectors in response to type I interferons.IMPORTANCE V

148 need to understand the role of innate immune effectors in the complex interactions between infections

149 hereas epilepsy genes function as downstream effectors in the same processes, offering one possible e

150 s in xanthomonads, such as type III secreted effectors including transcription activator-like effecto

151 pathways, such as Nfkb2, and its downstream effectors, including Csf-1 and Lgals3bp, directly involv

152 Our structure explains how up-stream effectors, including DOCK2 and ELMO1 phosphorylation, de

153 increase in multiple type 2 (anti-helminths) effectors, including interleukin-5 (IL-5), IL-13, immuno

154 learning comprises representations that are effector-independent.

155 technology is the efficient delivery of RNAi effectors into the cell.

156 omes, where it interacts with its downstream effector IRF3.

157 utilizing a limited array of G proteins and effectors is poorly understood, particularly in native c

158 ants that postlearning generalization across effectors is principally predicted by the level of an im

159 By contrast, an understanding of how effectors manipulate nonimmunity pathways is only beginn

160 ivated protein kinase pathway (SAPK) and its effector, MAPK Sty1, downregulates CAR assembly in S. po

161 er, this acquired protection depended on IgE effector mechanisms and MCs.

162 ostics and as research tools to evaluate the effector mechanisms driving rejection; (2) potential ass

163 and to induce expression of neuron-specific effector mechanisms.

164 ssion of RPS2 and thereby attenuates AvrRpt2 effector-mediated ETI.

165 ower pre-treatment terminally differentiated effector memory (TEMRA) cell frequencies were also seen

166 We showed that EBV-infected T cells had an effector memory activated phenotype, whereas EBV-infecte

167 uals develop a higher frequency of antiviral effector memory CD4(+) T(EM) cells specific to two immun

168 of long-lasting, pp65-specific T cells with effector memory phenotype were significantly higher in T

169 hat expressed markers for central memory and effector memory phenotype with minimal expression of coi

170 al blood of subjects with T1D and exhibit an effector memory phenotype.

171 ical viral sequences were most common in the effector memory population, and these identical sequence

172 LN-derived effector memory T (T(EM)) cells contained HIV-1 DNA that

173 ssociated with proinflammatory and activated effector memory T cells in the blood, evidence of treatm

174 texts for causal variants, implicating CD4 + effector memory T cells, as well as monocytes, B cells a

175 with TIGIT, an inhibitory molecule on CD8(+) effector memory T cells.

176 city to expand memory T-cell pool exhibiting effector memory T-cell phenotype, therefore offering gre

177 ls and accompanied by increased frequency of effector memory T-cells.

178 These HCV-specific CD4+ T cells had an effector-memory phenotype.

179 cell cycling and differentiation, expanding effector-memory T cells and inducing robust viral reacti

180 alphabeta TCR repertoires of human naive and effector/memory CD4(+) T-cell subsets, irrespective of a

181 pargylglycine demonstrated that H(2)S is the effector molecule regulating Mtb survival in macrophages

182 Thus, Fgl2 is a TFR cell effector molecule that regulates humoral immunity and li

183 tudy, we identify Fgl2 as a soluble TFR cell effector molecule through single-cell gene expression pr

184 Health-promoting effector molecules produced by probiotics are well docum

185 The production of these effector molecules relies on rapid changes of gene expre

186 , we discovered that influenza-generated CD4 effectors must recognize cognate Ag at a defined effecto

187 TAL effectors nuclear-localize in plants, where they bind an

188 n BdFTL2 functions as a potential epigenetic effector of BdFTL1 by interacting with a BdES43-H3K4me3

189 vations establish PKA as a locally regulated effector of cellular mechanotransduction and as a regula

190 studies showed that YAP1, a transcriptional effector of Hippo signaling regulated by 14-3-3sigma in

191 tic regulator that may function as a nuclear effector of MILI to silence TEs by DNA methylation.

192 MLKL is the essential effector of necroptosis, a form of programmed lytic cell

193 Loss of Xrcc1, a major downstream effector of PAR, also caused persistent PARP1 foci witho

194 MDM2 is a downstream effector of S6K1-mediated TKI resistance.

195 Our results demonstrate L-type VGCC as an effector of the Ahnak/p11/Anxa2 complex, revealing a nov

196 BRAF kinase, a critical effector of the ERK signaling pathway, is hyperactivated

197 Our findings show that TEAD4, an effector of the Hippo signaling pathway, is essential fo

198 upstream to inhibin beta A (inhba), a known effector of vertebrate regeneration.

199 ly kinase Fgr was identified as a downstream effector of Wnt5a.

200 uggesting Wnt-related genes to be downstream effectors of AnxA8.

201 A comparison of the downstream effectors of directional cues suggests that different ex

202 cochaperones are the most abundant cellular effectors of protein homeostasis, assisting protein fold

203 enome-wide screen designed to identify novel effectors of the aggregation process.

204 hat pharmacological inhibition of downstream effectors of the PI3K/GSK3 pathway, SGK1 and GSK3, induc

205 In addition, the PI4P effector Past1 is needed for formation of stable PI4KII-

206 inflammatory responses, albeit via different effector pathways.

207 inds effectors to transmit signaling through effector pathways.

208 including the balanced synthesis of its main effector peptides Ang (angiotensin) II and Ang (1-7).

209 r to the onset of the disease and during the effector phase in the ovalbumin-induced allergic airway

210 nner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.

211 -MHC class II epitopes to link inductive and effector phases to generate protective immunity.

212 mmunosuppression during both the priming and effector phases, provokes systemic T cell responses agai

213 D25 compared with adults, consistent with an effector phenotype.

214 glycoprotein (GP) VI, or the GPVI signaling effector phospholipase C (PLC) gamma2.

215 ng into pathogen-specific antibody-producing effector plasmablasts/plasma cells, memory cells, and im

216 in dampening mouse T cell activation-induced effector processes, relative to treatments with either m

217 differentiated IELs are able to preserve an effector program in the absence of TCR signaling.

218 em (T4SS) that mediates delivery of the CagA effector protein as well as nonprotein bacterial constit

219 ADP-ribosyltransferase domain of the related effector protein ExoT also participates.

220 Perforin is a key effector protein in the vertebrate immune system and is

221 d up-regulation of GADD45alpha, the ultimate effector protein of this stress signaling cascade.

222 indicate that CstK functions as a bacterial effector protein that interacts with the host protein TB

223 as a target of the Xanthomonas euvesicatoria effector protein Xanthomonas outer protein N (XopN), a s

224 ) that was derived from a CheY-like c-di-GMP effector protein.

225 tion to CRISPR/Cas systems and the different effector proteins and continue with reviewing the recent

226 lpha at Ser(51), upregulating its downstream effector proteins ATF4 and GADD45alpha.

227 Finally, the potential role of nematode effector proteins in triggering such epigenome changes i

228 secretion system (T3SS) to inject cytotoxic effector proteins into host cells.

229 of other core autophagy proteins and various effector proteins involved in trafficking or fusion even

230 uses two type-3 secretion systems to inject effector proteins that facilitate Salmonella entry, esta

231 h ZAR1 and provide specificity for different effector proteins, such as HopZ1a.

232 rulence factors, such as secreted toxins and effector proteins, to manipulate host cellular processes

233 lass of RAS variants with its regulatory and effector proteins.

234 AnkG is one of these anti-apoptotic effector proteins.

235 s' competence to bind multiple regulator and effector proteins.

236 eased lung B cell, natural killer and T cell effector responses in the lung upon infection.

237 phatidylinositol 3-kinase, or its downstream effectors, resulted in increased cell density to a level

238 Analysis of downstream effectors reveals that Nfatc1 promotes the expression of

239 How effector sensing triggers NLR activation remains poorly

240 Although most effectors show conserved spatiotemporal expression profi

241 stic and independent of canonical downstream effector signaling.

242 inked to the production of acquired immunity effectors such as antibodies.

243 ng that SE-mediated expression of downstream effectors such as CHPT1 can be viable targets to overcom

244 he tumor myeloid compartment are crucial for effector T cell recruitment to the tumor microenvironmen

245 tudy was to determine whether Tregs suppress effector T cell-mediated and inflammatory cytokine-induc

246 s exhibited the phenotype characteristics of effector T cells (CD45RA(+), CD45RO-/lo, CD62L(-), CD27l

247 xp3(+) T cells, whereas high levels expanded effector T cells and caused severe autoimmunity.

248 fatty-acid synthesis favors Treg cells over effector T cells and how this imbalance can be overcome.

249 P2X7 stimulation affected cell cycling of effector T cells and resulted in generation of mitochond

250 type 2 and type 17 helper (T(H)2 and T(H)17) effector T cells by Wnt and Hippo pathway-dependent mech

251 IL-10 from effector T cells signals to CD11c(+) myeloid cells to su

252 1 signaling; (2) PD-L1(+) T cells restrained effector T cells via the canonical PD-L1-PD-1 axis and w

253 ing into T(SCM) that acts as a reservoir for effector T cells with potent therapeutic characteristics

254 which transforms them into rapidly dividing effector T cells.

255 e to the retina and a significantly reducing effector T helper 17 cells and inflammatory macrophages.

256 This hinders effector T-cell infiltration, proliferation and immune r

257 Expansion of the peanut-specific effector T-cell repertoire is correlated with clinical s

258 ulation of pathogenic IL5(+) IL17A(+) CD4(+) effector T-cells.

259 The candidate type III effector TarP, which localized to focal adhesions during

260 ontributes to the upregulation of downstream effector TCDD-inducible poly(ADP-ribose) polymerase (TiP

261 ny of individual naive CD8+ T cells to the T effector (TEFF), T circulating memory (TCIRCM), and TRM

262 romoting expression of the Maf/IL-10 axis in effector Th cells, Malat1 is a nonredundant regulator of

263 licated HDAC7 as a prohypertrophic signaling effector that can induce c-Myc expression, indicating a

264 tes that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis vi

265 of L. pneumophila is an amoebae host-adapted effector that subverts encystation of the amoebae natura

266 n had a particularly strong effect on immune effectors that are predominantly activated by the Imd pa

267 nterconnected and act on a variety of common effectors that can lead to the development of resistance

268 Antibodies are key immune effectors that confer protection against pathogenic thre

269 e, regulate, and deliver multiple epigenetic effectors that maximize the longevity of the therapeutic

270 Although the main upstream effectors that regulate its activity have been extensive

271 permanent, low-level expression of antiviral effectors that safely protect them from various viruses.

272 With an additional Lshid(Ala2) effector, the female lethality of DH6 is 100% dominant a

273 veal that a pathogenic bacterium utilizes an effector to manipulate PD-mediated host intercellular co

274 f the binding of substrate in the absence of effector to the binding of the substrate in the presence

275 eedback loop among RhoA and its cytoskeletal effectors to inhibit contractility.

276 may be leveraged by delta-catenin and other effectors to sculpt the developing dendritic arbor.

277 rs effector binding, as activated RAC2 binds effectors to transmit signaling through effector pathway

278 ence of pathogen-derived virulence proteins (effectors) to induce immune responses.

279 and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion.

280 s efforts to identify the causal variant and effector transcripts at T2DM GWAS susceptibility loci.

281 istics highly reminiscent of tissue-resident effector Tregs.

282 Our data reveal effector-triggered and phosphorylation-regulated conform

283 To counteract an effector-triggered immune response, a third effector, Yo

284 qually redundant manner in basal resistance, effector-triggered immunity (ETI) and regulation of defe

285 In plants, pathogen effector-triggered immunity (ETI) often leads to program

286 mediated basal immunity without compromising effector-triggered immunity, because the ability of this

287 lator of both pattern-triggered immunity and effector-triggered immunity.

288 intains a high expression of the mesenchymal effector, TWIST-1.

289 ctors including transcription activator-like effectors, type II secretion systems, diversity resultin

290 ase-cyclase and allosterically activates the effector, typically a promiscuous ribonuclease.

291 Using gem-difluoromethylene alkynes as effectors, unprecedented diverse C-H activation/[4+2] an

292 unction, and reveal a link between Trib1 and effector versus exhausted T cell differentiation that ca

293 The Vibrio parahaemolyticus T3SS effector VopQ targets host-cell V-ATPase, resulting in b

294 One such effector was angiotensin-converting enzyme, which is a m

295 n have come from studies of several Yersinia effectors, which are injected into phagocytes and intera

296 netic marking by dCas9-based transcriptional effectors with a concomitant enhancement of transcriptio

297 ns, the activation of additional pleiotropic effectors with strong disease linkage.

298 through the activation of the Hippo pathway effector YAP1.

299 ll proliferation through the Hippo signaling effector Yki/YAP/TAZ, how intracellular force regulates

300 Two effectors, YopE and YopT, inactivate RhoA to disrupt pha

301 effector-triggered immune response, a third effector, YopM, binds to and inhibits pyrin by hijacking