ライフサイエンスコーパス: effector function

1 asis, as it allows T cells to moderate their effector function.

2 a that target membrane cholesterol for their effector function.

3 raction with Ppia, and this regulates T cell effector function.

4 erse roles of IL-21 in immune regulation and effector function.

5 ive roles of receptors and ligands in immune effector function.

6 and Treg differentiation, and development of effector function.

7 gulation of inhibitory receptors and loss of effector function.

8 tory receptors is uncoupled from the loss of effector function.

9 rade-off between rapid cell growth and rapid effector function.

10 ression correlated with T-bet expression and effector function.

11 d in human peripheral blood and had impaired effector function.

12 ind to HLA-E and block inhibition of NK cell effector function.

13 tlc2 impaired antiviral-T-cell expansion and effector function.

14 onizes differentiation and enforces terminal effector function.

15 ead to increased TCR expression and improved effector function.

16 an cause CD8 T-cell exhaustion, compromising effector function.

17 driven mTORC1 activation and reduced NK cell effector function.

18 established during differentiation impaired effector function.

19 n T cells, modifying antigen sensitivity and effector function.

20 o PD-1/PD-L1-mediated suppression and retain effector function.

21 t viruses and tumors through their cytotoxic effector function.

22 unctions, uncoupling their proliferation and effector functions.

23 on of airway hyperreactivity and lung T cell effector functions.

24 might define NKT cell subsets with distinct effector functions.

25 ing cells for activation of antiviral T cell effector functions.

26 to CD8(+) T cells, thereby paralyzing their effector functions.

27 circulating SARS-CoV-2 isolates and activate effector functions.

28 lycolysis and fuel specialized antimicrobial effector functions.

29 ce, neutralizing activity, and innate immune effector functions.

30 T-bet allowing for the acquisition of type 1 effector functions.

31 of MAIT cell responses involving a range of effector functions.

32 s that include pyroptotic and non-pyroptotic effector functions.

33 ression was associated with impaired T cells effector functions.

34 conventionally utilized for proinflammatory effector functions.

35 invariant gammadelta T cells with programmed effector functions.

36 ther mechanisms, including antibody-mediated effector functions.

37 perform unconventional innate-like antiviral effector functions.

38 uenza vaccination and influence CIML NK cell effector functions.

39 exiting the cell cycle and engaging acquired effector functions.

40 fy perturbations that enhance natural killer effector functions.

41 enerate a portfolio of mutants with tailored effector functions.

42 eby equally augmenting Ag-specific MAIT cell effector functions.

43 c pathways as a key part of how they promote effector functions.

44 stigated whether RSV affects their antiviral effector functions.

45 as well as a role for serum IgA in blocking effector functions.

46 l for T cell activation, differentiation and effector functions.

47 a critical checkpoint in the acquisition of effector functions.

48 g cellular homing, metabolism, and potential effector functions.

49 is coupled to downstream astrocyte-mediated effector functions.

50 rized by enhanced metabolic reprograming and effector functions.

51 howed that Pdia3 editing in T cells enhances effector functions.

52 signaling, resulting in increased neutrophil effector functions.

53 I inhibition efficiently evades CD8(+) T(RM) effector functions.

54 egulating B cell development, activation and effector functions.

55 ne milieu during infection regulates NK cell effector functions.

56 amma]) yet promoting M(interleukin-4 [IL-4]) effector functions.

57 ion demonstrates a potent ability to restore effector functions.

58 , resulting in enhanced FcgammaRIII-mediated effector functions.

59 ect K. pneumoniae against neutrophil-related effector functions.

60 as through the recruitment of innate immune effector functions.

61 ognized for its influence on Ig turnover and effector functions.

62 T cells persist longer and produce stronger effector functions.

63 he immune response and the plasticity of its effector functions.

64 elopment of natural killer T cell (NKT cell) effector functions.

65 eptors (FcgammaRs) could mediate an array of effector functions.

66 N-glycans, with significant impacts on their effector functions.

67 ites, likely influencing antigen binding and effector functions.

68 ated ILC2s to maintain their homeostasis and effector functions.

69 zation, but critically dependent on antibody effector functions.

70 e viability of ILC2s and downregulates their effector functions.

71 ed or cancerous tissue and block immune cell effector functions.

72 okine production, and enhances antimicrobial effector functions.

73 nce induction, terminal differentiation, and effector functions.

74 their respective adaptive and innate immune effector functions.

75 ss of well-coordinated events and downstream effector functions.

76 H to the neonatal Fc receptor, and to reduce effector functions.

77 biomass generation, rapid proliferation and effector function(2).

78 served differences indicate that Fc-mediated effector functions accounted for 25-45% of the total ant

79 tope, possessed neutralizing and Fc-mediated effector function activities, and potentiated neutraliza

80 results in licensed NK cells with heightened effector function against missing self-targets is not kn

81 oles in allergic diseases and for protective effector functions against parasitic infestation, often

82 1BBL axis enhanced costimulatory signals and effector functions among APC and autologous TILs.

83 eceptor T cells in proliferation, phenotype, effector function and antitumour activity in a mouse mod

84 th this deletion initially mediate increased effector function and cause more severe immunopathology,

85 ional profile, including genes mediating CD8 effector function and cell survival.

86 opportunities to investigate in parallel the effector function and evolution associated with differen

87 ished that glycosylation of IgG dictates its effector function and has disease-specific patterns.

88 ive immunity to influenza, delivering direct effector function and potentiating responses of other ly

89 nges to support their high energy demand for effector function and proliferation.

90 rks at the T-cell surface that culminates in effector function and subsequent aGVHD in target tissue.

91 ur findings identify an additional tuft cell effector function and suggest context-specific regulatio

92 iversal immune receptors can regulate T-cell effector function and target multiple antigens with a si

93 l mechanisms for LXA(4) regulation of T cell effector function and trafficking.

94 and kinetic specificity to Ca(2+)-dependent effector functions and Ca(2+) transport.

95 ls inside tumor were not able to exert their effector functions and influence tumor progression.

96 the effects of autophagy deficiency on ILC2 effector functions and metabolic balance.

97 hagy uncouples T-cell proliferation from its effector functions and offers a potential new strategy t

98 masome composition, assembly and activation, effector functions and role in infection and inflammator

99 1s signaling pathway contributes to enhanced effector functions and survival of human NK cells.

100 lay between MAIT cell-mediated antibacterial effector functions and the humoral immune response.

101 ey molecular mechanisms that drive MAIT cell effector functions and to identify those which are impai

102 nfer antigen specificity, (2) enhance T cell effector function, and (3) neutralize immunosuppressive

103 ys of T cell differentiation, acquisition of effector function, and cell cycle entry in response to L

104 ociated with differentiation, acquisition of effector function, and cell cycle entry.

105 This study elucidates the phenotype, the effector function, and the gene signatures of memory CD8

106 ion, strongly impaired lineage stability and effector function, and ultimately fatal autoimmunity in

107 not post-commitment defects in innate immune effector function, and underscore the importance of eval

108 naling axis and CD8(+) T cell proliferation, effector function, and/or survival is unknown.

109 mmation that resulted in activation, gain of effector functions, and better control of tumor growth.

110 the draining lymph node, to the execution of effector functions, and finally to the development of ti

111 CMV-specific proliferative responses, T-cell effector functions, and induction of the major type-1 tr

112 with cellular activation and proinflammatory effector functions, and TCR repertoire analysis indicate

113 IgA negatively modified infection risk by Fc effector functions, and that vaccine recipients with a s

114 were found to be neutralizing, to utilize Fc effector functions, and to be protective against lethal

115 cific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cell

116 Ameliorating T cell exhaustion and enhancing effector function are promising strategies for the impro

117 extracellular signals controlling tuft cell effector function are unknown, but signal transduction i

118 Their effector functions are closely linked to their cytotoxic

119 Evidence abounds that effector functions are important in controlling infectio

120 B cell activation and effector functions are regulated by immune checkpoints,

121 ese antibodies neutralize the virus, mediate effector functions, are broadly protective in vivo, and

122 estored IL-2 secretion which is a key T cell effector function as dependent on reconstitution dynamic

123 We propose that the Pit2 effector functions as a substrate mimicking molecule: Pi

124 d in the regression model exhibited enhanced effector functions as defined by in vitro cytotoxicity a

125 e in FcgammaR engagement and subsequent ADCC effector function, as they contain a decrease in afucosy

126 1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against

127 ate FcgammaR binding and downstream FcgammaR effector functions, as demonstrated by surface plasmon r

128 is required for basophil gene expression and effector function associated with helminth expulsion dur

129 e "preset" NKT and MAIT subsets with defined effector functions, associated with specific positioning

130 To generate antibodies with different effector functions, B cells undergo Immunoglobulin Heavy

131 intaining the balance between regulatory and effector functions become impaired, autoimmune diseases

132 defined times during development and acquire effector functions before exiting the thymus.

133 mobilize the immune system, such as Abs with effector functions, bispecific Abs, and checkpoint inhib

134 lation that was terminally fated with potent effector function but maintained memory T cell qualities

135 tibodies could not elicit Fc-mediated immune effector functions but could potentiate antibody-depende

136 the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm.

137 immune cell activation, differentiation and effector functions, but current metabolic approaches lac

138 is characterized by pre-formed mRNA encoding effector functions, but impaired proliferation marked by

139 In vitro, removal of this glycan impairs IgG effector functions, but its relevance to GAS infection i

140 sted" CD8 T cells with impaired HIV-specific effector functions, but its role on CD4 T cells and in H

141 control CD8 T cell expansion, survival, and effector function by regulating the expression of the pr

142 y activation vs subsequent proliferation and effector function by these cells.

143 findings suggest that T cell persistence and effector function can be coordinated in tumour immunity

144 n CD8 T cells revealed that DHX37 suppresses effector functions, cytokine production, and T cell acti

145 en together, these data demonstrate that IgA effector functions depend on subclass and glycosylation,

146 ith protection, suggesting that Fc-dependent effector function determines protective efficacy.

147 tic and biosynthetic requirements to support effector functions, differentiation, and longevity in th

148 d to the priming of CD8 T cells with partial effector function, driving the selection of a viral esca

149 NK cells activated with TEPP-46 had reduced effector function due to TEPP-46-induced increases in ox

150 neity in NK cell avidity diversifies NK cell effector function during antiviral immunity, and how avi

151 sphorylation limits T cell proliferation and effector function during chronic antigenic stimulation.

152 ently showed that MP cells exert innate-like effector function during host defense, but whether MP CD

153 ariant natural killer T (iNKT) cells acquire effector functions during development by mechanisms that

154 study demonstrates the induction of NK cell effector functions early after Ad26.ZEBOV, MVA-BN-Filo v

155 dy binding to cell-surface NS1 along with Fc effector functions engagement correlate with protection

156 on correlates with non-neutralizing antibody effector function, Env-specific CD4(+) T-cell responses,

157 e known role of SAAs in regulating Th17 cell effector function, epithelial RARbeta promoted IL-17 pro

158 eneration costimulated CAR T cells, elicited effector functions equivalent to CD28-costimulated CAR T

159 al control of CD8 T cell differentiation and effector function following T cell activation has been e

160 pendent cell cytotoxicity (ADCC) is a common effector function for nonneutralizing Abs and is known t

161 functional immune response involving several effector functions from all arms of the immune system.

162 nse provide a unique opportunity to separate effector functions from regulatory functions.

163 n of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development o

164 In this study, Fc-mediated effector functions have been quantified in vivo relative

165 n chronic infections and cancer have limited effector function, high co-expression of inhibitory rece

166 lls are characterized by progressive loss of effector functions, high and sustained inhibitory recept

167 ic infections often show progressive loss of effector functions, high expression of inhibitory recept

168 TS,S-induced antibodies mediate Fc-dependent effector functions, ii) functional antibodies were gener

169 ted the ability of ANXA1 to influence T cell effector function in relapsing/remitting MS (RRMS), an a

170 ation is essential for lineage stability and effector function in Treg cells.

171 accumulation, better persistence and robust effector function in tumours.

172 signaling pathways of ApoA-IV on eosinophil effector function in vitro and in vivo.

173 s were strong inhibitors of T helper-17 cell effector function in vitro, showing that this effect was

174 mononuclear cells remarkably improved T cell effector function in vitro.

175 Here, we formally test the role of effector function in vivo by comparing the rate and timi

176 conserved, pleotropic cells that display key effector functions in allergic diseases, such as asthma.

177 ification of pathogenic antibodies and their effector functions in autoimmune diseases or use of B ce

178 potent novel therapeutic agents with unique effector functions in cancer immunotherapy.

179 lpha) treatments to effectively enhance such effector functions in chronic progressor NK cells withou

180 igen induces a dynamic switch from antiviral effector functions in endosomes to a PI3K amplification

181 apeutics and shed light on the importance of effector functions in immunity against MACV.IMPORTANCE M

182 important implications for investigating Ab effector functions in macaques.

183 s a metabolic signal required for pathogenic effector functions in medium and large vessel vasculitis

184 CD8 Tem and T central memory cells displayed effector functions in response to virus challenge in viv

185 ta suggests a role for Fc-dependent antibody effector functions in RTS,S-induced immunity.

186 cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also aut

187 role for Map3k8 in the homeostasis of their effector functions in the lung.

188 tes Th1 and proinflammatory T-bet+ Th17 cell effector functions in vitro and in vivo.

189 e signaling to suppress proinflammatory ILC2 effector functions in vitro.

190 factor signaling, metabolic dependence, and effector functions in vitro.

191 B cells are capable of a wide range of effector functions including antibody secretion, antigen

192 -27 (Ebi3(-/-)) resulted in impaired NK cell effector functions including the generation of anti-vira

193 However, its effects on stimulating antibody effector functions, including NK cell activation, monocy

194 e with high avidity and promoted specific Fc effector functions, including phagocytosis by neutrophil

195 ated with increased T cell death, impaired T effector function, increased regulatory T cell frequency

196 for memory CD8 T cell activation and gain of effector functions, indicating tumor-derived inflammatio

197 idely distributed environmental sensors with effector functions interfacing type 2 immunity and neura

198 ed glucose uptake (2-NBDG(lo)) and decreased effector function (interferon gamma(lo)).

199 T cell effector functions (interferon gamma secretion, prolifer

200 nd provide a link between the suppression of effector function intrinsic to CD8 T cells and protectio

201 gulate mast cell subtype and their different effector functions is essential.

202 ne diseases, but the regulation of serum IgA effector functions is not well defined.

203 at robust PGE(2) production can suppress PMN effector functions, leading to decreased bacterial killi

204 rylation, T cell proliferation, and selected effector functions, leading to immunodeficiency.

205 Abs of the IgG isotype mediate effector functions like Ab-dependent cellular cytotoxici

206 onocyte subsets with distinct phenotypes and effector functions may be important in driving inflammat

207 erstrategies specifically neutralizing TRAIL effector functions mediated by a specific, tissue-reside

208 EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1.

209 nt of transcriptional programs that regulate effector function, metabolism and lysosomal biogenesis.

210 T cell effector function, migration and glycolytic responses we

211 is involved in regulating the expansion and effector function of a broad range of leukocytes, includ

212 y of calcineurin inhibitors and uncontrolled effector function of alloreactive T lymphocytes are main

213 mal therapy facilitates the accumulation and effector function of CAR T cells within solid tumors.

214 ancer immunotherapy restores or enhances the effector function of CD8(+) T cells in the tumour microe

215 signal transduction, cell-fate decisions and effector function of immune cells.

216 these findings identify haptotaxis as a key effector function of immune-responsive platelets.

217 ir IFN-gamma production, which is a critical effector function of MAIT cells in host defense.

218 ylic acid cycle is required for the terminal effector function of T(H)1 cells through succinate dehyd

219 tion activity, with little dependence on the effector function of the antibody.

220 vidence for a functional clock governing the effector function of these cells is sparse and contradic

221 -2)/STAT5 activation support the suppressive effector function of Treg cells, but how these regulator

222 stress, is a major negative regulator of the effector function of tumor-reactive CD8(+) T cells.

223 nstrate that BCG therapy results in enhanced effector function of tumor-specific CD4 T cells, mainly

224 The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells.

225 cell receptor signaling, loss of the B cell effector functions of antibody and cytokine production,

226 g microglia and monocytes, that regulate the effector functions of antiviral T and B cells as they ga

227 In this review, we summarize effector functions of caspase-11.

228 Our aim was to characterize the effector functions of ILC2(10)s in the development and p

229 d Treg to control airway hyperreactivity and effector functions of lung T cells was determined.

230 Given the unique effector functions of macrophages and their capacity to

231 The effector functions of macrophages became upregulated fol

232 drial metabolism support differentiation and effector functions of mouse T helper 1 (T(H)1) cells by

233 t of CD4(+) T(reg) cells and suppressing the effector functions of multiple effector T cell (T(eff))

234 vel role for IL-27 in regulating early-phase effector functions of NK cells during influenza infectio

235 cell-derived IL-27 regulates the early-phase effector functions of NK cells in the bronchioalveolar a

236 IL-27 alone was incapable of altering the effector functions of NK cells.

237 In fact, glucose is essential for the effector functions of NKT cells and a high lactate envir

238 rete cytokines typically associated with the effector functions of other CD4(+) T cell subsets.

239 strate that the differentiation and terminal effector functions of T helper cells are biochemically u

240 naling suppresses the thymic development and effector functions of T1D-protective invariant NKT cells

241 Proliferation and effector functions of Th17 require a specific mTOR-depen

242 is modulated by IL-4, and IL-3 regulates the effector functions of Th2 cells.

243 m virus neutralization by the Fab moiety and effector functions of the Fc region.

244 Differentiation stage and immune-effector functions of the underlying tumor cell are insu

245 uggesting a need to further characterize the effector functions of these cells and their role in HIV

246 cells and also examined the role of IL-3 in effector functions of these cells.

247 ogeneity in the transcriptional programs and effector functions of these rare pathogenic T cells.

248 channels in controlling lineage identity and effector functions of Treg cells.

249 rogrammed to promote either their short-term effector functions or long-term memory capacity.

250 dured long term yet never acquired antiviral effector functions or selected for viral escape mutation

251 lification of TCR-dependent and -independent effector functions, particularly inducing excessive inna

252 he human iG1 mAb, termed Avidimabs, retained effector functions, paving the way for the proinflammato

253 Concurrent administration of a neutralizing/effector function-positive bNAb via the airway and syste

254 inally differentiated NK cells with enhanced effector function predominate in blood, bone marrow, spl

255 iated MC degranulation, and histamine-driven effector functions preferentially in male mice.

256 in many cells and mediates numerous cellular effector functions ranging from gene transcription to ex

257 neutrophil and macrophage TNF production and effector functions, reduced bacterial clearance, and inc

258 nisms by which Treg cells regulate Th17 cell effector functions: reduction of APC density, limiting a

259 egulate these two subsets of ILC2s and their effector functions remains elusive.

260 -MHC structures translate to distinct T cell effector functions remains unknown.

261 s in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, di

262 eceptor (FcgammaR), which blocks Fc-mediated effector functions, such as Ab-dependent cellular cytoto

263 Coordinated crosstalk of effector function suggests that MARTX toxins are not sim

264 -clade reactivity, specificity for V1V2, and effector functions than in macaques primed with DNA lack

265 in MUC16, potentially representing a new IgG effector function that would concentrate certain antibod

266 finding shows that IRF3 is needed for T cell effector functions that are involved in anticancer immun

267 and helminth infection, performing critical effector functions that drive type 2 inflammation.

268 ted interest in how B cells mediate multiple effector functions that include antibody production, ant

269 ted interest in how B cells mediate multiple effector functions that include antibody production, ant

270 These CARs program highly performing effector functions that mediate potent tumor elimination

271 ngs and translate environmental signals into effector functions that regulate immune responses in the

272 tic mechanisms endowed T cells with improved effector functions that were conducive to more efficient

273 of the immune cells present in lymphoma have effector function, the immune system is unable to eradic

274 that in vivo, despite enhanced non-Tfh cell effector functions, the deletion of transcription factor

275 Natural killer (NK) cells acquire effector functions through education, a process that req

276 means to them, ranging from complete lack of effector function to altered functionality to prevent im

277 STING scaffold enabled a switch from direct effector function to regulation of antiviral transcripti

278 costimulation effectively potentiates T cell effector function to suboptimal Ag levels.

279 All cloned AHAs could restore immune effector functions to proteolytically generated F(ab')2

280 contribution of virus neutralization versus effector functions to the overall antiviral activity of

281 l expression and processing, enhancing TCR-T effector function, trafficking, expansion, persistence,

282 revented development of cells with antitumor effector function, transient LDH inhibition enhanced the

283 lls into the tumor, and activation of immune-effector functions, ultimately mediating tumor destructi

284 establish that the dichotomy of stemness and effector function underlies the heterogeneous T(H)17 res

285 result of both heme-blocking and Fc-mediated effector functions, underscoring the importance of targe

286 eptide concentration required for triggering effector function up to 3000-fold.

287 to CD8+ memory T cells with rapid and robust effector function upon re-stimulation, persistence, and

288 This included the ability to mediate effector functions via the fragment crystallizable (Fc)

289 instructing recruited cells to elicit their effector function, was, at least in part, dependent on f

290 lt in lack of glycosylation and thus loss of effector function, we demonstrate that the N297G variant

291 T cell effector functions were determined by enzyme-linked immu

292 iant TCRs and the intrathymic acquisition of effector functions were due to an intrinsic property of

293 DHS-IgG retains intact effector functions, which are important for the clearanc

294 human neutrophils affects several neutrophil effector functions, which bears important implications f

295 METH compromises phagocyte effector functions, which might have deleterious consequ

296 hrough Fc gamma receptor (FcgammaR)-mediated effector functions, which should affect the kinetics of

297 dichotomy, triggering suppression of T cell effector function while preserving stemness.

298 Ns suggest means to selectively regulate ILC effector functions, while our network approach is broadl

299 ation of small molecules that sustain T cell effector function with ACT could lead to long lasting re

300 tion of G236 only silences FcgammaR-mediated effector functions without affecting C1q-binding or acti