ライフサイエンスコーパス: effector molecule

1 (the proportion of cells producing multiple effector molecules).

2 d with high fidelity by sequestration of the effector molecule.

3 phosphoinositide 3-kinase (PI3K), a key IIS effector molecule.

4 reactive oxygen species, an antileishmanial effector molecule.

5 e, in which the cytokine IL-6 is a prominent effector molecule.

6 tight junction protein and a potent anti-HCV effector molecule.

7 s either a neutralizing decoy receptor or an effector molecule.

8 ry and secondary structure and their cognate effector molecule.

9 , Rab proteins interact with proteins termed effector molecules.

10 zation and rational design of novel cereblon effector molecules.

11 of GPCRs with heterotrimeric G proteins and effector molecules.

12 colytic activity and increased expression of effector molecules.

13 low extracellular pH, helping it to secrete effector molecules.

14 egs) and T(H)17 cells and controls important effector molecules.

15 CO-caged molecule was used to deliver active effector molecules.

16 or proper counteractions through adaptor and effector molecules.

17 n of cytosolic tyrosines, which then recruit effector molecules.

18 ession, in response to synthetic non-natural effector molecules.

19 t restrains the expression of genes encoding effector molecules.

20 signals in the extracellular environment via effector molecules.

21 onal changes promoting binding of downstream effector molecules.

22 te the biochemistry of hosts by secretion of effector molecules.

23 rough the recruitment of other antimicrobial effector molecules.

24 acity to produce an array of proinflammatory effector molecules.

25 terized T6SSs, binds specifically to cognate effector molecules.

26 connecting upstream receptors to downstream effector molecules.

27 f the vaccine, with an increase in cytolytic effector molecules.

28 the ability to produce distinct patterns of effector molecules.

29 n-1 and transcription-independent control of effector molecules.

30 n, and the production of cytokines and other effector molecules.

31 interact with cargo proteins, membranes, and effector molecules.

32 phages as well as key cytokine and chemokine effector molecules.

33 as ligand) and apoptotic (cleaved caspase-3) effector molecules.

34 ge, stimulating the activation of downstream effector molecules.

35 ective signaling and defective production of effector molecules.

36 large amounts of type-2 cytokines and other effector molecules.

37 Tumor Necrosis Factor Receptor to downstream effector molecules.

38 ant differences among the complexes with the effector molecules.

39 s to enable optimal interactions with murine effector molecules.

40 ethylated at the loci of classically defined effector molecules.

41 TCH downstream targets and B-cell maturation/effector molecules.

42 teins derives from their ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP.

43 n activate immune cells by shuttling various effector molecules, a process that may be relevant to ho

44 cate that KDM5C is a conserved and druggable effector molecule across a number of NDDs for whom the u

45 Recognition of certain effector molecules activates a strong defense, known as

46 ams that control expression of key cytolytic effector molecules, adhesion molecules, and cytokine and

47 -9 functioning as a potent antiviral defense effector molecule against HCMV infection and identifies

48 d activation of downstream insulin signaling effector molecules AKT and Foxo1, and decreased expressi

49 e for translocation of a wide range of toxic effector molecules, allowing predatory cells to kill bot

50 s: a receptor (aptamer) domain that binds an effector molecule and a regulatory domain (or expression

51 bility to link this regulation to downstream effector molecules and biological functions.

52 Ral GTPases are RAS effector molecules and by implication a potential therap

53 val by reducing intragraft expression of Th2 effector molecules and eosinophilic allograft infiltrati

54 ly polyfunctional, expressing high levels of effector molecules and exhibiting superior short-term co

55 CC secreted Th1, Th2, and Th22 cytokines and effector molecules and expressed TCR Vbeta 5.1, 16, 20,

56 modular fashion, which can be combined with effector molecules and half-life extension technologies.

57 ynapse, which mediates efficient delivery of effector molecules and intercellular signals across the

58 riptional signatures were maintained but key effector molecules and metabolic pathways were suppresse

59 ed virtually all arms, cellular players, and effector molecules and pathways involved in these crucia

60 nal properties of this subset and identified effector molecules and pathways which mediate their func

61 leptospiral proteases can deactivate immune effector molecules and represent potential targets to th

62 nti-inflammatory state; however, the biofilm effector molecules and the mechanism(s) of action respon

63 ular signaling pathways by engaging critical effector molecules and thus acts as a ligand-independent

64 T helper (Th) cell subtypes in both usage of effector molecules and transcription factors.

65 Sensor NLRs perceive pathogen-derived effector molecules and trigger robust host defense.

66 that reduce the expression of cytokines and effector molecules and upregulate the expression of inhi

67 We highlight the signaling pathways, effector molecules, and cell populations that are activa

68 ntibody against the target, potent cytotoxic effector molecules, and conjugation of the monoclonal an

69 rate-limiting glycolytic enzymes, cytolytic effector molecules, and essential chemokine and adhesion

70 ecause IL-10 production, expression of other effector molecules, and general immune homeostasis are n

71 h pathogen recognizing receptors, cytokines, effector molecules, and granules filled with reactive ox

72 cular innate and adaptive immune cell types, effector molecules, and pathways can sometimes collectiv

73 (TCIPS) or the molecular machinery by which effector molecules are released from platelets.

74 y, they are well suited for combination with effector molecules as well as half-life extension techno

75 Thus, PTX3, an effector molecule belonging to the humoral arm of innate

76 uPAR was physically associated with the WNT effector molecule beta-catenin on the membrane, cytoplas

77 These effector molecules bind interdependently to three anti-c

78 These effector molecules bind to IgG1 in the lower hinge-CH2 r

79 g these structures can receive the cytolytic effector molecules, but cytotoxicity is suboptimal.

80 artments through production of cytokines and effector molecules, but it is unclear how tissue site in

81 ing transcription of IFN-gamma and other key effector molecules by donor CD8 cells in the epidermis,

82 By controlling the activation of effector molecules by G protein alpha and betagamma subu

83 ere is much cross-talk between the activated effector molecules by IFN-1 and other cytokines.

84 valis signature genes based on its activated effector molecules can efficiently distinguish ESCC pati

85 Localized expression of effector molecules can initiate antitumor responses thro

86 Immune-mediated effector molecules can limit cancer growth, but lack of

87 code transcription factors (including Tcf7), effector molecules, cell cycle regulators, and proteins

88 e through its ability to bind and cleave the effector molecule complement Component 4 (C4).

89 These cells could produce effector molecules constitutively, in response to phorbo

90 tion are well-defined, little is known about effector-molecules contributing to malignant expansion a

91 Tregs among CD4(+) T cells, turnover of the effector molecule CTLA-4, and their suppressive activity

92 acellular levels of the nitric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP),

93 The composition of effector molecules deviates between different cell types

94 this body of work is that Arc is a critical effector molecule downstream of many molecular signaling

95 pression of a wide range of genes (including effector molecules downstream of IL-17 such as cytokines

96 rely on radiation, surgery, or inhibition of effector molecules downstream of these G proteins.

97 molecule hydrogen sulfide (H2S) as the major effector molecule driving apneas.

98 al mucosal homeostasis, as well as prominent effector molecules during chronic gut inflammatory disea

99 ent by competing nuclear receptors and their effector molecules, ecdysone and NO.

100 f granzymes and perforin, which are the main effector molecules expressed by CD8(+) cytotoxic T lymph

101 The granzyme family serine proteases are key effector molecules expressed by cytotoxic lymphocytes.

102 give rise to more terminally differentiated, effector-molecule-expressing daughter cells.

103 rylation and to suppress their IL-15-induced effector molecule expression and cytolytic capacity.

104 during DC:NK cell coculture enhanced NK cell effector molecule expression as well as their cytolytic

105 T-cell and NK-cell immune effector molecule expression correlated with tumour-asso

106 orm in the absence of ADAP were defective in effector molecule expression.

107 wnregulation of eomesodermin, which controls effector molecule expression.

108 on, proinflammatory cytokine production, and effector molecule expression.

109 Instead, chromatin loci of Th17 effector molecules failed to acquire an open conformatio

110 IGIT on Treg cells induced expression of the effector molecule fibrinogen-like protein 2 (Fgl2), whic

111 s demonstrate that IFN-gamma is an antiviral effector molecule for MPyV infection.

112 Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical

113 holipase C-gamma1 (PLC-gamma1), an important effector molecule for T cell activation.

114 e cytokine interleukin 13 (IL-13) is a major effector molecule for T-helper type 2 inflammation and i

115 xogenous galectin-9, in addition to being an effector molecule for Treg cells, acts synergistically w

116 A search of downstream effector molecules for CPK32 led to identification of a

117 in pH that accompanies the "uncaging" of an effector molecule from o-nitrobenzaldehyde, a photoisome

118 ctions requires analysis of large numbers of effector molecules from single cells.

119 ntrinsic mechanism governed by the NF-kappaB effector molecule GADD45beta that restricts tumor-associ

120 ly induced their expression of the cytotoxic effector molecules granzyme B and perforin; their degran

121 tion, type 1 CD8 cytotoxic T cell-associated effector molecules granzyme B(+), IFN-gamma(+), TNF-alph

122 The nanoscale organization of key effector molecules has been revealed by single-particle

123 Here, we investigate how the effector molecule HC-toxin (HCT), a histone deacetylase

124 ma by expressing higher levels of downstream effector molecules ido and nos2.

125 quired for the production of the key NK cell effector molecules IFN-gamma, which is important in deli

126 hile paradoxically repressing genes encoding effector molecules (IFN-gamma and granzyme B).

127 on of activation markers (CD69 and CD25) and effector molecules (IFN-gamma, granzyme B, and IL-10) di

128 The effector molecule IHP was found to lower nuFeHis selecti

129 rogram characterized by the induction of the effector molecules IL-7Ralpha, S1P1, and CCR7, but the u

130 These results reveal CdhR to be an effector molecule in a negative regulatory network that

131 lycogen phosphorylase (PYGM) as a novel Rac1 effector molecule in IL-2-stimulated cells.

132 cer treatment, and caspase-3 is an important effector molecule in NK cell-mediated apoptosis in cance

133 genic, conditions, ICOS emerges as a pivotal effector molecule in the early decision between toleranc

134 pathways, specifically placing it as a novel effector molecule in the non-canonical Wnt/PCP pathway.

135 Acute toxicity required two key effector molecules in CAR T cells-perforin and GM-CSF.

136 eactive and ACR patients exhibited increased effector molecules in CD8 T cells.

137 ls and induction of granzyme B and IFN-gamma effector molecules in CD8(+) T cells.

138 esting previously unknown functions of these effector molecules in endosomal trafficking.

139 f dithiolethione on NF-kappaB and downstream effector molecules in estrogen receptor-negative breast

140 one marrow (BM) and induce the expression of effector molecules in memory T cells, before their recru

141 eins (IFITMs) have been identified to be key effector molecules in the host type I interferon defense

142 icrobial proteins and peptides are essential effector molecules in this airway epithelial innate immu

143 large amounts of type 2 cytokines and other effector molecules in vitro and in vivo.

144 bolites that bind to and regulate downstream effector molecules including lipid-regulated potassium c

145 trolled the expression of specific Treg cell effector molecules, including IL-10 and SOCS1.

146 to produce an unusual spectrum of biological effector molecules, including IL-25, eicosanoids implica

147 , creatine inhibited the induction of immune effector molecules, including iNOS, by suppressing IFN-g

148 n suppresses the upregulation of a subset of effector molecules, including ISG56 and IFITM1.

149 Shuttling of these effector molecules, including the high mobility group bo

150 s factor alpha-positive [TNF-alpha(+)]), and effector molecule (inducible nitric oxide synthase-posit

151 endently affecting a small group of powerful effector molecules; induction tolerance represented a mo

152 a identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to

153 n rates (<10%) and minimal production of the effector molecules interferon-gamma, interleukin-17, and

154 EPEC translocates effector molecules into host cells via type III secretio

155 transfer through conjugation and delivery of effector molecules into host cells.

156 novel virulence mechanism, sending sRNAs as effector molecules into plant cells to silence plant imm

157 a bacterial nanomachine for the transport of effector molecules into prokaryotic and eukaryotic cells

158 ns use type III secretion systems to deliver effector molecules into the cytoplasm of a host cell.

159 thways inside of the macrophage by secreting effector molecules into the cytoplasm.

160 te infection by delivering a large number of effector molecules into the plant cell.

161 interfering RNA class of small RNAs are the effector molecules involved in direct silencing of CER3

162 tinct mechanisms drive the production of Tfh effector molecules, involving IL-12p70 for IL-21 and act

163 ma (STS), we show that disruption of the IFN effector molecule IRF8 decreases pSTAT1 and increases uS

164 anism in small GTPase signaling by which the effector molecule is autoinhibited for GTPase interactio

165 Expression of these effector molecules is however highly divergent, and tool

166 teins to regulate transcription via specific effector molecules is leveraged as a coupled assay that

167 ting TLR2-MyD88 signals in T cells increased effector-molecule levels and enhanced the clearance of L

168 from exposure and detection by innate immune effector molecules like the C-type signaling lectin Dect

169 by enabling chromatin accessibility of Th17 effector molecule loci.

170 pathology, and targeting IFN-I or downstream effector molecules may be an effective therapeutic appro

171 ediated phagocytosis (CDCP) by immunological effector molecules mediated the clearance of target cell

172 omerulonephritis by impacting both cell- and effector molecule-mediated pathways.

173 Taken together, mGBP2 is an essential immune effector molecule mediating antiparasitic resistance.

174 agellin receptor TLR5 and the TLR downstream effector molecules MyD88 and TIRAP that are associated w

175 of mice genetically deficient in TLR4 or its effector molecules MYD88 or TRIF.

176 rease in production of caspase 3, a terminal effector molecule of apoptosis.

177 Moreover, we found that a major effector molecule of ETEC, the heat-labile enterotoxin (

178 p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX), a gene fu

179 e tetraphosphate (ppGpp), which serves as an effector molecule of many processes including transcript

180 e-produced secretory IgA (sIgA), the primary effector molecule of mucosal immunity, in mice with homo

181 its antiproliferative effect by acting as an effector molecule of Ras, resulting in the inhibition of

182 iptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with auto

183 cytosolic phospholipase A(2) (cPLA(2)) as an effector molecule of Src-PLD1-PKCgamma signaling in the

184 ed the temporal transcription of RNAIII, the effector molecule of the agr quorum-sensing system.

185 mor-prone Beckwith-Wiedemann syndrome, is an effector molecule of the DNA-damage response.

186 Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and aber

187 novel and apparently essential bactericidal effector molecule of the innate immune system.

188 The key effector molecule of the natural protein C pathway, acti

189 ovel roles for myosin II as a key regulatory effector molecule of the pro-fibrotic phenotype, in resp

190 over, although angiotensin II is the classic effector molecule of the RAS, several RAS enzymes affect

191 l phosphorylation and activation of ERK, the effector molecule of the Ras/MAPK cascade.

192 Here, we identify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

193 MicroRNAs are effector molecules of gene silencing in RNAi, and their

194 human host requires mechanisms to resist the effector molecules of host immunity, which exert their b

195 Immunoglobulins are the effector molecules of the adaptive humoral immune system

196 h the discovery that IgE antibodies were the effector molecules of the allergic response.

197 lar patterns and inducing the release of the effector molecules of the immune system.

198 e recently been identified as important host effector molecules of the type I interferon response aga

199 n has been variously interpreted as a direct effector molecule on bacterial phagosomes or on other or

200 22-producing CD4(+) T cells may express some effector molecules on the membrane, and therefore synerg

201 gulate the function of any TALE either using effector molecules or a heterodimerization reaction.

202 irectly by allowing or preventing docking of effector molecules, or directly by changing the intrinsi

203 Importantly, ablation of the cytolytic effector molecule perforin fully protected against vascu

204 e an important role for the immune cytotoxic effector molecule perforin in regulating this process.

205 T-cells showed increased expression of the effector molecules perforin and interferon-gamma with hi

206 d to a lesser extent, CD8(+) T cells and the effector molecule, perforin.

207 ubset displaying low expression of cytotoxic effector molecules, perforin and granzyme beta, with red

208 Health-promoting effector molecules produced by probiotics are well docum

209 The relative contribution of the effector molecules produced by T cells to tumour rejecti

210 shown to regulate inflammatory cytokine and effector molecule production.

211 are harnessed to maximize proliferation and effector molecule production.

212 ent resulted in the reversal of the baseline effector molecule profile comparable with MAIT cells fro

213 ored these immune cells, augmented cytotoxic effector molecules, promoted systemic inflammatory respo

214 iated critical adaptor members to downstream effector molecules, promoting successful nuclear deliver

215 function, the process by which binding of an effector molecule provokes a functional response from a

216 Due to its fast pharmacokinetics, the small effector molecules reach the malignant tissue quickly an

217 pargylglycine demonstrated that H(2)S is the effector molecule regulating Mtb survival in macrophages

218 The production of these effector molecules relies on rapid changes of gene expre

219 ied many of the intracellular signalling and effector molecules required for the response to this sig

220 We show that the Agr-driven effector molecule RNAIII promotes cap expression largely

221 lence) decreased by up to 84% for two of the effector molecules, scorpine, a potent antiplasmodial pe

222 via the simultaneous measurement of a dozen effector molecules secreted from tumor antigen-specific

223 FLT3-TKD is able to activate the downstream effector molecule signal transducer and activator of tra

224 These included key CTL effector molecules, signaling proteins and a subset of m

225 on of the TGFbeta receptor TGFbetaR1 and its effector molecule SMAD4 was required for enrichment of C

226 to infections, neutrophils rely on preformed effector molecules stored in a variety of intracellular

227 unctions and enhance the function of several effector molecules such as FcgammaR, uPAR, and CD14.

228 L-15 also resulted in poor expression of key effector molecules such as IFN-gamma, granzyme A and C,

229 Although the NKR-P1B(+) NK cells can produce effector molecules such as IFNs and granzymes, their pro

230 sferred CD8(+) T cells in vivo, upregulating effector molecules such as perforin, granzyme B, and IFN

231 nd specificity for a tumor target that carry effector molecules such as toxins, cytokines, or radiola

232 ed cells through RLR induction of downstream effector molecules such as type I interferon (IFN) and o

233 m or stimulating the production of secondary effector molecules (such as proinflammatory cytokines) d

234 er certain conditions, these cells and their effector molecules, such as IL-17, IL-21, IL-22, GM-CSF,

235 concomitant reduced expression of antiviral effector molecules, such as MxA/B.

236 expression profiles and secretion of diverse effector molecules, suggesting functional heterogeneity.

237 ests in the upregulation of a poorly studied effector molecule, TGFbeta1-induced-1, which is a TGFbet

238 sults highlight TRAIL as a key ILC1-utilized effector molecule that can operate in defense against pe

239 de strong evidence that DSPP is a downstream effector molecule that mediates the roles of DMP1 in den

240 IL-10 is considered a chief effector molecule that promotes the vitamin D-induced im

241 protein 3 (TDRD3) is a major methylarginine effector molecule that reads methyl-histone marks and fa

242 Thus, Fgl2 is a TFR cell effector molecule that regulates humoral immunity and li

243 vesicles into the external milieu to deliver effector molecules that alter the host and facilitate vi

244 Furthermore, the screen identifies effector molecules that are necessary for cell-cell inte

245 ense system encompassing sensors and various effector molecules that arrange and achieve a fine-tuned

246 uggestion has been to develop genes encoding effector molecules that block parasite development withi

247 ly modified, resulting in the recruitment of effector molecules that can influence transcription.

248 en shown to carry a wide array of biological effector molecules that can play roles in cell-to-cell c

249 e developed a distinct profile of neutrophil effector molecules that closely reflected the one observ

250 high concentrations they act as microbicidal effector molecules that destroy intracellular pathogens,

251 similarities and differences in sensors and effector molecules that determine host resistance to the

252 anti-tumor immune responses are mediated by effector molecules that enable successful elimination of

253 sicular trafficking mechanisms controlled by effector molecules that include small GTPases and their

254 Tick saliva contains a number of effector molecules that inhibit host immunity and facili

255 Proteins are effector molecules that mediate the functions of genes(1

256 nd proteome are mediated by pathogen-encoded effector molecules that modulate host cells through a va

257 c neutrophils may serve to inactivate select effector molecules that promote the pro-inflammatory act

258 ike growth factor 1) signal to intracellular effector molecules that regulate glucose homeostasis, be

259 h can act either indirectly or via dedicated effector molecules that target degradosome assemblies.

260 lar messengers amplify signals by binding to effector molecules that trigger physiological changes.

261 h most CRP family members are coregulated by effector molecules, the activity of FixK2 is negatively

262 action profile between GR and its downstream effector molecules, the nuclear receptor coregulators, c

263 ll types through activation of intracellular effector molecules, the Smads (small mothers against dec

264 -specific memory CD8 T cells did not express effector molecules, their epigenetic landscape resembled

265 nize such DAMPs and PAMPs, or the downstream effector molecules they engender, to limit inflammation.

266 tudy, we identify Fgl2 as a soluble TFR cell effector molecule through single-cell gene expression pr

267 ory activity of NF-kappaB and its downstream effector molecules TNF-alpha, IL-1beta, and IL-6 at the

268 o measured the production of 8 HCMV-specific effector molecules (TNFalpha, IFNgamma, interleukin 2, g

269 immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the c

270 d inducible nitric oxide synthase (NOS2) (an effector molecule to inhibit T. gondii growth) and the n

271 unidentified switch region that engages with effector molecules to drive beta-arrestin signaling.

272 Fungal plant pathogens secrete effector molecules to establish disease on their hosts,

273 vesicles (EVs) that can transfer a range of effector molecules to host cells has made us re-think ou

274 omponents and play a role in the delivery of effector molecules to host cells.

275 because of the binding of specific signaling effector molecules to individual phosphorylated P-sites.

276 adelta T cells that produced IL-17 and other effector molecules to promote inflammation and tumor cel

277 proteins Nck1/2 interact with a multitude of effector molecules to regulate diverse cellular function

278 on between receptor proteins and adaptor and effector molecules to regulate signal generation, amplif

279 Pathogens release effector molecules to suppress PTI.

280 sCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anoph

281 es symbiotic bacteria to deliver antimalaria effector molecules to the midgut lumen, thus rendering h

282 Targeting effector molecules to tumor cells is a promising mode of

283 ariable domains bind but also in the various effector molecules to which their constant regions (Fc d

284 used chemical methods for the attachment of effector-molecules to the antibody of interest.

285 ated from human peripheral blood express the effector molecule TRAIL.

286 tinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73.

287 owever, little is known about mechanisms and effector molecules triggering fibrosis and angiogenesis

288 (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control

289 in mice deficient in STING or its downstream effector molecules was analyzed.

290 factor 1 (CNF1), an Escherichia coli-derived effector molecule, we showed the host indirectly sensed

291 st cancer, expression of IL12A and cytotoxic effector molecules were predictive of pathological compl

292 rients and facilitating the translocation of effector molecules, whereas the exo-oligoxylanase XynA p

293 These methyl marks are interpreted by effector molecules, which harbor protein domains that bi

294 ke and NK cells expressing antimycobacterial effector molecules, which may be novel targets for tuber

295 protoxin-neutralizing antibodies are the key effector molecules while a shift to Th1 or Treg cells ma

296 repressors, these RNA elements must bind an effector molecule with high specificity against a backgr

297 The small fast-clearing radiolabelled effector molecules with a complementary functionality di

298 ural injury involves multiple cell types and effector molecules with both positive and negative effec

299 em cell memory (TSCM) CD8 T cells identified effector molecules with demethylated promoters and poise

300 mas, resulting in elevated expression of the effector molecule Yes-Associated Protein (YAP).