ライフサイエンスコーパス: effector protein

1 ) that was derived from a CheY-like c-di-GMP effector protein.

2 elevated response is independent of the CagA effector protein.

3 , and ARGONAUTE4 (AGO4) is a major het-siRNA effector protein.

4 ation, as the most abundant type II secreted effector protein.

5 eraction with SidK, a Legionella pneumophila effector protein.

6 oviding a three-dimensional model of an Avr4 effector protein.

7 of its bifunctional role as a biomarker and effector protein.

8 morphisms in gasdermin D, the key pyroptotic effector protein.

9 to convey information from a receptor to an effector protein.

10 lass of RAS variants with its regulatory and effector proteins.

11 recruiting to the membrane a specific set of effector proteins.

12 lack of methods to target specific RNAs with effector proteins.

13 ls by injecting them with type III secretion effector proteins.

14 nds with different efficacy or intracellular effector proteins.

15 switch regions that interact with signalling effector proteins.

16 sed by the type III secretion system and its effector proteins.

17 AnkG is one of these anti-apoptotic effector proteins.

18 act host cell membranes and deliver type III effector proteins.

19 result in transcriptional down-regulation of effector proteins.

20 nt immunity that works by directly disarming effector proteins.

21 (a vesicle priming protein) as the relevant effector proteins.

22 members, which then recruit distinct sets of effector proteins.

23 at this pentameric assembly binds Legionella effector proteins.

24 al proteins and that compete with downstream effector proteins.

25 une responses, pathogens secrete an array of effector proteins.

26 alling molecules rather than specific CRISPR effector proteins.

27 fs and motif mimicry by pathogenic bacterial effector proteins.

28 te with intracellular pH regulate binding to effector proteins.

29 ed G protein-coupled receptors to downstream effector proteins.

30 domains that interact with distinct sets of effector proteins.

31 s' competence to bind multiple regulator and effector proteins.

32 d by a deregulated recruitment of downstream effector proteins.

33 ng competitors by translocating unique toxic effector proteins.

34 these probably encode the minimal core venom effector proteins.

35 Rab-GTPase binding effector protein 2 (RABEP2) was identified as a novel GS

36 or indirectly through translocated bacterial effector proteins [7-9].

37 Salmonella enterica translocates virulence (effector) proteins across its vacuolar membrane via the

38 egatively and has demonstrated regulation of effector protein activities by cognate metaeffectors as

39 The effector proteins, alkyl hydroperoxide reductase and ace

40 These effector proteins all engage the same face of Cdc42, the

41 tion to CRISPR/Cas systems and the different effector proteins and continue with reviewing the recent

42 ExoU is the most cytotoxic of the known effector proteins and has been associated with more seve

43 rface significantly reduced the secretion of effector proteins and HeLa cell cytotoxicity.

44 how higher oligomeric complexes assemble on effector proteins and if intermediates in assembly pathw

45 ytolytic potential by upregulating cytotoxic effector proteins and IFN-gamma.

46 ptors (NLRs), to recognize specific pathogen effector proteins and induce immune responses.

47 Pathogens secrete effector proteins and many operate inside plant cells to

48 al information about the interaction between effector proteins and the motor are scarce.

49 structures, and quaternary conformations of effector proteins and TPT were studied.

50 at (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to re

51 andidate effector genes revealed common smut effector proteins and unique members.

52 hroughput, modification or overexpression of effector proteins, and low temporal resolution.

53 clase activation, tuned binding constants of effector proteins, and physical interaction between cycl

54 tors of G proteins and randomly selected non-effector proteins, and tested their sensitivity and spec

55 engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit d

56 In this study, we identified the calcium-effector protein annexin A2 as a novel binding partner f

57 Second, effector proteins are injected.

58 While the Cas effector proteins are remarkably diverse, they commonly

59 Some effector proteins are secreted and are destined to be tr

60 Yet, how a large number of effector proteins are selectively recruited and processe

61 In this method Cas effector proteins are used as highly specific sequence r

62 em (T4SS) that mediates delivery of the CagA effector protein as well as nonprotein bacterial constit

63 es to effect different functions, binding to effector proteins as monomers, intercalated dimers or, u

64 lpha at Ser(51), upregulating its downstream effector proteins ATF4 and GADD45alpha.

65 ausal agent of tomato wilt disease, produces effector protein Avr2.

66 nse triggered by the Xanthomonas vesicatoria effector protein AvrBsT in Nicotiana benthamiana, sugges

67 The Pseudomonas syringae effector protein AvrRpm1 activates the Arabidopsis (Arab

68 ved protective protein serodominant secreted effector protein B (SseB-MB) was evaluated in a mouse in

69 Here we characterize a likely effector protein bearing a deubiquitylase (DUB) domain f

70 retion systems (T6SSs) deliver antibacterial effector proteins between neighboring bacteria.

71 h mediates its interaction with several host effector proteins, bind to intact HIV-1 cores or in vitr

72 enicity relies on secretion of more than 300 effector proteins by a type IVb secretion system.

73 Complement activation generates the core effector protein C5a, a potent immune molecule that is l

74 ty island contains genes encoding a secreted effector protein (CagA) and components of a type IV secr

75 tion system consisting of an injectisome and effector proteins, called Yersinia outer proteins (Yops)

76 es important proof of concept that bacterial effector proteins can be a useful toolbox to identify ho

77 Secreted effector proteins can either display their activity in t

78 k Cas1 and Cas2 and encompass a single large effector protein, Cas13b, along with one of two previous

79 ex comprised of CARMA3, Bcl10, and the MALT1 effector protein (CBM complex).

80 odifications (PTMs) and their recognition by effector protein complexes.

81 within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy.

82 CR repertoire, and accumulated intracellular effector proteins, consistent with a cytotoxic lymphocyt

83 gion of RAS interacts with a large number of effector proteins containing a common RAS-binding domain

84 By investigating C. burnetii effector proteins containing eukaryotic-like domains, he

85 ost cells, Chlamydia pneumoniae secretes the effector protein CPn0678, which facilitates internalizat

86 lating host-cell functions using hundreds of effector proteins delivered by its Dot/Icm secretion sys

87 type III secretion system to secrete various effector proteins directly into mammalian host cells.

88 nes widely used by bacteria to deliver toxic effector proteins directly into neighbouring cells.

89 eruginosa type III secretion system delivers effector proteins directly into target cells, allowing t

90 Although such effector proteins disrupt critical cellular signaling pa

91 Ca(2+) sensor, as the first neuroprotective effector protein downstream of the TF NPAS4.

92 silico analysis identified a small secreted effector protein dubbed Suppressor of Host Resistance 4z

93 i secretes many functionally uncharacterized effector proteins during infection.

94 Here, we show that the PgtSR1 effector proteins, encoded by two allelic genes (PgtSR1-

95 l established, and it is known that pathogen effector proteins encoding acetyltransferases can direct

96 ense research focus on secreted Phytophthora effector proteins, especially those containing a conserv

97 In the case of P. aeruginosa, the effector protein ExoS is central to limiting effector in

98 en species burst using two type III secreted effector proteins, ExoS and ExoT.

99 ADP-ribosyltransferase domain of the related effector protein ExoT also participates.

100 n kinase, catalytic subunit; WEE1; CDC7), or effector proteins for repair (POLQ [also referred to as

101 ike effectors (TALEs) are bacterial Type-III effector proteins from phytopathogenic Xanthomonas speci

102 the export element (PEXEL) found in malaria effector proteins from Plasmodium falciparum These findi

103 The ZAR1 NLR recognizes diverse effector proteins from Pseudomonas syringae, including H

104 test the ability of 200 type III and type IV effector proteins from six Gram-negative bacterial speci

105 folds or as decoys that recruit or sequester effector proteins from their DNA, RNA, or protein target

106 which is required to translocate at least 28 effector proteins from vacuolar-resident bacteria into h

107 he ICR2 using a transcription activator-like effector protein fused to the catalytic domain of TET1 (

108 ng either MuSK or rapsyn (a cytoplasmic MuSK effector protein) fused to green fluorescent protein (Mu

109 structural protein sigmaNS with the major SG effector protein G3BP1 and subsequent localization of G3

110 cleavage and activation of the pore-forming effector protein gasdermin D by inflammatory caspases.

111 nflammatory caspases activate the pyroptosis effector protein gasdermin D, but caspase-1 mostly activ

112 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling a

113 SipA, a multi-function effector protein, has been shown to affect intracellular

114 adaptive immune systems in prokaryotes whose effector proteins have become powerful tools for basic r

115 al shutoff environment.IMPORTANCE SGs and SG effector proteins have emerged as important, yet poorly

116 onfers resistance to calprotectin, an immune effector protein highly produced in neutrophils that has

117 isolated Response to the bacterial type III effector protein HopBA1 (RBA1), a gene that encodes a TI

118 ial pathogen Pseudomonas syringae deploys an effector protein, HopO1-1, that modulates PD function.

119 SP) and Ena-VASP-like (EVL) are cytoskeletal effector proteins implicated in regulating cell morpholo

120 ovide docking sites for distinct adapter and effector proteins important for regulating discrete SUMO

121 approach is to target other tumour-exclusive effector proteins important in RAS signalling.

122 cytoplasm to degrade lipids also acts as an effector protein in the host cell cytoplasm to suppress

123 Perforin is a key effector protein in the vertebrate immune system and is

124 To profile disease effector proteins in CAPN5-NIV patient vitreous, liquid

125 HI-base 4 are the direct targets of pathogen effector proteins in experimental and natural host organ

126 te the discovery of non-classically secreted effector proteins in Gram-positive bacteria and further

127 mechanisms by which H3 tails are read out by effector proteins in the cell.

128 Various PP2A-associated downstream effector proteins in the presence or absence of FTY720 w

129 strain of L. pneumophila in which all of the effector proteins in the SidE family were deleted; howev

130 Finally, the potential role of nematode effector proteins in triggering such epigenome changes i

131 kinase (MuSK) and rapsyn (a cytoplasmic MuSK effector protein) in the tibialis anterior muscle of wil

132 r the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and an

133 s and targeted by several bacterial type III effector proteins including the cysteine protease AvrRpt

134 generalizable approach to deliver a range of effector proteins, including nucleases, degradation mach

135 Many parasite effector proteins, including perforins, adhesins, and pr

136 he molecular weight and isoelectric point of effector proteins, induce their methylation or demethyla

137 However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by

138 protein from the first group is a bona fide effector protein injected into host cells during infecti

139 Effector proteins injected into the host cell by the C.

140 SS), which facilitates the delivery of toxic effector proteins into adjacent cells(4,5).

141 ecretion systems (T3SSs) to inject virulence effector proteins into eukaryotic cells.

142 have evolved to deliver bacterially encoded effector proteins into eukaryotic cells.

143 type III secretion system (T3SS) to deliver effector proteins into eukaryotic host cells.

144 ey illustrate how phytonematodes can deliver effector proteins into host cells and then hijack plant

145 I secretion systems (T3SSs) inject bacterial effector proteins into host cells and underlie the virul

146 ilament dynamics.Microbial pathogens secrete effector proteins into host cells to affect cellular fun

147 Pathogenic bacteria inject effector proteins into host cells to manipulate cellular

148 secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular

149 ella enterica serovar Typhimurium can inject effector proteins into host cells via type III secretion

150 ia, the type III secretion system transports effector proteins into host cells, converting resources

151 secretion system (T3SS) to inject cytotoxic effector proteins into host cells.

152 type III secretion system (T3SS) to deliver effector proteins into host cells.

153 ) is extremely versatile, translocating ~300 effector proteins into host cells.

154 To cause disease, diverse pathogens deliver effector proteins into host cells.

155 a type III secretion system (T3SS) to inject effector proteins into host cells.

156 m Type IV Secretion System (T4SS) to deliver effector proteins into host cells.

157 IV secretion system to translocate over 300 effector proteins into host cells.

158 te host cell pathways by directly delivering effector proteins into host cells.

159 ystem (T3SS) to promote disease by injecting effector proteins into host cells.

160 host immune systems, these yersiniae inject effector proteins into host macrophages.

161 s a Type IV secretion (T4S) system to inject effector proteins into human macrophages.

162 -negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kil

163 perature promotes translocation of bacterial effector proteins into plant cells and causes a loss of

164 SS) is a bacterial nanomachine that delivers effector proteins into prokaryotic and eukaryotic preys.

165 lycines, the soybean cyst nematode, delivers effector proteins into soybean roots to initiate and mai

166 ane of a eukaryotic cell to deliver multiple effector proteins into the cytosol of the target cell.

167 Dot/Icm apparatus translocates more than 300 effector proteins into the host cell cytosol.

168 ion system (T4SS) to translocate a cohort of effector proteins into the host cell, which modulate mul

169 Legionella pneumophila translocates over 300 effector proteins into the host cytosol, allowing the pa

170 retion system to translocate a repertoire of effector proteins into the hosts for their survival and

171 eudomonas syringae pv. tomato (Pst) delivers effector proteins into the plant cell to promote host su

172 of other core autophagy proteins and various effector proteins involved in trafficking or fusion even

173 Enhanced secretion of tumorigenic effector proteins is a feature of malignant cells.

174 Consequently, the identification of novel effector proteins is an important step in increasing our

175 of influenza lethality-associated neutrophil effector proteins is currently unknown.

176 robust host defense suppression by pathogen effector proteins is essential for infection success.

177 Common to many T3SSs is that injection of effector proteins is feedback inhibited.

178 In Yersinia, the switch to secretion of effector proteins is induced first after intimate contac

179 tosis, GSDMD (gasdermin D), the pore-forming effector protein, is cleaved, forms oligomers, and inser

180 ach, RNA-Seq studies confirmed that the RhoA effector Protein Kinase N1 (PKN1) transduces androgen-re

181 sion of antiviral responses dependent on the effector protein kinase R (PKR).

182 NP uptake; inhibiting TLR4 or its downstream effector protein kinase R improved delivery.

183 stigate auto-regulation of the innate immune effector protein kinase R, which phosphorylates the euka

184 SOCE also activated the cAMP effector, protein kinase A (PKA), as determined by the P

185 neurotransmitters via activation of its main effector, protein kinase A (PKA).

186 tes the activity of its essential downstream effector, protein kinase Ypk1.

187 sphorylation at the tandem site, through its effectors protein kinase A (PKA) and exchange proteins d

188 ins are critical upstream modulators of many effector protein kinases.

189 inhibition of protease LapG by the c-di-GMP effector protein LapD, and resulting in proteolysis of t

190 ful immune response by activating downstream effector proteins, leading to viral clearance, cell dorm

191 multimolecular complex including downstream effector proteins linked to AR (AR-axis) responsible for

192 introduce LOCALIZER for predicting plant and effector protein localization to chloroplasts, mitochond

193 sufficiently high concentrations to modulate effector proteins located in the intimate vicinity of th

194 Distinct receptors and effector proteins, many of which are glycosylated, are t

195 ic Escherichia coli through the action of an effector protein, McpM.

196 Here we identify the novel effector protein Mif1.

197 s factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase domain-like protei

198 oth RIPK1 and RIPK3, but not the necroptosis effector protein, MLKL.

199 These effector proteins modulate a variety of host transcripti

200 The type III secretion system effector protein NleE from enteropathogenic Escherichia

201 The bona fide F-box AnkB effector protein of L. pneumophila strain AA100/130b is

202 ets while in association with Argonaute, the effector protein of the miRNA-mediated silencing complex

203 d up-regulation of GADD45alpha, the ultimate effector protein of this stress signaling cascade.

204 HopAF1 is a type III effector protein of unknown function encoded in the geno

205 This highlights how target effector proteins of small-molecule ligands can promote

206 Because cAMP effector proteins often cluster together with their targ

207 Loss of either the I-B effector proteins or Cas3 reduced naive adaptation.

208 The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical pro

209 The secreted effector protein Pit2 is an inhibitor of papain-like cys

210 fat body including the presence of the piRNA effector protein Piwi and canonical 23-29 nt long TE-map

211 had been previously developed, including RAS effector protein-protein interaction inhibitors selected

212 ation and occurred via association of the SG effector protein, Ras-GAP SH3-binding protein 1 (G3BP1),

213 Here we show that the L. pneumophila effector protein RavD targets host membrane compartments

214 The effector proteins RavY and Lpg2505 were important for ef

215 ption of the host autophagy machinery by the effector protein RavZ.

216 Essential effector proteins read the tubulin glutamylation pattern

217 ied as a direct target of PthA4, a bacterial effector protein required to induce tumors in citrus.

218 d transmembrane proteins (IFITMs) are innate effector proteins restricting host cell entry of many en

219 how dynamic networks of sibling cyclases and effector proteins result in sensible outputs that govern

220 Loss-of-function mutations in genes encoding effector proteins resulted in host-specific or broad vir

221 ssociate with non-orthologous regulatory and effector proteins retaining functions similar to those i

222 recruitment, and complex formation with the effector protein SAV1, each increase the kinase domain p

223 ter model to identify a novel function of an effector protein secreted by Vibrio parahaemolyticus, wh

224 unteracts host cytotoxicity displayed by the effector protein SidI.

225 stal structure of the Legionella pneumophila effector protein, SidJ, in complex with the eukaryotic C

226 -diaminopimelic acid]) and the S Typhimurium effector protein SopE.

227 report that L. pneumophila translocates the effector protein sphingosine-1 phosphate lyase (LpSpl) t

228 t shell protein (PduA), a type III secretion effector protein (SteA), and a metabolic enzyme (malate

229 iptional response in macrophages through its effector protein SteE.

230 chanistic studies revealed "deactivation" of effector proteins such as Akt, Erk1/2, Src, STAT1, and S

231 verified that Rac1, RhoA, and some of their effector proteins such as PAK and ROCK, are likely anti-

232 Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have

233 h ZAR1 and provide specificity for different effector proteins, such as HopZ1a.

234 ins (ZFP), four transcription activator-like effector proteins (TALE), CRISPR associated protein 9 (S

235 The two Tribolium piRNA pathway effector proteins, Tc-Piwi/Aub and Tc-Ago3, are also exp

236 The Brucella effector protein TcpB suppresses Toll-like receptor 2 (T

237 one of the interacting partners of Brucella effector protein TcpB that negatively regulates TLR2 and

238 Pathogenic Yersinia bacteria inject effector proteins termed Yops, as well as pore-forming p

239 1 genes and secretes lesser amounts of SPI-1 effector proteins than S. Typhimurium, especially under

240 s the first to thoroughly characterize a Rab effector protein that contains two separate Rab binding

241 Helicobacter pylori CagA is a secreted effector protein that contributes to gastric carcinogene

242 Complexin-1 is a SNARE effector protein that decreases spontaneous neurotransmi

243 indicate that CstK functions as a bacterial effector protein that interacts with the host protein TB

244 invasion protein A (SipA) is a dual-function effector protein that plays roles in both actin polymeri

245 sponsible for the secretion of a plethora of effector proteins that alter the biology of the host cel

246 ght pathogen Phytophthora infestans secretes effector proteins that are delivered inside (cytoplasmic

247 a encodes a repertoire of over 300 different effector proteins that are delivered into host cells by

248 nt is in part due to the action of seven Yop effector proteins that are directly injected into host c

249 punctures adjacent cells and delivers toxic effector proteins that are harmless to bacteria carrying

250 f these 3'-UTR functions are accomplished by effector proteins that are recruited by RNA-binding prot

251 to modulate autophagy through the action of effector proteins that are translocated into the host ce

252 function largely through the recruitment of effector proteins that contain specialized "reader" doma

253 pe IV secretion system (T4SS) to translocate effector proteins that direct the formation of a parasit

254 y plant-pathogenic bacteria and fungi deploy effector proteins that down-regulate plant defense respo

255 uses two type-3 secretion systems to inject effector proteins that facilitate Salmonella entry, esta

256 II secretion system (T3SS) to translocate 50 effector proteins that hijack and manipulate host cell s

257 ic bacterium Legionella pneumophila secretes effector proteins that induce the conversion of the plas

258 anti-bacterial immunity through translocated effector proteins that inhibit pro-inflammatory signalin

259 ial pathogen Legionella pneumophila secretes effector proteins that manipulate host cell components,

260 s encode proteins that appear to function as effector proteins that may regulate symbiotic associatio

261 he identification and mode of action of T6SS effector proteins that mediate this protective effect re

262 The activity of the effector proteins that perform and coordinate these biol

263 gomers, and nanoclusters as landing pads for effector proteins that relay RAS signals.

264 ain binds, directly or indirectly, different effector proteins that transmit signals.

265 g pathogenesis, V. parahaemolyticus secretes effector proteins that usurp the host's innate immune si

266 Many bacterial pathogens secrete virulence (effector) proteins that interfere with immune signaling

267 From this niche, they secrete "effector" proteins, that modify cellular activities to e

268 F-box adaptor protein Dia2 and an endosomal effector protein, the phosphatidylinositol 3-kinase Vps3

269 Pathogenic Yersinia species deliver Yop effector proteins through a type III secretion system in

270 le or stabilisable orthologous dCas9 or Cpf1 effector proteins, thus opening options for multidimensi

271 s a restricted host range and uses different effector proteins to alter host signaling.

272 associated proteins and functions to recruit effector proteins to chromatin through its ability to bi

273 l G proteins, Cdc42 binds to many downstream effector proteins to elicit its cellular effects.

274 lant pathogen Phytophthora encodes conserved effector proteins to eliminate host secondary siRNAs.

275 their hosts, they employ a large arsenal of effector proteins to establish a successful infection.

276 arsenal of hundreds of Dot/Icm-translocated effector proteins to facilitate replication within eukar

277 , we show that Y RNAs tether Ro60 to diverse effector proteins to generate specialized RNPs.

278 Filamentous plant pathogens deliver effector proteins to host cells to promote infection.

279 Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways,

280 Plant pathogens employ effector proteins to manipulate their hosts.

281 topathogenic bacteria deploy a repertoire of effector proteins to perturb immune signaling.

282 orm of T-DNA (T-strands) and Virulence (Vir) effector proteins to plant cells.

283 Pathogens secrete effector proteins to suppress host immunity, mediate nut

284 rulence factors, such as secreted toxins and effector proteins, to manipulate host cellular processes

285 nd the intracellular replication of Coxiella Effector proteins, translocated into the host cell throu

286 le pore protein EspD, which is essential for effector protein translocation into host cells.

287 ripts, however the downstream mechanisms and effector proteins utilized by MIWI2 in directing de novo

288 One secreted effector protein, VopA, has potent inhibitory effects on

289 a four-subunit T4CP subcomplex bound to the effector protein VpdB reveals an interaction between Lvg

290 CR signaling shared a considerable number of effector proteins, we identified distinct phosphorylatio

291 system can be reprogrammed by replacing the effector protein, which may be relevant for maintenance

292 CDI(+) strains express cell-surface CdiA effector proteins, which carry a toxic C-terminal region

293 c2-b, also known as exophilin-5, is a Rab27b effector protein with a role in exosome transport and is

294 in eukaryotes, reportedly serve as bacterial effector proteins with deSUMOylase, deubiquitinase, or,

295 in the perception of many different pathogen effector proteins with specificity dictated by associate

296 as a target of the Xanthomonas euvesicatoria effector protein Xanthomonas outer protein N (XopN), a s

297 n immune response triggered by the bacterial effector proteins XopQ and HopQ1, respectively.

298 duct development by binding to Hippo pathway effector proteins YAP1, TAZ and TEAD4 and promoting thei

299 ractions with the WW-domain-containing Hippo effector protein Yes-associated protein (YAP).

300 ng et al. (2016) show that the Yersinia T3SS effector protein YopM counteracts this recognition pathw