ライフサイエンスコーパス: efficacious

1 imaging distinguishable and therapeutically efficacious.

2 xacin and levofloxacin were found to be >90% efficacious.

3 objectives) suggested that this agent may be efficacious.

4 ptor pathway blockade would be tolerable and efficacious.

5 o N. gonorrhoeae-colonized mice were equally efficacious.

6 ry checkpoint proteins CTLA-4 and PD(L)1 are efficacious across a broad range of cancers, resulting i

7 we report on a highly-specific, potent, and efficacious activator of brain GIRK1/2 channels.

8 Nivolumab remains an efficacious adjuvant treatment for patients with resecte

9 These findings provide novel data on efficacious administration strategies for ketamine in pa

10 egy to isolate such cells for safer and more efficacious adoptive cell therapy.

11 Though trametinib is highly efficacious, adverse side effects, including skin, gastr

12 y DAP (10 mg/kg) plus AMP or amoxicillin was efficacious against a DAP-R E. faecium strain, and pbp5

13 , or ceftaroline has been demonstrated to be efficacious against a DAP-tolerant Enterococcus faecium

14 ell tolerated in BALB/c nude mice and highly efficacious against AR42J tumors in vivo.

15 st that a single vaccine candidate should be efficacious against currently circulating lineages.

16 n (GRFT), has been shown to be both safe and efficacious against HSV-2 and HIV-1 infections in vivo.

17 anti-IFN-gamma) have been demonstrated to be efficacious against influenza and other respiratory infe

18 These studies reveal that H84T is efficacious against influenza virus in vivo, and that th

19 e kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies.

20 In addition, WM382 was efficacious against P. falciparum asexual infection in h

21 Moreover, CMP-Leg5,7Ac(2) was efficacious against several multidrug-resistant gonococc

22 able safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim

23 TAK-003 was well tolerated and efficacious against symptomatic dengue in children regar

24 TAK-003 was efficacious against symptomatic dengue in countries in w

25 ch re-empower the antibiotic agent to become efficacious against the resistant strain of interest.

26 These results indicate that ZIKV-IG is efficacious against ZIKV, suggesting this human polyclon

27 hile preserving the microbiome to develop an efficacious agent.

28 Although not the most efficacious agonist, RTI-76 was the most potent desensit

29 inetic analysis revealed that terpenoids are efficacious agonists for 5-HT(3)A receptors.

30 e partial agonists: they are among the least efficacious agonists of Ins(1,4,5)P(3)R yet identified,

31 ar septal defect (VSD) closure is a safe and efficacious alternative to surgery.

32 l cells, and have the potential to be a more efficacious alternative to traditional oral antibiotic r

33 ribed, with 20 and 26 identified as the most efficacious analogs with 3~8-fold and 2~4-fold greater p

34 Current treatments are insufficiently efficacious and associated with side effects.

35 3 by binding the cytokine's p19 subunit, was efficacious and demonstrated an acceptable benefit-risk

36 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines.

37 Lacosamide was efficacious and generally safe as adjunctive treatment f

38 n further improved with the licensure of the efficacious and less toxic letermovir.

39 f long-term follow-up, and the need for more efficacious and less toxic therapeutic approaches for ad

40 dence that these multi-action inhibitors are efficacious and more potent than single inhibitory chemo

41 r findings provide evidence that apixaban is efficacious and safe across the spectrum of weight, incl

42 tion of HIV infection was demonstrated to be efficacious and safe earlier this decade from pivotal st

43 sound-guided percutaneous liver biopsy is an efficacious and safe technique for the histological diag

44 esolution of MRONJ lesions and represents an efficacious and safe treatment for it.

45 n B and MIL combination for treating PKDL is efficacious and safe, with high tolerability.

46 the construction of attenuated strains more efficacious and safer than BCG.

47 BI in which the experimental therapy was 50% efficacious and the control was 80% efficacious, with an

48 adults, however vaccines are generally less efficacious and the molecular mechanisms that underpin t

49 irone, and agomelatine were also found to be efficacious and well tolerated but these findings were l

50 or with a Framingham score >=10% was highly efficacious and well tolerated, and improved the lipid p

51 -viremic grafts in the DAA era appears to be efficacious and well tolerated.

52 Imipenem/relebactam is an efficacious and well-tolerated treatment option for carb

53 mine (1), a highly potent, selective, orally efficacious, and first-in-class SHP2 inhibitor currently

54 ing of why the gB/MF59 vaccine was partially efficacious, and such investigations will inform future

55 2017, 60, 4969), was potent, selective, efficacious, and well tolerated in preclinical models, b

56 ious tool compound, 3 was potent, selective, efficacious, and well tolerated in preclinical models, b

57 y binding site is required to develop a more efficacious antibody.

58 tive of the future development of additional efficacious anticancer agents derived from natural produ

59 t drug target as it holds promise to deliver efficacious anticoagulation without an enhanced risk of

60 se tissues may guide the development of more efficacious antidepressant treatments.

61 There is an urgent need to develop new efficacious antimalarials to address the emerging drug-r

62 pplied to high-content screening of new more efficacious antiplatelet therapies.

63 WH) with persistently low CD4 counts despite efficacious antiretroviral therapy could have higher hos

64 In vivo, 15 showed more efficacious antitumor activity than the corresponding dr

65 SYNB1891 treatment results in efficacious antitumor immunity with the formation of imm

66 More efficacious antiviral immune interventions, perhaps pair

67 Thus, the identification of new and efficacious antivirals is of the highest importance.

68 Further efficacious application of the method to real samples re

69 Catheter ablation is the most efficacious approach to eradicate PVCs but may confer in

70 Inhibition of HSP70 was efficacious as a single agent in primary and metastatic

71 Y Phase 2 study showed brolucizumab to be as efficacious as aflibercept in a q8-week regimen with reg

72 able tafenoquine polymer were found to be as efficacious as an equivalent dose of the oral parent dru

73 triterpene oils, all of which are equally as efficacious as vaccine adjuvants based on physiochemical

74 AB569 was also efficacious at killing the model organism Pseudomonas ae

75 ivation in primary sensory neurons and to an efficacious attenuation of the pain perception in an in

76 of cyclopropylthiazines as potent and orally efficacious BACE1 inhibitors.

77 d sequentially, but that high doses are less efficacious because of excessive vessel pruning and hypo

78 to reduce the financial burden of the highly efficacious biologic therapy in retinal pathologies.

79 llectively, our findings have resulted in an efficacious, brain-penetrant GPR52 agonist as a valuable

80 , such as acyclovir and docosonal, which are efficacious but maintain the potential for the developme

81 , 6, and 4 mg/kg in combination with AMP was efficacious but showed delayed killing compared with 10

82 s with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning.

83 f stoichiometric In(2)O(3) are proving to be efficacious catalysts for the gas-phase hydrogenation of

84 ng unique transcription factor TWIST1 for an efficacious cell transplantation therapy to induce neova

85 tions and enable the development of safe and efficacious clinical genome editing.

86 brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorder

87 The efficacious combination of these compounds with doxorubi

88 Efficacious combination therapies are thus needed to blo

89 , thereby facilitating the discovery of more efficacious combination therapies to block drug-tolerant

90 ), biventricular single-site pacing was less efficacious compared to patients with LVEDVI(<=Median) (

91 in achieving stable and targeted delivery of efficacious concentrations within the desired brain regi

92 scovery of M-808 (16) as a highly potent and efficacious covalent menin inhibitor.

93 Efficacious decontamination reduces the risk of harm to

94 The efficacious dose of a drug is perhaps the most holistic

95 n vivo, and is projected to have a low human efficacious dose.

96 than most other antipsychotic drugs at their efficacious doses and likely contributes to the favorabl

97 Knowledge of efficacious dosing respective to exercise type and pain

98 efficient and cost-effective way to identify efficacious drug candidates.

99 To date, there are no efficacious drugs and vaccines against MERS-CoV, increas

100 able option in the race to identify safe and efficacious drugs that can be used to prevent and/or tre

101 g monoaminergic receptors identified several efficacious drugs with comparable mechanisms, the focus

102 rmacology, and medicine to discover safe and efficacious drugs.

103 have implications for the development of an efficacious EBV vaccine to prevent both EBV-1 and EBV-2

104 o enhance signaling of the most abundant and efficacious endocannabinoid ligand, 2-arachidonoylglycer

105 iology, which may, in turn, be necessary for efficacious episodic memory.

106 These inhibitors were found to be efficacious even in presence of cancer associated fibrob

107 ch of the domains within the path leading to efficacious, evidence-supported treatments for pediatric

108 Therefore, ASFV-G-DeltaI177L is a novel efficacious experimental ASF vaccine protecting pigs fro

109 Sulfonylureas (SUs) provide an efficacious first-line treatment in patients with hepato

110 ge Systems (UMLS) to make the mapping system efficacious for clinical treatments.

111 sis indicated that antidepressants were also efficacious for depressive symptoms in those without dia

112 s are either too cytotoxic or insufficiently efficacious for GC.

113 e of a video during bed bath simulations was efficacious for improving the performance of psychomotor

114 ting that this drug is likely to be the most efficacious for patients with chronic idiopathic constip

115 though disease-modifying therapies have been efficacious for reducing relapse rates in MS, such treat

116 Remdesivir is efficacious for severe COVID-19 in adults, but data in p

117 Such policies can be less efficacious for specific individuals and should be scrut

118 ratory analysis suggest that eribulin may be efficacious for the treatment of locally advanced/MBC fo

119 of migraine, and CGRP-based therapeutics are efficacious for the treatment of migraine in humans.

120 vival signaling such as venetoclax may prove efficacious for treating SEMA7A(+) tumors.

121 3 polyunsaturated fatty acids (PUFAs) may be efficacious for treatment of major depressive disorder (

122 Rivaroxaban has been shown to be efficacious for treatment of venous thromboembolism in a

123 sults demonstrated that antidepressants were efficacious for women with depressive syndromes during a

124 ur studies outline the development of a more efficacious formulation than clinically representative l

125 of a promoter instead led to safer but still efficacious gene therapy.

126 rehabilitative strategies that are based on efficacious glycemia regulation, even if initiated days

127 Several potent and efficacious GPR52 agonists (12c, 23a, 23d, 23e, 23f, and

128 rotein B protein vaccine (gB/MF59), the most efficacious HCMV vaccine evaluated in a clinical trial,

129 Efficacious HIV-1 vaccination requires elicitation of lo

130 IV-1 each year, making the development of an efficacious HIV-1 vaccine an important unmet medical nee

131 An efficacious human immunodeficiency virus (HIV) vaccine w

132 tiple distinct gene variants could be highly efficacious if designed appropriately.

133 rs, as treatments are available and are most efficacious if initiated early in life.

134 ve nanoparticle, PC7A, capable of priming an efficacious immune response without significant systemic

135 children and adults typically generate more efficacious immune responses to vaccines and infections

136 entiated monocytes may serve as a simple and efficacious immunotherapy for the treatment of human can

137 py, including how to make immunotherapy more efficacious in a broader range of cancer types and patie

138 us (rVSV) Ebola vaccine was shown to be very efficacious in a novel ring vaccination trial in Guinea.

139 available RSV inhibitor that was shown to be efficacious in a phase 2a challenge study in healthy adu

140 Conclusion: (67)Cu-CuSarbisPSMA is efficacious in a PSMA-expressing model of prostate cance

141 ster vaccine (RZV) is highly immunogenic and efficacious in adults >=50 years (Y) of age (YOA).

142 nd pathophysiological context and may not be efficacious in all contexts.

143 quilibrative nucleoside transporter 1 and is efficacious in an animal model of kidney ischaemia reper

144 nhibition of TWEAK/Fn14 interaction could be efficacious in anaphylaxis therapy.

145 enuate levels of S1P has been reported to be efficacious in animal models of diseases such as cancer,

146 (AAV) vectors have been shown to be safe and efficacious in clinical trials for diseases affecting di

147 ipid-based nutrient supplements (SQ-LNS) are efficacious in controlled settings; data are scarce on t

148 nation treatment with metformin and 2-DG was efficacious in dampening mouse T cell activation-induced

149 ding domain IgG titer convalescent plasma is efficacious in early-disease patients.

150 strong evidence that the energy drink is not efficacious in enhancing s-energy levels, nor any relate

151 mpounds discussed in this review have proven efficacious in human cell lines, patient-derived cells,

152 tformin, with or without basal insulin), was efficacious in improving glycemic control over 52 weeks.

153 To determine if the combination is efficacious in inhibiting metastasis, we treated mice wi

154 chotic drugs, such as aripiprazole, are less efficacious in internalizing D2R than most of the antipa

155 WASH interventions are needed that are more efficacious in interrupting fecal-oral microbial transmi

156 Furthermore, TLR4 signal blocking was less efficacious in limiting seizure susceptibility when AMPA

157 Both procedures are efficacious in lowering IOP in PACG, but the rate of com

158 Immune checkpoint blockade (ICB) is efficacious in many diverse cancer types, but not all pa

159 Longer acting forms of nomacopan were more efficacious in mouse EAU models, and the long-acting var

160 It is efficacious in murine models of both acute and establish

161 on of SU and incretin-based treatment may be efficacious in patients with HNF1A diabetes via potentia

162 Eribulin appeared efficacious in patients with locally advanced/MBC, irres

163 th erlotinib, methotrexate, and celecoxib is efficacious in platinum-refractory oral cavity cancers a

164 ng this TNFalpha-CCL5-macrophage axis may be efficacious in preventing breast cancer recurrence.

165 pathways that have shown to be individually efficacious in RA (in vitro, in vivo, and/or in humans)

166 n rat plasma and in rat liver microsomes and efficacious in rats when given orally to suppress rat pa

167 beta-adrenergic receptor antagonist that is efficacious in reducing facial pain.

168 nd personalizing prophylaxis for carriers is efficacious in reducing SSI.

169 lerated pan-Pim kinase inhibitor that proved efficacious in RPMI8226 and MM.1S human multiple myeloma

170 ific inhibitor FR900359 (FR) is unexpectedly efficacious in silencing the signaling of G(q) oncoprote

171 lts showed that the catholyte solutions were efficacious in the inactivation of the pathogen organism

172 For example, therapies targeting IL-17A are efficacious in the joint but not the gut, and interferin

173 Although proven efficacious in the management of moderate to severe acut

174 Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced

175 Whether they're still efficacious in the post-reperfusion era is currently deb

176 Posaconazole tablets are well tolerated and efficacious in the prophylaxis and treatment of aspergil

177 RZF was safe and efficacious in the treatment of candidemia and/or IC.

178 ydrogenase type 2 (17beta-HSD2), may be more efficacious in the treatment of osteoporosis.

179 Radioembolization is safe and efficacious in the treatment of patients with hepatocell

180 monstrate that modified UCN2 peptides may be efficacious in the treatment of type 2 diabetes by actin

181 vironment through engineering macrophages is efficacious in tumor therapy.

182 inhibitor, 2-2c, was identified as a novel, efficacious in vivo lead candidate.

183 PT2385 as a single-agent was efficacious in vivo, however, an increase in animal surv

184 papillomavirus (HPV) vaccination is safe and efficacious in women without human immunodeficiency viru

185 c driver event in cancer and its durable and efficacious inhibition is a focus in the development and

186 itor (IC(50), ~0.7-0.9 mum), is a potent and efficacious inhibitor of mouse AQP7 water permeability (

187 tious diseases enjoys an abundance of highly efficacious interventions (eg, antimicrobial agents, hum

188 Efficacious interventions are urgently needed for the tr

189 e dose proportional and exceeded preclinical efficacious levels.

190 n for more than 4 days post-implantation and efficacious local etoricoxib delivery.

191 MD-224 is thus a highly potent and efficacious MDM2 degrader and warrants extensive evaluat

192 ption of probiotic L. reuteri-lozenges is an efficacious measure to improve and maintain periodontal

193 Clinically efficacious medication in anticancer therapy has been su

194 Efficacious medication-based treatments are available an

195 non-invasive, cost-effective, and clinically efficacious modality to identify early damage and facili

196 Five compounds showed significantly more efficacious modulation of GABA-evoked currents than VA a

197 hlighted the urgency to design and test more efficacious next-generation malaria vaccines.

198 Herein, we report an efficacious, nickel-catalyzed synthesis of two important

199 In this study, we prepared the fully efficacious, nonbiased GPR84 agonist 6-hexylamino-2,4(1H

200 This study shows that OT-58 is a highly efficacious novel treatment for HCU on the background of

201 ffective, so there is a need to develop more efficacious NP attenuating drugs.

202 st in structure to epibatidine, was the most efficacious of the three compounds, also effectively act

203 cts, apomorphine sublingual film provided an efficacious, on-demand treatment for off episodes for mo

204 er the past few years provides hope for new, efficacious opioids devoid of the side effects that have

205 The availability of safe, efficacious, oral direct-acting antivirals (DAAs) have u

206 Despite being efficacious, oxytocin is enzymatically unstable and thus

207 ptors activated by acetylcholine alone, such efficacious PAMs may have cytotoxic side effects.

208 strategy is a promising candidate as a safe, efficacious pediatric bone tissue engineering strategy.

209 ty coupled with a low anticipated clinically efficacious plasma exposure for migraine also suggests a

210 Gamma knife radiosurgery is an efficacious primary method of treating uveal melanomas a

211 se problems will need additional work before efficacious pro-remyelination therapies will be ready fo

212 ith opening of the conjunctiva is a safe and efficacious procedure to lower IOP with comparable succe

213 ation range of 1.3-3.4 muM and provided more efficacious protection against Pg-induced inflammation i

214 n exists about potential adverse effects and efficacious readmission-reduction strategies are not wel

215 Our methodology provides an efficacious reference for the control and prevention of

216 urafine, and dynorphin peptides were equally efficacious regardless of the Galpha subunit present, th

217 DAP plus AMP was the only efficacious regimen against DAP-R R497 and prevented eme

218 iously reported the development of an orally efficacious ribonucleoside analogue inhibitor of influen

219 and reinstate the critical need for a safe, efficacious SPRM to treat UFs.

220 SD-36 is a potent, selective, and efficacious STAT3 degrader.

221 ith antibiotic treatment and drying the most efficacious steps.

222 ids enable the development of safer and more efficacious strategies in genetic and polynucleotide the

223 y involved in B-cell maturation, could be an efficacious strategy for treating B-cell malignancies.

224 ability of sequence-based design to deliver efficacious structure-specific compounds.

225 aria vaccine development in recent years, an efficacious subunit vaccine against Plasmodium falciparu

226 rine, MMCR may offer an efficient and highly efficacious surgery regardless of presenting MRD1.

227 ed as strategic goals for potent and broadly efficacious synthetic vaccines with potential market pro

228 study illuminates platelet activation as an efficacious target of aspirin, a widely available and af

229 Emapalumab was an efficacious targeted therapy for patients with primary h

230 Although colonoscopy is considered the most efficacious test, FIT might achieve higher participation

231 divided into 2 fractions over 2 wk was more efficacious than administration of a single fraction.

232 Doxycycline-sitafloxacin was more efficacious than doxycycline-moxifloxacin against infect

233 none of these medications appear to be more efficacious than first-generation antiseizure medication

234 cycline formulations were significantly more efficacious than free antibiotics in terms of survival r

235 At the mOTR, Pro(8)-OT was more efficacious than Leu(8)-OT in measures of G(q) activatio

236 rial treatment strategies that might be more efficacious than monotherapy.

237 s, MOE-modified ASO10-29 (MOE10-29) was more efficacious than morpholino-modified ASO10-29 (PMO10-29)

238 postoperative electrical stimulation is more efficacious than no stimulation or placebo in promoting

239 with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild

240 harmacologic interventions seemed to be more efficacious than pharmacologic interventions for reducin

241 (MD -2.45, 95% CrI -3.27 to -1.63) were more efficacious than placebo with relatively good acceptabil

242 tinib and gamitrinib were significantly more efficacious than single treatments and did not induce to

243 A-based gB vaccine may ultimately prove more efficacious than the gB/MF59 vaccine and should be furth

244 e combined use of sildenafil and NTG is more efficacious than using only one of these treatments for

245 e longer the time to viral rebound, the more efficacious the therapy.

246 le participants; assuming gentamicin was 80% efficacious, the trial would establish a 95% confidence

247 Moreover, PDE4 inhibitors may be used as efficacious therapeutic agents for asthma in obese and d

248 Gene network correction by the most efficacious therapeutic candidate, XCT790, generalized t

249 ctors involved in ZIKV replication may guide efficacious therapeutic interventions.

250 iduals is increasing yearly and there are no efficacious therapeutic interventions.

251 rtunities and challenges for the precise and efficacious therapeutic of nanogel formulations.

252 mers that amplify small acidic pH changes to efficacious therapeutic outputs.

253 Cost-effective, efficacious therapeutics are urgently needed to combat t

254 ccelerated the development of safer and more efficacious therapeutics, assisted significantly by insi

255 Specific efficacious therapies for acute liver failure (ALF) are

256 is, and may help to guide the development of efficacious therapies for MS.

257 The need for new safe and efficacious therapies has led to an increased focus on b

258 armacology could promote development of more efficacious therapies.

259 resection and highly lethal cancers with no efficacious therapies.

260 ation on day 5 (+/-1 d) of microbiologically efficacious therapy for fermenting, gram-negative bacter

261 essed by activated T cells and B cells-is an efficacious therapy for potentiating immune activation a

262 sing for the GSDs, promising to provide more efficacious therapy for these disorders in the foreseeab

263 many approaches being studied as potentially efficacious therapy.

264 ese data demonstrate that MR antagonists are efficacious to dystrophic skeletal muscles through both

265 luorometholone 0.1% is likely to be safe and efficacious to reduce postoperative TT following TT surg

266 class of amphipathic tetrapeptides that are efficacious toward a wide array of mitochondrial disorde

267 this protocol is part of the quest for more efficacious treatment approaches for this devastating an

268 g of human addiction neurobiology to develop efficacious treatment approaches.

269 to identify novel therapeutic strategies for efficacious treatment for NSCLC.

270 lasty with a retrievable stent is a safe and efficacious treatment for vasospasm secondary to SAH due

271 effect on the dose of cisplatin required for efficacious treatment of lung cancer.

272 Development of more efficacious treatment options is highly warranted.

273 of patient morbidity and mortality, with no efficacious treatment or management strategy.

274 mits the photothermal stability required for efficacious treatment.

275 VID-19, develop effective vaccines, identify efficacious treatments for the infection and its complic

276 Development of efficacious treatments has been stymied by the unknown a

277 Alongside efficacious treatments, validated and standardized drug

278 iciency approach toward rapid development of efficacious treatments.

279 in frequency in Western countries but lacks efficacious treatments.

280 The introduction of a single-dose, efficacious typhoid vaccine into countries with high bur

281 Herein we demonstrate efficacious utilization of covalently functionalized bet

282 A safe and efficacious vaccine against severe acute respiratory syn

283 refore a priority for immunisation should an efficacious vaccine be developed.

284 omatic individuals and the development of an efficacious vaccine for vivax malaria.

285 rotein subunit vaccine (gB/MF59) is the most efficacious vaccine tested to date for this indication.

286 KoRV infection is critical for developing an efficacious vaccine to protect koalas.

287 ntibiotic resistance, and lack of a robustly efficacious vaccine.

288 ease, making the development of new and more-efficacious vaccines against the pulmonary forms of TB a

289 ny months from the licensure process, making efficacious vaccines available more quickly.

290 While developing more efficacious vaccines is one strategy to mitigate this pr

291 he population, despite the implementation of efficacious vaccines.

292 elerate the testing and potential rollout of efficacious vaccines.

293 There is a critical need to develop more-efficacious vaccines.

294 ic viruses is crucial for the development of efficacious viral oncolytics.

295 ther-lumefantrine plus amodiaquine TACTs are efficacious, well tolerated, and safe treatments of unco

296 ons targeting multiple heteroresistance were efficacious, whereas those targeting homogenous resistan

297 Intravesical nadofaragene firadenovec was efficacious, with a favourable benefit:risk ratio, in pa

298 was 50% efficacious and the control was 80% efficacious, with an absolute 0.75% noninferiority margi

299 or use in the field, these solutions must be efficacious, with no negative effect on plant agronomy,

300 The development of a safe and efficacious Zika virus (ZIKV) vaccine remains a global h