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9 All test drugs evoke fluoxetine-sensitive efflux of [(3)H]5-HT from synaptosomes, but d-fenflurami
10 In vitro assays were performed to measure efflux of [(3)H]5-HT in rat brain synaptosomes and trans
15 icate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from
19 ol efflux from macrophages, since macrophage efflux of a fluorescent cholesterol analog (BODIPY-chole
20 solateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic
21 rther studies revealed that Q2 inhibited the efflux of a range of fluorescent substrates (rhodamine 1
22 sical perturbations and coincided with rapid efflux of a small-molecule fluorophore, suggesting that
23 ers belong to the ABC family and mediate the efflux of a sterol substrate, they have many distinct di
27 tained by the high internal pH caused by the efflux of acetic acid and exchange with AR-67, which und
28 es match local NAADP concentrations with the efflux of acrosomal calcium, thereby ensuring complete f
29 c22a1, we uncovered a role of SLC22A1 in the efflux of acylcarnitines from the liver to the circulati
30 kinase-1 and 2 (ERK-1/2), which promotes the efflux of adenosine triphosphate (ATP) from the macropha
31 ciated with transmembrane proteins mediating efflux of administered drugs, thereby keeping their intr
32 curves and through imaging of the uptake and efflux of Ag+ by living fibroblast cells in real time.
33 which this vestibule controls the entry and efflux of agonists from the orthosteric site and agonist
34 he activation of mTORC1, which regulates the efflux of amino acids from lysosomes into the cytoplasm.
36 utilizes energy from ATP hydrolysis for the efflux of amphipathic anticancer agents from cancer cell
40 and its homologues are major players in the efflux of anti-microbials out of Gram-negative bacteria.
41 adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the ba
42 ability of sessile cells to actively mediate efflux of antimicrobial compounds has a profound impact
44 e outer cell layer of the root, facilitating efflux of arsenic as arsenite back into the soil to limi
49 he caspase-activated Panx1 channels mediated efflux of ATP, but also ADP and AMP, with the latter two
50 in liver and kidneys, mediates the cellular efflux of ATP, which is rapidly converted into inorganic
52 energy-dependent protein responsible for the efflux of bile acids from hepatocytes, it was hypothesiz
53 ression of bile acid synthesis and increased efflux of bile acids into blood for renal excretion as w
58 significantly increased soil respiration and efflux of both CO2 and CH4 with a concomitant reduction
59 protein provided strong evidence for active efflux of Ca(2+) by LmrP with an apparent K(t) of 8.6 mu
60 and inhibited DHPR and SERCA, inducing a net efflux of Ca(2+) from loaded microsomes, whereas BPA exh
62 Hence, the second messenger NAADP, promoting efflux of calcium from lysosome-like compartments and on
64 ugh the TCR display impaired influx, but not efflux, of calcium, and ER calcium stores are increased
65 sistance protein MRP4 may play a role in the efflux of cAMP from exocrine cells and neurokinin recept
67 er from Lactococcus lactis that mediates the efflux of cationic amphiphilic substrates from the cell
68 in increased glycosphingolipid synthesis and efflux of Cav-1-sphingolipid particles containing mitoch
69 rtant event in cholesterol metabolism is the efflux of cellular cholesterol by apolipoprotein A-I (ap
73 act at the plasma membrane to facilitate the efflux of cellular sterols to exogenous high-density lip
75 ells seem to escape this effect by increased efflux of cGMP, as clinical studies have shown that extr
76 cell membrane transporter that mediates the efflux of chemically dissimilar amphipathic drugs and co
77 in extrusion (MATE) transporters couples the efflux of chemically dissimilar compounds to electrochem
80 al protein) binding to MDR1 resulting in the efflux of chemotherapeutic drugs (e.g. doxorubicin and p
83 e (by up-regulating scavenger receptors) and efflux of cholesterol (by activating the PPARgamma-LXR-A
84 se data, ABCG1 had a major role in promoting efflux of cholesterol and 7-KC in cultured human aortic
85 ain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving ac
86 transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macrophages, h
87 holesterol transport pathway and mediate the efflux of cholesterol and xenosterols to high-density li
88 a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoprot
89 for years, to their capacity to promote the efflux of cholesterol from activated cholesterol-loaded
91 les execute salient HDL functions, including efflux of cholesterol from macrophages, cholesterol deli
94 on atheroma macrophages leading to increased efflux of cholesterol to endogenous high-density lipopro
98 y, dCK overexpression blunted ABCG2-mediated efflux of clofarabine by increasing the formation of clo
99 roles of efflux pumps in both the influx and efflux of compounds in P. aeruginosa and to aid the chem
103 rane transporter that regulates the cellular efflux of cyclic nucleotides (cAMP and cGMP) involved in
104 isorder characterized by defective lysosomal efflux of cystine due to mutations in the CTNS gene enco
111 wn, in vitro, to participate in the cellular efflux of desmosterol and amyloid-beta peptide (Abeta).
113 re we show that surprisingly, MdfA catalyses efflux of divalent cations, provided that they have a un
114 periments revealed a constitutive, anomalous efflux of dopamine, and electrophysiological analyses id
115 where CK2 inhibition decreased MRP1-mediated efflux of doxorubicin and increased doxorubicin cytotoxi
116 cer resistance protein (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma mem
123 specifically bound to Cdr1p and blocked the efflux of entrapped fluorescent dyes from the AR (Gu5) i
126 s that adenosine is released into the venous efflux of exercising muscle and that adenosine is respon
128 ults, we conclude that FrvA functions in the efflux of Fe(II), and not heme during listerial infectio
129 if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may conf
137 TP2B1 mediate glutamate exchange, uptake and efflux of glutamate were investigated in Xenopus laevis
138 sults suggest that PfMRP plays a role in the efflux of glutathione, CQ, and QN and contributes to par
141 ells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the ce
142 e beginning of 2011, while a substantial net efflux of >600 g C/m(2) occurred over a 2 month period i
143 al achieved by breathing 40% O(2) attenuates efflux of H(+) and lactate, thereby decreasing the contr
146 ylase (HDAC) molecules, resulting in nuclear efflux of HDAC and consequent activation of the transcri
147 a specific activator of Epac, caused nuclear efflux of HDAC4-GFP, opposite to the effect of PKA.
148 the cytoplasm and perhaps importantly lower efflux of HgII by the cells, thus the "net" accumulation
150 1 (MDR1) transporter was responsible for the efflux of Hoechst from SP cells in our MYC-driven model.
151 binding cassette (ABC) transporter mediated efflux of Hoechst substrates (side population assay).
154 ume in response to hyposmotic stress via the efflux of inorganic and organic osmolytes is well docume
155 pe of cell death, dose-dependent uptake, and efflux of inorganic HgII (as HgCl(2)) and methylmercury
156 family that couples the import of G3P to the efflux of inorganic phosphate (P(i)) down its concentrat
157 that adenosine makes to exercise hyperaemia; efflux of inorganic phosphate and its contribution may l
158 us oocytes expressing either OAT4 or OATP2B1 efflux of intracellular [(14)C]glutamate could be stimul
159 the remarkable observation was made that an efflux of intracellular inorganic phosphate (P(i)) accom
161 alp3 inflammasome by silica required both an efflux of intracellular potassium and the generation of
162 were preceded by G1 or G2 APOL1-induced net efflux of intracellular potassium as measured by X-ray f
164 n mechanism in these channels for regulating efflux of K (+) ions through the selectivity filter.
165 ncentration and the depolarized PM drive the efflux of K(+) from the cell, resulting in loss of turgo
167 gh a type III secretion apparatus results in efflux of K(+) through glibenclamide-sensitive K(+) chan
168 The resulting net influx of Na(+) and net efflux of K(+), down their respective concentration grad
169 transporter that regulates the simultaneous efflux of L-glutamine out of cells and transport of L-le
170 ation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contrib
171 pindles (1.54 < R/r < 10) that arise from an efflux of LCs from the GUVs during the shape transformat
172 er, LXR target gene products facilitated the efflux of lipid and cholesterol from lipid-laden microgl
176 Unexpectedly, we detected a reproducible efflux of lymphoma cells from spleen and bone marrow, co
178 acAB-TolC transporter has been implicated in efflux of macrolide antibiotics and secretion of enterot
179 n controlling the early influx and the later efflux of macrophages out of the injured nerve, reduces
181 l vacuoles, specifically of K(+) and Mal(2-) Efflux of Mal(2-) from the vacuole is required for stoma
182 al electrical resistance, an increase in the efflux of mannitol across the monolayer, and a loss of i
183 C2) plays an important role in hepatobiliary efflux of many drugs and drug metabolites and has been r
184 mily of membrane proteins, and modulates the efflux of many drugs at the cell membrane, resulting in
185 How the protein shell directs influx and efflux of molecules in an effective manner has remained
187 ll plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) impor
188 l(-)) channels, which mediate the influx and efflux of monovalent anions in response to the levels of
189 ition of mTOR strongly reduced the lysosomal efflux of most essential amino acids, converting the lys
190 bution to multidrug resistance by catalysing efflux of myriad structurally and chemically different a
191 of the pore is closed, reversible influx and efflux of Na(+) through the selectivity filter occurred
193 one did not cause overt disease, but induced efflux of neutrophils into the airway lumen and producti
195 ripheral blood lymphocytes revealed dramatic efflux of NK and memory CD8 T cells from the circulating
198 analyses demonstrated capillary leakage with efflux of nutrients and antioxidants into the alveolar s
199 anism in renal epithelial cells enabling the efflux of one Ca(2+) ion and the influx of three Na(+) i
201 efflux transporters that mediates the apical efflux of organic anions from hepatocytes, enterocytes,
202 rter in mediating both epithelial uptake and efflux of organic cations in the secretory cells of sali
204 on of GPCRs facilitates the volume-dependent efflux of osmolytes from neural cells and permits them t
205 l to determine if plants can up-regulate the efflux of osmotically active substances into embolized v
206 al one, suggested that PAbetaN inhibited the efflux of other drugs by binding to the bottom of the di
208 e key cells involved in the accumulation and efflux of oxidized low density lipoprotein in the arteri
211 Our model considers the cellular uptake and efflux of PFOA via both passive diffusion and transport
214 tically, the HBL-induced pore results in the efflux of potassium and triggers the activation of the N
220 Pdu microcompartment) while restricting the efflux of propionaldehyde, a toxic intermediate of 1,2-p
221 recombinant EMCV L triggers the unregulated efflux of protein cargo from preloaded HeLa cell nuclei
226 ors tariquidar and vinblastine prevented the efflux of rhodamine 123 (rh123) from hCMEC/D3 cells, ind
228 tiproliferative activities but modulated the efflux of rhodamine 123 mediated by the ABCB1 transporte
231 decrease efficiently Pgp mediated influx and efflux of rhodamine-123 (Rho) and to restore the cytotox
232 cellular ion channels that results in a net efflux of salt and water into the intestinal lumen, culm
234 Endothelial cell-cell junctions control efflux of small molecules and leukocyte transendothelial
235 embrane machineries, or pumps, determine the efflux of small noxious molecules, such as detergents, h
239 uble proteins, a shift in equilibrium toward efflux of specific proteins from the brain, cell-mediate
240 ane lipid asymmetry, the cellular influx and efflux of sterols and phospholipids, and the egress of l
241 olesterol from modified lipoproteins and the efflux of stored cholesterol suggests that the process o
242 ) is an ATP-dependent pump that mediates the efflux of structurally diverse drugs and xenobiotics acr
244 ins (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain
245 cycle was active but was characterized by an efflux of substrates for use in biosynthetic pathways, p
247 ing in the inner membrane resulting in rapid efflux of succinate/fumarate and other dicarboxylates ca
248 cellular partitioning, and consequently, the efflux of sucrose from source leaves and the utilization
251 ially facilitate phloem loading by enhancing efflux of symplasmic Suc for subsequent active uptake in
255 e found that pdr8 mutants display defects in efflux of the auxin precursor IBA and developmental defe
257 ne conjugation of NO(2)-LA and MRP1-mediated efflux of the conjugates were associated with significan
258 12 transporter, pmp-5, and adjust influx and efflux of the cycle by activating msra-1 and repressing
259 nts necessary for cell function/survival and efflux of the desired cellular product, specifically ins
262 markers, drug transporters and the efficient efflux of the Hoechst 33,342 dye (side population).
266 2 protein, required for directional cellular efflux of the phytohormone auxin, and identify cis- and
268 ED (PIN) membrane proteins, which facilitate efflux of the plant hormone auxin from cells, is importa
270 RMED (PIN) proteins involved in the cellular efflux of the quintessential phytohormone auxin plays a
271 ious in vitro evidence that SetA can promote efflux of the stress-causing glucose analog alpha-methyl
272 These data provide compelling evidence that efflux of the substrate molecule from the bilayer, which
273 Recently, we provided evidence that the efflux of the substrate molecules from the bilayer is th
274 ransporter previously implicated in cellular efflux of the synthetic auxin 2,4-dichlorophenoxyacetic
275 roteoliposomes showed that AceI mediates the efflux of these short-chain diamines when energized by a
276 C-phages during infection could modulate the efflux of this potent greenhouse gas into the environmen
277 serve to protect the heart by mediating the efflux of toxic products of oxidative stress from mitoch
282 toxic compound extrusion family mediate the efflux of unrelated pharmaceuticals from the interior of
285 iminished capacities of (1) sodium-dependent efflux of vacuolar protons and (2) elicitor-triggered ov
286 idylcholine, and (2) a subsequent, transient efflux of vacuolar protons, resulting in a peak of cytos
287 displays variable activity in modulating the efflux of various drugs by P-gp, there is a correlation
289 promoted uptake of calcein AM and inhibited efflux of vinblastine with IC(50)'s of approximately 2 m
290 sponse to hyperosmotic stress involves rapid efflux of water and changes in intracellular ion and osm
291 exerts its antiedema effect by promoting an efflux of water from brain via the perivascular aquapori
292 ween the gating mechanism and the influx and efflux of water molecules in CrChR2, we have integrated
294 ng Cassette transporters are involved in the efflux of xenobiotic compounds and are responsible for d
295 y role in protecting the brain parenchyma by efflux of xenobiotics from capillary endothelial cells a
296 ultaneously measure the assimilation and the efflux of xylem-transported CO(2) exiting the leaf acros
297 O(3) ] dissolved in KCl water to measure the efflux of xylem-transported CO(2) exiting the leaf in th
300 natomy and biochemistry likely influence the efflux of xylem-transported CO(2) out of cut leaves of A