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1 s MdtD, is now designated IceT (iron citrate efflux transporter).
2 from the brain and spinal cord by the Abcg2 efflux transporter.
3 auxin maxima via the PINFORMED1 (PIN1) auxin efflux transporter.
4 in this region, is a hitherto unknown urate efflux transporter.
5 w to accurately measure the function of this efflux transporter.
6 indicating dependence on an apically located efflux transporter.
7 d-encoded membrane protein QacA, a multidrug efflux transporter.
8 es are consistent with a role for ALF5 as an efflux transporter.
9 en the gene family designation SET for sugar efflux transporter.
10 s transport substrates by the P-glycoprotein efflux transporter.
11 s interaction with the P-glycoprotein (P-gp) efflux transporter.
12 in the ABCC6 gene encoding ABCC6, a hepatic efflux transporter.
13 was recently revealed to function as a zinc efflux transporter.
14 they were not substrates for the ABCB1 drug efflux transporter.
15 opsis thaliana, AtDTX50, functions as an ABA efflux transporter.
16 for nectar production and can function as an efflux transporter.
17 range even for cell lines expressing the Pgp efflux transporter.
18 of sinusoidal uptake versus that of biliary efflux transporters.
19 ounding member of a family of bacterial drug efflux transporters.
20 , we identified a subfamily of SWEET sucrose efflux transporters.
21 and breast cancer resistance protein (ABCG2) efflux transporters.
22 udy investigates the status of the multidrug efflux transporters.
23 lence factors and multidrug resistance (MDR) efflux transporters.
24 ch copper is passed from ATOX1 to the copper efflux transporters.
25 -linking studies of bacterial and eukaryotic efflux transporters.
26 beta-catenin can influence the expression of efflux transporters.
27 ic phase I and II enzymes as well as hepatic efflux transporters.
28 ture of any MFPs associated with heavy-metal efflux transporters.
29 wo homologues of the SMR family of multidrug efflux transporters.
30 by decreasing the expression of cholesterol efflux transporters.
31 presence and absence of known inhibitors of efflux transporters.
32 s have been shown to be capable of bypassing efflux transporters.
33 e of compounds that are substrates for these efflux transporters.
34 ed here are likely employed by the multidrug efflux transporters.
35 essing large arsenals of predicted multidrug efflux transporters.
36 n of several cytochromes P450 (CYP) and drug efflux transporters.
37 E) family, which has homology with bacterial efflux transporters.
38 ce of cytochrome P450 enzymes and particular efflux transporters.
39 mediated by the ABCB1, ABCC1, and ABCG2 drug-efflux transporters.
40 nd MRP1, which are established cellular drug efflux transporters.
41 te major xenobiotic-metabolizing enzymes and efflux transporters.
42 generated by the PIN-formed family of auxin-efflux transporters.
43 iated by the ATP-binding cassette (ABC) drug efflux transporters.
44 oxidative stress and to eliminate silver via efflux transporters.
45 chieved through a system of auxin influx and efflux transporters.
47 ced the surface abundance of the cholesterol efflux transporter ABCA1, which in turn promoted lipid a
50 e promoter of the major cellular cholesterol efflux transporter, ABCA1, in LNCaP prostate cancer cell
51 ected the function of membrane-embedded drug efflux transporter ABCB1, triggering the integrated stre
52 duced inhibition of the multidrug-resistance efflux transporter ABCB1, which is frequently expressed
57 te that genetic variation within an ABC-drug efflux transporter (Abcb5) affected susceptibility to HI
64 polymorphic variant of the chemotherapy drug efflux transporter ABCG2, which contributes to normal ti
67 he yeast (Saccharomyces cerevisiae) arsenite efflux transporter ACR3 into Arabidopsis to evaluate how
70 ycoprotein (P-gp) was identified as the main efflux transporter across the BBB, in vivo and in vitro.
73 cytochrome P450 mono-oxygenase system, drug efflux transporter adenosine triphosphate-binding casset
74 e P-gp knockout mouse provided evidence that efflux transporters affected the amount of Abeta lowerin
75 the most studied ATP-binding cassette (ABC) efflux transporter and contributes to chemoresistance.
77 lasma membrane and functions as a nucleotide efflux transporter and thus plays a role in the regulati
78 of the Small Multidrug Resistance family of efflux transporters and actively expels positively charg
79 ytokinins mediated by the PIN class of auxin efflux transporters and AHP6, an inhibitor of cytokinin
80 hanisms include the regulation of uptake and efflux transporters and buffering of the free metal conc
81 of the anticancer drug vinorelbine with drug efflux transporters and cytochrome P450 3A drug-metaboli
82 le mice because of expression differences in efflux transporters and cytochromes in the liver, ileum
83 cerevisiae strain lacking sodium ion (Na(+)) efflux transporters and increased salt tolerance of wild
84 RACURVATA 2 or FKBP42, associates with auxin efflux transporters and is essential for their biologica
86 ecent reports on the structures of multidrug efflux transporters and their cognate regulators have su
88 C30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations b
89 PIN-FORMED (PIN) proteins are proposed auxin efflux transporters, and auxin fluxes can seemingly be p
90 ellular drug concentrations mediated by drug efflux transporters, and permeability barriers associate
91 ced effect on mitochondrial metabolism, drug-efflux transporters, and stress-response activation.
92 ROPIC DRUG RESISTANCE TRANSPORTER9, an auxin efflux transporter; and two APETALA2/ETHYLENE RESPONSE F
93 expression alters the trafficking of 2 auxin efflux transporters-Arabidopsis PM-located auxin efflux
98 and expression of the P-glycoprotein (P-gp) efflux transporter at the blood-brain interface further
99 east cancer resistance protein (ABCG2) are 2 efflux transporters at the blood-brain barrier (BBB) tha
100 le targeted therapies is severely limited by efflux transporters at the blood-brain barrier (BBB).
101 ants acting through AhR to target xenobiotic efflux transporters at the blood-brain barrier and thus
104 nt models of epilepsy suggest that multidrug efflux transporters at the blood-brain barrier, such as
105 oss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (
106 acrophage cholesterol by targeting the lipid efflux transporters ATP binding cassette (ABC)A1 and ABC
108 cimetidine, colchicine) and also affinity to efflux transporters (atropine and chloramphenicol) are t
109 ubstrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr thr
110 in plants is regulated in part by the borate efflux transporter Bor1, a member of the solute carrier
111 interaction of erlotinib with the multidrug efflux transporters breast cancer resistance protein (hu
112 negatively regulates PIN-FORMED (PIN) auxin efflux transporters by affecting their plasma membrane l
113 SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metaboli
114 that rte encodes a membrane-localized boron efflux transporter, co-orthologous to the Arabidopsis th
115 lC is a constitutively expressed, tripartite efflux transporter complex that functions as the primary
120 including those encoding putative multidrug efflux transporters, detoxification proteins, extracytop
121 an Arabidopsis (Arabidopsis thaliana) boron efflux transporter displayed boron deficiency phenotypes
122 hat the inhibition of ABCB and ABCC-types of efflux transporters disrupts the ordered distribution of
128 gnificantly to the flux towards product, and efflux transporters ensure the accumulation of product i
131 th tls1 and rotten ear (rte), the proposed B efflux transporter, exhibit a dosage-dependent defect in
132 6 gene, which encodes ABCC6, a transmembrane efflux transporter expressed primarily in the liver.
134 particular, neuronal activity regulates BBB efflux transporter expression and function, which is cri
136 In other barrier and excretory tissues, efflux transporter expression is regulated by certain li
139 ly of bacterial transporters, the SET (sugar efflux transporter) family, has been recently reported.
140 generated a conditional deletion of the iron efflux transporter ferroportin (Fpn) in astrocytes, and
143 the synergistic actions of the ferrous iron efflux transporter, ferroportin (Fpn) and a multicopper
145 ssette, subfamily B member 11 (ABCB11) is an efflux transporter for bile acids on the liver canalicul
146 TROPIC DRUG RESISTANCE9, encoding a putative efflux transporter for products from the phenylpropanoid
148 ere we utilized FrvA, a high-affinity Fe(2+) efflux transporter from Listeria monocytogenes, as an in
150 tentatively identified as a truncated cation efflux transporter gene and a PbrR family regulator gene
151 egulates the expression of the bmr multidrug efflux transporter gene in response to myriad lipophilic
154 rchin eggs and embryos express low levels of efflux transporter genes with homology to the multidrug
155 s overexpress CDR1 and CDR2, two fluconazole efflux transporter genes, and a cdr1 mutation decreases
156 stimulated the expression of Si channel and efflux transporter genes- Lsi1 and Lsi2 while the additi
163 ABCB1) provided evidence of the role of this efflux transporter in effectively restricting the brain
164 results provide evidence of ABCA3 as an MLF efflux transporter in human macrophages and support its
166 SLC30A10, a cell surface-localized manganese efflux transporter in the brain and liver, induce famili
167 strate activities of the cyclic prodrugs for efflux transporters in Caco-2 cells and in the intestina
171 r studies define a system of zinc influx and efflux transporters in the vacuole that play important r
173 ast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expressio
175 rug resistance protein 4 (MRP4), a cAMP/cGMP efflux transporter, in the regulation of fluid secretion
176 Our study, using specific inhibitors of efflux transporters, indicates that the major activity i
178 forming P-gp or an ABC drug exporter from an efflux transporter into a drug uptake pump would constit
181 tochemicals and is also one of the prominent efflux transporters involved in multidrug resistance (MD
183 that the model of dual acid influx and acid efflux transporters is sufficient to account for pHi reg
184 ely studied family of PIN-formed (PIN) auxin efflux transporters is unclear, and studies using hetero
185 ding cassette (ABC) membrane-associated drug efflux transporter, is known to localize at the blood-br
186 ding cassette transporter P-glycoprotein, an efflux transporter known to detoxify taxol, were found t
187 Multidrug resistance protein 4 (Mrp4) is an efflux transporter known to transport several xenobiotic
188 rcome the BBB, both passive permeability and efflux transporter liability of a compound must be addre
190 d advances in structure determination of ABC efflux transporters, little is known regarding the locat
192 both the lsi2 mutant lacking the Si/arsenite efflux transporter Lsi2 and its wild-type cultivar, with
193 We show how auxin response genes and auxin efflux transporters may be affected by the presence of c
194 -3, and KB-3 cell lines that overexpress the efflux transporters MDR1 (KBV-1) and BCRP (KBH5.0).
195 otein genes (MRP1/MRP2, which encode for the efflux transporter Mrp1/Mrp2) and the multidrug resistan
196 ters Oatp1a/1b (Slco1a/1b(-/-)/(-/-)) or the efflux transporter Mrp2 (Abcc2(-/-)) were intravenously
197 ical multidrug-resistance-associated protein efflux-transporters (MRPs) in the renal proximal tubule
198 affect transport activity of two other major efflux transporters, multidrug resistance protein 2 and
203 ted protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepato
207 lycoprotein functions as a broad specificity efflux transporter of structurally diverse natural produ
209 ted in the terminal ileum and colon, as were efflux transporters of breast cancer resistance protein
213 t of varying the concentrations of the auxin efflux transporters on the sizes of the different root r
214 temness signaling pathways, surface markers, efflux transporters, or components of complex tumor micr
215 , various conjugating enzymes, ATP-dependent efflux transporters, oxidative detoxification proteins,
216 at selectively kill cells overexpressing the efflux transporter P-glycoprotein (MDR1, P-gp, ABCB1).
217 ted concurrent inhibition of intestinal drug efflux transporter P-glycoprotein (P-gp) and drug metabo
218 increases the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by ABCB
219 Abeta across the blood-brain barrier is the efflux transporter P-glycoprotein (P-gp) in the luminal
220 coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distin
223 oupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as AB
224 that substrates and inhibitors have with the efflux transporter P-glycoprotein has been the subject o
226 However, the specific effect of VEGF on the efflux transporter P-glycoprotein, a critical component
230 er dysfunction is overexpression of the drug efflux transporters P-glycoprotein (P-gp) and breast can
232 ssion and transport activity of the key drug efflux transporter, P-glycoprotein (6 h EC(50) was appro
235 phic analyses in knockout mice showed that 2 efflux transporters-permeability glycoprotein (P-gp) and
236 mediated primarily by mutations in the drug efflux transporter PfCRT, we have explored whether PfCRT
237 ux transporters-Arabidopsis PM-located auxin efflux transporter PIN-formed 1 (PIN1) and Arabidopsis P
238 ed 1 (PIN1) and Arabidopsis PM-located auxin efflux transporter PIN-formed 3 (PIN3)-to the PM, thereb
240 Finally, both Arabidopsis thaliana auxin efflux transporter pin1 and influx transporter lax2 muta
246 with improved physicochemical properties and efflux transporter profiles while maintaining excellent
247 and property-based drug design and expanded efflux transporter profiling to identify structurally di
249 apolipoprotein E, and the major cholesterol-efflux transporter protein ATP-binding cassette transpor
250 a hypothetical, saturable renal basolateral efflux transporter provided the first unified explanatio
251 th reduced expression of a tonoplast sucrose efflux transporter, PtaSUT4, exhibit reduced shoot growt
252 As a substrate of the P-glycoprotein (P-gp) efflux transporter, quinacrine is actively exported from
253 Changes in the expression of drug influx and efflux transporters, rather than activation of cell grow
254 ated levels of drug-metabolizing enzymes and efflux transporters, resulting from CAR activation in va
255 lls stably expressing specific uptake and/or efflux transporters revealed that OATP1B1, OATP1B3, and
256 ndings argue that the inhibition of the P-gp efflux transporter should improve the poor pharmacokinet
257 enger receptors showed lower and cholesterol efflux transporters showed higher expression in CXCL4- t
261 sistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-fam
262 lin-resistant S. aureus strains that express efflux transporters such as NorC in hospital and communi
264 lthough doxorubicin is a known substrate for efflux transporters such as P-glycoprotein (P-gp; MDR1,
265 tumor homing capabilities, MSCs overexpress efflux transporters such as P-glycoprotein and are highl
266 l lines, both of which do not express common efflux transporters such as P-glycoprotein at the plasma
267 s that are often protected from treatment by efflux transporters, such as P-glycoprotein (P-gp) at th
270 stance-associated protein 1 (MRP1) is a drug efflux transporter that has been implicated in the patho
271 ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in
272 The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestina
273 ly downregulated the expression of BCRP1, an efflux transporter that is highly expressed in the CNS v
274 gp), an endogenous blood-brain barrier (BBB) efflux transporter that is involved in brain-to-blood tr
275 ancer resistance protein (BCRP, ABCG2) is an efflux transporter that plays a crucial role in multidru
276 is a proton motive force-dependent multidrug efflux transporter that recognizes multiple toxic chemic
279 that SLC30A10 is a cell surface-localized Mn efflux transporter that reduces cellular Mn levels and p
280 auxin within tissues are regulated by auxin efflux transporters that are polarly localized in cells.
281 ukaryotes use a highly conserved set of drug efflux transporters that confer pleiotropic drug resista
282 s/regulators, soluble chaperones, and influx/efflux transporters that control the Cu(+) levels in P.
283 r of the ATP binding cassette superfamily of efflux transporters that mediates the apical efflux of o
284 Although Pgp is generally thought to be an efflux transporter, the mechanism of action remains elus
285 ith the lack of expression of organic cation efflux transporters, there was little efflux of IDT307 i
286 n, composition and assembly of the triclosan efflux transporter TriABC-OpmH from Pseudomonas aerugino
287 of the wheat (Triticum aestivum) root malate efflux transporter underlying Al resistance, TaALMT1.
288 that the barriers are tightened selectively (efflux transporter upregulation) by oxidative stress, pr
289 In addition, Slc30a10, encoding a manganese efflux transporter, was one of the genes most induced by
290 rugs and thus their substrate activities for efflux transporters, we synthesized cyclic prodrugs of t
291 pression, and localization of the PIN1 auxin efflux transporter, were intact in bps1 mutants, suggest
292 bacterial heterodimeric ATP-binding cassette efflux transporter, were used to demonstrate the protein
293 erties of the cellular membrane augmented by efflux transporters, which preclude intracellular penetr
295 review, we summarize the RND superfamily of efflux transporters with a primary focus on the assembly
296 s, restrictive barrier formation, influx and efflux transporters with relevance to understanding peri
297 ticular, impairment of the astrocyte lactate efflux transporter, with resultant decrease of spinal co
299 pressing a native expressed endogenous auxin efflux transporter (ZmPIN1a) fused to yellow fluorescent