ライフサイエンスコーパス: egress

1 syndecan-1 by MMP-3 and MMP-7 supports viral egress.

2 in a cell-intrinsic manner following thymic egress.

3 nt, and therefore for host cell invasion and egress.

4 r lamina and thus facilitating viral nuclear egress.

5 on did not affect viral particle assembly or egress.

6 port protein Gramd1b to regulate cholesterol egress.

7 serine protease (SUB1) is a key mediator of egress.

8 e (NA) enzymatic activity, prohibiting viral egress.

9 ating that TgCDPK3 controls processes beyond egress.

10 of PfPLP2, reducing the efficiency of gamete egress.

11 of excystation, invasion, proliferation, and egress.

12 ontrast, silencing of CDPK5 had no effect on egress.

13 molecular machinery that drives invasion and egress.

14 , vesicular trafficking, and virus entry and egress.

15 and 20 h after in vitro infection, prior to egress.

16 f F-actin crucial for motility, invasion and egress.

17 otility, host cell attachment, invasion, and egress.

18 hat enlarge the putative openings for genome egress.

19 of this motif markedly impeded PCV2 nuclear egress.

20 g up a self-generated gradient driving tumor egress.

21 bited follicular features as early as thymic egress.

22 key regulator for porcine circoviral nuclear egress.

23 nuclear lamina and facilitate viral nuclear egress.

24 s in the regulation of HSPC localization and egress.

25 very-low-density lipoprotein (VLDL) for its egress.

26 cretion of adhesins, motility, invasion, and egress.

27 nd to host cell plasma membrane lysis during egress.

28 ing regulators of cGMP metabolism to control egress.

29 target for host-oriented inhibitors of EBOV egress.

30 hrocytes for compounds that inhibit parasite egress.

31 nuclear envelope, the site of their nuclear egress.

32 te endocytic pathways in HCMV maturation and egress.

33 D103 expression, proteins that prevent cells egress.

34 replication complex vesicles cannot form or egress.

35 exhibited defects in lymph node entrance and egress.

36 distinct functions from C5aR1 in neutrophil egress.

37 ors and baculoviruses during viral entry and egress.

38 ucleocapsids in the perinuclear space during egress.

39 nvelopment of the cytoplasmic virion and its egress.

40 orafenib, was found to be important for RVFV egress.

41 se that ubiquitinates VP40 and regulates VLP egress.

42 important for malaria parasite invasion and egress.

43 sue dissemination and host cell invasion and egress.

44 gumentation, secondary envelopment, and then egress.

45 nclosing erythrocyte membrane shortly before egress.

46 in increased vascular permeability and HSPC egress.

47 not ubiquitinate eVP40 or enhance eVP40 VLP egress.

48 parasites, we resolve intermediate steps in egress.

49 arrow time window within the final stages of egress.

50 asket structure for an alternative endosomal egress.

51 also contributes to promoting eVP40-mediated egress.

52 mplex is present on capsids prior to nuclear egress.

53 sms have been described with regard to viral egress.

54 proteins into the host cell, and eventually egress.

55 y, consistent with known mechanisms of virus egress.

56 st exosome machinery for virion assembly and egress.

57 ired for invasion, parasite development, and egress.

58 egion that control nucleolar association and egress.

59 e motility, host cell invasion, and parasite egress.

60 s tunnel abolishes NPC1-mediated cholesterol egress.

61 ife cycle, including entry, replication, and egress.

62 ferent phases of viral particle assembly and egress.

63 airway inflammation via promoting lymph node egress.

64 osphatidylcholine stimulates PfPP1-dependent egress.

65 exhibits increased local disorder, and water egresses.

66 s in the gene Suppressor of Ca(2+)-dependent Egress 1 (SCE1).

67 isolate two functional targets of PfPP1 for egress: a HECT E3 protein-ubiquitin ligase; and GCalpha,

68 rial cGMP-dependent protein kinase, triggers egress, activating malarial proteases and other effector

69 previous view of PKG-triggered initiation of egress and a gradual dismantling of the host erythrocyte

70 y HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity.

71 glia are removed by a dual mechanism of cell egress and apoptosis to re-establish the stable microgli

72 teins participate in motility, invasion, and egress and are subjected to proteolytic maturation prior

73 systems in reovirus entry, trafficking, and egress and comment on shared themes for diverse viruses.

74 sufficient to significantly inhibit parasite egress and dispersion.

75 enome packaging into infectious progeny, and egress and dissemination to the next target cell.

76 The series targets both merozoite egress and erythrocyte invasion, but crucially, also blo

77 usion appears to be fast compared with viral egress and has not been visualized by EM.

78 nique roles of geranylgeranylation in thymic egress and highlight that the interplay between cellular

79 led protein prenylation pathway in thymocyte egress and immune homeostasis.

80 and recombinantly active PMIX and PMX cleave egress and invasion factors in a 49c-sensitive manner.

81 In contrast, PMX is essential for both egress and invasion, controlling maturation of the subti

82 rylation- and calcium-based signaling during egress and invasion.

83 ile suppressing genes associated with tissue egress and recirculation.

84 s rings, trophozoites, and schizonts, before egress and reinvasion.

85 unity for a new strategy to inhibit parasite egress and replication.

86 p32 is a critical regulator of PCV2 nuclear egress and reveal the importance of this finding in circ

87 ted protein 1 (TRP1) is important for oocyst egress and salivary gland invasion, and hence for the tr

88 -oocyst motility and subsequently sporozoite egress and salivary gland invasion.

89 nt, our findings identify an initial step in egress and show that host cell cytoskeleton breakdown is

90 of eVP40 virus-like particles (VLPs) and for egress and spread of authentic EBOV.

91 at SUB1 is a key mediator of Cryptosporidium egress and suggest that interruption of the life cycle a

92 Pggt1b leads to marked defects in thymocyte egress and T cell lymphopenia in peripheral lymphoid org

93 e Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.

94 at ectopic YAP expression inhibits eVP40 VLP egress and that Amot co-expression rescues budding of eV

95 ening is hypothesized to facilitate parasite egress and the consequent dissemination of released mero

96 heckpoint in spermatogenesis, determines the egress and tolerogenicity of MGCA.

97 ells re-express L-selectin before lymph node egress and use L-selectin to locate to virus-infected ti

98 ssue residence (long-term retention, lack of egress) and/or can be replenished from the circulation r

99 eVP40 and a subsequent increase in eVP40 VLP egress, and (iii) an enzymatically inactive mutant of WW

100 rolling processes such as parasite invasion, egress, and development mediated by kinases, phosphatase

101 pment but reduces efficiency of rounding up, egress, and exflagellation of gametocytes following acti

102 it remained throughout maturation, merozoite egress, and host cell invasion.

103 mplex signaling pathways during replication, egress, and invasion in each of these stages.

104 ts of viral entry, translation, replication, egress, and the genes regulating these processes.

105 /C and facilitate porcine circoviral nuclear egress, and they certainly help understanding of the mec

106 antibodies to Plasmodium falciparum Schizont Egress Antigen-1 (PfSEA-1), and related these antibodies

107 Extracellular stimuli that modulate HIV-1 egress are currently unknown.

108 Cell entry and egress are essential steps in the viral life cycle that

109 virus aggregation, fusion with endosomes and egress are inhibited.

110 isms involved in virus particle assembly and egress are still elusive.

111 Following thymic maturation, T cells egress as recent thymic emigrants to peripheral lymphoid

112 s to ensure efficient entry, maturation, and egress as well as the avoidance of antiviral defenses th

113 They egressed as cargo in residual bodies and maintained Treg

114 ld-type T4 lysozyme also reveal that benzene-egress-associated dynamics in the L99A mutant are potent

115 ssing methods, details of virus assembly and egress at (sub)nanometer resolution were uncovered.

116 , parasites lacking PPM5C divide and undergo egress at a normal rate, but have a deficiency in attach

117 farnesylation, is dispensable for thymocyte egress but contributes to peripheral T cell homeostasis.

118 n receptor-like receptor (CALCRL) to promote egress by activating the Galpha(s)/adenylyl cyclase/cAMP

119 zole, were previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a mem

120 Heparin blocks egress by interacting with both the surface of intra-ery

121 that sorafenib causes a disruption in viral egress by targeting VCP and the secretory pathway, resul

122 al Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii.

123 to form daughter cells that eventually exit (egress) by sequential rupture of the vacuole and erythro

124 te this CD31(-)CD45RA(-) subpopulation, most egress-capable mature CD45RA(+) CD4 SP thymocytes expres

125 To examine only egress, cells were transfected with the double-stranded

126 g that it acts at a stage of assembly and/or egress common to both routes of spread.

127 heterodimeric basic structure of the nuclear egress complex (core NEC).

128 the nucleus is mediated by the viral nuclear egress complex (NEC).

129 These results identify CLN6 and the EGRESS complex as key players in lysosome biogenesis and

130 the single deficiencies, indicating that the EGRESS complex works as a functional unit.

131 nteractions may suggest the formation of an "egress complex" involved in the nuclear release or trans

132 opose that these viral proteins may form an "egress complex" that is involved in recruiting ESCRT-III

133 Despite the thymic and lymph node egress defects, sphingosine-1-phosphate signaling was no

134 to isolate gain-of-function mutants from an egress-deficient cdpk3 knockout strain.

135 This untimely egress depends on host cell acidification.

136 n recruiting ESCRT-III components to a virus egress domain on the nuclear membrane.IMPORTANCE The ESC

137 nent and suppressor of Ca(2+)-dependent cell egress during Toxoplasma lytic growth.

138 viral processes including assembly, budding, egress, entry, and fusion.

139 f a CLN6-CLN8 complex (herein referred to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal

140 pression of a CD69 mutant unable to bind the egress factor S1PR1) promoted CD8(+) T(RM) generation in

141 t promote M2 ATM polarization and macrophage egress from adipose tissue.

142 topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted

143 mune responses which also depend upon T cell egress from draining lymph nodes.

144 oove provides a potential path for substrate egress from EMC.

145 vasion of hepatocytes or the invasion of and egress from erythrocytes.

146 Egress from host cells is a key process for the completi

147 covered mutants that regained the ability to egress from host cells that harbored mutations in the ge

148 ream activator of signaling for 'programmed' egress from host cells.

149 ty between cells, as well as invasion of and egress from host cells.

150 ays with external signals to direct parasite egress from host cells.

151 Host mechanisms that contribute to HSV-1 egress from infected cells are poorly understood.

152 es not bind cAMP triggers premature parasite egress from infected cells followed by serial invasion a

153 Efficient viral egress from infected cells is an important step for HSV-

154 cycle of T. gondii, with particular focus on egress from infected cells, a key step for balancing sur

155 They also facilitate viral egress from infected cells.

156 ified disparate effects on infectious virion egress from infected cells.

157 syndecan-1, thereby further enhancing HSV-1 egress from infected cells.

158 site mutants did not adversely affect virion egress from infected cells.

159 erstanding of how these viruses assemble and egress from infected cells.

160 n microneme secretion and fail to invade and egress from infected cells.

161 s demonstrated, and inhibition of lymphocyte egress from lymph nodes using FTY720 abrogated the benef

162 amino acids of RAG1, required for efficient egress from nucleoli, reduces recombination activity.

163 eps: invasion of, asexual growth within, and egress from red blood cells.

164 hate receptor 1) agonists prevent lymphocyte egress from secondary lymphoid organs and cause a reduct

165 ing SPZ in the liver and by preventing their egress from sinusoids and traversal of hepatocytes.

166 nary tract, and newly formed viral particles egress from the apical side of the lung epithelium, we c

167 step of the biofilm life cycle, single cells egress from the biofilm to resume a planktonic lifestyle

168 r cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking

169 knockout mice exhibit an accelerated B cell egress from the bone marrow, resulting in the accumulati

170 L-33 plays a critical role in promoting ILC2 egress from the bone marrow.

171 cation within a parasitophorous vacuole, and egress from the cell.

172 ol lectin chaperone binding and glycoprotein egress from the ER.

173 s and increase their S1P-receptor-1 mediated egress from the intestine and recruitment to the bone ma

174 ced liver:lymph S1P gradient and limited HSC egress from the liver.

175 highly expressed in HSCs, induces stem cell egress from the niche due to impaired retention within t

176 enhance IRF-1 transcription and promotes its egress from the nucleus.

177 e an effective intraretinal barrier to fluid egress from the optic disc cavitation.

178 Deficiency of alphaMbeta2 suppressed Mvarphi egress from the peritoneal cavity, decreased the product

179 ny bacterial pathogens hijack macrophages to egress from the port of entry to the lymphatic drainage

180 nitiation of replication following bacterial egress from the SCV.

181 l infarction, we observed rapid myeloid cell egress from the spleen and bone marrow by in vivo (19)F-

182 able for thymocyte survival and development, egress from the thymus, and survival of recent thymic em

183 oteases of the plasmepsin family in parasite egress from, and invasion into, RBCs.

184 Nonsequestered MCGA (NS-MGCA) egressed from normal tubules, as evidenced by their abil

185 transplantation, we showed that Foxp3+ cells egressed from tolerant lung allografts via lymphatics an

186 When Toxoplasma gondii egresses from the host cell, glyceraldehyde-3-phosphate

187 ignaling pathway dictating Toxoplasma gondii egress have been identified, whether the parasite secret

188 dy elucidates a new connection between HSV-1 egress, heparanase, and matrix metallopeptidases; identi

189 viruses, M proteins drive viral assembly and egress; however, some paramyxoviral glycoproteins have b

190 ous WWP1 resulted in inhibition of eVP40 VLP egress, (ii) coexpression of WWP1 and eVP40 resulted in

191 nation, and regulation of EBOV VP40-mediated egress.IMPORTANCE Ebola virus (EBOV) is a high-priority,

192 onducive to productive viral replication and egress.IMPORTANCE HPV genome amplification and capsid fo

193 we investigated varicella-zoster virus (VZV) egress in a cell line from a child with Pompe disease, a

194 DPK3 knockout (Deltacdpk3) parasites fail to egress in a timely manner.

195 ytic reovirus exit, we imaged sites of virus egress in infected, nonpolarized human brain microvascul

196 elope (E) glycoprotein is critical for virus egress in mammalian cells, but not in tick cells.

197 influx, intracellular iron trafficking, and egress in normal cells, and their perturbations in cance

198 Increased alpha-synuclein egress in serum neuronal exosomes precedes the diagnosis

199 stalk between PKA and PKG pathways to govern egress in T. gondii.

200 cGMP-dependent protein kinase G (PKG) blocks egress induced by PKAc1 inactivation or environmental ac

201 rapidly as minutes, after which neutrophils egress intact.

202 Prior to entering the brain, iMOs must egress into the blood from the bone marrow through a mec

203 e, including atherosclerosis, where monocyte egress into the intimal space is central to formation of

204 the local lymph nodes but were not detected egressing into the hepatic vein.

205 o secretory organelle protein processing for egress, invasion, and effector export.

206 ular dynamics simulations reveal that sterol egress involves widening of the fracture, penetration of

207 ts support an exosome-like mechanism of eHAV egress involving endosomal budding of HAV capsids into m

208 Thymocyte egress is a critical determinant of T cell homeostasis a

209 The path observed for benzene egress is a multistep ligand migration from the buried c

210 However, the machinery of circovirus nuclear egress is currently unknown.

211 This egress is locally supported by light-triggered sympathet

212 viral entry, gene expression, assembly, and egress is poorly understood.

213 This unconventional egress is regulated by the Arf-like small GTPase Arl8b a

214 erebral hemorrhages, with accompanying fluid egress, may cause fatal brain swelling.

215 usly undescribed, membrane-engaged, nonlytic egress mechanism and highlights a potential new target f

216 amine actin tail formation, one of the viral egress mechanisms for cell-to-cell dissemination, and re

217 Last, we explore alternative egress mechanisms, including tunnelling nanotubes and ho

218 ulation of microneme exocytosis that ensures egress, motility, and invasion.

219 ame Syk kinase inhibitors suppress merozoite egress near the end of the parasite's intraerythrocytic

220 The egress of alpha-synuclein in neuronally derived exosomes

221 hinery, is necessary for efficient entry and egress of Autographa californica multiple nucleopolyhedr

222 st-cell invasion, growth, proliferation, and egress of blood-stage Plasmodium falciparum, yet our und

223 to midgut triggers "rounding up" followed by egress of both male and female gametes.

224 is required for efficient entry and nuclear egress of budded virions of AcMNPV.IMPORTANCE Little is

225 ese results suggest their involvement in the egress of BV.

226 hingosine-1-phosphate pathway, restrains the egress of CCR7(+) lymphocytes from lymphatic tissues int

227 er influenza infection is contemporized with egress of CD69+/CD103+ CD8+ T cells to the draining medi

228 , IFN-gamma, TNF-alpha) correlated with both egress of circulating virus-specific T(H)1 cells and wor

229 nd Rom1 reduced invasion, proliferation, and egress of Cryptosporidium.

230 The literature on the egress of different herpesviruses after secondary envelo

231 us Amot is crucial for positively regulating egress of eVP40 virus-like particles (VLPs) and for egre

232 res NF-kappaB signaling as well as apoptotic egress of excessive cells.

233 hesis that hnRNPA2B1 plays a key role in the egress of exosomes and HSV-1 from infected cells.

234 ell adhesion genes, consistent with enhanced egress of FA HSPCs from bone marrow to peripheral blood.

235 hrough signals that enhance the retention or egress of hematopoietic stem cells (HSCs) from bone marr

236 noradrenergic activity causes predominant BM egress of HSPCs and leukocytes via beta(3)-adrenergic re

237 mpathetic noradrenergic tone and decrease BM egress of HSPCs and leukocytes.

238 l ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow.

239 on induced reticulocytosis and the premature egress of immature progenitors to the systemic circulati

240 Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the

241 during La Crosse Virus-induced encephalitis, egress of iMOs was surprisingly independent of CCR2, wit

242 y conserves this activity in vivo to promote egress of infected B cells from lymph nodes into periphe

243 n and also a later stage during assembly and egress of infectious virus, with COPI-knockdown reducing

244 ia-mediated CCR1 upregulation in driving the egress of multiple myeloma PCs from the bone marrow.

245 During herpesvirus infection, egress of nascent viral capsids from the nucleus is medi

246 use a common mechanism of action by blocking egress of nascent virions from infected cells, thereby p

247 ely, constitutive loss of sema3f accelerated egress of neutrophils from the tail injury site in fish,

248 replication, but is absolutely essential for egress of parasites from host red blood cells.

249 quired for efficient entry of BV and nuclear egress of progeny nucleocapsids of baculoviruses.

250 mponents) are required for efficient nuclear egress of progeny nucleocapsids.

251 -I) are also necessary for efficient nuclear egress of progeny nucleocapsids.

252 ted in a discernible effect on the entry and egress of progeny Sendai virus.

253 This in turn facilitates the nuclear egress of progeny viral capsids and thus the formation o

254 e in rate constants for both the ingress and egress of substrate.

255 sphate receptor 1 (S1P1) is critical for the egress of T and B cells out of lymphoid organs.

256 lar pathogen Listeria monocytogenes promotes egress of the bacteria from vacuolar compartments into t

257 , weakening the plasma membrane and allowing egress of the bacteria.

258 The egress of the genome from SBPV virions is associated wit

259 g the T3SS2 appeared to lack a mechanism for egress of this bacterium from the invaded host cell.

260 identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.

261 dy revealed that S1P1 not only regulated the egress of Treg cells out of lymphoid organs and subseque

262 oat around the capsid, leading to productive egress of UL25-decorated capsids.

263 ng of phagocytosed material, replication and egress of viral particles, and regulation of inflammator

264 cation compartments, and the envelopment and egress of virions.

265 hat ubiquitination of eVP40 by WWP1 enhances egress of VLPs and concomitantly decreases cellular leve

266 e GLI1 association with LAP2alpha, promoting egress off the INM.

267 Indeed, inhibitors of invasion and egress offer hope for a desperately needed new drug to c

268 ng as a mechanism that restricts viral entry/egress or transports RABV particles through axons.IMPORT

269 mobilization, gamete formation, and gametes egress out of erythrocytes.

270 ecular properties of the residues lining the egress path suggest that protein surface electrostatic p

271 and HSV1 laboratories about evidence for two egress pathways are included.

272 duces effects that biologically resemble the egress phenotype taken on by CLL cells treated with idel

273 rove our understanding of the viral assembly/egress process and point to potential interactions with

274 tilize host cytoplasmic resources, elaborate egress processes have evolved to minimize the time betwe

275 ced exploitation of lysosomal organelles for egress provides insights into the cellular and immunolog

276 onaviruses utilize lysosomal trafficking for egress rather than the biosynthetic secretory pathway mo

277 ruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric basic

278 s between these proteins during assembly and egress remain to be fully understood.

279 and replication pathways, but their mode of egress remains uncertain.

280 cGMP-phosphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisation.

281 Egress requires secretion of a perforin-like protein, Pf

282 Lysosomal cholesterol egress requires two proteins, NPC1 and NPC2, whose defec

283 Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects o

284 failed to migrate within oocysts and did not egress, suggesting that TRP1 is a vital component of the

285 eractions are essential for normal thymocyte egress, T cell trafficking, and homeostasis.

286 hypoxia, protein deposition and immune cell egress that allows the development of a CNS-specific imm

287 of porcine circovirus type 2 (PCV2) nuclear egress that forms a complex with the viral capsid (Cap)

288 o investigate how Ca(2+) signaling activates egress through CDPKs, we performed a forward genetic scr

289 e antigen could also inhibit virus entry and egress to provide host protection.

290 emonstrate that the CCR2 requirement for iMO egress to the blood is not universal for all viruses.

291 nyon virus also induced CCR2-independent iMO egress to the blood.

292 While MR1 egress to the cell surface is ligand-dependent, the abil

293 lls that have completed thymic selection and egress to the lymphoid periphery.

294 arin surprisingly inhibited malaria parasite egress, trapping merozoites within infected erythrocytes

295 rving replication, virion assembly, or virus egress via budding out of infected cells.

296 the sympathetic nervous system regulate HSC egress via its niche, but how the brain communicates wit

297 , the entire infection cycle (i.e., entry to egress) was considerably slower for the T2SS mutant than

298 ell-intrinsic regulator of T cell lymph node egress, we conclude that the druggable Notch signaling p

299 ls (HBMECs) and observed one or two distinct egress zones per cell at the basal surface.

300 scopy and 3D electron tomography (ET) of the egress zones revealed clusters of virions within membran