ライフサイエンスコーパス: electroneutral

1 bOH and by a mechanism that is predominately electroneutral.

2 nic, that mediated by human SLC26A6 appeared electroneutral.

3 rginine, which is a mutation that makes NapA electroneutral.

4 - 2, 2'-disulfonates and may not be strictly electroneutral.

5 (+) binding, so that the overall reaction is electroneutral.

6 hermus thermophilus, renders the transporter electroneutral.

7 ay, thus allowing the second oxidation to be electroneutral.

8 nd complex, on the other hand, appears to be electroneutral.

9 demonstrated that this transport process is electroneutral.

10 6A6-mediated oxalate transport appears to be electroneutral.

11 odium/hydrogen exchanger, NHE1, mediates the electroneutral 1:1 exchange of Na+ and H+ across the pla

12 TP stoichiometry of the Na(+),K(+)-ATPase to electroneutral 2Na(+):2K(+):1ATP stoichiometry similar t

13 eral ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.

14 hia coli, the UhpT transporter catalyzes the electroneutral accumulation of sugar 6-phosphate by exch

15 in tissue we find that compensation involves electroneutral active transport of Na(+), K(+), and Cl(-

16 nions, opposing a long-standing dogma of the electroneutral activity of pendrin.

17 nd extracellular osmolytes, both charged and electroneutral) adds complexity, but does not change the

18 We conclude from these data that electroneutral, amiloride-sensitive NBC is encoded by NB

19 17 mM, transport by all three ionophores is electroneutral and apparently occurs through complexes o

20 We propose that both, electroneutral and electrogenic Na(+)/H(+) antiporters,

21 ic structure of the translocation complex in electroneutral and electrogenic Na(+)/H(+) exchangers.

22 ransports 1 Na(+), 1 K(+) and 2 Cl(-), it is electroneutral and its activation had little effect on m

23 running in the forward direction, NDCBE1 is electroneutral and mediates increases in both pH(i) and

24 atalyzes inorganic phosphate transport in an electroneutral and pH gradient-dependent manner across t

25 (+)/H(+) exchangers, electrogenic as well as electroneutral, and elegantly explains their pH regulati

26 in AE1 membrane-spanning domain convert the electroneutral anion exchanger into a Na(+) and K(+) con

27 uctive pathway has some commonality with the electroneutral anion-exchange pathway.

28 Electroneutral ApNEAAT1 transport is driven by amino aci

29 Thus, these chimeras were electroneutral, as were two others consisting of NBCe1(N

30 t is regulated through the Ca(2+)-activated, electroneutral ATP-Mg/P(i) carrier (APC).

31 enic chloride, electrogenic bicarbonate, and electroneutral bicarbonate secretion.

32 at transmembrane redox mediated by SP-AQ was electroneutral, but reaction by the other quinone-contai

33 ) antiporter NapA from being electrogenic to electroneutral by the mutation of a single lysine residu

34 The electroneutral C932R mutant of the Na(+),K(+)-ATPase ret

35 upper limit of what is accessible within the electroneutral, canonical base pairing framework.

36 NKCC1, is a member of a small gene family of electroneutral cation-chloride cotransporters (CCCs) wit

37 sporters (KCCs) belong to the gene family of electroneutral cation-chloride cotransporters, which als

38 family consists of SLC12A1-SLC12A9, encoding electroneutral cation-coupled chloride co-transporters.

39 rted 5-HT and ions is predicted to result in electroneutral charge movement.

40 Of these, seven are known to be electroneutral chloride transporters.

41 rbonate transporter family SLC4, mediates an electroneutral chloride/bicarbonate exchange in physiolo

42 e or oxalate for chloride or bicarbonate and electroneutral chloride:bicarbonate exchange.

43 293 cells, mDRA conferred Na(+)-independent, electroneutral Cl(-)/CHO(3)(-) exchange activity.

44 ouse slc26a6 and human SLC26A6 each mediated electroneutral Cl(-)/HCO(3)(-) and Cl(-)/OH(-) exchange.

45 nism, and acute regulation, but both mediate electroneutral Cl(-)/HCO(3)(-) exchange.

46 The SLC12 family of genes encodes electroneutral Cl--dependent cation transporters (i.e.,

47 oth of these exchangers probably mediate the electroneutral Cl--dependent HCO3-transport observed in

48 st for HCO3- transport via conductive versus electroneutral Cl-/HCO3- exchange (anion exchange, AE) p

49 - transporters while Slc26a4 functions as an electroneutral Cl-/I-/HCO(3)- exchanger.

50 found that, whereas AE1Delta(6: 7) has some electroneutral Cl-base exchange activity, the protein al

51 erefore suggest a shift from a predominantly electroneutral Cl-HCO3- exchange in normal mice, to a pr

52 red cell anion exchanger AE1 (band 3) is an electroneutral Cl-HCO3- exchanger with 12-14 transmembra

53 cument that HCO3- transport is a reversible, electroneutral, Cl dependent, Na+-independent process.

54 ments suggest that MARCKS-(151-175) forms an electroneutral complex with approximately 4 PIP(2).

55 Despite this electroneutral cotransport activity, the transporter med

56 f cellular cystine uptake via system xc-, an electroneutral cystine-glutamate exchanger.

57 human Na(+)/H(+) exchanger NHA2 (SLC9B2) is electroneutral, despite harboring the two conserved aspa

58 led pH(i) recovery rates, suggesting that an electroneutral, DNDS-sensitive, Cl(-)-HCO(3)(-) exchange

59 The exchange is probably electroneutral, energized by the transmembrane pH gradie

60 Our data are consistent with electroneutral entry of Na(+) occurring in axons and con

61 troduced as perturbations away from a nearly electroneutral equilibrium environment.

62 ta from two experimental approaches supports electroneutral exchange (one Na+ exchanged for one proto

63 The mechanism appears to involve electroneutral exchange of a TBT-dicarboxylate-H complex

64 ent cellular acidification by catalyzing the electroneutral exchange of extracellular sodium for an i

65 he cation proton antiporter family drive the electroneutral exchange of H(+) against Na(+) ions and e

66 The gastric H,K-ATPase catalyzes electroneutral exchange of H(+) for K(+) as a function o

67 In contrast to the electroneutral exchange of H+ for Na+ and neutral amino

68 ies with both AE1 and NBCe1 by mediating the electroneutral exchange of sodium-carbonate with chlorid

69 YqkI mediated an electroneutral exchange, which is proposed to be a malic

70 Here we show that ASCT1 functions as an electroneutral exchanger that mediates negligible net am

71 encompasses a P2 ATPase pump (which shuttles electroneutral function at low pH) along with different

72 he vesicular gastric H,K-ATPase catalyzes an electroneutral H for K exchange allowing acidification o

73 Functional studies show that TsFpn is an electroneutral H(+)/Fe(2+) antiporter so that transport

74 In contrast, amiloride-sensitive, electroneutral, [H(+)]-dependent NBC activity is present

75 However, in CF, carbachol resulted in an electroneutral HCO(3)(-) secretion, whereas STa induced

76 report that SLC26A4 functions as a coupled, electroneutral I(-)/Cl(-), I(-)/HCO(3)(-) and Cl(-)/HCO(

77 This attributed the DeltaV(S+) to an electroneutral increase in the effective osmotic activit

78 charge stabilization can favor pathways with electroneutral intermediates resulting from proton-coupl

79 In contrast, expression of Slc9A (NHE3), an electroneutral ion channel, and of GlyR, an inactive Cl(

80 fficult to pursue through the application of electroneutral ionophores.

81 Under conditions that promoted electroneutral K(+)-K(+) exchange by the Na,K-ATPase, st

82 in Xenopus oocytes show that NHA1 acts as an electroneutral K(+)/H(+) antiporter.

83 Electroneutral K+/Cl- cotransport was demonstrated in Si

84 Electroneutral K+/H+ exchange, which we propose is perfo

85 uctance, Ca 2+ -sensitive K channel, and the electroneutral K:Cl cotransporter-leading to sickle cell

86 Electroneutral lysine mutants show similar ion affinitie

87 nsport of Cl(-) with K(+) and/or Na(+) in an electroneutral manner.

88 Monensin transports Pb(2+) by an electroneutral mechanism in which the complex PbMonOH is

89 that DC5-DC10 can also be transported by an electroneutral mechanism mediated by tributyltin, a pote

90 DC6-DC10 are also transported by an electroneutral mechanism that appears to reflect transpo

91 9 and 250 microM, La3+ is transported by an electroneutral mechanism, predominately through mixed co

92 m-hydrogen exchanger (NHE-1) is a ubiquitous electroneutral membrane transporter that is activated by

93 In electroneutral membranes, the concentration of the posit

94 Electroneutral monovalent cation/proton antiport across

95 we have developed a hypothesis involving the electroneutral movement of Na(+) ions across the axon me

96 HCO 3 " cotransporter NBCe1 (SLC4A4) and the electroneutral Na + -driven Cl-"HCO 3 " exchanger NDCBE

97 ility to mannitol at 1 hour and decreases in electroneutral Na(+) absorption, Na(+)-dependent glucose

98 ajor transport protein responsible for ileal electroneutral Na(+) absorption.

99 onsistent with a warming-induced increase in electroneutral Na(+) entry.

100 boxylic acid ionophore monensin, known as an electroneutral Na(+) ionophore, an anticoccidial agent,

101 Part, but probably not all, of the electroneutral Na(+) movement is eliminated by removing

102 Blocking electroneutral Na(+) movement is predicted to be useful

103 nce of bumetanide and amiloride (blockers of electroneutral Na(+) movement), the action potential amp

104 yperpolarization that is reduced by blocking electroneutral Na(+) movement.

105 Conversely, electroneutral Na(+), K(+), and Cl(-) absorption was dra

106 The slc4a10 gene encodes an electroneutral Na(+)-dependent HCO(3)(-) importer for wh

107 The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na(+)-dependent transporter responsible f

108 The electroneutral Na(+)-driven Cl-HCO3 exchanger is a key m

109 Thus, NDCBE1 encodes a human, electroneutral Na(+)-driven Cl-HCO3 exchanger.

110 Electroneutral Na(+)-H(+) exchange is present in virtual

111 Cl(-)-HCO(3)(-) exchanger (AE2) but not the electroneutral Na(+)-HCO(3)(-) cotransporter NBCn1.

112 Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1)

113 ents generated by Na,K-ATPase functioning in electroneutral Na(+)-Na(+) exchange mode were measured a

114 rst electrophysiological investigation of an electroneutral Na(+)/H(+) exchanger, NhaP1 from Methanoc

115 nformational changes in MjNhaP1, an archaeal electroneutral Na(+)/H(+)-antiporter resembling the huma

116 The electroneutral Na(+)/HCO(3) (-) cotransporter NBCn1 (Slc

117 ere, we identified two novel variants of the electroneutral Na(+)/HCO3- cotransporter NBCn1, one full

118 er vertebrates is likely responsible for the electroneutral Na(+)/lactate cotransport reported in mam

119 /L [mucosal], 0 mmol/L [serosal]) stimulated electroneutral Na+ absorption, which was inhibited by bi

120 port is distinct from epinephrine-stimulated electroneutral Na+ absorption.

121 SLC4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regu

122 , the Na+-driven Cl-/HCO3- exchanger and the electroneutral Na+/HCO3- cotransporter, have crucial rol

123 e report the cloning of three variants of an electroneutral Na+/HCO3- cotransporter, NBCn1, from rat

124 Electroneutral Na-(K)-Cl cotransporters are present in m

125 In vascular endothelium, the electroneutral Na-K-Cl cotransport system is thought to

126 We propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2.

127 th residues at the corresponding site of all electroneutral Na/HCO(3) transporters.

128 , and humans; approximately 73% to mammalian electroneutral Na/HCO3 cotransporters (NBCn1); 71% to mo

129 assium absorption in the rat distal colon is electroneutral, Na(+)-independent, partially chloride-de

130 NBCn1-B (which encodes 1,218 amino acids) is electroneutral, Na+-dependent and HCO3(-)-dependent, but

131 Two electroneutral, Na+-driven HCO3- transporters, the Na+-d

132 -)/HCO(3)(-) exchanger coupled with Nhe3 for electroneutral NaCl absorption across mammalian small in

133 Electroneutral NaCl absorption across small intestine co

134 electrogenic Cl(-) secretion, inhibition of electroneutral NaCl absorption and in some cases, downre

135 Electroneutral NaCl absorption mediated by Na+/H+ exchan

136 c adenosine monophosphate with inhibition of electroneutral NaCl absorption.

137 (36)Cl flux across murine jejunum, a site of electroneutral NaCl absorption.

138 NCC helps to retain potassium by increasing electroneutral NaCl reabsorption, therefore reducing Na(

139 ecently described a novel thiazide-sensitive electroneutral NaCl transport mechanism resulting from t

140 Both electrogenic and electroneutral NBC activities are saturable processes wi

141 ough it was slowed significantly, suggesting electroneutral NBC may also be operational.

142 t NBC isoforms [i.e. electrogenic (NBCe) and electroneutral (NBCn)] that exhibit tissue specific expr

143 t are controversial, with reports suggesting electroneutral (NBCn; 1HCO(3)(-) : 1Na(+); coupling coef

144 , we constructed chimeras of NBCe1-A and the electroneutral NBCn1-B, and used two-electrode voltage c

145 ominantly expressed in proximal colon, while electroneutral NBCn1C or NBCn1D (NBCn1C/D) is expressed

146 or increases in root respiration, suggesting electroneutral NH3 transport.

147 , capable of mediating both electrogenic and electroneutral (nonelectrogenic) transport processes.

148 ld exert repulsive forces on any approaching electroneutral object in close proximity, resulting in s

149 selective for sodium (apparent Km=31 mm) and electroneutral (one sodium ion for each proton).

150 ve higher yields for benzyl alcohols bearing electroneutral or electron-withdrawing substituents.

151 Each mutation replaced an electroneutral or electronegative residue with one that

152 n its anionic form despite its binding being electroneutral overall.

153 tric H(+)/K(+) pump, a strict H(+)-dependent electroneutral P-type ATPase, into a bona fide Na(+)-dep

154 ast, we demonstrated that oxalate shares the electroneutral pathway mediating Na+-independent sulfate

155 ow pK(a), consequently, they cannot catalyze electroneutral proton transport in the bilayer and canno

156 mbrane potential, even when a hypothetically electroneutral pump is used in calculations and K+ and N

157 Positively charged and electroneutral redox partners tend to react at the acidi

158 The results are consistent with electroneutral release of ADP before Na(+) is deoccluded

159 No electroneutral reversed uptake was detected, contradicti

160 NKCC1) is a member of a small gene family of electroneutral salt transporters that play essential rol

161 NKCC1 is a member of a small gene family of electroneutral salt transporters.

162 members of the NKCC1 gene family (slc12) of electroneutral salt transporters.

163 Short-term K(+) release is electroneutral, since electrophysiological measurements

164 fish SLC5A8 ortholog, and zSMCTn is a novel, electroneutral SMCT (zSlc5a12).

165 ium intake and plasma potassium are low, the electroneutral sodium chloride cotransporter is activate

166 With-no-lysine kinase 4 (WNK4) inhibits electroneutral sodium chloride reabsorption by attenuati

167 ogeneity is present along this segment, with electroneutral sodium transport dominating more proximal

168 rter isoforms 1 and 2 (NBCe1 and NBCe2), the electroneutral sodium-bicarbonate cotransporter (NBCn1),

169 r and electrophysiological properties of the electroneutral sodium/bicarbonate cotransporter (NBCn1)

170 e resolved the substrate ion in the dimeric, electroneutral sodium/proton antiporter PaNhaP from Pyro

171 Transport of the electroneutral solute sorbitol via the NPPs was found to

172 nge of transport techniques to study whether electroneutral solutes use these channels or altered/sep

173 Although their transport cycle is overall electroneutral, specific partial reactions are electroge

174 electron-withdrawing, electron-donating, and electroneutral substituents enables investigation of mul

175 chiometry, which exceeds that predicted from electroneutral substrate transport.

176 transporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na(+), 1 K(+), and 2 Cl(-) a

177 e cotransporters (CCCs) mediate the coupled, electroneutral symport of cations with chloride across t

178 tion-chloride cotransporters (CCCs) catalyze electroneutral symport of Cl(-) with Na(+) and/or K(+) a

179 nalysis established that SdcS facilitates an electroneutral symport reaction having a 2:1 cation/dica

180 ly, some of the assemblies that form are not electroneutral-that is, they possess a net charge.

181 If the BNC reduction is electroneutral, then the heme a E(m) is independent of t

182 the dianions yielded the stable and isolable electroneutral title biradicals.

183 ated Cl(-)-dependent HCO(3)(-) secretion and electroneutral transepithelial NaCl reabsorption in micr

184 Gastric H,K-ATPase is an electroneutral transmembrane pump that moves protons fro

185 a(+):2K(+):1ATP stoichiometry similar to the electroneutral transport mode of the H(+),K(+)-ATPase.

186 inding at the third site is decisive for the electroneutral transport mode of this pump.

187 f almost all cells and which mediate the 1:1 electroneutral transport of a proton and a lactate ion.

188 wo protons, performing both electrogenic and electroneutral transport of a single substrate.

189 n-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or s

190 Coupled electroneutral transport of Na+, K+ and Cl- is mediated

191 Second, it mediates coupled, electroneutral transport of proton or hydroxide with chl

192 te stoichiometry in the same membrane domain-electroneutral transport), the CF-associated aberrant HC

193 ree shows that Sp-NBC branches closer to the electroneutral type of HCO3- transporters.

194 Na(+)/ ClO(4)(-) transport stoichiometry is electroneutral, uncovering that NIS translocates differe

195 an SERTs, the transport cycle is reported as electroneutral, with a translocation of zero net charge,

196 rs such as 99mTc-sestamibi, this compound is electroneutral, with biodistribution not affected by per

197 ish (Danio rerio), electrogenic (zSMCTe) and electroneutral (zSMCTn).