ライフサイエンスコーパス: electrophilic

1 his paper, we report the formation of highly electrophilic 1,1-deactivated olefins, their use as nove

2 nes with triflic anhydride (Tf(2)O) forms an electrophilic 1-trifloyl-aziridin-2-yl triflate species

3 oup, oxidation of an alpha-boryl radical, or electrophilic activation of an alkenyl boronate complex.

4 the concept of boronic acid catalysis (BAC), electrophilic activation of carboxylic acids leads to th

5 The electrophilic activation of double bonds in the bicyclic

6 The C-terminal electrophilic activation of peptides by alpha-thioesteri

7 The opening of epoxides typically requires electrophilic activation, and subsequent nucleophilic (S

8 Together, these observations show that more electrophilic active-oxygen species (i.e., lower-energy

9 roperoxy derivative 7'' that evolved into an electrophilic acyl azolium, opening to the aldehyde-to-e

10 a vinyl cation from arylglyoxal and alkyne, electrophilic addition of the vinyl cation to the ipso c

11 as synthesized using a straightforward click/electrophilic addition or click/oxidative coupling tande

12 b (m/z 295 and m/z 323, respectively) via an electrophilic addition pathway.

13 tu under catalytic hydrogenation conditions, electrophilic addition to the keteniminate was achieved

14 describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization o

15 A showed increased tolerance to oxidants and electrophilic agents.

16 al Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl m

17 acid from the 4-position to afford a highly electrophilic alkenediazonium ion.

18 A novel reaction of tetranitromethane with electrophilic alkenes in the presence of triethylamine a

19 s, with alpha,beta-unsaturated aldehydes and electrophilic alkenes proceed with total periselectivity

20 polar cycloaddition between imino esters and electrophilic alkenes, employing chiral metal complexes

21 is process provides the heterocyclization of electrophilic alkenes.

22 , this ligand-free CrCl(2) enables efficient electrophilic alkenylations of primary, secondary, and t

23 nucleophilic attack at the less substituted electrophilic alpha'-carbon.

24 based key intermediates including a 1,4-(bis)electrophilic alpha,beta-unsaturated ketenyl phosphonium

25 egrees C generated in situ the corresponding electrophilic alpha-trifluoromethyl N-acyliminium ions t

26 In the case of electrophilic amidyl radicals, cascade processes involvi

27 d is dependent on the generation of a potent electrophilic aminating agent released by in situ deprot

28 This copper can react with an electrophilic aminating reagent, 1,2-benzisoxazole, to p

29 Attempted electrophilic amination of aromatics such as benzene and

30 describe a chiral phosphoric acid catalyzed electrophilic amination of enecarbamates with dibenzyl a

31 the enantioselective tandem three-component electrophilic amination of enecarbamates.

32 Electrophilic amination often requires a disparate toolk

33 ly formation of the heterotricyclic core, an electrophilic amination, and the stereoselective hydroge

34 n and chemically intuitive to assign cations electrophilic and anions nucleophilic reactivity, respec

35 ir molecular analogues because they are less electrophilic and dynamic, as revealed by their (13)C NM

36 depends strongly on the distance between the electrophilic and nucleophilic carbon atoms and the stru

37 droxy groups can be exploited to enable both electrophilic and nucleophilic modes of activation in va

38 complexes with beta-diketiminate ligands in electrophilic and nucleophilic oxidation reactions is re

39 ble to quantitation of other nucleophilic or electrophilic and perhaps even more reactive metabolites

40 l or aryl group; M = a transition metal) are electrophilic and thermally unstable.

41 allenging to identify and study due to their electrophilic and transient nature.

42 w chemical concept of "dipole-discriminating electrophilic anions."

43 Nitro-fatty acids are electrophilic anti-inflammatory mediators which are gene

44 polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet-Spe

45 Classical electrophilic aromatic halogenations are a powerful type

46 Enantioselective electrophilic aromatic nitration methodology is needed t

47 the rich mechanistic landscape of the iconic electrophilic aromatic substitution (EAS) reaction class

48 eveal two mechanisms for C-H borylation, (i) electrophilic aromatic substitution (prevalent with B-X

49 ort the development of remote regioselective electrophilic aromatic substitution (S(E)Ar) reactions t

50 s was achieved with a highly atroposelective electrophilic aromatic substitution catalyzed by a chira

51 gh the nature of the oxidants that carry out electrophilic aromatic substitution has been deduced fro

52 Electrophilic aromatic substitution is one of the most i

53 The electrophilic aromatic substitution of a C-H bond of ben

54 Ability of indole to undergo electrophilic aromatic substitution reaction was studied

55 Here we perform an abiotic electrophilic aromatic substitution reaction, which is d

56 odel able to predict the reactive site of an electrophilic aromatic substitution with an accuracy of

57 ing cyclization of the E-enone (via Nazarov, electrophilic aromatic substitution, and elimination rea

58 The reaction is thought to proceed via electrophilic aromatic substitution, catalyzed by enzyma

59 the catalytic residue determines the site of electrophilic aromatic substitution.

60 ngement, 6-exo-trig cyclization, and a final electrophilic aromatic substitution.

61 rings can be exploited to precisely control electrophilic aromatic substitutions.

62 an anionic CF(3) group is transferred to an electrophilic aryl group.

63 chemiluminescence (CL) based on the specific electrophilic attack of (*)OH.

64 ssential step in the mechanism that makes an electrophilic attack on the olefin bond possible as the

65 heterolytic cleavage, sigma-bond metathesis, electrophilic attack, etc.

66 ole in activating the olefin for concomitant electrophilic attack.

67 s, iodine(III) salts feature two directional electrophilic axes perpendicular to each other.

68 y an intermolecular C-N bond formation using electrophilic azidoiodinane.

69 igations reveal the intermediacy of a highly electrophilic Bi(V) species, which rapidly eliminates ph

70 rylation of (hetero)arenes and alkenes using electrophilic boranes is a powerful transition metal fre

71 ategy that applies unique features of highly electrophilic boron catalysts, such as tris(pentafluorop

72 Acyl-directed electrophilic borylation can be extended to carbazoles a

73 Herein, a facile one-pot hydroboration electrophilic borylation cascade/dehydrogenation approac

74 pyridyl ring have been prepared via directed electrophilic borylation.

75 We also show for the first time that an electrophilic borylene such as 1 can react with N2 rever

76 his mechanism and is found to involve double-electrophilic bromination followed by thermal eliminatio

77 A highly reactive electrophilic bromodifluoromethylthiolating reagent, alp

78 ing between a tertiary carbon radical and an electrophilic butenolide resulting in the stereoselectiv

79 is typically nucleophilic, has been rendered electrophilic by changes to the oxidation state.

80 dented pathway that avoids the production of electrophilic byproducts, a severe limitation that has p

81 with no evidence for attachment at the more electrophilic C(2)-position.

82 undergoes a C-C bond cleavage to produce an electrophilic C-3 site in N-pyridyl indole.

83 zirconia, imbuing high levels of activity in electrophilic C-H bond functionalization reactions such

84 hetic procedures reported for intramolecular electrophilic C-H borylation contain many common feature

85 s, with acyl group installation and directed electrophilic C-H borylation enabling selective formatio

86 To date, intramolecular electrophilic C-H borylation is utilised mainly for acce

87 Less prevalent intramolecular electrophilic C-H borylation reactions that proceed by i

88 nts are used for sequential nucleophilic and electrophilic C-N bond formations, with the latter effec

89 4+1]-cycloaddition between diazooxindoles as electrophilic C1 synthons and 1,3-heterodienes for the c

90 nation, the pentacyclic core was accessed by electrophilic C19-amide activation and transannular spir

91 We show that despite the presence of the electrophilic carbamoyl chloride function the products s

92 previously demonstrated that stable singlet electrophilic carbenes can behave as metal surrogates in

93 Cl](+) ([4](+) ; Xan=9-xanthylium) where the electrophilic carbenium moiety is juxtaposed with the me

94 mplex that controls the configuration at the electrophilic carbon and a copper catalyst that controls

95 tional reactions, such as methyl transfer to electrophilic carbon atoms, sulfur to Calpha atom thioet

96 he nucleophile prefers to attack at the more electrophilic carbon of the pai-allyl iridium intermedia

97 ave been dicarbofunctionalized here with two electrophilic carbon sources under reductive conditions.

98 ually, ynamides are excellent acceptors for "electrophilic" carbon-centered radicals.

99 ofur is an antineoplastic drug containing an electrophilic carbonyl reactive group that targets the c

100 With the view of developing self-activating electrophilic catalysts, we are now investigating comple

101 relectrophiles that are composed of a strong electrophilic center firmly embedded in a negatively cha

102 bond formation and at a later stage a remote electrophilic center to facilitate OH(-) nucleophilic at

103 inetics, consistent with the presence of two electrophilic centers in NO2-CLA located on the beta- an

104 ch as TiO(2), constitute remarkable powerful electrophilic centers, capable of capturing an electron

105 f Z-type ligands can be used to modulate the electrophilic character and catalytic properties of coor

106 Most notably, the electrophilic character at the 4-position of pyridine in

107 h molecular orbital analysis, which suggests electrophilic character at the nitride functionality.

108 65e and +0.64e, respectively, indicating the electrophilic character of the phosphinidene {(NHC)C(Ph)

109 gations is the development of catalysts with electrophilic character that transfer electrophilicity t

110 presents a unique challenge for introducing electrophilic chemical groups.

111 Directed nucleophilic and electrophilic chemistry was developed to vary this 5-pos

112 We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis

113 oate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chloros

114 (E=S, Se) dianion, which can be reacted with electrophilic [ClP(mu-NR)]2 to give P(III) /P(V) hexamer

115 MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide u

116 ethod to monitor the metabolic regulation of electrophilic cofactors and discover novel types of elec

117 s are typical hydroxylations, mediated by an electrophilic compound I mechanism.

118 We further show that electrophilic compounds can impair T cell activation by

119 Electrophilic compounds originating from nature or chemi

120 in mass spectrometry to profile specifically electrophilic compounds originating metabolites.

121 and-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AI

122 The TRPA1 ion channel is activated by electrophilic compounds through the covalent modificatio

123 an enzyme that catalyzes the conjugation of electrophilic compounds with glutathione to facilitate t

124 forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formati

125 s occurs to access a uniquely effective acyl electrophilic coupling partner.

126 ides or pseudohalides were the only suitable electrophilic coupling partners.

127 Employing the electrophilic cyanating reagent N-cyano-N-phenyl-p-tolue

128 to internally substituted 1,3-dienes and an electrophilic cyanating reagent with high regio and ster

129 nzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malon

130 organylchalcogenyl)isoquinoline-2-oxides via electrophilic cyclization between alkynylbenzaldoximes a

131 inolines and azido-iodo-pyranoquinolines via electrophilic cyclization of o-alkynylaldehydes in the p

132 lenides and iron(III) chloride, but a direct electrophilic cyclization, promoted by the in situ forme

133 ts new role as an alkynophilic Lewis acid in electrophilic cyclization/dealkylation reactions.

134 The angular methyl groups were attached by electrophilic cyclopropanation-ring opening.

135 propane hydrolase activity that converts the electrophilic cyclopropane of the colibactins into an in

136 NRPS-PKS assembly line and incorporating two electrophilic cyclopropane warheads into the final natur

137 hat colibactin alkylates DNA with an unusual electrophilic cyclopropane.

138 iotic fungal metabolites possessing a masked electrophilic cyclopropane.

139 or 12% of the oxidation products, as well as electrophilic dehydration products of the cholesterol hy

140 sphirene (1) was prepared by treatment of an electrophilic diamidocarbene with tert-butylphosphaalkyn

141 ity toward diacetyl and methylglyoxal, toxic electrophilic dicarbonyls.

142 ion of chlorine gas followed by Cl2-mediated electrophilic dichlorination.

143 n, hydrodehalogenation of halothiophenes, or electrophilic "dimerization".

144 ctive interactions between a nucleophile and electrophilic dye in complex environments is a central g

145 However, electrophilic early transition metal (groups 3 and 4)-ca

146 An electrophilic enantioselective catalytic method for the

147 t umpolung via N-oxide addition generates an electrophilic enolonium species that can be coupled with

148 bs molecular O(2), forming a rarely reported electrophilic eta(2)-O(2) species at 298 K.

149 ated dienes enable the formation of a highly electrophilic eta(3) Pd-allyl species and greatly facili

150 Herein, the anti-neoplastic effects of the electrophilic fatty acid nitroalkene derivative, 10-nitr

151 Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammato

152 l bromides is observed in the presence of an electrophilic fluorinating reagent containing a weak N-F

153 s of alpha-fluoro-beta-ketosulfides using an electrophilic fluorination method has been reported for

154 The reaction proceeds via an electrophilic fluorination of alpha-sulfenyl-beta-diketo

155 The large majority of known methods employ electrophilic fluorination reagents, but methods combini

156 The main focus has been directed to the electrophilic fluoroalkylation and arylation methods.

157 report the synthesis of a diverse library of electrophilic fragments and demonstrate an integrated us

158 -NRF2 pathway, to discover cysteine-reactive electrophilic fragments from a reporter-based screen for

159 mits reversible fragment screening, but such electrophilic fragments were considered nonselective and

160 enge and constructed a library of 993 mildly electrophilic fragments.

161 ium methylating reagent that preserves other electrophilic functionalities on the substrate.

162 xploited the reactivity of novel unsaturated electrophilic functions such as vinyl-sulfones, -ketones

163 the carbonyl carbon of a peptide bond or an electrophilic group of an inhibitor.

164 Electrophilic groups that target amino-acid nucleophiles

165 Electrophilic halofunctionalization reactions have under

166 (XB), the noncovalent interaction between an electrophilic halogen atom and a Lewis base, with highly

167 ssically, this reaction is performed with an electrophilic halogen source and leads to regioselective

168 he first concept of copper-catalyst-promoted electrophilic halogenation of carbazoles.

169 al phosphoric acid catalyzed atroposelective electrophilic halogenation of N-aryl quinoids, a class o

170 intrinsic reactivity profile of the method (electrophilic halogenation or C-H borylation) so selecti

171 s reagent IPy2BF4 is used to generate a soft electrophilic halonium species for the iodination of the

172 ons of sodium thiomethoxide (NaSMe) with two electrophilic hemicyanine dyes bearing Btz (1) or Ind (2

173 7) which Fukui analysis shows to proceed via electrophilic insertion of the nitride into the Si-H bon

174 major line of defense to combat oxidative or electrophilic insults.

175 facilitated by an unusual interception of an electrophilic intermediate by water generated via acetat

176 is the first report of hydration through an electrophilic intermediate generated during [3,3]-acylox

177 in a ribosomally synthesized peptide, via an electrophilic intermediate that may be the intended prod

178 An oxidative procedure for the electrophilic iodination of phenols was developed by usi

179 Mechanistic investigations support that an electrophilic iron carbene mediates homolytic C-H cleava

180 e, were investigated in reactions with three electrophilic iron complexes of varying electronic prope

181 ow-threshold sensor for structurally diverse electrophilic irritants, including small volatile enviro

182 tions as a sentinel for structurally diverse electrophilic irritants.

183 opening for selective covalent attachment of electrophilic ligands in eubacterial TGTs.

184 A new study shows that a small electrophilic, lipid-derived molecule protects both land

185 al oxidation of TEMPO-Me produces a powerful electrophilic methylating agent in situ.

186 to directly interrogate how these individual electrophilic modifications at low occupancy functionall

187 philic cofactors and discover novel types of electrophilic modifications on proteins in human cells.

188 r has received clinical approval and several electrophilic modifiers of the cysteine-based sensor KEA

189 main line of cellular defense against these electrophilic molecules is conjugation to glutathione, t

190 d anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can eng

191 ate, radical C-H fluorinations mainly employ electrophilic N-F fluorination reagents but a unique Mn(

192 The electrophilic nature of the [B12 Cl11 ](-) anion is conf

193 The success of this pathway is due to the electrophilic nature of the Cp ligand in the cation, [OR

194 termined to be inversely correlated with the electrophilic nature of the sulfimide.

195 in a way that is not obvious considering the electrophilic nature of these activations.

196 This reactivity is facilitated by the electrophilic nature of these open-shell intermediates a

197 Herein we report that electrophilic nitro-fatty acids (nitro-oleic acid and ni

198 -), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO2 -FAs), such as nitr

199 By contrast, electrophilic nitrogen-containing compounds are much rar

200 proved safety profiles compared to the known electrophilic Nrf2 inducers.

201 This electrophilic oncometabolite can alter gene activity at

202 to transient allylmetal species that display electrophilic or nucleophilic properties.

203 cyclization, promoted by the in situ formed electrophilic organoselenium species, cannot be ruled ou

204 intermediate to be ambiphilic, acting as an electrophilic oxidant in the initial N-hydroxylation of

205 osts accumulate lipid bodies (LB) containing electrophilic oxidatively truncated (ox-tr) lipids.

206 y of peroxides, including those in which the electrophilic oxygen is formally isobutyl or neopentyl.

207 opropanes using a bis(silyl) peroxide as the electrophilic oxygen source.

208 al that competition between nucleophilic and electrophilic palladium difluorocarbene ([Pd]=CF(2)) is

209 4,7-dihydroindole with aryl-aldehydes as an electrophilic partner followed by an oxidation step to d

210 hydrogen bonding (HB) a nucleophilic and an electrophilic partner form a new bond that is based on a

211 Considering aryl azides as electrophilic partners for the TosMIC mediated Van Leuse

212 reaction conditions across a broad range of electrophilic partners remains elusive.

213 tion using trifluoroacetimidoyl chlorides as electrophilic partners.

214 ade reactions: those involving nucleophilic, electrophilic, pericyclic, and radical reactions.

215 addition is a classical reaction between the electrophilic phosphinidene and an alkene.

216 of pinacolborane through addition across the electrophilic phosphorus and nucleophilic N-methylanilid

217 most nucleophilic (sigma donating) and also electrophilic (pi-accepting) stable carbenes known to da

218 The covalent electrophilic polymerization generates polymers with liv

219 g their superior dienophilic, enophilic, and electrophilic power.

220 Small-molecule-based electrophilic probes for H(2) O(2) require many minutes

221 Unlike other electrophilic probes, the current probe acts as a nucleo

222 he side chains of serine and cysteine, using electrophilic probes.

223 several reaction sites with nucleophilic or electrophilic properties.

224 rgets the same cysteine residue and that our electrophilic quinazolines modulate the function of V-AT

225 The process involves the addition of an electrophilic radical to the electron-rich alkenyl boron

226 re found between the experimentally observed electrophilic reactivities of 44 Michael acceptors and t

227 In order to quantify the electrophilic reactivities of common Michael acceptors,

228 echanisms and to elucidate the origin of the electrophilic reactivities.

229 the method of choice for a rapid estimate of electrophilic reactivities.

230 Our bioconjugation technique exploits the electrophilic reactivity of an oxidized selenocysteine r

231 rmation, a new mechanism is proposed for the electrophilic reactivity of the phosphaethynolate ion.

232 by transformations relying on their inherent electrophilic reactivity.

233 tion reaction using substrate 2 as a 1,3-bis-electrophilic reagent.

234 roxyl group derivatization with a variety of electrophilic reagents are discussed.

235 heterocycles are easily functionalized using electrophilic reagents, enabling divergent access to var

236 ble and thermodynamically favored through an electrophilic rearrangement and concomitant 1,9-aryl mig

237 In the absence of an external Bronsted base, electrophilic, remote zeta C-H activation takes place, f

238 on of thiiranium ion derivatives became more electrophilic (rho = +1.69; R(2) = 0.974).

239 This study focuses on the formation of electrophilic ring cleavage products-a class of compound

240 verts nucleophilic cysteine residues into an electrophilic S-aryl-Pd-X unit by taking advantage of an

241 tablish a series of synthetically accessible electrophilic scaffolds tunable across multiple centers.

242 This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to ac

243 sition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl borona

244 action of beta,gamma-unsaturated oximes with electrophilic selenium and tellurium species, affording

245 ustrates the pharmacological utility of this electrophilic series.

246 nge of hydrosilation mechanisms that feature electrophilic silicon centers.

247 Additionally, other electrophilic silicon species, such as silylene complexe

248 lladium cations to behave as sources of both electrophilic silylium ions and nucleophilic L(n)Pd(0).

249 of a heteroatom nucleophilic site and a pai-electrophilic site.

250 nconventional new platform for incorporating electrophilic sites at remote sp(2) C-H linkages.

251 e use of ES(r), one can identify the various electrophilic sites within a molecule and correctly pred

252 fication of the surface and formation of the electrophilic sites.

253 able cysteines in human T cells and point to electrophilic small molecules as a fertile source for ch

254 d rapid profiling of the cellular targets of electrophilic small molecules.

255 onal sites and can frequently be targeted by electrophilic small molecules.

256 are susceptible to covalent modification by electrophilic small molecules.

257 the targets and signaling roles of reactive electrophilic species (RES) at a specific cellular space

258 d crosstalk choreographed by native reactive electrophilic species (RES).

259 visible light, probably due to formation of electrophilic species such as QMs.

260 These highly electrophilic species undergo polarized radical addition

261 gh protonation of an oxo ligand to give more electrophilic species.

262 intermediate as the more plausible transient electrophilic species.

263 te connecting cell metabolism, oxidative and electrophilic stress responses and immune responses.

264 ne of the master regulators of oxidative and electrophilic stress responses.

265 omine (HOBr) was found to react with DOM via electrophilic substitution (</=40%), forming AOBr, and t

266 ct as alkenyl silanes in Hiyama coupling and electrophilic substitution and as dienes in Diels-Alder

267 l NHCs, which show superior stability toward electrophilic substitution and cyclometalation chemistry

268 gated terminal alkyne toward Lewis-activated electrophilic substitution and led to the isolation of F

269 through sequential nucleophilic addition and electrophilic substitution followed by a Mamedov rearran

270 [B(12)X(11)](-) reacts by an electrophilic substitution of a proton in an alkane resu

271 ns as well as provide new strategies for the electrophilic substitution of aromatic rings.

272 The chlorination pathway of electrophilic substitution of Cl at the ortho or para po

273 led) by chlorine to HOBr, leading to further electrophilic substitution of unaltered DOM sites and ch

274 in, we report a new approach that allows the electrophilic substitution of YMs.

275 The electrophilic substitution reaction of 4,7-dihydroindole

276 One consisted of electrophilic substitution, whereby the nitrosonium ion

277 acidic and therefore require highly reactive electrophilic substrates to be effective.

278 ion of Cu-H monomer from Cu-H dimer for more electrophilic substrates, and hydride transfer from a tr

279 nsfer from a transient Cu-H monomer for less electrophilic substrates.

280 nantioselective, cyclization of phenols with electrophilic sulfenophthalimides onto isolated or conju

281 difunctionalization of alkenes initiated by electrophilic sulfenyl group transfer.

282 A method for electrophilic sulfenylation by organophosphorus-catalyze

283 C)(CO)(m) ](x) (n=5,6; m=15,16; x=0,-2) with electrophilic sulfur sources (S(2) Cl(2) , S(8) ) result

284 Furthermore, the electrophilic sulfur strategy has been extended to provi

285 n anchors the organometallic proximal to the electrophilic, tetrasubstituted sulfone to override comp

286 ligands render a Mo-alkylidyne a priori more electrophilic than analogous monodentate triarylsilanols

287 ly activating the alkyne, despite being less electrophilic than other known alkyne-activating reagent

288 Lewis base/Bronsted acid cocatalysis for electrophilic thiocyanation of olefins is reported.

289 ic route to convert nucleophilic thiols into electrophilic, thiol-selective vinylphosphonothiolates:

290 rein, we report a ligand-free Cu(I) mediated electrophilic thiolation of organostannanes with sulfur

291 substitution of the heteroaryl halide by an electrophilic thiyl radical, highlighting an underdevelo

292 t, by rendering the alpha-position of amides electrophilic through a mild and chemoselective umpolung

293 hilic substitution, photoredox coupling, and electrophilic transfer reactions allowing the generation

294 relevant conditions via isomerization to an electrophilic vinyl sulfone.

295 surface while simultaneously introducing an electrophilic 'warhead' to covalently react with a nucle

296 xplored di- and tripeptides with beta-lactam electrophilic warheads as inhibitors of dengue and West

297 Their utility as alternative electrophilic warheads for chemical biological probes an

298 X4-inhibiting molecules have uncovered novel electrophilic warheads that bind and inhibit GPX4.

299 re equal in terms of their reactivity toward electrophilic warheads.

300 inding ligands with appropriately positioned electrophilic warheads.