ライフサイエンスコーパス: elucidation

1 ands as an eminent challenge for mechanistic elucidation.

2 n reported, several details still await full elucidation.

3 ring host-to-host transmission needs further elucidation.

4 tructive sleep apnea (OSA) patients requires elucidation.

5 S. aureus, and a platform enabling its full elucidation.

6 id cells in these opposing processes require elucidation.

7 edictable fragmentation for glycan structure elucidation.

8 ns facilitate L1 retrotransposition requires elucidation.

9 echanisms, and their temporal dynamics await elucidation.

10 underlying mechanisms of which need further elucidation.

11 spectrometric analysis to conduct structural elucidation.

12 , but how U6/L1 chimeras are formed requires elucidation.

13 nfident isomer differentiation and structure elucidation.

14 pharmacology, and even facilitate structure elucidation.

15 mass spectrometry as a valuable tool for HOS elucidation.

16 e structural organization of the SDBC awaits elucidation.

17 hreats to public health that warrant further elucidation.

18 onic genes, although their functions require elucidation [1-9].

19 ended as a tutorial for MS-based protein HOS elucidation and as a reference for investigators seeking

20 n, we propose an approach for the Systematic Elucidation and Assessment of Regulatory Cell-to-cell In

21 The elucidation and characterization of heme transport and h

22 This work will enable the elucidation and characterization of the nonNLR plant imm

23 kinetics parameters suitable for mechanistic elucidation and mathematical fitting.

24 is most suited for instances where structure elucidation and metabolite annotation are critical for t

25 The described approach should enable the elucidation and redesign of specificity landscapes of a

26 hods including chemical synthesis, structure elucidation and standard-addition experiments.

27 t another significant challenge in structure elucidation and stereochemistry assignment, as more than

28 novative approaches that combine mechanistic elucidation and the discovery of potential biomarkers.

29 Against this background, the elucidation and visualization of the three-dimensional s

30 filing, imaging mass spectrometry, structure elucidation, and bioassays, we found that the helper bac

31 rotein folding, membrane proteins, structure elucidation, and epitope mapping are showcased.

32 is formed or not, NMR for the stoichiometry elucidation, and UV-visible spectrophotometry to obtain

33 a set of computationally assisted structural elucidation approaches in the discovery of a new class o

34 ars that computational methods for structure elucidation are gradually becoming a better alternative,

35 ypes, but methodologies for their systematic elucidation are lacking.

36 entification, quantification, and structural elucidation at a molecular level.

37 The same setup enables structure elucidation based on TIMS aligned fragmentation experime

38 and feasibility of enhancing the structural elucidation by atom substitution.

39 Structure elucidation by NMR spectroscopy was a significant challe

40 subjected to chemical formula and structure elucidation by respective magnetic resonance mass spectr

41 which can be potentially used for structure elucidation by X-ray crystallography.

42 The structure of this region has defied elucidation due to its size, regional complexity, and ha

43 zable strategy to control wettability and an elucidation for the profitability of so-called low salin

44 nsing mechanism remains unknown and requires elucidation for understanding the aetiology of secondary

45 action energy profiles to aid in mechanistic elucidation has long been the domain of the expert compu

46 Our elucidation is also remarkable for having revealed that

47 The value in structural elucidation is derived from its application to better de

48 Further elucidation is necessary, however, especially of phenyla

49 cepts to assist those undertaking structural elucidation is therefore of paramount importance, such t

50 ps are implicated in disease risk, and their elucidation may inform prevention and treatment of stres

51 Structural elucidation, molecular modeling, and mutational analysis

52 llowed us to achieve the complete structural elucidation of 19 TPs.

53 Structural elucidation of 2D polymer monolayers proving long-range

54 By elucidation of a genome-wide polyadenylation landscape o

55 tudy, we report the discovery and functional elucidation of a human B cell-specific lncRNA with high

56 cle, and kinetic analysis, allowed the sound elucidation of a plausible catalytic working mode.

57 These results provide a direct elucidation of a resource allocation tradeoff between gr

58 These results, together with the recent elucidation of a thylakoid membrane complex that functio

59 The elucidation of all inter-protein interactions would sign

60 The first step involves the elucidation of all intracellular fluxes in a core model

61 otein-protein partner identification and the elucidation of alternative protein conformations for sig

62 itional collisional activation methods allow elucidation of basic structural features of lipids but f

63 The detailed elucidation of BBB-crossing nanotechnology in this revie

64 eness of amyloid aggregation inhibitors, the elucidation of binding sites in amyloid structures, and

65 n proposed to suppress mosquito populations, elucidation of biological processes that enable males an

66 nate treatment responses, whereas structural elucidation of biologically significant intramuscular me

67 r model network hydrogels and facilitate the elucidation of bond lifetimes.

68 ation and standardized methods for structure elucidation of candidate disease biomarkers.

69 This capsid assembly repertoire enables elucidation of capsid recognition modes by known capsid-

70 ingle-cell technologies are enabling precise elucidation of cellular activity and fate during bone re

71 used for isolation and subsequent structure elucidation of chloroxanthic acid A as the founding memb

72 The structure and sequence elucidation of complex homo- and copolymers is key for f

73 sent an exploratory approach to the targeted elucidation of complex, local, acutely temporally dynami

74 g cleavage ions, enabling on-spot structural elucidation of composition, sequence, branching, and lin

75 Structural information is crucial for the elucidation of cross-reactivity of marker allergens such

76 Structural elucidation of CRY-CRY homo-oligomers and a CRY-BIC hete

77 The elucidation of cytosine demethylation has drawn added at

78 This process allows for the elucidation of differentially expressed genes across two

79 Exclusive elucidation of differentially expressed membrane glycopr

80 creens, have made major contributions to the elucidation of diverse signaling pathways.

81 We propose that elucidation of DNA repair mechanisms elicited by differe

82 cal development, viewed simply as structural elucidation of drug metabolites, completed only once com

83 to which the drug imatinib binds enabled the elucidation of drug-resistance mechanisms.

84 The elucidation of dysfunctional cellular processes that can

85 vation of hTSCs from naive hPSCs will enable elucidation of early mechanisms that govern normal human

86 netic resources in Nb, which will facilitate elucidation of EDS1 functions.

87 A fundamental elucidation of electrode-electrolyte interface behaviors

88 ional electron-gas materials and enables the elucidation of electron/plasma dynamics and properties t

89 fore act as useful pharmacological tools for elucidation of EPAC function and promising drug leads fo

90 The further elucidation of epigenetic modifications thus may increas

91 asingly important in neuro-oncology, and the elucidation of escape mechanisms that lead to treatment

92 populations have so far prevented a detailed elucidation of evolutionary dynamics.

93 The recent structural elucidation of ex vivo Drosophila Orb2 fibrils revealed

94 A repair enzymes and cell-cycle checkpoints, elucidation of factors enabling the genomic instability

95 tion behavior in CE also supports structural elucidation of FAs in conjunction with high resolution M

96 Elucidation of four new GH74 tertiary structures, as wel

97 Elucidation of functional traits may enable the microbia

98 For the structural elucidation of Gd(3)N@I(h)-C(80) tris- and tetra-adducts

99 Elucidation of gene function by reverse genetics in anim

100 etry (PGC-LC-MS/MS) enables the quantitative elucidation of glycan fine structures.

101 Elucidation of HELLS as one of the downstream effectors

102 Recent omics analysis has led to the elucidation of hemp candidate genes involved in the synt

103 Top-down proteomics has enabled the elucidation of heterogeneous protein complexes with diff

104 covery of an intratumoral microbiome and the elucidation of host-microbe interactions that curtail an

105 genome-packaging machinery has prevented the elucidation of how these multi-step reactions, which req

106 ing of HEU infants for infection and further elucidation of immune mechanisms is needed.

107 The elucidation of immune mechanisms underpinning the parasi

108 umber of studies referring to the structural elucidation of intact biomolecular systems using mass sp

109 ant progress has been made in the structural elucidation of integrins in recent years.

110 rapid progress has been made for structural elucidation of isolated MPs.

111 omic analysis, with the main emphasis in the elucidation of isomer-specific lipid biological activiti

112 he active state are quite subtle, making the elucidation of its allosteric mechanism difficult.

113 the most heritable mental illnesses, but the elucidation of its genetic basis has proven to be a very

114 MRI to aid in diagnosing MMN and in further elucidation of its pathophysiological mechanisms.

115 (24-29) loop (peptide 3(F20Cha)) and permits elucidation of its structure and assembly by X-ray cryst

116 d theoretical studies, there are gaps in the elucidation of key steps in the catalytic cycle of kines

117 enetic mechanisms of adaptation requires the elucidation of links between the evolution of DNA sequen

118 The elucidation of lipoprotein metabolism ultimately led to

119 se pathologies can be understood through the elucidation of localized biomolecular networks, or micro

120 application of strategies for their use, and elucidation of mechanisms by which they suppress soilbor

121 alkene coupling, and create a firm basis for elucidation of mechanisms in the growing class of HAT al

122 of mammalian heart and blood vessels and the elucidation of mechanisms involved in cardiovascular dev

123 , novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduct

124 approaches have rarely been applied for the elucidation of mechanisms of such transformations.

125 Elucidation of mechanisms underlying the increased andro

126 ed at low temperatures allowing experimental elucidation of mechanistic details of chain propagation

127 etic and environmental influences and allows elucidation of metabolic pathways associated with infant

128 This is an innovator view in elucidation of metabolic pathways that represent the bio

129 n this study, we discuss how a more detailed elucidation of miRNA-driven inflammasome regulation help

130 ane curvature for a comprehensive structural elucidation of MPs that rely on these chemical and physi

131 Extensive efforts have led to the elucidation of multiple strategies employed by HCMV to e

132 and simple approach for the rapid functional elucidation of neurodevelopmental disease-associated gen

133 e that our screening method not only enables elucidation of new ChR variants that affect microbial op

134 anism of the mu-OR activation, following the elucidation of new crystal structures such as the antago

135 efluorination from CF(3)COO(-), leads to the elucidation of new mechanistic insights into PFAS degrad

136 etabolites including the complete structural elucidation of niacinamide and uric acid, two compounds

137 derstanding of resistance mechanisms and the elucidation of novel predictive biomarkers.

138 l studies have resulted in a highly detailed elucidation of one of the underlying microscopic mechani

139 ave been used extensively for the structural elucidation of organic compounds in tandem mass spectrom

140 we highlight the importance of ticks for the elucidation of paradigms in arthropod immunology.

141 ll provide an important resource for further elucidation of phenotypic and genetic traits in this glo

142 Thus, our results complete elucidation of phenylalanine biosynthesis via phenylpyru

143 Tumor-specific elucidation of physical and functional oncoprotein inter

144 This work has direct implications toward the elucidation of possible mechanisms of acid-assisted vaca

145 t this improved methodology will lead to the elucidation of previously unreported reader-histone inte

146 excited-state aromaticity concerns with the elucidation of processes and properties in the excited s

147 Traditional approaches to elucidation of protein structures by Nuclear Magnetic Re

148 own as PHR1), in Wallerian pathways; and the elucidation of protein structures to drive further under

149 ystals to monitor chemical reactions for the elucidation of reaction mechanisms and measurement of ki

150 In-depth elucidation of redox analysis has been presented in term

151 Altogether, this approach allows the elucidation of regulatory mechanisms in EV-mediated RNA

152 Further elucidation of relevant signaling pathways may direct fu

153 However, elucidation of RNA editing events at transcriptome-wide

154 Despite recent advances in the structural elucidation of SARS-CoV-2 proteins, the detailed archite

155 of serotonergic neurons in mice and rats for elucidation of serotonergic roles in anxiety-like behavi

156 Elucidation of signaling and transcriptional events for

157 These results provide a framework for the elucidation of similar mechanisms governed by other RNA-

158 cular level in multicellular eukaryotes, the elucidation of similar processes in bacterial assemblage

159 interior for the complexation and structure elucidation of small molecule fragments of the stereoche

160 This technique facilitated the elucidation of solid-state structures of all five compou

161 Although much work has focused on the elucidation of somatic alterations that drive the develo

162 ian decision theory provides a simple formal elucidation of some of the ways that representation and

163 k establishes a systematic approach enabling elucidation of specific mechanisms by which plant-derive

164 teine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting mole

165 screen demonstrates that the approach allows elucidation of structure-activity relationships.

166 the zebrafish lipidome, and could aid in the elucidation of structure-function associations in the co

167 n have embryo lethal phenotypes that prevent elucidation of subtle, but physiologically important, me

168 Our aim is to speed elucidation of such explanations and, in some cases, fin

169 The elucidation of such genetic modifiers provides insight i

170 ., identifying suppressors), and mechanistic elucidation of synergistic interactions, including an un

171 OAT1 and OAT3) and microorganisms led to the elucidation of ten known flavones (1-4, 6-10, 12) and tw

172 e corresponding experimental data led to the elucidation of the absolute configuration as (-)-(R)-ter

173 The structure elucidation of the acetylated product made it possible t

174 Elucidation of the adaptive immune response is valuable

175 L is a useful approach for providing further elucidation of the additive and epistatic sources contri

176 llosteric modes of activation, discusses the elucidation of the allosteric binding sites, and summari

177 hese interactions, have limited atomic-level elucidation of the amyloid-promoting mechanism(s) by the

178 Elucidation of the basic mechanisms underlying human dis

179 Elucidation of the biosynthesis by heterologous pathway

180 Identification of genes and elucidation of the biosynthetic pathway leading to tript

181 These advances include the elucidation of the biosynthetic steps in the betalain pa

182 ct biology of ovarian cancer metastasis, the elucidation of the cellular and molecular mechanisms und

183 ation of the DNA molecule and genes, and the elucidation of the central dogma of biology.

184 Collectively, elucidation of the complex roles of lipid rafts and raft

185 Despite the elucidation of the complexoform, it remains unclear how

186 The elucidation of the critical intercellular dependencies t

187 The elucidation of the CSP.c-di-GMP complex structure by NMR

188 The elucidation of the detailed mechanism mediated by hTRPV1

189 The elucidation of the detailed mechanism used by F(0) to co

190 Elucidation of the differences between wild and domestic

191 rom diverse Wolbachia clades will aid in the elucidation of the different symbiotic mechanisms(s).

192 ing point in the field that, with subsequent elucidation of the distinct structures and functions of

193 gnetophoretic mobility method allows further elucidation of the distribution of Hb concentration with

194 lue of chemically synthesized probes for the elucidation of the enzyme mechanism underpinning the com

195 One crucial challenge remains the elucidation of the factors that determine the selectivit

196 However, elucidation of the factors that underlie the sensitivity

197 Elucidation of the function of many imprinted genes has

198 This work is the first step in elucidation of the function of this enigmatic protein.

199 ranscriptome shaping is instrumental for the elucidation of the functional roles of specific RNA modi

200 cer, and to emphasize the need for continued elucidation of the functions of MELK.

201 The elucidation of the fundamental reactions leading to PAHs

202 diverse representations are critical to the elucidation of the genetic basis of disease and biologic

203 udies of arapaima populations, including the elucidation of the genetic status of described discrete

204 analysis represents a major step towards the elucidation of the genetic susceptibility to PD.

205 Better elucidation of the heritability of psoriatic disease sub

206 ry, providing the possibility for structural elucidation of the highly oxygenated organic molecules (

207 Further elucidation of the interplay between these complementary

208 The elucidation of the involved mechanisms remains a challen

209 Elucidation of the key structural modifications incorpor

210 clearance and review new methods for future elucidation of the kinetics of their turnover in humans.

211 Elucidation of the levan polymerization mechanism is imp

212 se amphipathic lipids has largely focused on elucidation of the lipid A substructures.

213 Herein, we describe the structural elucidation of the main metabolites of ezutromid, the re

214 Here, we report complete elucidation of the malbrancheamide biosynthetic pathway

215 a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to a

216 En masse, elucidation of the mechanism by which H. pylori evolved

217 Elucidation of the mechanism by which Npro antagonises t

218 Elucidation of the mechanism of dopamine signaling to ER

219 Elucidation of the mechanisms conferring this selectivit

220 systems, and their small genomes facilitate elucidation of the mechanisms involved.

221 ents with heart failure; and on the basis of elucidation of the mechanisms of amyloid formation, ther

222 ssentially inter-changeable, focusing on the elucidation of the mechanisms of disease pathogenesis to

223 th defined gene defects have been helpful in elucidation of the mechanisms of ectopic mineralization

224 Through elucidation of the mechanisms that inhibit reduction of

225 Elucidation of the mechanisms through which miR-128 impa

226 This comprehensive elucidation of the mechanisms underlying mycobacteria-in

227 etric organometallic studies has enabled the elucidation of the mechanistic underpinnings to a photoc

228 tic variation of the P/G molar ratio enables elucidation of the minimum number of phosphate groups pe

229 Elucidation of the molecular and genetic pathways drivin

230 Elucidation of the molecular genetic landscape of HNSCC

231 The elucidation of the molecular machinery that regulates re

232 may facilitate biomarker development and the elucidation of the molecular mechanisms that underly MDD

233 bility and resistance to Pst and will enable elucidation of the molecular mechanisms underlying these

234 Elucidation of the molecular pathogenic mechanism of the

235 Elucidation of the molecular regulation of VEGF and the

236 Our elucidation of the natural history will provide clinicia

237 Here, we report the discovery and structure elucidation of the NOCAP (nocardiosis-associated polyket

238 terologous system allowing in the future the elucidation of the pathological role of individual viral

239 The elucidation of the pharmacological and molecular mechani

240 Using cyclic voltammetry experiments, the elucidation of the potentiometric properties of the lock

241 Elucidation of the prefusion structure of the RSV F glyc

242 The elucidation of the processes and pathways that mediate t

243 ovide a maturing, although still incomplete, elucidation of the protein dynamics and mechanisms of su

244 Here we report the elucidation of the RA biosynthetic pathway in Phacelia c

245 The elucidation of the reaction mechanism and the intermedia

246 mited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radia

247 This study paves the way for the elucidation of the relationship between Li cerebral dist

248 ques have led to significant progress in the elucidation of the role of bacteria and fungi and their

249 Elucidation of the role of this intermediate leveraged a

250 model of A3H restriction and a step-by-step elucidation of the roles of RNA-binding residues in A3H

251 d genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for pol

252 Further elucidation of the shared mechanisms underlying abnormal

253 Elucidation of the smallest fungal cell wall-associated

254 As a first step toward the elucidation of the structural basis of this phenomenon,

255 Here we review recent progress in the elucidation of the structural dynamics of MATs and their

256 Elucidation of the structure and interactions of protein

257 Here, we focus on recent advances in the elucidation of the structure and mechanism of mycobacter

258 nsive NMR spectroscopic analysis allowed the elucidation of the structure of cebulantin.

259 ally stable pre-catalysts and intermediates, elucidation of the structures of transient reactive inte

260 f 80 phosphosites on WC-1 and 15 on WC-2 and elucidation of the time-of-day-specific code, requiring

261 Elucidation of the various mechanisms that enable cells

262 able nature and heterogeneous state disrupts elucidation of their explicit role in AD progression, im

263 es need to be characterized structurally for elucidation of their folding pathways.

264 s present at these sites is a premise to the elucidation of their function.

265 Identification of such proteins and elucidation of their functions are ongoing challenges.

266 der pressure by specific HLA alleles and the elucidation of their impact on viral function can help i

267 re discovery of novel mRNA interactions, and elucidation of their potential downstream molecular effe

268 dependence of cognitive processes along with elucidation of their respective neuroanatomical substrat

269 Ts are often lacking in selectivity, and the elucidation of their sensing mechanisms remains challeng

270 e {Zn(II)-cat-SQ-Zn(II)} analog have allowed elucidation of thermodynamic parameters governing the on

271 ent that is permissive for hepatic fibrosis; elucidation of these early events in the fibrotic proces

272 The elucidation of these features unlocks the opportunity to

273 Elucidation of these global epigenetic changes may infor

274 at correlate long- to short-range structural elucidation of these newly developed solid-state white-l

275 Further elucidation of these parameter values in real-world typh

276 Elucidation of these previously unknown RMC hallmarks pa

277 Elucidation of these signals could enable better strateg

278 Herein, we discuss the elucidation of this cascade reaction mechanism and the c

279 The elucidation of this complicated structure illustrates th

280 eciprocity will facilitate a molecular level elucidation of tropomyosin regulation of myosin interact

281 for the application of MD simulations to the elucidation of UGT-aglycone interactions.

282 cation of biologically relevant features and elucidation of underlying biological processes.

283 gy was complemented with CID for the de novo elucidation of unknown CLs in biological extracts.

284 with suppressed backbone cleavage and allows elucidation of unknown epitopes.

285 for the purification and de novo structural elucidation of urinary metabolites.

286 nto the structure-property relationship, the elucidation of which will accelerate the development of

287 the CASE-3D (computer-assisted 3D structure elucidation) protocol.

288 Traditional methods of protein structure elucidation remain expensive and labor-intensive and req

289 nd related fields, but metabolite structural elucidation remains highly challenging.

290 tion of these elusive species for structural elucidations remains a challenge.

291 Complete structural elucidation revealed cinnapeptin as a cyclic depsipeptid

292 The flux elucidation revealed nearly complete conversion (greater

293 Experimental elucidation shows that the fracture energy obeys a simpl

294 Sophisticated structural elucidation studies identified the major fractions and s

295 Despite the enormous progress in structure elucidation, the Mpro's structure-function relationship

296 sent our strategic approach using structural elucidation to enable chemistry design/SAR development.

297 molecular mechanisms of Rg3 require further elucidation to establish its mode of action.

298 putationally assisted quantifiable structure elucidation tools.

299 Its elucidation will advance the understanding of HPV contro

300 copic experiments, in a systematic structure elucidation workflow, revealed that peyssonnosides A-B (