ライフサイエンスコーパス: embryoid body

1 ive splice variant CoAM in the cavity of the embryoid body.

2 this mark in mouse ESCs and differentiating embryoid bodies.

3 type and mutant ES cells and differentiating embryoid bodies.

4 ive vascular network from SIRT1(-/-)-derived embryoid bodies.

5 ed for protocols based on stromal feeders or embryoid bodies.

6 tion was substantially blunted in Gsk3b(-/-) embryoid bodies.

7 o S phase and mES cells differentiating into embryoid bodies.

8 as a floating scaffold to generate elongated embryoid bodies.

9 to promote vascular development in Fgfr1-/- embryoid bodies.

10 ce positioning in Dab2-deficient embryos and embryoid bodies.

11 form a primitive endoderm outer layer in the embryoid bodies.

12 under hypoxia provided enhanced formation of embryoid bodies.

13 icient at generating neurectoderm-containing embryoid bodies.

14 othelial cell precursors in developing mouse embryoid bodies.

15 LK1(+)CD4(-) cells first arise in developing embryoid bodies.

16 vivo and in embryonic stem (ES) cell-derived embryoid bodies.

17 arker, Hnf4, and prevents cavitation in PSA1 embryoid bodies.

18 tion of, visceral endoderm and cavitation of embryoid bodies.

19 ion factors in nuclear extracts from ES cell embryoid bodies.

20 ptional regulation in murine ES cell-derived embryoid bodies.

21 lian embryogenesis can be studied in ES cell embryoid bodies.

22 for the formation of a basement membrane in embryoid bodies.

23 formed a complex neurite network around the embryoid bodies.

24 xic Hif1a-/- embryonic stem cells and cystic embryoid bodies.

25 erved more often in wild type than in mutant embryoid bodies.

26 mechanism is also adopted in differentiated embryoid bodies.

27 tion both in ES cells and in differentiating embryoid bodies.

28 ection neurons in monolayer culture and from embryoid bodies.

29 ronal differentiation and the utilization of embryoid bodies.

30 , the level of Yes1 was reduced in Etv2 null embryoid bodies.

31 by loss-of-function experiments in chimeric embryoid bodies.

32 ), and differentiated cells via formation of embryoid bodies (16, 20 days) were analyzed.

33 l cultures are thought to self-organize into embryoid bodies, able to undergo symmetry-breaking, germ

34 PP2 during embryoid body adhesion dramatically increased cardiomyoc

35 ditions and the avoidance of feeder cells or embryoid bodies allowed synchronous and reproducible dif

36 tes were seen in both wild-type and Gata4-/- embryoid bodies, although cardiomyocytes were observed m

37 lpha5-null ES cells were differentiated into embryoid bodies, although they were delayed in growth an

38 apoptosis-dependent process of cavitation in embryoid bodies and apoptosis associated with embryonic

39 tro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types.

40 Pten-/- ES cells formed aberrant embryoid bodies and displayed an altered ability to diff

41 how that Bmp2 and Bmp4 are expressed in PSA1 embryoid bodies and embryos at the stages when visceral

42 Upon differentiation into embryoid bodies and further into mineral-producing osteo

43 on of flk1(+) angioblasts in differentiating embryoid bodies and increased the number of PECAM (plate

44 is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organ

45 rs while increasing the numbers of secondary embryoid bodies and mixed hematopoietic colonies obtaine

46 Although embryoid bodies and organoids can exhibit some spatial o

47 o the NA extract enhanced differentiation of embryoid bodies and resulted in the early appearance of

48 haracterized by vigorous beating activity of embryoid bodies and robust expression of cardiac Mef2c,

49 em cell markers; have the capability to form embryoid bodies and teratomas, and can differentiate int

50 as the TaqMan hPSC Scorecard Assay) through embryoid body and directed differentiation experiments a

51 o iPSCs and differentiated into iPSC-CMs via embryoid body and monolayer-based differentiation protoc

52 during differentiation of ES cells in vitro (embryoid bodies) and in vivo (teratomas).

53 ere first expressed at day 4 in hanging drop embryoid bodies, and adhesion of embryoid bodies to surf

54 re differentiated into cardiomyocytes within embryoid bodies, and contracting cells expressing myocar

55 Here we isolate primordial germ cells from embryoid bodies, and derive continuously growing lines o

56 d spontaneous differentiation in cultures of embryoid bodies, and each of these steps involves signif

57 ized with flk1 expression in differentiating embryoid bodies, and HoxB5 potently transactivated the f

58 e hematopoietic stem cell differentiation in embryoid bodies, and large embryonic stem cell (ES)-deri

59 gocytosis were detected in PU.1(Spi-B/Spi-B) embryoid bodies, and myeloid colonies were present in he

60 progenitor cells present in differentiating embryoid bodies, and that these correspond to erythro-my

61 naling assay; 3) Pofut1(-/-) and Pofut1(+/+) embryoid bodies are indistinguishable in their ability t

62 cells before and during differentiation into embryoid bodies as well as various types of normal and t

63 he activation of developmental regulators in embryoid body assays.

64 For example, embryoid body-based analyses demonstrated that BAF250a-a

65 xpansion of the ESC population and growth of embryoid bodies, but release from the drug after an init

66 mesodermal lineages do not form in Wt1-null embryoid bodies, but this effect is rescued by the expre

67 mouse ES cells and that FAK signaling within embryoid bodies can direct stem cell lineage commitment.

68 activated cell sorting purification of human embryoid body cells differentially expressing endothelia

69 t the growth or viability of ES cell-derived embryoid body cells known to have extinguished TDH expre

70 Immunohistochemical analysis of embryoid bodies collected from these cultures revealed a

71 tiate in vitro into cystic structures called embryoid bodies consisting of tissue lineages typical of

72 Embryonic stem cell-derived embryoid bodies contain a unique precursor population wh

73 Nodal-expressing hESCs developing as embryoid bodies contained an outer layer of visceral end

74 inoic acid, into either parietal endoderm or embryoid bodies, containing an outer visceral endoderm l

75 on of primitive ectoderm and neurectoderm in embryoid body culture.

76 Depletion of Smad1 in embryoid body cultures before hemangioblast commitment l

77 We find that in embryoid body cultures containing even a low ratio of th

78 Using embryoid body cultures of mouse embryonic stem cells, we

79 e cell suspensions obtained from day 7 human embryoid bodies (d7EBs) injected i.v. 1 hour after cecal

80 A study using embryoid bodies demonstrated a nonimmediate role played

81 Embryoid bodies derived from embryonic stem cells recapi

82 s also different from the null phenotype, as embryoid bodies derived from ES cells in which endogenou

83 Differentiated embryoid bodies derived from GATA6(-/-) ES cells lack a

84 ind that hematopoietic CD34(+) cells in spin embryoid bodies derived from human embryonic stem cells

85 We demonstrate that embryoid bodies derived from KLF2(-)(/)(-) ES cells can

86 In this study, we used differentiating embryoid bodies derived from mouse embryonic stem cells

87 The embryoid bodies derived from mutant cells are also unabl

88 Embryoid bodies derived from these cell lines are unable

89 ls derived from embryonic germ cells, termed embryoid body-derived (EBD) cells, introduced into the C

90 undifferentiated embryonic stem (ES) cells, embryoid body-derived cells (EBCs), or mammalian embryos

91 ntification and characterization of an early embryoid body-derived colony, termed the transitional co

92 We show that embryoid body-derived hematopoietic progenitors expressi

93 In this study, the osteoinductivity of embryoid body-derived material (EBM) was compared to DBM

94 onal mutation, and has been termed EB-PE for embryoid body-derived primitive erythroid.

95 We sought to use human embryoid body-derived stem cells (EBDs) to populate live

96 in mouse embryonic stem cells and from human embryoid-body-derived cells, but not from human adult so

97 1 in ES cells and used ES/OP-9 coculture and embryoid body development followed by hematopoietic colo

98 at develops early and is lost quickly during embryoid body development.

99 and impaired primitive ectoderm formation in embryoid bodies differentiated from mouse embryonic stem

100 zyme activity occurring at later stages when embryoid bodies differentiated toward cardiomyocytes.

101 Upon aggregation to embryoid bodies, differentiating ES cells formed large n

102 In an embryoid body differentiation assay, BMP4-dependent diff

103 sion of the transcription factor Pax3 during embryoid body differentiation enhances both paraxial mes

104 nd endothelial progenitor cells by using the embryoid body differentiation method.

105 Using the embryoid body differentiation system, we demonstrate tha

106 ematopoietic lineage (from day 4 to day 6 of embryoid body differentiation) significantly enhances th

107 a) gene between 14 and 18 days of ES-derived embryoid body differentiation, we investigated the effec

108 illary-like structures during late stages of embryoid body differentiation.

109 Levels of Neu5Gc on HESC and embryoid bodies dropped after culture in heat-inactivate

110 s study, using ESC derived aggregates called embryoid bodies (EB) as a model, we characterized the bi

111 Here, a live stem cell derived embryoid body (EB) based cardiac cell syncytium served a

112 d development by means of coculture of CD34+ embryoid body (EB) cells with OP9 stromal cells.

113 ) hPGCLCs [ approximately 43% of FACS-sorted embryoid body (EB) cells] from primed-state induced plur

114 ental patterns of cellular expression during embryoid body (EB) differentiation can address this issu

115 jnk3 genes were derived and submitted to an embryoid body (EB) differentiation protocol.

116 The process of embryoid body (EB) differentiation, like teratoma format

117 of cells present at early and late stages of embryoid body (EB) differentiation.

118 We differentiated hESCs by embryoid body (EB) formation and compared the miR expres

119 Embryoid body (EB) formation is a requisite step in the

120 val, using annexin V staining, and secondary embryoid body (EB) formation were also evaluated.

121 to decreased pluripotency marker expression, embryoid body (EB) formation, cell survival, and loss of

122 er capacity to self-renew based on secondary embryoid body (EB) formation.

123 l fate at the expense of the endoderm during embryoid body (EB) formation.

124 gnificant haploinsufficient determinants for embryoid body (EB) formation.

125 aucity of paraxial mesoderm formation during embryoid body (EB) in vitro differentiation and to the l

126 S and ES cells were differentiated using the embryoid body (EB) method.

127 h the number and the size of beating foci in embryoid body (EB) outgrowths.

128 em (ES) cells undergo differentiation in the embryoid body (EB) system, with peak levels in cell popu

129 stablishment of the blood islands and in the embryoid body (EB)-derived blast-colony-forming cells (B

130 To improve the efficiency of embryoid body (EB)-mediated ES cell differentiation, we

131 e ES cells than in differentiating mouse ES (embryoid body, EB) cells.

132 yonic stem (ES) cells were differentiated as embryoid bodies (EBs) and assayed for blast colony-formi

133 bstrates generate size- and shape-controlled embryoid bodies (EBs) and can be easily modified to cont

134 mically defined medium supports formation of embryoid bodies (EBs) and differentiation of hepatic lin

135 We found that ERbeta was induced in embryoid bodies (EBs) and neural precursor cells (NPCs)

136 (VE-cadherin)-expressing cells generated in embryoid bodies (EBs) and on OP9 cells.

137 iation, as seen in poorly differentiated TKO embryoid bodies (EBs) and teratomas.

138 at hTERT silencing during differentiation to embryoid bodies (EBs) and to fibroblast-like cells was d

139 , we used embryonic stem cell-differentiated embryoid bodies (EBs) as a model and found that Bnip3 (B

140 dy we used mouse embryonic stem cell-derived embryoid bodies (EBs) as a model for peri-implantation d

141 S) cells can differentiate in vitro, forming embryoid bodies (EBs) composed of derivatives of all thr

142 Embryoid bodies (EBs) derived from cells lacking the aut

143 e stages of ExEn differentiation in cultured embryoid bodies (EBs) derived from either embryonic stem

144 Compared to wildtype (WT) controls, embryoid bodies (EBs) derived from either Lefty or Cerb-

145 Measuring the Shh response in neuralized embryoid bodies (EBs) derived from embryonic stem (ES) c

146 n, calponin, and LPP, were down-regulated in embryoid bodies (EBs) derived from embryonic stem cells

147 Here we demonstrate that embryoid bodies (EBs) differentiated from talin1-null em

148 cadherin positive cells developed within the embryoid bodies (EBs) formed by differentiating ES cells

149 ut embryonic stem cells (VIM -/- ESCs) using embryoid bodies (EBs) formed from both cell types.

150 Embryoid bodies (EBs) generated from embryonic stem cell

151 Wnt2(-/-) embryoid bodies (EBs) generated increased numbers of Flk

152 te into cell types of all germ layers within embryoid bodies (EBs) in a highly variable manner.

153 endoderm following their differentiation to embryoid bodies (EBs) in culture.

154 describe the internal organization of murine embryoid bodies (EBs) in terms of the structures and cel

155 tiating ES cells into cardiomyocyte-positive embryoid bodies (EBs) in vitro.

156 Rac1 ablation in embryonic stem cell-derived embryoid bodies (EBs) leads to massive apoptosis of epib

157 arge numbers of homogeneous and synchronized embryoid bodies (EBs) of defined sizes from dissociated

158 lls was dramatically delayed and impaired in embryoid bodies (EBs) of Shp-2 mutant origin.

159 c stem (ES) cells as they differentiate into embryoid bodies (EBs) or into extraembryonic endodermal

160 Here, we differentiated mouse iPSCs into embryoid bodies (EBs) or representative cell types spann

161 Expression of RUNX1a in embryoid bodies (EBs) promotes definitive hematopoiesis

162 ere are numerous AS events observed in mouse embryoid bodies (EBs) undergoing a neuroectoderm-like st

163 h endogenous nuclear huntingtin in wild-type embryoid bodies (EBs) was associated with PRC2 subunits

164 oximately 65%) of cocultured ES cell-derived embryoid bodies (EBs) were enriched in cardiac myocytes

165 l patterning signals, murine ES cell-derived embryoid bodies (EBs) were grafted into avian hosts.

166 m and abnormal PPAR-gamma pathway in beating embryoid bodies (EBs) with defined media, we established

167 peptide to the media enhanced the growth of embryoid bodies (EBs), increased the expression of hemat

168 Upon ES cell differentiation into embryoid bodies (EBs), we observed a shift in expression

169 In vitro, ES cells aggregate to form embryoid bodies (EBs), which differentiate into multiple

170 rmation of multicellular aggregates known as embryoid bodies (EBs), yet cell fate specification withi

171 affected by the size of ES cell colonies and embryoid bodies (EBs).

172 enerated in embryonic stem (ES) cell-derived embryoid bodies (EBs).

173 ions of hES-CMs in spontaneously contracting embryoid bodies (EBs).

174 arliest surface marker missing from SCL(-/-) embryoid bodies (EBs).

175 elopment in embryonic stem (ES) cell-derived embryoid bodies (EBs).

176 lished from in vitro-differentiated progeny (embryoid bodies [EBs]) of embryonic stem (ES) cells usin

177 layed a significant reduction in activity in embryoid bodies, embryos, and adult animals.

178 cultivation in vitro as 3D aggregates called embryoid bodies, ES cells can differentiate into derivat

179 Pharmacological responses of beating embryoid bodies exposed to a comprehensive panel of drug

180 Flk-1(+) Tet-notch4 cells from d 3 embryoid bodies exposed to doxycycline (Dox(+)) were com

181 with retinoic acid, the majority of cells in embryoid bodies expressed markers for neural progenitors

182 The ID6 line formed embryoid bodies, expressing genes representing all 3 ger

183 -1alpha/ARNT heterodimers) because Arnt(-/-) embryoid bodies fail to exhibit hypoxia-mediated progeni

184 different culture systems: FAK+/+ and FAK-/- embryoid bodies, FAK+/+ and FAK-/- endothelial cells, an

185 ion of a primitive streak-like population in embryoid bodies, followed by specification to hematopoie

186 g Ptp gamma antisense constructs and assayed embryoid bodies for the presence of hematopoietic precur

187 nd growth factors by ESCs differentiating as embryoid bodies for up to 14 days was assessed using PCR

188 Differentiating embryoid bodies form blood islands, providing an in vitr

189 ce markers, and differentiation potential in embryoid body formation and teratoma assays.

190 ed pluripotent stem cells (hiPSC), bypassing embryoid body formation and the use of exogenous molecul

191 of ectodermal and mesodermal lineages during embryoid body formation and under inductive conditions u

192 l direct plating method in which intervening embryoid body formation does not occur.

193 into multiple hematopoietic lineages during embryoid body formation in vitro, but to date, an ES-der

194 s required embryoid body formation; however, embryoid body formation often results in heterogeneous d

195 Data from embryoid body formation studies indicated that the Mp(-/

196 Embryoid body formation yielded beating cardiomyocyte-li

197 ed almost 30-fold during the first 3 days of embryoid body formation, a culture system model of early

198 ifferent in vitro differentiation protocols (embryoid body formation, endodermal induction, directed

199 for human embryonic stem (hES) cells rely on embryoid body formation, stromal feeder co-culture or se

200 ariants prevents the switch and disrupts the embryoid body formation.

201 ull differentiation capacity as indicated by embryoid body formation.

202 ted Nanog levels persisted through 5 days of embryoid body formation.

203 ifferentiation of ES cells in the absence of embryoid body formation.

204 ES cells overlapped with the changes during embryoid body formation.

205 ation from sorted single cells, and enhanced embryoid body formation.

206 ion of chondrogenesis by human ESCs required embryoid body formation; however, embryoid body formatio

207 roarrays to identify targets of Brachyury in embryoid bodies formed from differentiating mouse ES cel

208 lar criteria in the outer PE-like lineage of embryoid bodies formed from embryonic stem cell lines ge

209 Embryoid bodies, formed from mouse embryonic stem cells,

210 S) cells made extensive skeletal muscle, but embryoid bodies from myogenin (-/-) ES cells had greatly

211 oderm, which are prominent features of early embryoid bodies from normal ES cells.

212 Differentiated embryoid bodies from wild-type embryonic stem (ES) cells

213 ree media, human embryonic-stem-cell-derived embryoid bodies generate a KDR(low)/C-KIT(CD117)(neg) po

214 C development, spontaneously differentiating embryoid bodies give rise to CD105(+)CD90(+)CD73(+)CD31(

215 ) cell line H9, when cultured in the form of embryoid bodies, give rise to cells with markers of the

216 imitive endoderm cells of the outer layer of embryoid bodies gradually polarise, and formation of a p

217 irst appeared in embryonic stem cell-derived embryoid bodies grown for 7 days (7d).

218 Moreover, A(-)/A(-) embryoid bodies grown in suspension culture constantly s

219 Using our 3D human embryoid bodies (hEBs) formation technology, we interlac

220 nd definitive erythromyelopoiesis from human embryoid bodies (hEBs) in serum-free clonogenic assays.

221 The developmental sequence of human embryoid body hematopoiesis is remarkably congruent to t

222 ent development of keratinocytes from single embryoid bodies in cell culture.

223 re functionally abnormal; they yielded small embryoid bodies in in vitro differentiation experiments

224 Cells cultured in HESCO readily form embryoid bodies in tissue culture and teratomas in mice.

225 The resulting iPSCs formed embryoid bodies in vitro and teratomas in vivo.

226 AdiPS cells also generate embryoid bodies in vitro and teratomas in vivo.

227 cardiac differentiation was recapitulated in embryoid bodies in vitro.

228 n by HNF-3alpha and HNF-3beta was studied in embryoid bodies in which one or both HNF-3alpha or HNF-3

229 e was also reproduced in beta1 integrin-null embryoid bodies, in which primitive endoderm cells segre

230 at addition of BMP protein to cultures of S2 embryoid bodies induces expression of Hnf4 and other vis

231 alable two-dimensional method that avoids an embryoid-body intermediate.

232 levels of unbound histones, and formation of embryoid bodies is accelerated.

233 dent differentiation of endothelial cells in embryoid bodies is also antagonized by BMPER.

234 system, we found that induction of VEGFR1 in embryoid bodies is also associated with ETS1 and HIF-2al

235 cells into endothelial cells in an in vitro embryoid body is paralleled by an amplification of hepar

236 Studies of morphogenesis in embryoid bodies led to the current belief that it is pro

237 stem cells compromised their ability to form embryoid bodies, likely because of defects in cell proli

238 nd MyoD to support muscle differentiation in embryoid bodies made from myogenin (-/-) ES cells.

239 Like ES cells, embryoid bodies maintained constitutive Src and Fyn kina

240 Both HESC and derived embryoid bodies metabolically incorporate substantial am

241 human iPS clones were differentiated through embryoid body method and MYF5-GFP(+) myogenic cells were

242 Using a modified embryoid body method, we provided gene expression eviden

243 r cell, serum, conditioned culture medium or embryoid body, methods that cannot avoid undefined cultu

244 , we generated genetically mosaic neuralized embryoid bodies (nEBs) from mouse embryonic stem cells (

245 lated during development of Nodal-expressing embryoid bodies, nor was there induction of markers for

246 patic differentiation protocol starting from embryoid bodies of hiPSCs (hiPSC-EBs) for robust mass pr

247 up to 200 microm within 1 day of plating P19 embryoid bodies on laminin-1 (EHS laminin).

248 (LIF) and could initiate differentiation in embryoid bodies or chimeric embryos, but failed to commi

249 tides (DR1, DR2, DR5), we show that in mouse embryoid bodies or F9 embryonal carcinoma cells, RARs oc

250 Whether formed from embryoid bodies or in nodules, hES-derived keratinocytes

251 differentiated cells, methods that generate embryoid bodies or organoids do not yield consistent and

252 re, which does not require the generation of embryoid bodies or prospective cell isolation, entails f

253 eased on differentiation into differentiated embryoid body or neurospheres.

254 m the drug after an initial treatment aborts embryoid body or teratoma formation.

255 The inducible expression of EWS-FLI1 in embryoid bodies, or collections of differentiating stem

256 n vitro using the F9 teratocarcinoma derived embryoid body outgrowth system and, show here that PE mi

257 actor-beta treatment of isolated N629D/N629D embryoid bodies partially rescued this phenotype.

258 In particular, embryoid bodies produced from these Pgk-Pem ES cells do

259 4+ cells during ES cell differentiation from embryoid bodies provides an excellent model system and m

260 ction of mMix in embryonic stem cell-derived embryoid bodies results in the early activation of mesod

261 lly undefined factors including 3D nature of embryoid body, sera from animals, and the feeder cells i

262 ne embryonic stem cells converted to beating embryoid bodies showed that only the proximal active reg

263 organoid methodology, with modifications of embryoid body size and shape to increase surface area an

264 mbryos and mouse embryonic stem cell-derived embryoid bodies substantially decrease the emergence of

265 ighted morphogenic cell processes within the embryoid bodies, such as cell growth, migration, and int

266 differentiation of mouse embryos and ES cell embryoid bodies suggest that aspects of early mammalian

267 these cells were induced to differentiate as embryoid bodies suggested that quite a few of the downre

268 We show that embryoid bodies support maturation of the primordial ger

269 Because embryoid bodies sustain blood development, we reasoned t

270 nalyses, we used an inducible embryonic stem/embryoid body system and observed that ER71 overexpressi

271 hat utilizes the differentiating ES cell and embryoid body system to define the modules and enhancers

272 Embryoid bodies that are cultured in the presence of nep

273 hibitory factor, mouse ES cells give rise to embryoid bodies that can differentiate into mesoderm.

274 e previously used two cell lines, which form embryoid bodies that do (PSA1) or do not (S2) cavitate,

275 When aggregated into embryoid bodies they develop disorganised masses of diff

276 that (a) laminin enables beta1-integrin-null embryoid bodies to assemble basement membrane and achiev

277 Finally, exposure of stem cell-derived human embryoid bodies to hsa-miR-1294 mimic or antagomir oligo

278 anging drop embryoid bodies, and adhesion of embryoid bodies to surfaces at or before that day strong

279 We exposed stem cell-derived human embryoid bodies to the microRNA mimic or antagomir oligo

280 IF-deficient cells and enabled AIF-deficient embryoid bodies to undergo cavitation, a process of prog

281 ricle with 40 to 75 rhythmically contracting embryoid bodies (totaling 1.3-2x10(6) cells).

282 ctopic beats were observed in 33% and 40% of embryoid bodies treated with sotalol and quinidine, resp

283 From day-6 embryoid bodies, under the influence of Stat5 signaling,

284 Differentiation of ES cells to embryoid bodies was associated with rapid transcriptiona

285 a dominant negative FAK, cell migration from embryoid bodies was inhibited, whereas alpha-myosin heav

286 wly developed loss-of-function technology in embryoid bodies, we find that Gata2 and Smad5 cooperate

287 n of this pathway in the primitive endoderm, embryoid bodies were cultured in the presence of a small

288 METHODS AND Embryoid bodies were derived from human keratinocytes, t

289 mRNA levels induced upon differentiation to embryoid bodies were down-regulated in homozygous null H

290 suppress cardiogenesis through Src kinases, embryoid bodies were exposed to the small molecule PP2,

291 organogenesis protocol was optimised whereby embryoid bodies were formed and patterned towards an eye

292 The outer cells of these embryoid bodies were found to gradually acquire the hall

293 e cloning efficiency and the ability to form embryoid bodies were restored in embryonic stem cells, i

294 ment membrane assembly was also evaluated in embryoid bodies where it was found that both LG1-3 and L

295 hen slowly decreased upon differentiation to embryoid bodies, whereas 5-methylcytosine levels increas

296 hat defined differentiation of ES cells into embryoid bodies with Activin-A and selection for T expre

297 Early treatment of NFATc1-DTR mouse embryoid bodies with diphtheria toxin efficiently ablate

298 They produce embryoid bodies with elevated levels of the primitive en

299 accomplished by reconstitution of PTEN-null embryoid bodies with PTEN mutants that lack only PTEN's

300 Incubation of embryoid bodies with the vital dye, Dil, revealed the pe