ライフサイエンスコーパス: embryonic cell

1 e and the identity of any cell to that of an embryonic cell.

2 paucity of molecular material in the single embryonic cell.

3 s or comparisons of multiple biopsies of few embryonic cells.

4 e of the body, is an evanescent attribute of embryonic cells.

5 against decapentaplegic homolog 2 (Smad2) in embryonic cells.

6 n, which is required in highly proliferating embryonic cells.

7 constructs were microinjected into zebrafish embryonic cells.

8 king processes observed in oocytes and early embryonic cells.

9 size, as originally reported for C. elegans embryonic cells.

10 M and H2AX exhibit nonredundant functions in embryonic cells.

11 -l-norleucine and are not toxic toward human embryonic cells.

12 issues is functionally distinct from Sdc2 in embryonic cells.

13 edd8 conjugation pathway components in early embryonic cells.

14 1 mRNA is distributed equally throughout all embryonic cells.

15 f the polycomb group repressive complexes in embryonic cells.

16 essing of let-7 family microRNAs (miRNAs) in embryonic cells.

17 n differentiated but not in undifferentiated embryonic cells.

18 blocks the processing of pri-let-7 miRNAs in embryonic cells.

19 a transfer of Eomes protein between adjacent embryonic cells.

20 nd cytoplasmic/cortical cell compartments in embryonic cells.

21 with Dnmt3a or Dnmt3b but not with Dnmt1 in embryonic cells.

22 with act-2 for cytoplasmic function in early embryonic cells.

23 ically plastic, sharing many properties with embryonic cells.

24 olecules determines the fate and movement of embryonic cells.

25 fferentiation in a manner similar to that in embryonic cells.

26 trols differentiation of CDX2-positive extra-embryonic cells.

27 rofiling the transcriptomes of 86,024 single embryonic cells.

28 the expression of diverse proteins in single embryonic cells.

29 ormation and increased rates of apoptosis in embryonic cells.

30 to the domain of metabolites between single embryonic cells.

31 re mediate instruction of early cell fate in embryonic cells.

32 ate regulatory networks in human and primate embryonic cells.

33 n induce viral restriction pathways in early embryonic cells.

34 uring Ras(V12) immortalization of Drosophila embryonic cells, a phenomenon not well characterized.

35 es that progressively instruct proliferating embryonic cells about their identity and behavior.

36 paired-end Illumina sequencing in C. elegans embryonic cells, adult somatic cells, and a mix of adult

37 During the short interphase of early embryonic cells, AL are rapidly delivered into the nucle

38 Embryonic cell and tissue generated forces and mechanica

39 FP reporter was expressed cytoplasmically in embryonic cells and also was incorporated into contracti

40 eins at TAD borders, with BEAF-32 present in embryonic cells and CTCF in neuronal cells.

41 t worms is due to two defects, starvation of embryonic cells and general developmental defects.

42 rotects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle.

43 resulted in expression of beta(m)-globin in embryonic cells and in a significant decrease in express

44 Here we demonstrate in primary human embryonic cells and in the chicken embryo that thalidomi

45 It is essential in embryonic cells and in the hematopoietic lineage yet dis

46 GAA.TTC triplet-repeat instability occurs in embryonic cells and involves the highly active mismatch

47 ive role in oncogenesis and is found only in embryonic cells and malignancies.

48 that mediates oriented migration of multiple embryonic cells and mice deficient for Sdf1 or its recep

49 eth can form from cell mixtures that include embryonic cells and populations of postnatal dental pulp

50 the spliced repertoire of RNAs in mammalian embryonic cells and primordial cells.

51 TERT is highly expressed in undifferentiated embryonic cells and silenced in the majority of somatic

52 a novel regulator of Snail1-dependent EMT in embryonic cells and suggest that multiple defects in FAK

53 d Smad2/3 signaling occurs preferentially in embryonic cells and transformed cells.

54 ls at the esophagogastric junction (residual embryonic cells and transitional basal cells).

55 raced heritable L1 insertions to pluripotent embryonic cells and, strikingly, to early primordial ger

56 ily member Xnr2 is secreted efficiently from embryonic cells, and a new method of tissue recombinatio

57 n microscopy study of intact vitrified mouse embryonic cells, and in an ultrastructural mapping of a

58 Invaginations in the membranes of embryonic cells appear to orient cell division in sea sq

59 how that rapidly proliferating early Xenopus embryonic cells are able to regulate replication licensi

60 Despite this hypoxia, the embryonic cells are able to undergo remarkable growth, m

61 Embryonic cells are expected to possess high growth/diff

62 Embryonic cells are highly distinct in their gene expres

63 Carbohydrates on embryonic cells are often highly expressed in cancer and

64 cess in which a subset of dormant YPs within embryonic cells are reincorporated into the endocytic sy

65 Embryonic cells are tagged by AID(cre) in the submandibu

66 Mouse embryonic cells are unable to support the replication of

67 Early embryonic cells are, so far, not sensitive to the lack o

68 c mosaicism and variation in the fraction of embryonic cells bearing targeted alleles are observed, a

69 Pluripotent embryonic cells become progressively lineage restricted

70 matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of deve

71 In humans and mice, including early embryonic cells, BRCA1 commonly associates with interpha

72 med approximately 1 to 2 h before S phase in embryonic cells but 6 h before S phase in somatic cells.

73 es of development of SMC from multipotential embryonic cells but did not elucidate the underlying mec

74 rotein turnover: ZFP809 protein is stable in embryonic cells but highly unstable in differentiated ce

75 ffect of MIF was absent in Cxcr7(-/-) murine embryonic cells but pronounced in CXCR7-transfected Madi

76 Depolarization of embryonic cells by misexpression of KCNE1 non-cell-auton

77 ted retroelements are potently restricted in embryonic cells by postintegration transcriptional silen

78 adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oo

79 Here, using a bioactivity test based on embryonic cells (C3H10T1/2) transfected with a BMP-respo

80 e shed new light on an elusive population of embryonic cells called neuromesodermal progenitors.

81 r endogenous nor exogenous sdc2 expressed in embryonic cells can compensate for knockdown of sdc2 in

82 Direct delivery of Syn into mouse embryonic cells conferred resistance to proapoptotic cas

83 >1600 proteins from ~130 mum Xenopus laevis embryonic cells containing <6 nL of cytoplasm.

84 f reprogramming when using donor nuclei from embryonic cells could be explained, at least in part, by

85 However, transplanted embryonic cells could provide factors that promote the s

86 the determination of lactate in a commercial embryonic cell culture medium providing excellent agreem

87 with genetically engineered mice as well as embryonic cell culture systems.

88 ve been employed to measure lactate level in embryonic cell culture, beverages, urine, and serum samp

89 actate is an essential metabolite present in embryonic cell culture.

90 iosensor for the detection of lactate within embryonic cell cultures media.

91 evel role for positive-feedback loops in the embryonic cell cycle and provides an example of how osci

92 ases during progression throughout the early embryonic cell cycle and shed new light on potential def

93 d spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including t

94 This implies that most of the first embryonic cell cycle can be bypassed in sperm genome rep

95 24% of control rates, depending when in the embryonic cell cycle injection took place.

96 CSF establishment in oocytes and the normal embryonic cell cycle is unknown.

97 so, causes damage-dependent delays in early embryonic cell cycle progression and subsequent lethalit

98 We use a model of the embryonic cell cycle to illustrate the approaches that c

99 f Emi2, but it is resynthesized in the first embryonic cell cycle to reach levels 5-fold lower than d

100 after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf i

101 orylation is restricted throughout the early embryonic cell cycle, not just during M-phase, and how T

102 s the timing of the M-phase entry during the embryonic cell cycle.

103 rA(Thr-295) phosphorylation during the early embryonic cell cycle.

104 role for Sin3a in regulating the pluripotent embryonic cell cycle.

105 mical circuits in the context of the Xenopus embryonic cell cycle.

106 essential for CDK1 oscillations in the early embryonic cell cycle.

107 arrest first appears during the seventeenth embryonic cell cycle.

108 ery before segregation, explaining why early embryonic cell cycles are so error-prone.

109 Fast, early embryonic cell cycles have correspondingly fast S phases

110 eminin slows down, but neither arrests early embryonic cell cycles nor affects endogenous geminin lev

111 cle 14 and the midblastula transition, rapid embryonic cell cycles slow because S phase lengthens, wh

112 cations, which appear only later, when rapid embryonic cell cycles slow down at the midblastula trans

113 , we extend an earlier mathematical model of embryonic cell cycles to include experimentally motivate

114 ngth are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepressio

115 During embryonic cell cycles, B-cyclin-CDKs function as the cor

116 activity and INCENP oscillated in subsequent embryonic cell cycles.

117 rol of cyclin B translation and of the early embryonic cell cycles.

118 s of PAN GU kinase, which is crucial for S-M embryonic cell cycles.

119 y is due to a requirement for DmBlm in early embryonic cell cycles; embryos lacking maternally derive

120 In cultured S2 embryonic cells, Ddok tyrosine phosphorylation is Src de

121 nsumption does not appear to be triggered by embryonic cells declining to a critically small size.

122 he islet beta-like cells produced from human embryonic cell-derived beta-cell clusters.

123 d may have also occurred in the germ line or embryonic cells developmentally upstream to germline spe

124 aling occurred similarly in all species once embryonic cell diameter reduced to 140 mum.

125 imes opposite outcomes that help to generate embryonic cell diversity.

126 elated, but the association breaks down when embryonic cell division ceases.

127 ngest specific suppressors rescued the early embryonic cell division defects in rfl-1(or198ts) mutant

128 specific enhancers did not affect the early embryonic cell division defects observed in rfl-1(or198t

129 s, an act-2 deletion did not result in early embryonic cell division defects, suggesting that additio

130 Past studies of embryonic cell division discovered that calcium concentr

131 Variable post-embryonic cell division failures in ventral cord motoneu

132 e lengths of the first 8 out of 10 rounds of embryonic cell division in Caenorhabditis elegans, we id

133 The most potent block in early embryonic cell division was obtained by RNAi of the poly

134 les, and in the most severe case, absence of embryonic cell division.

135 d concentrates at the cleavage furrow during embryonic cell division.

136 that RUB1/2 proteins are essential for early embryonic cell divisions and that they regulate diverse

137 ne lineage tracing through the last round of embryonic cell divisions and we applied these methods to

138 During embryonic cell divisions, cell size changes rapidly in b

139 e chiral twist that takes place during early embryonic cell divisions.

140 of AURKB, to support both meiotic and early embryonic cell divisions.

141 as it separates from the soma during initial embryonic cell divisions.

142 rk for proteins involved in C. elegans early-embryonic cell divisions.

143 ial for zygotes to progress beyond the first embryonic cell divisions.

144 caused defects in oocyte formation and early embryonic cell divisions.

145 xpression of proteins with critical roles in embryonic cell divisions.

146 rapid genome duplication during synchronous embryonic cell divisions.

147 te that the two daughter cells of many early embryonic cell-doubling events contribute asymmetrically

148 ation and proper differentiation of specific embryonic cells during development.

149 for Geminin, a nuclear protein expressed in embryonic cells, during neural fate acquisition from mou

150 In many types of Notch-activated embryonic cells, ectopic ELT-2 is sufficient to drive ex

151 ivation of the anaphase-promoting complex as embryonic cells exit mitosis and return to interphase.

152 from the Nkx2.1 locus to follow the fate of embryonic cells expressing these genes within the arcuat

153 Stem and embryonic cells facilitate programming toward multiple d

154 al Wnt signaling pathway and are crucial for embryonic cell fate and bone formation.

155 We propose that the role of LEC1 in embryonic cell fate control requires auxin and sucrose t

156 One of the first embryonic cell fate decisions (that is, mesendoderm dete

157 ignaling protein Notch, which is crucial for embryonic cell fate decisions, has 36 extracellular EGF

158 zoans, the T-box genes are involved in early embryonic cell fate decisions, regulation of the develop

159 ch retinal determination cascade involved in embryonic cell fate determination.

160 Embryonic cell fate specification and axis patterning re

161 The role of microRNAs in embryonic cell fate specification is largely unknown.

162 egulating germline stem cell totipotency and embryonic cell fate specification.

163 The NOTCH1 gene, which is essential for key embryonic cell-fate decisions in multicellular organisms

164 rovide an example of the regulation of early embryonic cell fates by direct competition for a secrete

165 nsplanted Spemann's organizer induces dorsal embryonic cell fates such as the nervous system and somi

166 elopment is to establish embryonic and extra-embryonic cell fates.

167 in primary cultures derived from Drosophila embryonic cells follows the same developmental course as

168 case study we choose Drosophila melanogaster embryonic cells, for which both data types are available

169 In response to microenvironmental cues, embryonic cells form adhesive signaling compartments tha

170 f increased cellular transformation of mouse embryonic cells from the DFF/CAD-null mice and significa

171 tered cell-to-cell positioning, we separated embryonic cells from the yolk and allowed them to develo

172 In addition, early embryonic cells from this strain fail to establish embry

173 e for GDF6 and BMP signaling in governing an embryonic cell gene signature to promote melanoma progre

174 e first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival.

175 ion of the Trap220/Med1 gene in mice impairs embryonic cell growth, yet the underlying mechanism is u

176 However, embryonic cells had undergone remarkable architectural r

177 The identity of these extra-embryonic cells has been controversial, and we use RNA s

178 of ChIP-seq data from human cancer and mouse embryonic cells identified a significant number of putat

179 ine the specification of embryonic and extra-embryonic cell identities.

180 of embryogenesis, involved in the control of embryonic cell identity by currently unknown mechanisms.

181 When tested in vitro with cultured zebrafish embryonic cells, IGFBP-1 itself had no mitogenic activit

182 g preimplantation development is to maintain embryonic cells in a pluripotent state, little is known

183 ion as a fundamental property of pluripotent embryonic cells in vivo.

184 ipient models that may permit engraftment of embryonic cells include the use of submyeloablated or ge

185 le copy of K-ras oncogene in cultured murine embryonic cells induced the expression of a high level o

186 ns follow the ancestral pattern in which all embryonic cells inherit YPs from the egg cytoplasm.

187 Mouse embryonic cells isolated from focal adhesion kinase (FAK

188 by comparing this to genome organization in embryonic cells (Kc167).

189 sive cancer cells, expressing a multipotent, embryonic cell-like phenotype, engage in a dynamic recip

190 peat type galectin was characterized from an embryonic cell line (Bge) and circulating hemocytes of t

191 With the human embryonic cell line H1, CNN achieves an accuracy of 97.9

192 In human embryonic cell line H1, we mutated only the found DNA mo

193 ms for differential cell division timing and embryonic cell lineage differentiation evolved before 55

194 Specification of an embryonic cell lineage is driven by a network of interac

195 cells, but they are derived from a different embryonic cell lineage, and little is known of the mecha

196 -dependent imprinting is largely lost in the embryonic cell lineage, but at least five genes maintain

197 these features we determined the C. briggsae embryonic cell lineage, using the tools StarryNite and A

198 tain their imprinted expression in the extra-embryonic cell lineage.

199 conserved phenotypes and divergent genomes: embryonic cell lineages and gene expression patterns are

200 ciple, can provide insights into early human embryonic cell lineages and their contributions to adult

201 splay embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are

202 stem cells (iPSCs) efficiently generate all embryonic cell lineages but rarely generate extraembryon

203 ovel cell type evolved by outcompeting other embryonic cell lineages for an essential signaling ligan

204 MATER complex provides a molecular marker of embryonic cell lineages, but it remains to be determined

205 ge with establishment of the trophoblast and embryonic cell lineages.

206 bryogenesis and the initial establishment of embryonic cell lineages.

207 ired for proper division patterns of various embryonic cell lineages.

208 opmental potency for all embryonic and extra-embryonic cell lineages.

209 unoprecipitation (ChIP)-seq in two different embryonic cell lines and found that AGO2 localizes to eu

210 ling of exosome by ChIP-seq in two different embryonic cell lines reveals extensive and specific over

211 med damage to the squamous epithelium, these embryonic cells migrate toward adjacent, specialized squ

212 t for 3D migration in other settings such as embryonic cell migration and wound healing.

213 e essential for cytoskeletal reorganization, embryonic cell migration, and morphogenesis.

214 neural crest is an excellent model to study embryonic cell migration, since cell behaviors can be st

215 ent model to better understand mechanisms of embryonic cell migration.

216 to collect and analyze live imaging data of embryonic cell migration.

217 ecovery, we employed an in vitro primary rat embryonic cell model of oligodendrocyte progenitor cells

218 To assess the function of Tid1 in embryonic cells, mouse embryonic fibroblasts with the ho

219 ol and steroid hormone metabolism with early embryonic cell movements.

220 c and conserved role for Git2 in controlling embryonic cell movements.

221 Throughout animals, embryonic cells must ultimately organize into polarized

222 rter activity during formation of sea urchin embryonic cells necessary for the production of gametes,

223 that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but

224 dherin at the cell surface of either Xenopus embryonic cells or Colo 205 cultured cells, demonstratin

225 cient but is more efficient when nuclei from embryonic cells or embryonic stem cells (ECNT) are emplo

226 we show that a discrete population of these embryonic cells persists in adult mice and humans at the

227 Through cell fusion the embryonic cell phenotype can be imposed on somatic cells

228 2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that ma

229 oidy, autophagy, and apoptosis to refine the embryonic cell population and ensure only chromosomally

230 Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual migra

231 Transient maintenance of a pluripotent embryonic cell population followed by the onset of multi

232 The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to

233 The neural crest (NC) is an embryonic cell population that contributes to key verteb

234 Neural crest cells are an embryonic cell population that is crucial for proper ver

235 To define the early embryonic cell population that responds to Mesp1, we per

236 ment of the neural crest, a highly migratory embryonic cell population whose behavior has been likene

237 st cells, a highly migratory and multipotent embryonic cell population, whose behaviour has been like

238 sttranscriptional signaling cascades in this embryonic cell population.

239 lopment of the multipotent neural crest (NC) embryonic cell population.

240 in Xenopus neural crest, a highly migratory embryonic cell population.

241 stream cranial neural crest or from multiple embryonic cell populations evolving most quickly and int

242 ce transcription profiles for seven specific embryonic cell populations from gastrulation to the onse

243 Transcriptomes recovered from these embryonic cell populations revealed striking, early diff

244 e witnessed renewed interest in defining the embryonic cell populations that directly contribute to t

245 sensory nervous system are derived from two embryonic cell populations, the neural crest and cranial

246 efore arise in germ cells and in pluripotent embryonic cells, prior to germline specification, yet th

247 occur on multiple chromosomes in very early embryonic cells, prior to their allocation to the germli

248 emaining differences between naive hESCs and embryonic cells related to mono-allelic XIST expression

249 pha-synuclein over-expressed in human neural embryonic cells results in patterns of degeneration that

250 Studies with cultured cell lines and primary embryonic cells showed that miR-665 represses the expres

251 lications for transcriptional regulation and embryonic cell sorting and suggesting a putative mechano

252 or bioengineering new teeth if suitable, non-embryonic cell sources can be identified.

253 ical and legal complications associated with embryonic cell sources, investigators have proposed the

254 el strategy for identification of genes with embryonic cell-specific functionality.

255 apse, inducing spatial self-organization and embryonic cell specification.

256 uing possibilities for stabilizing ephemeral embryonic cell states and enhancing desired fate transit

257 clear within the confines of extremely large embryonic cells, such as the early divisions of the vert

258 estigate dynamic mechanisms that pattern the embryonic cell surface.

259 , most likely for its function in sustaining embryonic-cell survival, which requires its association

260 ect a fundamental structural property of the embryonic cell that is essential to Hh signaling.

261 rest cells (NCCs) are migratory, multipotent embryonic cells that are unique to vertebrates and form

262 l neural crest (CNC) consists of multipotent embryonic cells that contribute to craniofacial structur

263 ve in spite of the fact that many cancer and embryonic cells that have gone through EMT still coopera

264 such marks occur in descendant, multipotent embryonic cells that have restricted cell fate choices.

265 ural crest cells (NCCs) are highly patterned embryonic cells that migrate along stereotyped routes to

266 Embryonic cells that migrate long distances must critica

267 ers from embryonic cells, yet it is only for embryonic cells that we have a quantitative understandin

268 ansition from the G2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somati

269 itro expansion, and at ratios >1:3 postnatal:embryonic cells, they inhibit the ability of embryonic d

270 rs are overwhelmingly important in directing embryonic cells to a particular differentiation pathway,

271 h animal, demonstrating the contributions of embryonic cells to adult tissues.

272 This function relies on the ability of embryonic cells to couple their autonomous random motili

273 Using early embryonic cells to determine the functional relationship

274 ore, our findings reveal that the ability of embryonic cells to differentially reset their intrinsic

275 Ventx2 knockdown restored the competence of embryonic cells to differentiate.

276 the mesenchymal characteristics of FAK-null embryonic cells to generate committed mouse embryonic fi

277 mouse 17 clone 1 fibroblast cells and mouse embryonic cells to the same extent as the parental wild-

278 vestigate the role of Utf1 (Undifferentiated embryonic cell transcription factor 1) in mouse germ cel

279 derm cell fate and that the loss of this key embryonic cell type in mutant embryos results in pattern

280 as a result of inductive signaling from one embryonic cell type to another.

281 The neural crest, a multipotent embryonic cell type, originates at the border between ne

282 Six1 is expressed in multiple embryonic cell types and plays important roles in prolif

283 strate that TACC3 acts as a +TIP in multiple embryonic cell types and that this requires the conserve

284 d Sage and Fkh cannot alter the fate of most embryonic cell types even when expressed early and conti

285 romatin structure and organisation over many embryonic cell types for both human and mouse that, for

286 We identify various embryonic cell types that were not previously known to b

287 ology," a strategy of using in-vitro-derived embryonic cell types to elucidate both fundamental and e

288 imb and hindlimb, and between limb and other embryonic cell types, are correlated with tissue-specifi

289 ycle regulatory components between these two embryonic cell types.

290 stead form teratomas: tumors containing many embryonic cell types.

291 overlapping with TACC1 and TACC3 in multiple embryonic cell types.

292 ll spectrum of gene expression from discrete embryonic cell types.

293 r time in the oocyte and between ovarian and embryonic cell types.

294 f the mouse CV nerve with respect to the two embryonic cells types that produce it, specifically, the

295 e show that RLIM levels are downregulated in embryonic cells undergoing rXCI.

296 hen Xist is deleted systemically in post-XCI embryonic cells using the Meox2-Cre driver, female pups

297 , unlike X-chromosome inactivation in female embryonic cells, where 25-30% of X-linked structural gen

298 niotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular

299 ison of cyt c-deficient HeLa cells and mouse embryonic cells with those expressing a full complement

300 mitotic entry in somatic cells differs from embryonic cells, yet it is only for embryonic cells that