ライフサイエンスコーパス: embryonic lethal

1 Mice lacking Ankmy2 are mid-embryonic lethal.

2 atRA clearing enzymes Cyp26a1 or Cyp26b1 are embryonic lethal.

3 Homozygosity for H is embryonic lethal.

4 Homozygous Sptlc2-deficient mice are embryonic lethal.

5 Null alleles of SIEL are embryonic lethal.

6 is essential for life, as Dhps-null mice are embryonic lethal.

7 at the mice homozygous mutant for SEL1L were embryonic lethal.

8 y compatible with life, Rela(-/-) mice being embryonic lethal.

9 Most mutant alleles of pAbp are embryonic lethal.

10 Mice totally lacking in SPT are embryonic lethal.

11 ockout mice for PCNA (Pcna(-/-)), which were embryonic lethal.

12 ental animals because perlecan disruption is embryonic lethal.

13 nockout of FAK in endothelial cells (ECs) is embryonic lethal.

14 e been hampered because BRG1 inactivation is embryonic lethal.

15 nd knockdown of smn-1 by RNA interference is embryonic lethal.

16 imal, suggesting that the latter genotype is embryonic lethal.

17 selves, double mutants missing both are also embryonic lethal.

18 rotein null phenotype is severely anemic and embryonic lethal.

19 asts and the Rb null phenotype is anemic and embryonic lethal.

20 k the diphthamide modification on eEF-2, are embryonic lethal.

21 rdiac-restricted Myo18a deletion in mice was embryonic lethal.

22 hrough either the PDGFRalpha or PDGFRbeta is embryonic lethal.

23 Homozygous Pax3(Cre/Cre) embryos are embryonic lethal.

24 e F0 and F1 domains (R35E,R118E), which were embryonic lethal.

25 pporting the suggestion that the mutation is embryonic lethal.

26 ved and after several generations, became an embryonic lethal.

27 rast, homozygous deletion of the NRC gene is embryonic lethal.

28 us knockout of the single murine Smn gene is embryonic lethal.

29 a-secretase family, and mice lacking SPP are embryonic lethal.

30 of function of this tumor suppressor gene is embryonic lethal.

31 stem because homozygous disruption of Hex is embryonic lethal.

32 ring defects, whereas homozygous mutants are embryonic lethal.

33 ased four-fold over normal levels, were also embryonic lethal.

34 The deletion when homozygous is embryonic lethal.

35 haliana PABs, AtPAB2, AtPAB4, and AtPAB8, is embryonic lethal.

36 ine transmission of an inactive Piga gene is embryonic lethal.

37 that the mutation of the TRalpha gene is not embryonic lethal.

38 tm1b, or tm1d alleles) of Myo18a in mouse is embryonic lethal.

39 omozygous 7901delG mutation in humans is not embryonic lethal.

40 ival motor neuron gene ( Smn ) whose loss is embryonic lethal.

41 any of the PDGF ligand and receptor genes is embryonic lethal.

42 ast, homozygous Kcnt1(R455H/R455H) mice were embryonic lethal.

43 ce homozygous knockout mice (ubc13(-/-)) are embryonic lethal.

44 in mice on a predominantly B6 background is embryonic lethal.

45 Loss of UTX in female mice is embryonic lethal.

46 ert syndrome, while the mouse null allele is embryonic lethal.

47 onserved protein whose germ line deletion is embryonic lethal.

48 hat homozygous Setd1a knockout (KO) mice are embryonic lethal.

49 ngle-copy gene whose insertional alleles are embryonic lethal.

50 ormal lifespan, while homozygotes were early embryonic lethal.

51 report that claimed TSPO knock-out mice were embryonic lethal.

52 s lacked hematoendothelial lineages and were embryonic lethal.

53 undly alters mitochondrial morphology and is embryonic lethal.

54 e because germ-line deletion of GSK-3beta is embryonic-lethal.

55 However, URO-synthase null mice were early embryonic lethals.

56 ne identified during screens for conditional embryonic lethals.

57 gosity, which led to the identification of 1 embryonic lethal, 1 larval lethal, and 1 adult recessive

58 Although Ini1-null mice are embryonic lethal, 15-30% of mice heterozygous for Ini1 p

59 Because Mpi ablation is embryonic lethal, a murine CDG-Ib model will require hyp

60 HuR, a ubiquitously expressed member of the embryonic lethal abnormal vision (ELAV) family of RNA-bi

61 Among these proteins, embryonic lethal abnormal vision (ELAV) proteins are amo

62 The embryonic lethal abnormal vision (ELAV)-like RNA-binding

63 or RNA-binding proteins (RBPs) including the embryonic lethal abnormal vision (ELAV)/Hu family protei

64 By using cloned promoter fragments of the embryonic lethal abnormal vision gene or the myosin heav

65 We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also kn

66 a ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding

67 Previously, we reported that an embryonic lethal abnormal vision-like (ELAV) protein bin

68 The four Hu [embryonic lethal abnormal vision-like (ELAVL)] protein f

69 nylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human a

70 e RNA-binding proteins: CUG-binding protein, embryonic lethal abnormal vision-type RNA-binding protei

71 g protein 3, and the CUG-binding protein and embryonic lethal abnormal vision-type RNA-binding protei

72 The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu protein family, play

73 Here we demonstrate a role for the embryonic lethal abnormal visual (ELAV) RNA-binding prot

74 Hu proteins are homologs of the Drosophila embryonic lethal abnormal visual protein and contain thr

75 The Drosophila locus embryonic lethal abnormal visual system (elav) encodes a

76 The embryonic lethal abnormal visual system (ELAV) is a gene

77 The product of the Drosophila embryonic lethal abnormal visual system is a conserved p

78 Mammalian neuron-specific embryonic lethal abnormal visual-like Hu proteins (HuB,

79 enes, Jagged-1, a Notch-receptor ligand, and embryonic-lethal abnormal vision, Drosophila-like 2 (ELA

80 We show that ELAV (embryonic-lethal abnormal visual system) is a key mediat

81 Adhesion Molecule (Dscam) gene and iii) the embryonic lethal/abnormal visual system (elav) gene, whi

82 lso dominant maternal enhancers of recessive embryonic lethal alleles of dpp and screw.

83 Embryonic lethal alleles of ed reveal a role of Ed in re

84 m intercrosses between F0 animals that carry embryonic lethal alleles recapitulate loss-of-function p

85 C8 has been defined by temperature-sensitive embryonic lethal alleles that strongly affect germline m

86 Rae1-null and Bub3-null mice are embryonic lethal, although cells from these mice did not

87 ted deletion of the murine Acf gene is early embryonic lethal and Acf(-/-) blastocysts fail to implan

88 Null mutations in this gene are embryonic lethal and can be rescued by expression in the

89 s MLL4 enzyme-dead KI (Mll4(KI/KI)) mice are embryonic lethal and die around E10.5, which phenocopies

90 Mice with mWh knockout are early embryonic lethal and display DNA damage.

91 in null alpha- and beta-spectrin mutants are embryonic lethal and display severely disrupted neurotra

92 The syx(4) mutant animals are embryonic lethal and display severely impaired neuronal

93 MDKOs were embryonic lethal and displayed a variety of defects in c

94 PS1 null mice are embryonic lethal and exhibit axial skeleton malformation

95 However, FADD-deficient mice are embryonic lethal and FADD(-/-) T cells developed from FA

96 und mutants lacking Jnk1 and Jnk2 genes were embryonic lethal and had severe dysregulation of apoptos

97 are live born, Bmp7(R-GFlag) homozygotes are embryonic lethal and have broadly reduced BMP activity.

98 ShcA knockout mice are embryonic lethal and have clearly suggested an important

99 probably explains why loss of Ezh2 is early embryonic lethal and obligatory for the derivation of pl

100 -receptor (PDGFR beta) deficiency in mice is embryonic lethal and results in cardiovascular, renal, p

101 Mice lacking Mdm2 in the heart were embryonic lethal and showed defects at the time recombin

102 Homozygous mutants were embryonic lethal and showed impaired neural tube closure

103 onstrated that ablation of FKRP functions is embryonic lethal and that the homozygous-null embryos di

104 ls have demonstrated that Slc7a5 deletion is embryonic lethal and that these embryos lack a fully for

105 notypes than OVCA1(-/-) mice (which are 100% embryonic lethal) and a small fraction survived to adult

106 the SHR-binding protein SIEL (SHR-INTERACING EMBRYONIC LETHAL) and localizes to both microtubules and

107 e that germline deletion of Ada3 in mouse is embryonic lethal, and adenovirus-Cre mediated conditiona

108 Plk1 homozygous null mice were embryonic lethal, and early Plk1(-/-) embryos failed to

109 Homozygous knock-in TRalpha1(PV/PV) mice are embryonic lethal, and heterozygous TRalpha1(PV/+) mice d

110 We found that nullizygosity for Srsf6 was embryonic lethal, and therefore, to decrease SRSF6 level

111 FADD-null mutations in mice are embryonic-lethal, and analysis of FADD(-)/- T cells from

112 complete knock-out of Cdc42 in the mouse is embryonic-lethal, and its targeted deletion in various t

113 and found that systemic Snx13-null mice were embryonic lethal around midgestation.

114 This model was proved embryonic lethal as a result of severe anemia by embryon

115 Col5a2(-/-) homozygosity is embryonic lethal at approximately 12 days post conceptio

116 In contrast, the Polg2(-/-) is embryonic lethal at day 8.0-8.5 p.c. with concomitant lo

117 Meckel syndrome (MKS) is an embryonic lethal, autosomal recessive disorder character

118 As the mouse Gata-4 knock-out is early embryonic lethal because of a defect in ventral morphoge

119 e, we previously showed that TEL-/- mice are embryonic lethal because of a yolk sac angiogenic defect

120 Disruption of the gene encoding Cited2 is embryonic lethal because of defects in the development o

121 However, mice lacking both PAXX and XLF are embryonic lethal because postmitotic neurons undergo mas

122 Homozygosity for the genetrap allele was embryonic lethal before embryonic day E10.5, whereas the

123 A null mutation in the Fpn1 gene is embryonic lethal before gastrulation, hypomorphic Fpn1(f

124 Germ line disruption of the TAF7 gene is embryonic lethal between 3.5 and 5.5 days postcoitus.

125 In mice, Adar1 mutations are embryonic lethal but are rescued by mutation of the Mda5

126 Mice lacking the mTLL-1 gene Tll1 are embryonic lethal but have pCP activity levels similar to

127 ozygous knockout alleles of mouse Rabl3 were embryonic lethal, but a viable hypomorphic allele (xiame

128 Ablation of the exchanger is embryonic lethal, but contractility can be studied in em

129 gat1 gene responsible for their synthesis is embryonic lethal, but homozygous mutant blastocysts are

130 Smg1 homozygous KO mice were early embryonic lethal, but Smg1 heterozygous mice showed a pr

131 The homozygous mutation is embryonic lethal by 13.5 days post coitum, demonstrating

132 developmentally retarded, disorganized, and embryonic lethal by day 9.5 of embryonic development (E9

133 is, we studied Tmod3(-/-) embryos, which are embryonic lethal by E18.5.

134 Loss of Hand2 is embryonic lethal by E9.5, obviating a genetic analysis o

135 ce and found that the homozygous mutation is embryonic lethal by embryonic day (E) 12.5 and associate

136 out mice and found that Hrpt2(-/-) mice were embryonic lethal by embryonic day 6.5 (E6.5).

137 present study shows that P3H2-null mice are embryonic-lethal by embryonic day 8.5.

138 d two temperature-sensitive and semidominant embryonic-lethal Caenorhabditis elegans mutants, each wi

139 he cardiac-specific NCX1 (NCX1h) gene causes embryonic lethal cardiac arrhythmia in zebrafish tremblo

140 t studies by us and others have demonstrated embryonic lethal cardiovascular phenotypes in SRF-null a

141 Loss of NFAR function, which was embryonic-lethal, caused an increase in protein synthesi

142 talpid3 is an embryonic-lethal chicken mutation in a molecularly un-ch

143 Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in

144 howing germline deletion of the miR217HG was embryonic lethal, CRISPR-Cas9 deleted portions of the 5'

145 hh is sufficient to rescue most of the early embryonic lethal defects in a Disp1-null mutant backgrou

146 Knockout of Palladin in mice is embryonic lethal, demonstrating the importance of Pallad

147 es of two members of the Halloween family of embryonic lethals, disembodied (dib) and shadow (sad), c

148 Similar to MKS, congenital loss of Mks6 is embryonic lethal, displaying cilia loss and altered cyto

149 Targeted alpha(v) or beta8 deletion is embryonic lethal due to defective placenta and brain ang

150 wever, because Runx1 knockout mice are early embryonic lethal due to failure of hematopoiesis, the ro

151 we show that loss of Prmt5 function is early embryonic-lethal due to the abrogation of pluripotent ce

152 The homozygous Dab2-deficient mutant is embryonic lethal (earlier than E6.5) due to defective ce

153 The TSK/TSK mutation is embryonic lethal; embryos have been reported to die at 7

154 Mouse knockouts for Shoc2 are embryonic lethal, emphasizing the need for additional an

155 the other hand, blocked all locomotion, was embryonic lethal even in syt I heterozygotes, and result

156 /-) mice were not viable because of an early embryonic lethal event.

157 ror in meiotic segregation, is invariably an embryonic lethal event.

158 ion can rescue multilineage hematopoiesis in embryonic lethal gata1-/- mutants for over 6 months.

159 nal phenotypes after RNA interference of 147 embryonic lethal genes previously identified in a system

160 ouse genome contains approximately 3479-4825 embryonic lethal genes, or about 13.7%-19% of all genes.

161 Interestingly, embryonic lethal genes, the most essential genes in mous

162 like in rodents, where the grin1 knockout is embryonic lethal, grin1 double-mutant fish (grin1a (-/-)

163 The mutation, designated dek38-Dsg, is embryonic lethal, has a defective basal endosperm transf

164 ein isoforms (EcR-A, EcR-B1, and EcR-B2) are embryonic lethal, hindering analysis of EcR function dur

165 Whereas homozygous KO mice were embryonic lethals, homozygous KI and compound heterozygo

166 Deletion of APE-1 activity is embryonic lethal in animals and is lethal in cells.

167 bservations that loss of function of FLNA is embryonic lethal in males but manifests in females as a

168 Loss of SMN entirely is embryonic lethal in mammals.

169 monoallelic expression of CDK1(AF) is early embryonic lethal in mice and induces S phase arrest acco

170 iency of the C3 convertase regulator Crry is embryonic lethal in mice unless C3 also is absent.

171 Loss of ARGLU1 is embryonic lethal in mice, and knockdown in zebrafish cau

172 Usp16 knockout is embryonic lethal in mice, but does not affect ESC viabil

173 zyme in repairing abasic sites in DNA, is an embryonic lethal in mice.

174 tations of GINS component-encoding genes are embryonic lethal in mice.

175 ransfer protein large subunit (lMTP) gene is embryonic lethal in the homozygous state in mice.

176 Several participants are embryonic lethals in knockout mice.

177 The RyR2-V2475F mutation appears embryonic-lethal in homozygous mice, but heterozygous mi

178 LRP1 gene deletion is embryonic-lethal in mice.

179 Ticrr deficiency is embryonic-lethal in the absence of exogenous DNA damage

180 However, only Vdac2(-/-) (V2(-/-)) mice are embryonic lethal, indicating a unique and fundamental fu

181 Here, we find by positional cloning that the embryonic lethal island beat (isl) mutation in zebrafish

182 These findings contrast with those in the embryonic-lethal knockout mouse, highlighting difference

183 lities in embryo and placental structures of embryonic lethal lines.

184 es for dosage-sensitive phenotypes and mouse embryonic lethals mapped to the vicinity.

185 ns for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have identified 32 mu

186 t Rb-/- prostatic tissue can be rescued from embryonic lethal mice and used to test its susceptibilit

187 Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were ge

188 While germ-line deletion of Thap1 is embryonic lethal, mice lacking one Thap1 allele-which in

189 Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/- mice spontaneously devel

190 nder the strongest selection are enriched in embryonic lethal mouse knockouts, Mendelian disease-asso

191 evalence of concomitant placental defects in embryonic lethal mutants is highly underestimated and in

192 is for each modifier using four unrelated ts embryonic lethal mutants.

193 ormation, we have identified a collection of embryonic-lethal mutants in which cell divisions are del

194 Finally, we characterize an embryonic lethal mutation caused by endogenous splicing

195 ong loss-of-function, temperature-sensitive, embryonic lethal mutation in the maternally required gen

196 ur insertional alleles of foxi one (foo), an embryonic lethal mutation in zebrafish that displays def

197 d with this type of insertional mutagen is 1 embryonic lethal mutation per 70-100 proviral insertions

198 nionless (amn) mouse, which has a recessive, embryonic lethal mutation that interferes specifically w

199 A recessive embryonic lethal mutation was obtained.

200 We have isolated an embryonic lethal mutation, SBU2, that causes somite form

201 ross revealed that Mom2R encodes a recessive embryonic lethal mutation.

202 Embryonic lethal mutations (total of 34) were overwhelmi

203 We have screened for zygotic embryonic lethal mutations affecting cuticular morpholog

204 that are expressed in mast cells, including embryonic lethal mutations, in vitro or in vivo.

205 rtially ventralized phenotype similar to dpp embryonic lethal mutations.

206 om 92 F(2) families and obtained 9 recessive embryonic lethal mutations.

207 interactions, both partners show overlapping embryonic lethal or high incidence of males RNAi phenoty

208 Unlike PAK4-null mice, which are embryonic lethal, PAK5-null mice develop normally and ar

209 Homozygous brec mutants are embryonic lethal, paralyzed, and show no detectable syna

210 ene) during murine development results in an embryonic lethal phenotype characterized by a complete l

211 orphogen Indian hedgehog (IHH) results in an embryonic lethal phenotype characterized by the conspicu

212 mTOR was recently knocked out in mice; the embryonic lethal phenotype demonstrates a critical role

213 d deletion of Foxm1 gene in mice produces an embryonic lethal phenotype due to severe abnormalities i

214 and found that hemizygous deletion led to an embryonic lethal phenotype due to severe anemia resultin

215 k1 gene in mice and zebrafish resulted in an embryonic lethal phenotype due to severe dilation of blo

216 for a MTAP null allele (Mtap(lacZ)) have an embryonic lethal phenotype dying around day 8 postconcep

217 In contrast to recent observations of an embryonic lethal phenotype for TRF2 inactivation in Caen

218 of the Shh signaling pathway or to the early embryonic lethal phenotype in Ptc null mutants.

219 e belly spot and intercrossing results in an embryonic lethal phenotype in the homozygous state.

220 Analysis of the embryonic lethal phenotype indicates that mutant alleles

221 The DDK syndrome is an early embryonic lethal phenotype observed in crosses between f

222 . remanei homologs, can fully complement the embryonic lethal phenotype of a C. elegans med-1,2(-) st

223 The embryonic lethal phenotype of knock-out mice because of

224 physiological function is highlighted by the embryonic lethal phenotype of Tfr1-knockout (Tfrc(-/-))

225 This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice and to def

226 In contrast to the embryonic lethal phenotype of the homozygous betaARK1 kn

227 tive function of TRAP220 is evidenced by the embryonic lethal phenotype of Trap220(-)(/)(-) mice and

228 Crry(-/-) is an embryonic lethal phenotype secondary to the maternal com

229 ymes to blastoderm-stage embryos leads to an embryonic lethal phenotype that results from the failure

230 Through the use of a chimeric approach, the embryonic lethal phenotype was circumvented and a role f

231 Among the double mutants, an embryonic lethal phenotype was observed for mice that we

232 combination results in a partially penetrant embryonic lethal phenotype with severe developmental car

233 In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di

234 on of CeWwp1 via RNA interference yielded an embryonic lethal phenotype, despite the presence of at l

235 ption of the murine RAD51 gene results in an embryonic lethal phenotype, indicating that Rad51 protei

236 whole-body deletion of the p32 results in an embryonic lethal phenotype, mice heterozygous for p32 ar

237 he single gene that encodes AtUBP14 cause an embryonic lethal phenotype, with the homozygous embryos

238 at the mutant allele (Tsc1-) has a recessive embryonic lethal phenotype.

239 ge, edema, and developmental delay, and late embryonic lethal phenotype.

240 al models in which HAS2 null animals have an embryonic lethal phenotype.

241 ypoplasia and 3 days before the onset of the embryonic lethal phenotype.

242 hibit skin and skeletal abnormalities and an embryonic lethal phenotype.

243 m line and is tightly linked to a recessive, embryonic lethal phenotype.

244 a reduced APC function background caused an embryonic lethal phenotype.

245 r target genes and might contribute to their embryonic lethal phenotype.

246 In contrast to the embryonic-lethal phenotype of alpha4 integrin-null mice,

247 ull allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype.

248 ified that, when hemizygous, caused specific embryonic lethal phenotypes (exencephaly and edema) in m

249 ncluding excess D-glucose) that give rise to embryonic lethal phenotypes during organogenesis are ass

250 Among them are 121 genes that have embryonic lethal phenotypes in mice, cause defects in tr

251 Genetic tests on the embryonic lethal phenotypes indicated that for 13 genes,

252 in endothelial biology is underscored by the embryonic lethal phenotypes of knock-outs in mice due to

253 notypes in PPS patients are less severe than embryonic lethal phenotypes of Pofut2-null mice.

254 In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely rescued

255 s were identified as null mutants with early embryonic lethal phenotypes that could be rescued by GRX

256 in BCKDH function manifest larval arrest and embryonic lethal phenotypes, and mmBCFA supplementation

257 ca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a ho

258 day 13 (e13) fetal liver of mice exhibiting embryonic-lethal phenotypes.

259 ial for angiogenesis, as demonstrated by the embryonic lethal phentoype when targeted for deletion in

260 Phenotype genes were further divided into 'embryonic lethal', 'postnatal lethal', and 'non-lethal p

261 While Wls-EKO was embryonic lethal precluding further analysis in adult he

262 Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney developmen

263 Embryonic lethal ptip-null mutants and conditional mutan

264 Male mutant monkeys were embryonic lethal, reiterating that RTT is a disease of f

265 Although most genes with sterile or embryonic lethal RNAi phenotypes are involved in basal c

266 D), and interaction with the SHR INTERACTING EMBRYONIC LETHAL (SIEL) protein, little information is k

267 s in mis-localization of the SHR-INTERACTING EMBRYONIC LETHAL (SIEL) protein, which has been shown to

268 fied a novel protein, SHORT-ROOT INTERACTING EMBRYONIC LETHAL (SIEL), that interacts with SHR, CAPRIC

269 ally screened EMS-mutagenized Drosophila for embryonic lethal strains with defects in glutamatergic s

270 cinerea, whereas T-DNA insertion alleles are embryonic lethal, suggesting an essential role for MED21

271 PIGA-null mutations are thought to be embryonic lethal, suggesting that p.Arg412( *) PIGA has

272 s with wild-type pollen result in occasional embryonic lethals that also stain for GUS activity.

273 As global alphaII spectrin knockout mice are embryonic lethal, the in vivo roles of alphaII spectrin

274 Because the c-jun-null mutation is early embryonic lethal, thereby hindering a genetic analysis,

275 etic deletion of c-Jun in transgenic mice is embryonic lethal; therefore, transgenic mice encoding a

276 Because global loss of both pRb alleles is embryonic lethal, this hypothesis has not been tested in

277 t displayed a range in disease severity from embryonic lethal to viable with mild neuromuscular defic

278 While loss of mouse Smn is embryonic lethal, two copies of SMN2 prevents this embry

279 ontaining T-DNA insertions in both genes are embryonic lethal, under ideal laboratory growth conditio

280 ECs and hematopoietic cells and resulted in embryonic lethal vascular defects by e11.5.

281 Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mous

282 Given that HDAC3 null mice are embryonic lethal, we used for our analyses a combination

283 to be allelic, and at least two of these are embryonic lethal when homozygous.

284 highly similar, but Erk2 deletion in mice is embryonic lethal whereas Erk1 deletion is not.

285 ation had critical functions (knockouts were embryonic lethal), whereas the knockouts of 5 less criti

286 null for the alpha2(V) gene Col5a2 are early embryonic lethal, whereas haploinsufficiency caused aber

287 When homozygous, the D61G mutant is embryonic lethal, whereas heterozygotes have decreased v

288 T (e.g., Tg737 or the IFT kinesin Kif3a) are embryonic lethal, whereas kidney-specific disruption of

289 SART1(-/-) mice were embryonic lethal, whereas male SART1(+/-) mice spontaneo

290 ous Erg(DeltaEx4/DeltaEx4) knockout mice are embryonic lethal, which is associated with a marked redu

291 Caspase-8-deficient mice are embryonic lethal, which makes study of caspase-8 in prim

292 etic knockout of RuvBL1 in a murine model is embryonic lethal while conditional inactivation in the h

293 Homozygous R173Q mice were embryonic lethal, while R167Q homozygous mice (R167Q+/+)

294 Its germ line deletion is embryonic lethal with abnormal cardiovascular system for

295 Rnf4 deficiency is embryonic lethal with higher levels of methylation in ge

296 Germ-line deletion of either HIF subunit is embryonic lethal with unique features suggesting importa

297 AE2 and the SUMO-conjugating enzyme SCE1 are embryonic lethal, with arrest occurring early in embryo

298 Homozygous mutants were embryonic lethal, with death at mid-gestation from cardi

299 ut mice and determined that the phenotype is embryonic lethal, with embryos and the few stillborn pup

300 disturbed the developing vasculature and was embryonic lethal within days of the heart beating.