ライフサイエンスコーパス: emigrant

1 n of CD62L(high) and CD69(low) recent thymic emigrants.

2 spaces and reduced numbers of recent thymic emigrants.

3 but positively correlated with recent thymic emigrants.

4 the CD25(-) subset and are not recent thymic emigrants.

5 transferred mature T cells and recent thymic emigrants.

6 + regulatory T cells among the recent thymic emigrants.

7 nerated through the production of new thymic emigrants.

8 rast, thymectomy eliminated LN recent thymic emigrants.

9 CD45RA CD31, suggesting they were new thymic emigrants.

10 nly after the removal of CD25- recent thymic emigrants.

11 om the thymus, and survival of recent thymic emigrants.

12 flects the phenotype of recent normal thymic emigrants.

13 are phenotypically described as naive thymic emigrants.

14 D3 and differed from classical CD14+ dermal emigrants.

15 ion of truly naive T cells and recent thymic emigrants.

16 ls, including CD31(+)/CD4(+) putative thymic emigrants.

17 de novo responses derived from later thymic emigrants.

18 owed the highest percentage of recent thymic emigrants.

19 ary sources to estimate rates of death among emigrants.

20 also observed in adult CD4(+) recent thymic emigrants.

21 nd to be functionally immature recent thymic emigrants.

22 identification and analysis of recent thymic emigrants.

23 had a lower proportion of recent CD4 thymic emigrants (10.9% vs 18.6%, P = .05), a higher proportion

24 acer requires that all western Pacific Ocean emigrants acquire the (134)Cs signal, a radioisotope und

25 igration pattern, attenuates the response of emigrants against antigens that did not induce their del

26 ut no consistent pattern is observed between emigrant and in-country rates.

27 TCR excision circles and CD31+ recent thymic emigrants and a substantial expansion of the active thym

28 ts of immune responses such as recent thymic emigrants and dendritic cells strongly relate to product

29 Recent advances in identifying thymic emigrants and development of safe methods to study thymi

30 ls, we traced the phenotype of recent thymic emigrants and found that most were CD44low.

31 thymocyte numbers, increasing recent thymic emigrants and improving TCR diversity of peripheral T ce

32 2009-2019 reporting HBsAg seroprevalence in emigrants and in-country populations of 117 countries.

33 n vivo numbers of naive CD4(+) recent thymic emigrants and peripheral dendritic cells correlated well

34 re are age-dependent contributions of thymic emigrants and proliferation of postthymic T cells to mai

35 f FasR on the vast majority of recent thymic emigrants and resting peripheral T lymphocytes.

36 Whereas the frequency of recent thymic emigrants and the differentiation of induced Treg cells

37 esis by CD31(+) naive T cells (recent thymic emigrants) and homeostatic proliferation by Ki-67(+) T c

38 ntaining CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.

39 ive CD45RA(+)/CCR7(+) T cells, recent thymic emigrants, and TCR excision circles.

40 ased intrahepatic apoptosis of recent thymic emigrants appears in part responsible for lymphopenia in

41 Recent thymic emigrants are newly generated T cells that need to under

42 matory signals, and priming of recent thymic emigrants are not sufficient to maintain virus-specific

43 Functional assays support recent thymic emigrants as the precursors of CD4 T(SCM).

44 Th1 or Th2 cells and were not recent thymic emigrants as they were present in mice thymectomized bef

45 tics and reactivity from CD40L-deficient new emigrant B cells were similar to those from healthy dono

46 The protagonist, a child of Russian emigrants, became interested in antibodies as a postdoc

47 continues in the periphery in recent thymic emigrants, before these newly produced T cells gain func

48 A greater understanding of recent thymic emigrant biology has come with the development of method

49 ysfunctional phenotypes, distinct from blood-emigrant bystanders and regulatory TILs.

50 rradiated hosts suggested that recent thymic emigrants can undergo homeostatic proliferation and acqu

51 All infants had fewer than 50 recent thymic emigrants (CD3(+)CD45RA(+)CD62L(+)) per cubic millimeter

52 originate from CD31(+)CD4(+) T recent thymic emigrants, CD31 was downregulated prior to secretion of

53 nal anti-CD4 and anti-CD31 and recent thymic emigrants (CD4+recently emigrated from the thymus (RTE),

54 8 (CD8N) T lymphocytes and CD4 recent thymic emigrants (CD4RTE) were quantified in the peripheral blo

55 mune system and defines the nature of tissue-emigrant CD8(+) T cells that recirculate via TDL.

56 ircles (TRECs) as a measure of recent thymic emigrant cells in peripheral blood lymphocytes of 50 HIV

57 he cells left the transitional recent thymic emigrant compartment.

58 Although new thymic emigrants contributed to the peripheral T cell response

59 een inward-migrating sensory neuroblasts and emigrant cranial neural crest cells (NCCs) play a role i

60 cell death contributes to the patterning of emigrant crest cells into three discrete streams.

61 These data suggest that brain-emigrant DCs are sufficient to support activated T cells

62 indicating that the cells were recent thymic emigrants derived from immature progenitors.

63 thymocyte export is reduced, and most thymic emigrants disappear rapidly from peripheral lymphoid tis

64 Under these conditions, thymic emigrants displayed the expected phenotype, that of matu

65 T cells (CD62L(hi)CCR7(hi)) from CXCR5(lo) 'emigrant' effector helper T cells and CXCR5(hi) 'residen

66 Besides MME+ recent thymic emigrants, effector-like clusters are identified in this

67 n peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than mature

68 to that of tissue resident or recent thymic emigrants, explained this increase, as seen using parabi

69 In vivo, however, thymic emigrants failed to induce an acute graft-versus-host re

70 s, with the characteristics of recent thymic emigrants, failed to move away from CXCR4-deficient feta

71 c proliferation in the absence of new thymic emigrants for maintenance of the naive peripheral pool.

72 We identified 256 seroprevalence surveys in emigrants from 52 countries (including 689,078 persons)

73 The number of emigrants from an origin depended on both its population

74 DR-positive DCs that migrated from the skin, emigrants from both dermis and epidermis, 60-80% express

75 compared to those typed in the South Indian emigrants from Malaysia and groups from Madras, Karnatak

76 lated to switched memory cells and are early emigrants from the germinal center reaction.

77 In the PB, recent LN emigrants had higher Bcl-XL and Mcl-1 expression than di

78 We hypothesized that DP-BB recent thymic emigrants have a shortened life span and disappear by ap

79 We show that a major subset of bone marrow emigrant immature human B cells, the transitional 2 (T2)

80 y, resulting in a frequency of recent thymic emigrants in aged mice that is similar to that of young

81 ssay to quantify the number of recent thymic emigrants in blood based on the detection of a major exc

82 owed that the concentration of recent thymic emigrants in blood decreased with age over a 2-log unit

83 Recent thymic emigrants in chickens transiently express the chicken T

84 luding enhancing the number of recent thymic emigrants in circulation although direct targeting of GP

85 s only a modest fall in recent CD4(+) thymic emigrants in secondary lymphoid tissues.

86 importance of peripheral T cells and thymic emigrants in the elicitation and maintenance of CD8 T-ce

87 role of regulatory T cells among new thymic emigrants in the induction of tolerance, we showed that

88 Measurement of recent thymic emigrants in the periphery thus provides an accurate ind

89 an nondivided eGFP(hi)CD44(lo) recent thymic emigrants in the periphery.

90 R4 expression is regained in FoxP3(+) thymic emigrants in the periphery.

91 ly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies.

92 C3-deficient naive T cells are recent thymic emigrants, indicating a block in T cell maturation.

93 s important for integration of recent thymic emigrants into the mature naive compartment.

94 activation and differentiation of new thymic emigrants is affected by chronic inflammation, as well a

95 The roles of emigrant Langerhans cells and corneal lymphatics in the

96 n integrated approach to characterize tissue-emigrant lineages in thoracic duct lymph (TDL).

97 Here, we show that recent thymic emigrant maturation is a progressive process and is prom

98 eterogeneous subsets including recent thymic emigrants, mature naive phenotype cells, memory phenotyp

99 ent with this switch, recent FoxP3(+) thymic emigrants migrate exclusively to secondary lymphoid tiss

100 (3)-1574/mm(3)), a mean of 437 recent thymic emigrants/mm(3) (range, 196/mm(3)-785/mm(3)), and normal

101 r, these results point to the recruitment of emigrant monocytes and mononuclear cell granuloma format

102 The only marker on emigrants not found on either intrathymic cells or matur

103 whereas none were isolated from naive, early emigrant, or immature B cells.

104 s, but appears abruptly in the recent thymic emigrant population, suggesting that the lyp locus does

105 cell response are apparent in recent thymic emigrant populations, additional defects develop during

106 the appropriate regulatory cells from thymic emigrant precursors.

107 ut affecting thymocytes and/or recent thymic emigrants remains unknown.

108 CD8+ thymic emigrants require presence of MHC class I molecules in t

109 Recent thymic emigrant (RTE) cells are nascent T cells that continue t

110 thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation.

111 increased peripheral naive and recent thymic emigrant (RTE) populations, demonstrating its effect on

112 insight into the frequency of recent thymic emigrants (RTE) and, therefore, into thymic function.

113 Recent thymic emigrants (RTE) are an important subpopulation of naive

114 mice have poor accumulation of recent thymic emigrants (RTE) in the periphery.

115 used two approaches to isolate recent thymic emigrants (RTE) in young and aged mice and have compared

116 have been identified for these recent thymic emigrants (RTE), it is presently impossible to measure h

117 nd their exact relationship to recent thymic emigrants (RTE).

118 tudy, we show levels of CD8(+) recent thymic emigrants (RTEs) accounted for the prognostic power of a

119 udy we show that murine CD4(+) recent thymic emigrants (RTEs) are programmed to facilitate tolerance

120 Recent thymic emigrants (RTEs) are the youngest peripheral T cells tha

121 Recent thymic emigrants (RTEs) are the youngest subset of peripheral T

122 Recent thymic emigrants (RTEs) are the youngest T cells in the lymphoi

123 CD4(+) recent thymic emigrants (RTEs) comprise a clinically and immunological

124 epends on the context in which recent thymic emigrants (RTEs) encounter antigen.

125 fter developing in the thymus, recent thymic emigrants (RTEs) enter the lymphoid periphery and underg

126 have been used as markers for recent thymic emigrants (RTEs) in assessing human thymic function.

127 Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven

128 Analysis of gammadelta recent thymic emigrants (RTEs) indicated that most gammadelta T cell R

129 ere we demonstrate that CD8(+) recent thymic emigrants (RTEs) migrated directly into the small intest

130 Recent thymic emigrants (RTEs) must undergo phenotypic and functional

131 levels of alpha4beta7 endowed recent thymic emigrants (RTEs) of unconventional types with higher SI-

132 Such recent thymic emigrants (RTEs) undergo both phenotypic and functional

133 These recent thymic emigrants (RTEs) underwent phenotypic maturation in the

134 )CD8(-)Foxp3(-) thymocytes and recent thymic emigrants (RTEs), contrarily to peripheral naive mature

135 ge as naive T cells, including recent thymic emigrants (RTEs), expanded preferentially, whereas the p

136 decrease in the generation of recent thymic emigrants (RTEs), resulting in a reduced response to imm

137 explore the TCR sensitivity of recent thymic emigrants (RTEs), we triggered T cells with altered pept

138 ch are also characteristics of recent thymic emigrants (RTEs).

139 gous graft-vs-host disease are recent thymic emigrants (RTEs).

140 cells in CSA-treated rats are recent thymic emigrants (RTEs).

141 ytometry measurements of CD31+ recent thymic emigrants (RTEs).

142 t contains a high frequency of recent thymic emigrants (RTEs).

143 ture CD8 T cells with those of recent thymic emigrants (RTEs).

144 n increase in the frequency of recent thymic emigrants (RTEs, CD4(+) CD31(+) ) at 12-month posttransp

145 e youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive T

146 d naive T cells (also known as recent thymic emigrants) (RTEs) in mice, and followed their presence,

147 hese T cells may not represent recent thymic emigrants, since naive T cells may maintain this phenoty

148 New B cell emigrants slowly transited the HEV perivenule space, and

149 ceptor (TCR) excision circles, recent thymic emigrant T cells and naive CD4+ T cells, and low overall

150 CD3(+)CD45RA(+)CD62L(+)CD31(+) recent thymic emigrant T cells and non-class-switched CD19(+)IgD(+)CD2

151 assessed by quantification of recent thymic emigrants, T-cell receptor excision circle levels, and T

152 ated with CD4(+) T-cell count, recent thymic emigrants, TCR excision circles, and TCR diversity.

153 underdeveloped cities with large numbers of emigrants than would be expected by chance (p = 0.011; b

154 Recent thymic emigrants that fail postpositive selection maturation ar

155 ircles (TRECs), a molecular marker of thymus emigrants that have divided few times after leaving the

156 hat TCR revision is limited to recent thymic emigrants that have maintained RAG expression and TCR lo

157 ells, and activated alloreactive CD8+ thymic emigrants that have repopulated the periphery after tole

158 t of the surface markers on alphabeta-thymic emigrants (Thy1, CD44, CD69, CD25, leukocyte functional

159 igrants (graft to thymus pathway) and thymic emigrants (thymus to graft pathway) are involved in tole

160 s CTLA-4, which could dampen the response of emigrants to peripheral antigens.

161 maturation, T cells egress as recent thymic emigrants to peripheral lymphoid organs where they under

162 rather than from increased trafficking of BM emigrants to peripheral lymphoid tissues.

163 w incidence of breast cancer, but that among emigrants to the United States, the second generation, b

164 a region with lower CHB rates, but many more emigrants to the United States.

165 This enables some recent thymic emigrants to undergo LIP and convert into long-lived mem

166 We found that before HSC-GT, new emigrant/transitional and mature naive B cells from ADA-

167 New emigrant/transitional and mature naive B cells from AID-

168 We found that new emigrant/transitional and mature naive B cells from carr

169 er frequencies of poly- and autoreactive new emigrant/transitional and mature naive B cells in NMOSD

170 The antibody-coding genes from new emigrant/transitional and mature naive B cells were clon

171 with decreased frequency of autoreactive new emigrant/transitional B cells exiting the BM, indicating

172 nd reactivity of antibodies expressed by new emigrant/transitional B cells from IPEX patients were si

173 We found that new emigrant/transitional B cells from patients with XLP wer

174 e normally low frequency of polyreactive new emigrant/transitional B cells in DOCK8-deficient patient

175 phenotype also found on mature recent thymic emigrant Treg cells.

176 The FoxP3(+) thymic emigrants undergo the second switch in trafficking recep

177 (+) CD45RA(+) CD62L(+) CD31(+) recent thymic emigrants was associated with a loss of sense of taste a

178 ve contribution of CD4 and CD8 recent thymic emigrants was modulated as they entered the peripheral T

179 ng gene 2 promoter to identify recent thymic emigrants, we now show that T cell differentiation conti

180 in the face of increasing numbers of thymic emigrants, whereas IL-7 potently accomplished this.

181 Trajectory simulations show that 80% of emigrants will reach regions suitable for winter breedin

182 We hypothesized that recent thymic emigrants with regulatory function are important in the

183 main subset consists of naive recent thymic emigrants, with effector memory T cells (T(EM)) found on

184 Levels of recent thymic emigrants within the peripheral blood were assessed thro