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1 strate the therapeutic potential of the R(+) enantiomer.
2 he tricyclic diastereomer from the (1 S,2 S)-enantiomer.
3 though Gce preferentially bound a natural JH enantiomer.
4 ms of the preferential formation of the ( R)-enantiomer.
5 evant pathway in the production of the major enantiomer.
6 quantification of each E and Z isomer of the enantiomer.
7 erence for the experimentally observed major enantiomer.
8 leaving the filtrate enriched with the other enantiomer.
9 all the desired activity comes from a single enantiomer.
10 e acceleration of more than 40 for the major enantiomer.
11 splayed more favorable kinetics toward the D-enantiomer.
12 arating (sub)micrometer-scale chiral crystal enantiomers.
13 racemates with a mixture of equal amounts of enantiomers.
14 response of the isostructural phen analogue enantiomers.
15 ssibilities for easy and fast analysis of AA enantiomers.
16 reened by chiral HPLC for resolvability into enantiomers.
17 igned the absolute configurations of the two enantiomers.
18 acrocyclic compound has been obtained as two enantiomers.
19 n enantioenriched form without resolution of enantiomers.
20 5]diazahelicene, enriched in (P,P)- or (M,M)-enantiomers.
21 ceptor binding behavior of the 2 radioligand enantiomers.
22 and a strong stereospecific preference for S-enantiomers.
23 nter will produce all four possible isobaric enantiomers.
24 ted at semipreparative level into their pure enantiomers.
25 e amenable to resolution into optically pure enantiomers.
26 exhibited similar turnover rates as their l-enantiomers.
27 -tetrapetalones A and C and their respective enantiomers.
28 CdTe QDs led to chiral recognition of these enantiomers.
29 ino sugars, 18 amino acids, and 4 amino acid enantiomers.
30 inactive state of D3R in complex with these enantiomers.
31 he first to generate these targets as single enantiomers.
32 kably more potent than the corresponding (R)-enantiomers.
33 .e., the change of the relative abundance of enantiomers.
34 ough for the satisfactory differentiation of enantiomers.
35 to potential existence of inactive and toxic enantiomers.
36 ents of chirality were synthesized as single enantiomers.
37 e almost perfect discrimination of their two enantiomers.
38 ls were measured to be different for the two enantiomers.
39 ere more potent than their corresponding (R)-enantiomers.
41 nd enantiopure samples revealed that the two enantiomers (1M and 1P) tend to narcissistically self-so
43 racemic mixture and ascertained that the two enantiomers (30a and 30b) are equiactive inhibitors for
46 lective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)
47 posite spiraling directions for the two PdGa enantiomers, a direct manifestation of the change of sig
49 d the identification of the eutomer, the (S)-enantiomer, allowed to halve the dose totally relieving
52 ormations: kinetic differentiation of allene enantiomers and desymmetrization of intermediate pai-all
53 emonstrate a work-flow for speciation of the enantiomers and diastereomers of 2-aminocyclohexanol as
54 h the understanding of assembly processes of enantiomers and racemates, in both dilute solution and c
55 paring the gelation propensity of individual enantiomers and racemates, we find that racemates of car
56 on that occurs between photoexcited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enantiose
60 rmance liquid chromatography (HPLC) into its enantiomers, and all four inherently chiral bambusuril p
61 rs: CycA and CycH (cyclosporin H), which are enantiomers, and isocyclosporin A (a structural isomer o
62 ors of Raman scattering (EFs) for particular enantiomers, and the SERS intensity was proportional to
63 rs of dimeric phenylpropanoyl-phloroglucinol enantiomers, (+)- and (-)-xanthchrysones A-C [(+)- and (
64 hat differ considerably in efficacy: the (R)-enantiomers are antagonists/weak partial agonists, where
66 tivity relationship showed that (R)- and (S)-enantiomers are equally avid for GR by occupying discret
69 ar mechanism identified the R(+)-propranolol enantiomer as a small molecule inhibitor of the SOX18 tr
75 e abiotic processes usually act identical on enantiomers, biotic processes, such as biodegradation of
76 ciparum 80S ribosome with the (+)-mefloquine enantiomer bound to the ribosome GTPase-associated centr
77 e electrochemical discrimination between two enantiomers, but most importantly also allow stereospeci
78 ligand binding site induced by the bound (S)-enantiomers, but not by the (R)-enantiomers, that are fe
79 pene could be enhanced relative to the other enantiomer by the application of a sequence of microwave
80 16b, Ki = 24.3 nM] was resolved into its two enantiomers by chiral HPLC, and the absolute configurati
82 han enantiopure compounds, and the mixing of enantiomers can enhance the aggregation propensity of pe
83 ived molecules for the preparation of single enantiomer compounds is an effective method to reduce th
84 [Cr(dqp)(2)](3+) and MM-(-)-[Cr(dqp)(2)](3+) enantiomers could be separated and isolated by using cat
86 enabled separation and determination of 2HG enantiomers (D- and L-2HG) in frozen and FFPE tissues.
88 From the peptides designed, RR4 and its D-enantiomer, D-RR4, emerged as the most potent analogues
92 ype II E) are possible, leading to different enantiomers depending on the imine configuration (E- or
94 nce is the tiny difference in energy between enantiomers due to parity violation in the weak force.
95 mer of fadrozole, and CYP11B1 binds to the S enantiomer, each with distinct orientations and interact
97 -)-verticilide had no effect, its nonnatural enantiomer [ent-(+)-verticilide] significantly reduced R
98 icated for determination of thalidomide (TD) enantiomers (especially towards the toxic (S)-enantiomer
100 tructures with the addition of the Bay K8644 enantiomers exhibit similar inactivated conformations, s
101 otoswitches with chirality and the separated enantiomers exhibit tuneable chiroptical properties by p
102 es with mesomeric species, all of the tested enantiomers exhibited high SERS-ChA asymmetry factors (g
103 ave dose-limiting hepatotoxicity, 27 and its enantiomers exhibited limited off-target effects, result
104 at the transition state leading to the major enantiomer features a better steric fit and favorable pa
106 hthol moiety (BINOL and VANOL), whereas diol enantiomers form complexes with the enantiopure amine-ty
110 tablished model for interpreting isotope and enantiomer fractionation patterns showed potential for a
112 dition, some of these reactions use a single enantiomer from racemic nucleophiles to afford stereopur
113 was achieved by selective adsorption of one enantiomer from the aqueous racemic mixture into the chi
114 combination with the ability to access both enantiomers from the carbene-catalyzed reaction is a pow
115 e and Cinchonidine epimers and amino alcohol enantiomers, from which the quantitative determination o
116 ed by single-isomer, and particularly single-enantiomer, fullerenes in organic electronic materials a
119 ree synthesis of the natural product and its enantiomer has been achieved through the modified Knoeve
120 d host molecules for discrimination of guest enantiomers has been largely overlooked, which is surpri
123 to produce each of the two possible product enantiomers (i.e., stereodivergence) of a new-to-nature
124 we determined that D-2HG is the predominant enantiomer in human breast tumors and show that the D-2H
125 is utilized to determine the amount of each enantiomer in the mixture with an error of <1% e.e. This
126 centers can be used to predict the er of the enantiomers in each diastereomeric set, along with the d
127 ranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing m
128 drug is responsible for racemic switch with enantiomers in presence of chiral environment for human
130 ring between the inherently chiral AuNPs and enantiomers in the first filter holder, which results in
136 tial spaces and preferential partitioning of enantiomers into SPs, which can be further enhanced by c
137 (ITC) show that the stronger binding of one enantiomer is accompanied by an increased gain in enthal
141 , the colorimetric discrimination of alanine enantiomers is examined and, more importantly, AuNPs-emb
142 20 and 23.6 nM, respectively] into their two enantiomers, isolating the affinity on the corresponding
143 fferent combinations of ligand and substrate enantiomers, it is now possible to access all four stere
145 ost selective compound is a glucose-appended enantiomer, its cellular entry is not mainly glucose tra
146 strategy to interface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality
147 gher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of A
150 are also active, while their corresponding d-enantiomers, methyl alpha-d-glucopyranoside 2,3,6-trisph
151 mechanism for how biomineralization-related enantiomers might exert hierarchical control to form ext
153 d a synthesis for optically active (d- and l-enantiomers) nonhydrolyzable analogs of 2-arachidonoyl-l
155 Specifically, the population of a specific enantiomer of a chiral terpene could be enhanced relativ
156 we describe an enantiospecific route to one enantiomer of a common decalin core that is present in n
157 ompared the properties of B-973B, the active enantiomer of B-973, with those of GAT107 regarding the
160 nating the heme iron, CYP11B2 binds to the R enantiomer of fadrozole, and CYP11B1 binds to the S enan
162 intranasal formulation of esketamine, the S enantiomer of ketamine, in conjunction with an oral anti
164 orted d-allo-ShK was in fact d-ShK, the true enantiomer of natural l-ShK toxin, and that the apparent
166 methods used, experimental data for the (-)-enantiomer of tert-butylphenylphosphinoamidate were meas
168 lows convenient access to either the R- or S-enantiomer of the chiral amine products in high yields a
171 rentially utilized the naturally occurring l-enantiomer of the ether analog of lysophosphatidylcholin
173 folds, and notably (-)-ent-quiannulatene, an enantiomer of the fungal metabolite (+)-quiannulatene.
174 de novo synthesis of l-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preli
179 ng stoichiometric amounts of the (+)- or (-)-enantiomer of the scarcely available and expensive diami
182 may be applied to (S)-carvone to afford the enantiomer of this common intermediate for other applica
183 igate the performance characteristics of the enantiomers of (11)C-Me-NB1, a recently reported PET ima
184 ed assay for determining e.e. in mixtures of enantiomers of 1,2- and 1,3-diols, chiral amines, amino
189 eved through the new approach to access both enantiomers of 4,5-di-O-benzyl-myo-inositol, derived fro
190 teps and 22% overall yield by employing both enantiomers of a BINOL-derived chiral phosphoric acid (C
191 me a valuable tool with which to access both enantiomers of a broad range of chiral arylaliphatic aci
192 ative populations of two otherwise identical enantiomers of a large gas-phase molecule using resonant
194 By switching the achiral proton source, both enantiomers of a series of tertiary alpha-aryl-1-indanon
195 nantiodivergent catalyst pair delivering the enantiomers of alpha-functionalized aldehyde products in
197 Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous s
198 polymers were treated with a mixture of the enantiomers of an amino alcohol, no fluorescence enhance
199 d by using a Cyclosil B column, on which the enantiomers of camphor, menthone, piperitone and carvone
202 Despite their general absence in nature, the enantiomers of natural products may harbor unprecedented
203 3,5,6TMP-TQS isomers and active and inactive enantiomers of other TQS-related compounds identify the
205 This allowed for the preparation of both enantiomers of the bicyclic product with near-identical
207 that reacts at different rates with the two enantiomers of the electrophile, which interconvert unde
211 nt radical 1,5-C-H amination, producing both enantiomers of the strained five-membered cyclic sulfami
215 on of a racemic intermediate to provide both enantiomers of this unusual bicyclic monosaccharide.
216 ridine with an equimolar mixture of opposite enantiomers of trans-1,2-diaminocyclopentane and trans-1
218 the work published on the adsorption of pure enantiomers, of enantiomeric mixtures, and of prochiral
220 lity status (either racemates, single active enantiomer or achiral) of medicines circulated on the ma
223 voted to understanding how enrichment of one enantiomer over the other might have emerged from a preb
226 ce in both biotic and abiotic samples (seven enantiomer pairs d/l-Ala, -Asp, -Glu, -His, -Leu, -Ser,
227 specialist herbivore to linalool depends on enantiomer, plant genotype, and environmental complexity
228 However, the chain is helical, with only one enantiomer present, resulting in a chiral, noncentrosymm
229 peutic consisting of the pure cationic lipid enantiomer R-1,2-dioleoyl-3-trimethyl-ammonium-propane (
232 ith agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effe
237 cific recognition at A2BAR, with the (S)-16b enantiomer retaining all the affinity (Ki = 15.1 nM), as
239 158 muM; CVX, IC50 = 11 muM) than any of its enantiomers S (6c) (collagen, IC50 = 25.3 muM; CRP-XL, I
240 -Bay K8644, and a titration of its agonistic enantiomer (S)-(-)-Bay K8644 at resolutions of 2.9-3.4 a
241 cally expressing linalool synthases for both enantiomers, (S)-(+)- and (R)-(-)-linalool, reported to
242 ectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral st
247 with fluorescently labeled analogues of the enantiomers showed their colocalization in racemic fibri
248 stically self-sort in the dimer regime, each enantiomer showing a strong preference to associate with
249 d to be a racemic mixture of the (R) and (S) enantiomers, so it has been unclear whether one or both
253 were unresolvable in a mixture, whereas the enantiomers studied did not exhibit statistically differ
255 conformational changes of FliY, where the l- enantiomer-substrate-binding protein complex interacted
257 he bound (S)-enantiomers, but not by the (R)-enantiomers, that are features of partially activated re
258 ultrasonication increased levorotatory rutin enantiomers, that can be used to further modify physico-
259 Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effective cell ki
260 route was designed to enable access to both enantiomers, the absolute configuration of the natural p
261 accelerating the transformation of the major enantiomer through attractive non-covalent interactions
262 kinetic differentiation of the cyclic allene enantiomers through stereoselective olefin insertion, lo
264 ence quenching due to the tendency of chiral enantiomers to form complexes with gamma-CD in different
266 -oxazolidine-2-one, was resolved into single enantiomers using a chiral auxiliary to access enantio-e
268 x formed from them, have been separated into enantiomers using HPLC with a chiral stationary phase.
271 nsferring information between orthogonal DNA enantiomers via an achiral intermediary, opening the doo
272 llenging to obtain these compounds as single enantiomers via the established synthetic procedures due
273 ute configuration of the more slowly eluting enantiomer was established by X-ray crystallography.
278 pecific rotation of tetrafluoro[6]helicene 6 enantiomers was found to be approximately 25% lower than
284 nantiomerically pure natural product and its enantiomer were prepared in seven steps and 22% overall
286 Hyperpolarized (13)C-labeled dl-methionine enantiomers were differently observed with a single-scan
287 n slightly acidic soils, differences between enantiomers were not pronounced, and in strongly acidic
288 mprove its aqueous solubility, 5 and its two enantiomers were synthesized and converted into their co
289 benzo[d]azepin-1-ol ((11)C-NR2B-SMe) and its enantiomers were synthesized as candidates for imaging t
291 , and the unnatural and heretofore unknown l-enantiomer, were converted to disaccharide derivatives c
292 have synthesized the highly active (-)-KF116 enantiomer, which displayed EC(50) of ~7 nM against wild
294 suggested a specific interaction of the (-) enantiomer with alpha7T106, and allosteric activation of
295 ure can be transformed into an excess of one enantiomer with the aid of chiral auxiliaries, but has b
296 ge, this is the first example of one pair of enantiomers with contrasting selectivity for human telom
297 ved through the self-assembly of alternating enantiomers with hydrogen bonds as the intermolecular dr
299 ivatives (12d, 13c, and 14c) provided single enantiomers with significant enantioselectivity in HIV-1
300 namically isomerize, interconverting between enantiomers without cleavage of a constituent bond, nor