ライフサイエンスコーパス: enantiomeric

1 Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidin

2 restrictine L have been synthesized from the enantiomeric (4R)- and (4S)-4-(tert-butyldimethylsiloxy)

3 stream module by a paralog that produced the enantiomeric ACP-bound diketide caused no changes in pro

4 The binding of enantiomeric amines induces distinct (19)F NMR shifts of

5 s derived from D-mannose and D-galactose are enantiomeric and are useful linkers for the synthesis of

6 groundwater systems through a combination of enantiomeric and carbon isotope fractionation to charact

7 r current knowledge of the distributions and enantiomeric and isotopic compositions of amino acids an

8 ther analogues are available, including some enantiomeric and structurally isomeric forms.

9 the XB interactions in orientating the bound enantiomeric anion guests for chiral selectivity, as wel

10 Opposite-handed PCG helical chains in the enantiomeric BCPs* were identified by the vibrational ci

11 We also apply our enantiomeric biosensors to the optimization of reaction

12 ad, they are antipodes arising from separate enantiomeric biosyntheses.

13 Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose

14 The diketone derived from the enantiomeric C12-fragment (R)-30 underwent reductive cyc

15 tric route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpenoid skeleton

16 Here we present the synthesis of two enantiomeric cell-permeant and photocaged (PP)(2)-InsP(4

17 ls a drastic chiral phase transition from an enantiomeric chiral domain to a meso-isomeric achiral do

18 es an imbalance in the population of the two enantiomeric coconformations.

19 Chiroptical analysis of the enantiomeric composition and concentration of minute sam

20 determination of the absolute configuration, enantiomeric composition and concentration of unprotecte

21 this method has the ability to evaluate the enantiomeric composition and discriminate between enanti

22 on the sulfenyl moiety prevented erosion of enantiomeric composition at these elevated temperatures.

23 crystal surface was studied as a function of enantiomeric composition by temperature programmed desor

24 neous determination of the concentration and enantiomeric composition of small sample amounts and are

25 The cyclization reaction mechanism and the enantiomeric composition of the peropyrene products are

26 escent probe can be applied to determine the enantiomeric composition of the structurally diverse chi

27 tions between the induced CD signals and the enantiomeric composition or concentration of the chiral

28 determination of the absolute configuration, enantiomeric composition, and overall amount of cysteine

29 his method was then applied to determine the enantiomeric compositions of eight chiral pharmaceutical

30 wide concentration range and largely varying enantiomeric compositions.

31 gaine and (-)-voacangine are of the opposite enantiomeric configuration compared to the other major a

32 al subclasses and displaying a predominant R-enantiomeric conformation have been isolated from N. nuc

33 racemic mixtures of rapidly interconverting enantiomeric conformers able to recognize a chiral analy

34 The rate of interconversion of their enantiomeric conformers depends on solvent polarity.

35 Enantiomeric Cp(R)2TiCl2 complexes have been prepared; t

36 microfluidic strategy for the separation and enantiomeric detection of D-methionine (D-Met) and D-leu

37 bles high-throughput real-time evaluation of enantiomeric/diastereomeric excess (e.e./d.e.) and produ

38 dic alkaloid that exists as a pair of pseudo-enantiomeric diastereomers.

39 ric and internal confinement effects for the enantiomeric difference in l- and d-Lys adsorption.

40 The origin of the enantiomeric difference is discussed considering both ac

41 The X-ray structure shows enantiomeric discrimination where 9a optimally addresses

42 chiral micropollutants and maintaining their enantiomeric distribution during deployment.

43 SPME) was used in order to verified linalool enantiomeric distribution in two feijoa varieties.

44 ect of our approach is the implementation of enantiomeric DNA biosensors, which are synthesized from

45 of a homochiral guest liquid crystal, these enantiomeric domains become diastereomeric, exhibiting u

46 Further enantiomeric enrichment of PCBs 95, 132, and 149 occurre

47 ecies in the vapor phase, with a significant enantiomeric enrichment relative to the solid.

48 single regioisomers with excellent levels of enantiomeric enrichment.

49 o allylic substrates or deliver little to no enantiomeric enrichment.

50 ot-mean-square error (rmse) in the predicted enantiomeric excess (%ee) of about 8.4 +/- 1.8 compared

51 h, producing a good yield (71%) and a higher enantiomeric excess (64%).

52 Determining enantiomeric excess (e.e.) in chiral compounds is key to

53 Using the enantiomeric excess (ee %) of the vapor-phase monomer as

54 ectrocatalytic system was 25.5 mM with 81.2% enantiomeric excess (ee(p)).

55 e 27.6% highest faradaic efficiency and >99% enantiomeric excess (ee(p)).

56 olution of homochirality requires an initial enantiomeric excess (EE) between right and left-handed b

57 Enantiomeric excess (ee) determination is crucial in man

58 A method for enantiomeric excess (ee) determination of THFA is presen

59 We report herein an unprecedentedly high enantiomeric excess (ee) for Pd patches deposited onto C

60 Methods for the rapid determination of enantiomeric excess (ee) in asymmetric synthetic methodo

61 diastereomeric excess (de) limits the final enantiomeric excess (ee) of any phosphorus products deri

62 sented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole rang

63 s were observed leading to variations in the enantiomeric excess (ee) of the chemisorbed layers with

64 Broadly useful chiroptical enantiomeric excess (ee) sensing remains challenging and

65 an be furnished with yields up to 92% and an enantiomeric excess (ee) up to 99%.

66 ns with total turnovers (TTN) up to 4070 and enantiomeric excess (ee) up to 99%.

67 from 88 to 96% and in enantioselectivities (enantiomeric excess (ee)) ranging from 85 to 97%, with d

68 very high levels of enantioselectivity (>95% enantiomeric excess (ee)).

69 ical analysis of reaction parameters such as enantiomeric excess (ee), diastereomeric excess (de), an

70 izontal lineC bond were hydrogenated in high enantiomeric excess (up to >99% ee).

71 ould be successfully obtained with excellent enantiomeric excess (up to >99% ee).

72 ective cyclobutane products with significant enantiomeric excess (up to 95% ee).

73 drogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).

74 e challenges to yield gamma-lactones in high enantiomeric excess (up to 99%) using hydrogen peroxide

75 n of l-norleucine achieved 0.36 mM with >99% enantiomeric excess and 82% Faradaic efficiency.

76 determination of the absolute configuration, enantiomeric excess and concentration of the target comp

77 is often challenging for mixtures with high enantiomeric excess and for complex molecules with stron

78 ethod that accomplishes determination of the enantiomeric excess and overall amount of a large variet

79 ha-disubstituted aldehyde hydrazones in high enantiomeric excess and yield.

80 molecules and quantitative determination of enantiomeric excess can be achieved in a table-top instr

81 , thus locking the induced chirality with an enantiomeric excess close to 25%.

82 t- (left-)handed twisted nanoribbons with an enantiomeric excess exceeding 30%, which is approximatel

83 methylformamide) and observed an increase in enantiomeric excess for 1-phenylethanol of 35% with the

84 eous determination of percent conversion and enantiomeric excess for each substrate.

85 chiral inorganic compounds with significant enantiomeric excess has been demonstrated.

86 Good results in terms of yield and enantiomeric excess have been obtained in ionic liquid g

87 sly from reaction mixtures, with an enhanced enantiomeric excess if initially enantioenriched, which

88 tract about 3.5 mg of glutamic acid with 95% enantiomeric excess in 24 h.

89 Enantiomeric excess is strikingly insensitive to tempera

90 olysis in giving unsaturated alcohol with an enantiomeric excess of >95%.

91 ms are achieved in yields as high as 99% and enantiomeric excess of 97% under aqueous conditions at r

92 ane in satisfactory yield and with excellent enantiomeric excess of 99%.

93 ve linear model was applied to determine the enantiomeric excess of samples of two alcohols without a

94 inkers, impacts on the reaction rate and the enantiomeric excess of the aldol products.

95 amplitudes of the specific Cotton effect and enantiomeric excess of the parent amine gives potentiali

96 tic amounts of host are able to increase the enantiomeric excess of the products formed.

97 vided strong evidence that the modulation of enantiomeric excess of the reaction product indeed stems

98 lent enantioselectivity is achieved, with an enantiomeric excess of up to 99%.

99 S)-alpha-phenyltryptamine derivative with an enantiomeric excess over 99%.

100 In one case, the enantiomeric excess reaches 95:5 er, and the reactions c

101 ng asymmetric Doyle-Kirmse reactions with an enantiomeric excess up to 71 %.

102 This method provides high conversion and enantiomeric excess up to 84% of the desired chiral seco

103 -polyheterocycles of complex topologies with enantiomeric excess values up to 90%.

104 ogenation of benchmark substrates furnishing enantiomeric excess values up to 96%.

105 good chemical and radiochemical purities and enantiomeric excess values.

106 with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

107 ith esters bearing alpha-stereocenters, high enantiomeric excess was maintained during ketone formati

108 r the syn or anti adduct selectively in high enantiomeric excess when an appropriate chiral ligand wa

109 ssfully cross-coupled in excellent yield and enantiomeric excess with prior conversion of the pinacol

110 94%) with high enantioselectivity (up to 99% enantiomeric excess) and excellent chemoselectivity.

111 high enantioselectivity (typically 90 to 99% enantiomeric excess), and afford products that are key p

112 ctivity and 97%, please refer to compound 2v enantiomeric excess), and can be performed easily on pre

113 es (up to 99 per cent yield with 99 per cent enantiomeric excess), which otherwise are difficult to a

114 e reacted with high optical purities (89-98% enantiomeric excess).

115 synthesized in enantioenriched forms (86-90% enantiomeric excess).

116 for selective catalysis with 93% and 79% ee (enantiomeric excess).

117 ns of carbenes into C-H bonds with up to 98% enantiomeric excess, 35,000 turnovers, and 2550 hours(-1

118 Whereas the er (or enantiomeric excess, ee) of chiral molecules is readily

119 lucidate the correlation between defects and enantiomeric excess, five characterization techniques (F

120 into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in p

121 ions, nonanionic conditions, and with a high enantiomeric excess.

122 d reactivity and generate products with high enantiomeric excess.

123 th up to >98% conversion and with up to >98% enantiomeric excess.

124 ith aniline afforded the urea product in 51% enantiomeric excess.

125 hesis of tertiary phosphine oxides with high enantiomeric excess.

126 robenzofurans in consistently high yield and enantiomeric excess.

127 in up to 98 % yield and greater than 99.5 % enantiomeric excess.

128 nd provides the title compounds in excellent enantiomeric excess.

129 oth natural products were obtained in >/=99% enantiomeric excess.

130 btained in high chemical yield and with high enantiomeric excess.

131 y been impeded by insufficient yield and low enantiomeric excess.

132 ohols, yielding up to 96% conversion and 99% enantiomeric excess.

133 ical yield and 100% diastereoselectivity and enantiomeric excess.

134 enantiopure configuration, dimerize without enantiomeric excess.

135 lated by catalyst design, with no erosion of enantiomeric excess.

136 to 93% and enantioselectivities of up to 88% enantiomeric excess.

137 ubstrates in high yields and with up to 99 % enantiomeric excess.

138 ently cyclized in high yields with up to 99% enantiomeric excess.

139 of substituted d-tryptophan analogs in high enantiomeric excess.

140 This is one of the highest enantiomeric excesses (ee %) and yields reported so far

141 ed syn-products (de = 60-99%), with moderate enantiomeric excesses (ee = 43-56%) but did not produce

142 Therefore, the detection of l- or d-enantiomeric excesses (ee) of chiral amino acids and sug

143 d the SERS intensity was proportional to the enantiomeric excesses (ee) values.

144 Primary allylic amines with enantiomeric excesses from 97 to >99% were prepared by a

145 ropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a rhodium catal

146 e presented, which consistently provide high enantiomeric excesses in the range 91-98%.

147 3-substituted morpholines in good yield and enantiomeric excesses of >95%.

148 er of substituents in the 4-position, giving enantiomeric excesses of greater than 82%.

149 s and sugar acids (aldonic acids) with large enantiomeric excesses of the same chirality as terrestri

150 entenols 3a-l in good to excellent yields in enantiomeric excesses up to 99%.

151 exo/endo ratios and excellent diastereo- and enantiomeric excesses when in situ formed [Ir(I)/Tol-SDP

152 ydrofurans are formed with good to excellent enantiomeric excesses.

153 Therefore, it is expected that enantiomeric fidelity has to be a key component of all o

154 For example, its enantiomeric fluorescent enhancement ratios ( ef or Delt

155 CD8(+) T-cell response was dependent on the enantiomeric form of abacavir at both cyclopropyl and cy

156 ral symmetry break, resulting in a preferred enantiomeric form of the gyroid structure.

157 ), revealing the exclusive presence of the S-enantiomeric form.

158 have been designed and prepared in their two enantiomeric forms in order to probe their second-order

159 l (E = 22) allowed rapid preparation of both enantiomeric forms of a C21-oxygenated precursor for syn

160 ning substrates that led selectively to both enantiomeric forms of an epoxy vinyl stannane, and a ser

161 Enantiomeric forms of BTD-2, PG-1, and PM-1 were synthes

162 mbiguously reveal the coexistence of the two enantiomeric forms of opposite handedness: the left- and

163 Chemical synthesis of the L- and D-enantiomeric forms of Rv1738 enabled facile crystallizat

164 seco-analogue of 2) of both the (-)- and (+)-enantiomeric forms of the alkaloid galanthamine [(-)-1]

165 selective total syntheses of the non-natural enantiomeric forms of the recently isolated protoilludan

166 Both the enantiomeric forms of the trans isomer are obtained in e

167 th natural and unnatural complements in both enantiomeric forms.

168 layed atropisomeric enrichment in the cells (enantiomeric fraction [EF] = 0.55-0.77) and dishes (EF =

169 sses, such as biodegradation often result in enantiomeric fractionation (EFr), i.e., the change of th

170 cross China, we measured the concentrations, enantiomeric fractions (EFs), compound-specific carbon i

171 While selective recognition of an enantiomeric guest from a racemic mixture by a chiral ho

172 A comparison of enantiomeric haptens and the racemate elucidated the imp

173 The enantiomeric homogeneity of light-driven molecular motor

174 rther optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the f

175 f chiral medicines by conducting analysis of enantiomeric impurity.

176 oth MOFs allow for only direct gauche-gauche enantiomeric interconversion of the glutarate moieties.

177 e cap-core interaction (C-H...pai), only two enantiomeric isomers are formed (secondary structure).

178 curate environmental risk assessments at the enantiomeric level.

179 oisomers derived from each configurationally enantiomeric macrocycle was investigated in CD3SOCD3 sol

180 handedness is dictated by the choice of the enantiomeric macrocyclic dimer.

181 ed on the adsorption of pure enantiomers, of enantiomeric mixtures, and of prochiral molecules on chi

182 When equimolar solutions of the enantiomeric naphthalenediimide-based highly rigid trian

183 The enantiomeric Nazarov transition structures, which are co

184 CN5 bromodomain, together with GSK4028 as an enantiomeric negative control.

185 mage form of KRas bound to its corresponding enantiomeric nucleotide triphosphate, this study sets th

186 trated, including natural variants and novel enantiomeric or diastereomeric counterparts.

187 Petromyroxol is a nonracemic mixture of enantiomeric oxylipids isolated from water conditioned w

188 An enantiomeric pair of chiral metal-organic materials (CMO

189 The two enantiomeric pairs of saddles were characterized by (1)H

190 l-mannose are delineated, and for all eight enantiomeric pairs, d and l entities display different c

191 e the in vitro and in vivo efficacy of the D-enantiomeric peptide RD2, a rationally designed derivati

192 Comparison of native and enantiomeric peptides has long been used as a powerful a

193 yclable polymer system, requires blending of enantiomeric polymer chains produced from respective ena

194 ents the first direct evidence that they are enantiomeric polymers: WTA is made of sn-glycerol-3-phos

195 Finally, we also discovered that enantiomeric PORCN inhibitors show very different activi

196 Using these enantiomeric probe pairs, or 'enantioprobes', we identif

197 ely directing the formation of either of two enantiomeric products by a reaction involving 1,22-remot

198 les obtained for the pathways leading to the enantiomeric products suggest that the rate- and stereod

199 and assign the absolute configuration of the enantiomeric products.

200 Its enantiomeric profiling was studied for the first time in

201 e stereoinvertivebly cross-coupled with high enantiomeric purities (77-97% ee).

202 ly active aziridine can be coupled with high enantiomeric purity (>99% ee).

203 in good yield ( approximately 40%) and high enantiomeric purity (ee >93%).

204 s confirm, that the observed small losses of enantiomeric purity are traced to a triflate-mediated do

205 The enantiomeric purity could be substantially enhanced to 9

206 A simple NMR-based determination of enantiomeric purity is also described.

207 The retention of enantiomeric purity is attributed to a high binding affi

208 The high enantiomeric purity of a chiral N-(diphenylphosphinoyl)p

209 In contrast, the enantiomeric purity of gamma-C6 significantly decreased

210 agonal crystalline domains regardless of the enantiomeric purity of the perylene bisimide.

211 n conditions on the substrate conversion and enantiomeric purity of the products were investigated.

212 urity were characterised by gamma-C6 of high enantiomeric purity remaining stable during the whole po

213 a-hydroxy-gamma-lactone derivative with high enantiomeric purity using Sharpless dihydroxylation as t

214 livers alpha-aminocarbonyl compounds in high enantiomeric purity.

215 utyrolactone derivatives, without erosion of enantiomeric purity.

216 ivers beta-aminocarbonyl compounds with high enantiomeric purity.

217 o-arylated benzylamines are obtained in high enantiomeric purity.

218 sh the desired Z-homoallylic alcohol in high enantiomeric purity.

219 both epoxide and thiirane in high yields and enantiomeric purity.

220 trahydrofuran derivatives without erosion of enantiomeric purity.

221 e a class of tetracyclic compounds with high enantiomeric purity.

222 paration of organofluorine compounds in high enantiomeric purity.

223 ands (-)-6 and (+)-6 were obtained with high enantiomeric purity.

224 provided a library of P-chiral TPOs in high enantiomeric purity.

225 of components of a diastereomeric (E,Z) and enantiomeric (R,S) oxime into a third reactor column whe

226 ves in good yield (up to 86 %) and excellent enantiomeric ratio (up to 99.5:0.5 e.r.).

227 Quimba variety showed an enantiomeric ratio 75:25 while for Mammoth variety, lina

228 a turnover frequency of 6,100 h(-1), a 99:1 enantiomeric ratio and 100% chemoselectivity.

229 cost-effective, and fast assessment of their enantiomeric ratio and total concentration.

230 nalysis of the temperature dependence of the enantiomeric ratio established a linear relationship of

231 gives the corresponding cyclopropane with an enantiomeric ratio of 70/30 and, thus, provides proof of

232 io 75:25 while for Mammoth variety, linalool enantiomeric ratio was 95:5 (R:S).

233 were easily synthesized in good to excellent enantiomeric ratio with good yields.

234 determination of the absolute configuration, enantiomeric ratio, and total amount of standard amino a

235 carbon center with up to 90% yield and 97:3 enantiomeric ratio, with only water as the byproduct.

236 s were formed selectively with up to a 96:04 enantiomeric ratio.

237 re isolated in up to 97 % yield and 98.5:1.5 enantiomeric ratio.

238 % yield, >98% diastereoselectivity and >99:1 enantiomeric ratio.

239 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio.

240 y, >95:5 Z:E selectivity, and 81:19 to >99:1 enantiomeric ratio.

241 yield, 88:12 diastereomeric ratio, and 94:6 enantiomeric ratio.

242 8:2 S(N)2'/S(N)2 selectivity, and 85:15-99:1 enantiomeric ratio.

243 llylic alcohols in up to 98% yield and >99:1 enantiomeric ratio.

244 esired products in up to 83 % yield and 98:2 enantiomeric ratio.

245 eomeric ratio (for allyl additions) and 99:1 enantiomeric ratio.

246 obtained in 60 to >98 % yield and up to 99:1 enantiomeric ratio.

247 ition of NBu4BAr(F)4 leading to a diminished enantiomeric ratio.

248 enantiomeric reductions and the experimental enantiomeric ratio.

249 al ligands in 52-96% yield and 93:7 to >99:1 enantiomeric ratio.

250 electivity, >98:2 Z:E selectivity, and >99:1 enantiomeric ratio.

251 % yield with >98:2 Z/E selectivity and 99:1 enantiomeric ratio.

252 ing products in 42-99% yield and up to >99:1 enantiomeric ratio.

253 cal relationship is derived for relating the enantiomeric ratios (er values) of two individual stereo

254 The enantiomeric ratios (er) of all but two examples exceede

255 ch to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er).

256 High enantiomeric ratios (up to 98.5:1.5) and excellent diast

257 ted product mixtures with diastereomeric and enantiomeric ratios close to unity.

258 the lower nanomolar concentration range, and enantiomeric ratios could be readily determined from the

259 The method demonstrated capable to determine enantiomeric ratios down to 2.5% with detection limits f

260 ion or hydrosilylation of cyclic imines with enantiomeric ratios of up to 97:3.

261 centers are afforded in excellent yields and enantiomeric ratios of up to 99:1.

262 f a base, affording new chiral alcohols with enantiomeric ratios of up to 99:1.

263 ary boronic esters with yields up to 87% and enantiomeric ratios up to 96:4 e.r.

264 3 and 16, 17, and 21 in yields up to 96% and enantiomeric ratios up to 99:1.

265 in the corresponding isoquinolines with high enantiomeric ratios.

266 iral Cu-alkyl species, resulting in improved enantiomeric ratios.

267 to synthetically valuable aziridines in high enantiomeric ratios.

268 hese strained rings with high diastereo- and enantiomeric ratios.

269 covering a wide range of concentrations and enantiomeric ratios.

270 heterocyclic amine derivatives in excellent enantiomeric ratios.

271 This work constitutes a rare example of enantiomeric recognition resulting in spontaneous resolu

272 ons of catalytically competent poses for the enantiomeric reductions and the experimental enantiomeri

273 stable than the RR dimer as a result of the enantiomeric relationship between R-Delta and S-Delta, a

274 Enantiomeric resolution, at the same time with stronger

275 rescence response that is independent of the enantiomeric sample composition and readily correlated t

276 helical conformations, the equally populated enantiomeric screw-sense conformers of which are in slow

277 e use of additives (i.e., cyclodextrins) for enantiomeric separation as well as any covalent immobili

278 Proton nuclear magnetic resonance and enantiomeric separation identified D-tryptophan.

279 MS-TOFMS) has been developed to achieve fast enantiomeric separation of amino acids (AAs).

280 The synthesis, the enantiomeric separation, and the characterization of new

281 enges to overcome in this field such as high enantiomeric separation.

282 ng ones, significantly improving preparative enantiomeric separations.

283 can produce interesting secondary effects in enantiomeric separations.

284 Therefore, both enantiomeric series of spiro compounds can be obtained b

285 on to accessing synthetic steroids of either enantiomeric series, these steroidal products have been

286 hesis of hydromorphone was completed in both enantiomeric series.

287 use fatty acids attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.

288 nd chiral separations of complex mixtures of enantiomeric species.

289 Collectively, these findings demonstrate the enantiomeric specificity and saturated acyl-CoA selectiv

290 The conformational dynamics and enantiomeric stability of the N-oxide products have been

291 lies on the fact that carbohydrates exist in enantiomeric states, several conformations, anomeric con

292 educed neuroactive steroids, and natural and enantiomeric steroids.

293 des and of AAD-2, which has the opposite (S)-enantiomeric substrate specificity, reveal the structura

294 icient differentiation of the NMR signals of enantiomeric substrates.

295 Each enantiomeric thread induces CPL responses of opposite si

296 olute configuration (3R,5S,6S,7R,11S,14R) is enantiomeric to that originally proposed by the isolatin

297 teric crowding in the catalyst pocket of one enantiomeric transition state, is the main cause for ste

298 s found to be the key interaction in the two enantiomeric transition states.

299 After optimizing the assay condition, the enantiomeric version of the aptasensor (L-RNA and L-DNA)

300 particular emphasis on the first syntheses, enantiomeric versions, and syntheses that led to the rev