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2 assembly of diastereomerically distinct and enantiomerically antipodal metabolites, have remained la
3 cyclobutanol 37, which is combined with the enantiomerically defined building blocks ent-15 and 16.
4 Diastereoisomerically pure (dr > 99:1) and enantiomerically enriched (er up to 98:2) substituted pr
5 (Ar=2-MeOPh and related species) results in enantiomerically enriched (up to 93:7 e.r.) cyclopentadi
6 the structurally modified N-aryl unit afford enantiomerically enriched (up to 95% ee) products in up
9 ma-hydroxyalkenes with aryl bromides affords enantiomerically enriched 2-(arylmethyl)tetrahydrofuran
11 ylation and oxy-Cope rearrangement delivered enantiomerically enriched 2-methyl 3-allyl cyclohexanone
12 olidine-chiral ligand complexes provided the enantiomerically enriched 2-substituted pyrrolidines.
13 d, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alp
15 TP, catalytic C-C coupling occurs, providing enantiomerically enriched 5-substituted alpha-exo-methyl
17 t a biomimetic approach for the synthesis of enantiomerically enriched aglains and rocaglamides via k
18 s, and its ready removal provides a route to enantiomerically enriched alcohols that would otherwise
19 ) system as the hydrogen source and provided enantiomerically enriched alcohols with good yields and
20 ols is illustrated through conversion of the enantiomerically enriched alkylation products to a range
21 -selective NHC-Cu-catalyzed hydroboration of enantiomerically enriched allenes and conversion to the
22 selective fashion that could be converted to enantiomerically enriched allylic alcohols through a cat
24 ne products provides rapid access to acyclic enantiomerically enriched alpha,alpha'-dialkyl-substitut
25 protecting group on the alpha-oxygen provide enantiomerically enriched alpha,beta-dihydroxy esters wi
26 y esters of alpha-methoxyacetic acid provide enantiomerically enriched alpha,beta-dihydroxy esters wi
28 strategy for the conversion of aldehydes to enantiomerically enriched alpha-amino boronates through
29 steine were successfully employed, as was an enantiomerically enriched alpha-OMTM-aldehyde derived fr
30 ecific variant of this reaction provides the enantiomerically enriched alpha-quaternary substituted a
32 ding an effective means for accessing highly enantiomerically enriched amines bearing contiguous ster
35 s reaction significantly expands the pool of enantiomerically enriched and functionally complex terti
36 These reactions provide convenient access to enantiomerically enriched and protected beta-hydroxy-alp
44 s of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched bicyclo[3.3.0]octenones, and t
45 tes are treated with Rh2(S-NTTL)4 to provide enantiomerically enriched bicyclobutanes, which can subs
46 le [3,3]-sigmatropic rearrangement to afford enantiomerically enriched BINAM derivatives in good to e
47 n this report, configurationally defined and enantiomerically enriched bromonium and chloronium ions
51 reactions provide access to a wide array of enantiomerically enriched chemical diversity that was no
53 hols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols wi
54 ble prochiral starting materials into highly enantiomerically enriched chiral gamma-amino ketones in
55 a powerful strategy for the construction of enantiomerically enriched complex molecules, often with
62 addition to the stereospecific conversion of enantiomerically enriched cyclopropanes into nonracemic
63 ylidenecyclopropanes can be synthesized from enantiomerically enriched cyclopropene derivatives with
65 The Suzuki-Miyaura cross-coupling of chiral, enantiomerically enriched dibenzylic boronic esters is d
67 enantioselective annulation reaction to form enantiomerically enriched dihydropyranones via an N-hete
70 icient and selective synthesis of a range of enantiomerically enriched EAS products, which cannot be
72 n proceeds stereospecifically, generating in enantiomerically enriched form products containing allyl
73 ation, allowing formation of the products in enantiomerically enriched form, despite the intermediacy
74 use of this umpolung synthon has enabled, in enantiomerically enriched form, the first total synthesi
75 thesis of the tricycle ABC-ring system in an enantiomerically enriched form, the use of a formal [3+3
77 The carbonyl allylation reactions provide enantiomerically enriched functionalized homoallylic alc
79 strategy to target a series of versatile and enantiomerically enriched gamma-amino esters/lactones in
80 ynamic kinetic resolution (DKR) that affords enantiomerically enriched hemiaminal esters derived from
83 ters were found to lead to the corresponding enantiomerically enriched homoallyl alcohols with exclus
84 le method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed ba
87 s use of chiral malonic esters prepared from enantiomerically enriched monoesters of disubstituted ma
89 lecular aza-Michael reaction gives access to enantiomerically enriched nitrogen-containing heterocycl
90 symmetric method for the syntheses of highly enantiomerically enriched non-natural amino acids using
92 tures include the stereoselective opening of enantiomerically enriched oxetanes by hydrogen peroxide,
93 , key intermediates for the synthesis of new enantiomerically enriched P,N-ligands, have been compare
94 ophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode
95 oronium ions are generated (by solvolysis of enantiomerically enriched precursors) and shown to be in
96 yclizations involving the alkyne unit of the enantiomerically enriched products are presented as a de
101 AP, catalytic C-C coupling occurs, providing enantiomerically enriched products of carbonyl allylatio
105 ed hydroxy-directed reductive coupling of an enantiomerically enriched propargylic alcohol and an int
107 stituted allenoates with imines, we obtained enantiomerically enriched pyrrolines in good yields with
109 se can be trapped with electrophiles to give enantiomerically enriched quaternary substituted product
111 tical and observed % ee values for CSA-3 and enantiomerically enriched samples of mandelic acid has b
112 high demand, as they facilitate synthesis of enantiomerically enriched small molecules that are criti
113 h the subsequent iodination of the remaining enantiomerically enriched starting material using a chir
117 by haloalkylation and cyclization led to the enantiomerically enriched tertiary phosphine sulfide, po
118 conversion of tertiary propargyl alcohols to enantiomerically enriched tetrasubstituted allenes and b
121 Under the conditions of nickel(0) catalysis, enantiomerically enriched vinyl dioxanones engage boroxi
122 bes a method for the laboratory synthesis of enantiomerically enriched, chiral tetrahydroisoquinoline
123 chanistic studies involving amination of the enantiomerically enriched, deuterium-labeled acetate 1h
124 proach offers the first method for preparing enantiomerically enriched, side chain unprotected alpha-
125 of asymmetric synthesis, the preparation of enantiomerically pure (>/=99% ee) compounds remains a ch
131 ethyl (Weinreb) beta-ketoamides derived from enantiomerically pure (EP) alpha-amino acids affords the
133 nd (R(M)R(1))-2, respectively, where 1 is an enantiomerically pure (R) phenoxide and Ar = 2,6-diisopr
135 ion-metal-free protocol for the synthesis of enantiomerically pure (R)-(+)-2'-amino-1,1'-binaphthalen
136 7)O,(18)O]phosphoenol pyruvate starting from enantiomerically pure (R)-2-chloro-1-phenylethanol, whic
139 es than in the original report starting from enantiomerically pure (S)- and (R)-alpha-methyl-serine,
142 fficient strategy for the total synthesis of enantiomerically pure 1 is described, starting from the
146 d the NMDA and sigma(1) receptor affinity of enantiomerically pure 2-(2-phenyl-1,3-dioxan-4-yl)ethana
147 iodine reagents gives a facile synthesis of enantiomerically pure 2-arylproline derivatives for the
149 enzymatically resolved, providing access to enantiomerically pure 2-pyrones, or converted to alkenyl
150 ormylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.
152 relationship studies led to the discovery of enantiomerically pure 39 endowed with a good efficacy in
154 The photoactivated evolution of a series of enantiomerically pure 5-oxymethyl-2(5H)-furanones has be
157 resent the synthesis and characterization of enantiomerically pure [6]helicene o-quinones (P)-(+)-1 a
159 a convenient and efficient method to access enantiomerically pure alcohol and amine derivatives.
161 d electrophilic trapping delivers a range of enantiomerically pure alpha-alkoxy and alpha-amino subst
164 carbonyls; the products of the reactions are enantiomerically pure amines and alcohols, which might s
166 es may be inserted by this method, including enantiomerically pure amino acids, enabling us to explor
173 ent-2-en-1-one to the acetonide derived from enantiomerically pure and enzymatically derived cis-1,2-
179 ly by a ligand exchange process involving an enantiomerically pure aryloxide, a class of ligands scar
181 by an iridium complex for the preparation of enantiomerically pure beta-arylamines is described.
184 nds between isocytosine units embedded in an enantiomerically pure bicyclic framework is reported.
185 erationally simple and scalable synthesis of enantiomerically pure bicyclo[2.2.2]octadiene (bod*) lig
187 y the Cu complex of a commercially available enantiomerically pure bis-phosphine and are complete in
190 ring-opening polymerization of a mixture of enantiomerically pure but different monomers using an yt
195 able catalytic methods for the production of enantiomerically pure chiral amines is a key challenge f
199 n achieved using the microbially derived and enantiomerically pure cis-1,2-dihydrocatechol 5 as start
202 ate-stage regioselective carbonylation of an enantiomerically pure cis-epoxide to a trans-beta-lacton
206 can be easily converted into a wide array of enantiomerically pure compounds that are difficult to ob
207 uman recombinant enzymes, primary cells, and enantiomerically pure compounds we found that the synthe
213 nt here a facile synthetic route that yields enantiomerically pure derivatives comparable in potency
214 yl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98 % yield
215 hese four has been carried on to a different enantiomerically pure diastereomer of 13-F4t-neuroprosta
216 A critical observation is that the four enantiomerically pure diastereomers of an intermediate a
217 that could allow ready access to each of the enantiomerically pure diastereomers of the several regio
218 itriles were deprotonated and alkylated with enantiomerically pure dibromides to afford the first rin
220 iol 2b were converted into the corresponding enantiomerically pure diones 4b, the absolute configurat
221 tocol was also used for the synthesis of two enantiomerically pure drug molecules (R)-Naftopidil (alp
222 ic A-alt-B copolymers, where A and B are two enantiomerically pure endo-2-substituted-5,6-norbornenes
223 (slow)) of 370 for propylene oxide, allowing enantiomerically pure epoxide to be recovered in nearly
224 on assisted epoxide ring-opening reaction of enantiomerically pure epoxides can account for ring-size
227 inazolin-4-yl) series B, were synthesized in enantiomerically pure form and evaluated for their inhib
228 techol-simulating moiety were synthesized in enantiomerically pure form and investigated for their me
229 lsilyl)butyl side chain has been prepared in enantiomerically pure form as a potential inhibitor of t
230 d synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence base
232 cyclooctadienol shown, readily available in enantiomerically pure form from D-glucose, has given ris
233 onsisting of 4 and 5, which are available in enantiomerically pure form from d-glucose, resulted in t
235 2-(1-hydroxy-2-oxocyclohexyl)acetic acid in enantiomerically pure form is reported using environment
236 can be prepared from beta-amino alcohols in enantiomerically pure form through a three-step sequence
237 ich can be isolated and further converted in enantiomerically pure form to beta-methoxy or beta-benzy
238 diformine A, B, and C were synthesized in an enantiomerically pure form using a reductive cyclization
245 ng to chromatographically separable pairs of enantiomerically pure forms of regioisomeric methyl half
251 work the catalytic properties of substituted enantiomerically pure halo-triazolium salts were explore
252 nthesized through cross-couplings of various enantiomerically pure haloconduritols or certain deoxyge
255 The chiral catalyst is generated from an enantiomerically pure imidazolinium salt (prepared in th
257 tially in mycobacteria, but the synthesis of enantiomerically pure InoAz analogues via traditional ap
259 cascade sequences that efficiently produced enantiomerically pure key building blocks 15b (ent-zingi
261 ic PET imaging agents for breast cancer, and enantiomerically pure materials of defined stereochemist
264 , to the catalytically active diastereo- and enantiomerically pure N-heterocyclic carbene (NHC) by th
266 ein present an efficient synthetic access to enantiomerically pure noncanonical strigolactones by a S
268 he adverse effects of two methyl-substituted enantiomerically pure oxaliplatin analogs [[(1R,2R,4R)-4
269 ntary resolution protocols provide access to enantiomerically pure oxetin and epi-oxetin on gram-scal
271 yielding and practical two-step synthesis of enantiomerically pure perfluorobutanesulfinamide from Se
274 ulations confirmed that the formation of the enantiomerically pure product proceeds via the nonracemi
279 ese studies provide a rationale for pursuing enantiomerically pure RJW100 derivatives: they establish
282 by comparison with a library of synthesized, enantiomerically pure standards, suggesting that the bio
284 nyl sulfide are promoted by 0.5-5.0 mol % of enantiomerically pure stereogenic-at-Ru complexes with a
285 methodologies for the rapid construction of enantiomerically pure substituted indole has had a fruit
286 en costly and inefficient, and may not yield enantiomerically pure terpenes, whereas large-scale micr
287 a new strategy for the formation of valuable enantiomerically pure tetrahydrothiophenes and 2,3-dihyd
288 the stereospecific Corey-Link reaction of an enantiomerically pure trichloromethylcarbinol to give a
295 ng reagents, enabling the syntheses of other enantiomerically pure, stereodefined trisubstituted alke
296 y impure, epoxypolyene substrate provides an enantiomerically pure, trans-fused, podocarpane-type tri