ライフサイエンスコーパス: encoded protein

1 don substitutions that impair folding of the encoded protein.

2 ysis predicted that the mutation damages the encoded protein.

3 with increased expression of HIBCH mRNA and encoded protein.

4 n PPMS patients and loss of function for the encoded protein.

5 netics at the level of both the mRNA and the encoded protein.

6 t motif located in the central domain of the encoded protein.

7 and results in an E102D substitution in the encoded protein.

8 or cassette or the resulting activity of the encoded protein.

9 tructural features of the MG192 gene and its encoded protein.

10 and are located in functional domains of the encoded protein.

11 uman cancers are immunoreactive for a LINE-1-encoded protein.

12 unctionalization, likely at the level of the encoded protein.

13 to aberrant subcellular localization of the encoded protein.

14 s for anticancer drugs, alternatively to the encoded protein.

15 d coordinate co-translational folding of the encoded protein.

16 iciencies in the accumulation of chloroplast-encoded proteins.

17 them into an outer shell or capsid of virus-encoded proteins.

18 hout affecting the abundance of the mRNAs or encoded proteins.

19 them into an outer shell or capsid of virus-encoded proteins.

20 ccurately reflect changes in levels of their encoded proteins.

21 eptides from vaccinia- and influenza A virus-encoded proteins.

22 process that is largely dependent on nuclear-encoded proteins.

23 consequently increases accumulation of their encoded proteins.

24 variants suggests deleterious effects to the encoded proteins.

25 d concomitant differential expression of the encoded proteins.

26 vely of either chromosome-encoded or plasmid-encoded proteins.

27 the optimal functional range of genetically encoded proteins.

28 y of chloroplast transcripts and chloroplast-encoded proteins.

29 roteins and diminished expression of plastid encoded proteins.

30 e transcripts associate independent of their encoded proteins.

31 that serve to increase or decrease levels of encoded proteins.

32 A ratios, and both nuclear and mitochondrial encoded proteins.

33 enome is carried out by a set of key nuclear-encoded proteins.

34 f RNAs that correlate with properties of the encoded proteins.

35 ectly coupled to a reduced production of the encoded proteins.

36 IV, including both nuclear and mitochondrial-encoded proteins.

37 s the functional analysis of influenza virus-encoded proteins.

38 pecific characteristics in their genomes and encoded proteins.

39 tion of methionines in the N-terminus of the encoded proteins.

40 mutations within the binding sites of their encoded proteins.

41 erologous genes by reporting the dynamics of encoded proteins.

42 uses requires efficient translation of viral-encoded proteins.

43 ch less is known about the properties of the encoded proteins.

44 demonstrated functional conservation of the encoded proteins.

45 ent side chains corresponding to genetically encoded proteins.

46 oth in mutation type and location within the encoded proteins.

47 d protein synthesis and expression of 5'-TOP encoded proteins.

48 heir expected effects on the evolution of so-encoded proteins.

49 variety of mechanisms involving small phage-encoded proteins.

50 frameshifting to regulate production of the encoded proteins.

51 hloroplast genes relies on a host of nucleus-encoded proteins.

52 e content and at the amino acid level of the encoded proteins.

53 etermine the effects of combined loss of the encoded proteins.

54 identified new phosphorylation sites on IAV-encoded proteins.

55 volutionary functional divergence of homolog-encoded proteins.

56 Biochemical analysis of the encoded proteins, a cobalamin (Cbl)-dependent S-adenosyl

57 nal alpha-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated

58 These transcripts and their encoded proteins accumulate abnormally in TTP knockout (

59 nsert stability and consistency of transgene encoded protein accumulation through commercially releva

60 nt stem cells demonstrate loss of the ANKS1B-encoded protein AIDA-1, a brain-specific protein highly

61 The encoded proteins, AIF1 and AIF1L, are 80% similar in seq

62 EBV-encoded proteins, along with noncoding RNAs and microRNA

63 to promote retrotransposition in cis The L1-encoded proteins also promote the retrotransposition of

64 A world, before the evolution of genetically encoded proteins, ancestral organisms contained RNA gene

65 NF13 variants confer gain of function to the encoded protein and thereby lead to altered signaling of

66 ns recapitulates both the depletion of mtDNA-encoded proteins and a lipid-depleted metabolic phenotyp

67 fl, and the levels of transcripts and their encoded proteins and phosphoproteins were highly congrue

68 cells, such as the decrease of mitochondrial-encoded proteins and surviving cells were also seen in t

69 eader sequences, the functional landscape of encoded proteins and the impact of light on gene express

70 human nervous system that uses its own virus-encoded proteins and the normal cellular ESCRT machinery

71 in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interfer

72 n of chloroplast transcripts and chloroplast-encoded proteins, and defective processing of chloroplas

73 a membrane and mitochondria-associated Abcc9-encoded proteins, and found that the myocardium failed t

74 ovel phosphorylation sites were found on IAV-encoded proteins, and the functional analysis of selecte

75 DIRS-1 transcripts, the expression of DIRS-1-encoded proteins, and the loss of most DIRS-1-derived se

76 works guided predictions for function of the encoded proteins, and the predictions were confirmed by

77 duced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effectors that are critical

78 ructural reactivity and the structure of the encoded protein are related.

79 Finally, we found that all RNA1-encoded proteins are cis-acting relative to RNA1.

80 genes between these gene cassettes and their encoded proteins are distinguished by %G + C and protein

81 conditional knockdowns to determine that the encoded proteins are essential and to identify their sta

82 Nuclear-encoded proteins are imported into the organelle, and th

83 plicated in inherited retinal dystrophy; the encoded proteins are involved in a broad spectrum of pat

84 nes are somatically mutated in CMM, or their encoded proteins are involved in melanomagenesis.

85 inducers of the operon, confirming that the encoded proteins are involved in the utilization of beta

86 Importantly, the encoded proteins are linked to neuronal processes shared

87 Whereas the encoded proteins are most homologous to Dicistrovirus po

88 c mechanisms, while structural properties of encoded proteins are non-debilitating and might only cha

89 as to determine whether mitochondrial genome-encoded proteins are regulated by microRNAs inside the m

90 cted hepatoma cells to define viral and host-encoded proteins associated with mature virions.

91 We show that the encoded protein associates with rRNA and plays a highly

92 The encoded proteins (AtTAD2 and AtTAD3, for tRNA-specific a

93 om the population, that is, the gene and its encoded protein become harmful after a mutation occurred

94 Here we report that LEF-10, a baculovirus-encoded protein, behaves as a prion.

95 The encoded protein belonged to a huge family of glutamine a

96 s from cone-setting acrocona plants, and the encoded protein belongs to the MADS box gene family of t

97 onstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known

98 pt ATP production and translation of nuclear encoded proteins--both of which are shown to disrupt mit

99 catae in the tick versus the mammal, and the encoded protein (BTA121) is predicted to be surface loca

100 y, structure, and biological function of the encoded protein, but the effects of these mutations are

101 ral selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitnes

102 ssed in platelets and neutrophils, where its encoded protein CalDAG-GEFI facilitates the activation o

103 he 'reverse' reaction requires another phage-encoded protein called the recombination directionality

104 versely, understanding the activities of MGE-encoded proteins can elucidate MGE function.

105 s in these genes remains a challenge, as the encoded proteins can theoretically regulate thousands of

106 previously described RIP family member, the encoded protein carries an RNA recognition motif (RRM) a

107 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied.

108 lative increase in the synthesis of TOP mRNA-encoded proteins compared to other proteins.

109 re novel at the genus level, and most of the encoded proteins comprise unknown functions.

110 Two of these FPI-encoded proteins constitute effectors, whereas the other

111 Fifteen genes encoded proteins contributing to IgE class switch recomb

112 To ascertain if phage encoded proteins could form the basis of a gonococcal va

113 most RNAs sedimented differently than their encoded protein counterparts.

114 Three mitochondrial DNA-encoded proteins, Cox1, Cox2, and Cox3, comprise the cor

115 Expression of the mitochondrially encoded proteins Cytochrome oxidase subunit 1, Apocytoch

116 5% of its phylogenetically tractable nucleus-encoded proteins deriving from green algae.

117 SpyCatcher is a genetically-encoded protein designed to spontaneously form a covalen

118 between an X-encoded RNA and an autosomally encoded protein dictates Xist induction.

119 The encoded protein, EGLN1/PHD2, is an O(2) sensor that cont

120 ifferential nuclear levels of L1ORF1p, an L1-encoded protein essential for L1 ribonucleoprotein parti

121 e a close evolutionary relationship, and the encoded proteins exhibit highly conserved G-protein acti

122 ributed the greatest proportion of total RNA-encoded protein expression, despite being the lowest fre

123 rmits temporal and dose-dependent control of encoded protein expression.

124 hloroplast genes and 7621 homologous nuclear-encoded proteins, for 157 and 76 taxa, respectively.

125 The encoded proteins form multiple homo- and hetero-interact

126 we describe the application of a genetically encoded Protein-fragment Complementation Assay (PCA) bas

127 IMPORTANCE HBZ, the antisense transcript-encoded protein from HTLV-1, is now well recognized as a

128 revealed that these virulence-related genes encoded proteins from almost all functional classes, whi

129 that influences gene expression rather than encoded protein function.

130 result in a complete loss of function of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulat

131 Arabidopsis (Arabidopsis thaliana) GTs whose encoded proteins glucosylate a diversity of terpenes.

132 We identified the Kallithea virus-encoded protein gp83 as a potent inhibitor of Toll signa

133 histiocytosis (LCH) and demonstrate that the encoded protein has strong gain-of-function properties.

134 The encoded protein has two conserved domains with homology

135 ree-dimensional spatial relationships in the encoded protein have yet to be systematically explored.

136 und in the genomes of higher plants, and the encoded proteins have been found localized both to the n

137 Chimeric RNAs and their encoded proteins have been traditionally viewed as uniqu

138 Whereas, the ICE-encoded proteins have characteristic features of DinJ-Ya

139 duce PrgB, even independently of other pCF10-encoded proteins, have severely compromised cell envelop

140 In this study, we found that the HTLV-1-encoded protein HBZ activates expression of BDNF, and co

141 s (RNPs) formed by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) perform e

142 is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1

143 onucleoprotein (RNP) complex with the intron-encoded protein (IEP), which is essential for splicing.

144 splicing is partially restored by the intron-encoded protein (IEP).

145 mitochondrial genome and additional nuclear-encoded proteins imported from the cytosol.

146 HD patients have reduced levels of nuclearly encoded proteins imported through TIM23.

147 on in CISD2 which all altered the respective encoded protein in a manner that did not correlate to th

148 beta-lyase activity has been assigned to the encoded protein in the genome data bank, is a CCBL2 (syn

149 folding can alter the folded structure of an encoded protein in vivo, versus the structure formed whe

150 etics and distribution of h-alpha-Gal A mRNA encoded protein in WT mice demonstrated prolonged half-l

151 ing Agrobacterium-mediated expression of CTV-encoded proteins in N. benthamiana, we found that p33, a

152 can translationally regulate mitochondrially encoded proteins in spatially distinct mitochondrial sub

153 on were analysed and involvement of selected encoded proteins in the tick midgut physiology discussed

154 However, the functions of cell-encoded proteins in virions remain largely unknown.

155 rologous viruses to express individual virus-encoded proteins in wheat.

156 reased, reducing accumulation of chloroplast-encoded proteins, in such plants compared to wild-type p

157 d an essential role for P58, one of the RNA2-encoded proteins, in the process of RNA2 replication.

158 pre-mRNA splicing can be devastating for the encoded protein, inducing a frameshift or in-frame delet

159 have uncovered new mechanisms by which virus-encoded proteins inhibit Ub and Ub-like (Ubl) modificati

160 gulated by the microRNA miR164 Moreover, the encoded proteins interacted physically with the chloropl

161 trate that modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM2

162 Protein import of nucleus-encoded proteins into plant chloroplasts is a highly reg

163 specifically evolved to deliver bacterially encoded proteins into target eukaryotic cells.

164 the extrinsic arm from 23 additional nuclear-encoded proteins, iron-sulfur clusters, and flavin monon

165 Although the encoded protein is integral to the host membrane, its pr

166 eveloping transplant recipients and that the encoded protein is localized within mitochondria.

167 alleles can be dominant-negative even if the encoded protein is produced in significantly smaller amo

168 Divergence of the two encoded proteins is associated with a loss of similarity

169 Avoiding activation of immunity to vector-encoded proteins is critical to the safe and effective u

170 ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery o

171 ssed when and the amino acid sequence of the encoded proteins, is direly needed for the development o

172 ided by the gene sequence independent of the encoded protein isoform.

173 We generate a novel genetically encoded protein kinase A (PKA) biosensor anchored onto t

174 The chromosome 21 encoded protein kinase DYRK1A is essential for normal hu

175 tion, reflecting the expression of the phage-encoded protein kinase, T7PK.

176 olved in latency, UL133-UL138, and a virally encoded protein kinase, UL97, which plays crucial roles

177 their lytic replication cycle through virus-encoded protein kinases.

178 thylation, can directly interact with the L1-encoded protein L1-ORF1p, stimulate its polyubiquitylati

179 The EBV-encoded protein LMP1 is essential for promoting viral tu

180 In patient fibroblasts, dual mRNAs encoded proteins localize in mitochondria and produce hi

181 broadly expressed in neural tissue, and its encoded protein localizes to the primary cilium in an in

182 This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector functio

183 We observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive

184 The majority of crAssphage-encoded proteins match no known sequences in the databas

185 f iron overload, suggesting that the stm3944-encoded protein may mediate iron efflux.

186 ctural relationships between mRNAs and their encoded proteins may have evolved to allow efficient and

187 his trend is most likely because the nuclear-encoded proteins mediating these processes eventually le

188 ncreatic islet beta-cells that lack the MEN1-encoded protein menin develop into tumors.

189 ly result in the loss of function of the NF2-encoded protein, Merlin.

190 Depletion of the nuclear-encoded protein MSH1 causes dramatic and heritable chang

191 yeast Saccharomyces cerevisiae, the nuclear-encoded proteins Mss51 and Pet309 specifically activate

192 ASD-associated SCN2A mutations impair the encoded protein Na(V)1.2, a sodium channel important for

193 rphism at the locus SCN4A, which renders the encoded protein (Na(v)1.4) less vulnerable to TTX.

194 (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of An

195 se risk by characterizing its effects on the encoded protein, NIPA.

196 the tight junction barrier while the non-LEE-encoded proteins NleH1 and NleH2 possess significant ant

197 r this distinction we designate the gene and encoded protein nonA/NonA.

198 ght reflect the fact that one or both of its encoded proteins (NS1 and NEP) are maladapted for replic

199 probe that can be targeted to a genetically encoded protein of interest (POI) through a modular SNAP

200 nery while the other is fused to the nuclear-encoded protein of interest translated in the cytosol, t

201 nectria hypovirus 1 was detected in the ORFA-encoded protein of L2-dsRNA/SsMBV1.

202 ed by ycf1, so it would be the first plastid-encoded protein of this apparatus; (2) ycf1 is unique to

203 tment is limited in cases where the genes or encoded proteins of co-infecting strains are functionall

204 These replicons produce SG RNAs and encoded proteins of interest 10- to 50-fold more efficie

205 DhMRE proteins show similarities to nuclear-encoded proteins of the AMF Rhizophagus irregularis, whi

206 Defects in nuclear-encoded proteins of the mitochondrial translation machin

207 arts, although they do not express a virally encoded protein on their surface, thus distinguishing th

208 is observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, and found

209 focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT proces

210 A levels and subsequent expression of the L1-encoded proteins (ORF1p and ORF2p).

211 cone-shaped structure, composed of the HIV-1-encoded protein p24(CA), which contains the viral RNA an

212 ic mutations cause a loss of function of the encoded protein Parkin.

213 ven mRNA is unlikely to generate more of the encoded protein, particularly at low ribosome availabili

214 The encoded protein, PLPHP is believed to be crucial for B6

215 tin-like polypeptides (ELPs) are genetically encoded protein polymers that reversibly phase separate

216 ever, the biochemical characteristics of its encoded protein product (MtRecD) remain largely unknown.

217 ly as functional RNAs rather than through an encoded protein product.

218 f mutations relative to the structure of the encoded protein products.

219 The UL33-encoded protein (pUL33) interacts with pUL28, but its pr

220 The virus-encoded protein pUS9 promotes axonal dissemination by so

221 ble in the host cell membrane from the virus-encoded protein PVAP and open at the end of the infectio

222 Genetic evidence has suggested that pLS20-encoded protein RcoLS20 represses expression of a large

223 Mutants deficient in GlgA, a chromosome-encoded protein regulated by pGP4, also consistently col

224 Several of the repressed genes encoded proteins related to plant defence (e.g. a putati

225 d the causative gene but the function of the encoded protein remains unknown.

226 they may be under immune selection, and the encoded proteins require investigation.

227 evolution to ~30% or 0% the rate of standard-encoded proteins, respectively.

228 days resulted in a decrease of mitochondrial-encoded proteins, respiration and membrane potential, an

229 New work in aphids shows that a nuclear-encoded protein resulting from a horizontal gene transfe

230 potential to increase the expression of the encoded protein(s).

231 The high hydrophobicity of mitochondria-encoded proteins seems to be one of the main factors pre

232 -phenotype theory embraces the view that the encoded protein shape together with gene expression leve

233 five transcripts in S. moellendorffii whose encoded proteins share homology with BBI inhibitory loop

234 The encoded proteins share ~85% amino acid sequence identity

235 Plastid-encoded proteins showed a comparable distribution of N-t

236 reflected in a significant decrement of its encoded protein SNAT2.

237 The encoded proteins, SP-A1 and SP-A2, differ quantitatively

238 suggests a loss-of-function mechanism of the encoded protein, spatacsin.

239 The encoded protein SRRM2 (also called SRm300) is part of th

240 ynthesis of all 13 mitochondrial DNA (mtDNA)-encoded protein subunits of the human oxidative phosphor

241 t probes combining advantages of genetically-encoded proteins such as green fluorescent protein and e

242 The properties of the encoded proteins, such as disorder and aggregation prope

243 of conserved positions in mitochondrial DNA-encoded proteins suggest that CUU and CUA codons corresp

244 tochondria leads to defects in mitochondrial-encoded protein synthesis and abnormal mitochondrial dyn

245 decreases IRE-mRNA/IRP1 binding, increasing encoded protein synthesis.

246 ule fluorescent indicators using genetically encoded protein tags yields new hybrid sensors for biolo

247 We have identified a virus-encoded protein termed gp37/Dip, which directly binds an

248 iability as they are more likely to alter an encoded protein than a SNV, which has important implicat

249 antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellula

250 cterial F plasmids relies on TraM, a plasmid-encoded protein that recognizes multiple DNA sites to re

251 l design and implementation of a genetically encoded protein that specifically inhibits GBA motifs: G

252 the Toll pathway and identified gp83 as a KV-encoded protein that underlies this suppression.

253 viruses is greatly affected by numerous host-encoded proteins that act as restriction factors.

254 Chloroplasts contain thousands of nucleus-encoded proteins that are imported from the cytosol by t

255 anterograde control by a battery of nucleus-encoded proteins that are imported in the chloroplast, w

256 studies to comprehensively characterize loci-encoded proteins that are involved in beta-mannan captur

257 is accomplished by spanins, which are phage-encoded proteins that connect the cytoplasmic membrane (

258 mitochondrial import of hundreds of nuclear-encoded proteins that control genome maintenance, replic

259 ivery and removal challenges, or genetically encoded proteins that form or bind a native photosensiti

260 nally controlled by a complex of six virally encoded proteins that hijack the host transcription mach

261 tions (2) , DNA modifications (3) , or phage-encoded proteins that interfere with the CRISPR-Cas syst

262 al for the prodigious translation of plastid-encoded proteins that is required during the installatio

263 not survive for 2 years, whereas mRNAs that encoded proteins that regulate glutathione metabolism we

264 Two pKM101-encoded proteins, the pilus-tip adhesin TraC and a prote

265 007 to March 2019 on bacteriophage and phage-encoded protein therapies of relevance to clinical micro

266 Virally encoded proteins therefore exist to limit, inhibit or ta

267 to actively replicating DNA with the element-encoded protein TnsE.

268 : brain gene expression atlases, genetically encoded proteins to monitor and manipulate neuronal acti

269 aE') removes a single glutamic acid from the encoded protein, torsinA.

270 (DSB) repair pathway disrupt binding of the encoded proteins, transport into the nucleus and initiat

271 The Escherichia coli F element-encoded protein TraR is a distant homolog of the chromos

272 Thus, our study identifies GASTs and their encoded proteins, uncovers their structure, novel motifs

273 evance of UMOD for CKD is clear, because the encoded protein, uromodulin (Tamm-Horsfall protein), is

274 The soluble poxvirus-encoded protein viral CC chemokine inhibitor (vCCI), a C

275 The encoded protein was expressed but devoid of negative reg

276 Additionally, the FTS_1680-encoded protein was identified as a membrane-associated

277 ntial impact on structure and/or function of encoded proteins was examined using human gene mutation

278 mitochondrial localization of the AT3G11470-encoded proteins was validated by the ability of their N

279 In addition, DSY3157, an adjacently encoded protein, was shown to be a methylcobalamin:tetra

280 By analyzing the encoded proteins, we discovered concurrent amino acid ch

281 genome-wide bioinformatics analysis of ISKNV-encoded proteins, we found that ISKNV open reading frame

282 Expression and functional studies of the encoded protein were performed and included measurement

283 were isolated from five cultivars, and their encoded proteins were biochemically analyzed.

284 The functions of the encoded proteins were investigated by complementation ex

285 Encoded proteins were investigated in skin biopsy specim

286 thogenic SVBP variants demonstrated that the encoded proteins were unstable and non-functional, resul

287 esulting in gain or loss of function for the encoded protein, whereas most fall in noncoding regions

288 ria, TOM and TIM complexes transport nuclear-encoded proteins, whereas the Oxa1 is required for the i

289 dioxygenase gene (QDO) and characterized the encoded protein, which catalyzed cleavage of the flavono

290 sequestration leads to reduced levels of the encoded proteins, which is sufficient to bring about dis

291 Two of the five encoded proteins, which we named E. histolytica ILWEQ (E

292 pesvirus late genes depends on several virus-encoded proteins whose function is not completely unders

293 confirming the reduction in abundance of the encoded protein will often aid the link between genotype

294 ssed upon GlcNAc accumulation, many of which encoded proteins with an extracellular Domain of Unknown

295 The 12 genes controlled by NrrF encoded proteins with biological functions including ene

296 More than half encoded proteins with known enzymatic activity, and six

297 Both SLC43A3 variants encoded proteins with similar functional properties.

298 s and studied electrogenic properties of the encoded proteins with whole-cell patch-clamp recording.

299 ssessing the effects of the mutations on the encoded proteins Wolframin and ERIS, in a cohort of 12 p

300 DsRed2 and tTAV gene products (e.g. mRNA and encoded proteins) would have a negligible impact on on-t