ライフサイエンスコーパス: encounter complex

1 d undergoes partial dissociation to form an "encounter complex".

2 tion (through noncovalent interaction in the encounter complex).

3 tration, as expected for the existence of an encounter complex.

4 e 20-ns molecular dynamics simulation of the encounter complex.

5 al readjustments then occur in the resulting encounter complex.

6 ormation of a Michaelis-type serpin-protease encounter complex.

7 vent-separated, electrostatically stabilized encounter complex.

8 the structure, of the initial, low-affinity encounter complex.

9 ptide lies farther from the heme when in the encounter complex.

10 robably involving an electrostatically bound encounter complex.

11 ing, H(ab), for electron transfer within the encounter complex.

12 ns, are involved in formation of the initial encounter complex.

13 RRKR interactions with DID form a productive encounter complex.

14 on spectrum of the species emerging from the encounter complex.

15 e pre-association of the acid and base in an encounter complex.

16 ng" groove plays the major role in making an encounter complex.

17 with the same nonnative salt bridges in the encounter complex.

18 ientations for productive binding within the encounter complex.

19 e complex is preceded by the formation of an encounter complex.

20 pid formation of transient structures in the encounter complex.

21 er activation entropy hinder assembly of the encounter complex.

22 ADH binary complex) to form a protein-ligand encounter complex.

23 tional changes after formation of an initial encounter complex.

24 ccumulation of an intermediate, non-blocking encounter-complex.

25 complex formation by the study of transient encounter complexes.

26 Arg(+) promotes the dissociation of encounter complexes.

27 pectroscopy for the in actu detection of FLP encounter complexes.

28 asic motif of DAD, resembling those found in encounter complexes.

29 thod captures both specific and non-specific encounter complexes.

30 me activity through formation of competitive encounter complexes.

31 ally demonstrated the existence of transient encounter complexes.

32 as a function of SK concentration, reporting encounter complex affinities of 62-110 nm in the absence

33 lex activates RfaH, probably via a transient encounter complex, allowing the refolded CTD to bind rib

34 promote folding-competent topologies in the encounter complexes, allowing rapid subsequent formation

35 ers is much longer than the half-life of the encounter complex and also guarantees that the concentra

36 racterized by a approximately 25-fold weaker encounter complex and approximately 40-fold faster off-r

37 ucture that these residues assume before the encounter complex and not just to their loci.

38 s cannot access the widest range of possible encounter complexes and therefore cannot be analyzed eas

39 The interactions in the encounter complex are usually dominated by electrostatic

40 Three structures of intrahelical oxoG-encounter complexes are compared with sequence-matched s

41 These "unproductive" encounter complexes are favored because Arg(+) binding t

42 We show that Gag-protease encounter complexes are primarily mediated by interactio

43 The encounter complexes are stabilized by electrostatic inte

44 The encounter complexes are stabilized primarily by non-spec

45 ation parameters for the reaction within the encounter complex, at the higher ionic strength, are del

46 inter-molecular interactions and develop an encounter complex-based NMA (cNMA) framework.

47 mulations reveal that ArkA enters a flexible encounter complex before forming the fully engaged bound

48 s are discussed in the context of a putative encounter complex between apo-HasAp and hemoglobin that

49 nder conditions where [substrate] << Km; the encounter complex between enzyme and substrate partition

50 tic barrier to reorganization of the initial encounter complex between enzyme, substrate, and an esse

51 h LDH/NADH suggest that the evolution of the encounter complex between LDH/NADH and oxamate collapses

52 A model that couples the formation of a weak encounter complex between p53TAD and hRPA701-168 to the

53 tatively consistent with the formation of an encounter complex between the cyanine dye and ionized th

54 atiotemporal resolution we characterized the encounter complex between the RecA filament and dsDNA.

55 Here, we provide experimental evidence that encounter complexes between FeP and MoFeP play a functio

56 ly casting" type of model in which transient encounter complexes between the ligand and the extended

57 preferentially excluded from protein-protein encounter complexes but not from dissociated protein mol

58 iation of the proteins or separated from the encounter complex by only a small energy barrier.

59 y optimize the diffuse background of protein encounter complexes by just single-point mutations, and

60 ng agent-based simulations, we find that the encounter complexes can be cooperative or competitive so

61 pid first binding step involves formation of encounter complexes captured through a fly casting mecha

62 netically labeled HPr, two distinct types of encounter complex configurations along the association p

63 In contrast, the second class of encounter complex configurations can coexist with the sp

64 Encounter complex conformations are generated by samplin

65 nsmembrane cargo reaches endosomes, where it encounters complexes dedicated to opposing functions: re

66 ative salt bridges stabilize kinetically the encounter complex during binding.

67 psin actually decreases on conversion of the encounter complex E.I to E*I*.

68 e alpha1-antichymotrypsin.alpha-chymotrypsin encounter complex, E.I, to E*I*.

69 The proposed mechanism involves an encounter complex (EC) stabilized by electrostatic inter

70 echanism, in which tightening of the initial encounter complex (EI) results in a final complex (EI*)

71 The encounter complex ensemble includes conformations with s

72 rther, a fundamental question is whether the encounter complex ensemble is an effectively homogeneous

73 The ET rate determined for the encounter complex ensemble of states is only about a fac

74 ability distribution map of the non-specific encounter complex ensemble that qualitatively correlates

75 ecause of fluctuations of the cyt within the encounter complex ensemble through configurations having

76 ntermediary of a transient, lowly populated, encounter complex ensemble.

77 rect dimer orientation is sampled within the encounter complex ensemble.

78 cterial ribonuclease P (RNase P) involves an encounter complex (ES) that isomerizes to a catalytic co

79 The encounter complex features the prealigned binding partne

80 We show the initial encounter complex formation between the ITAM-Y2P and tan

81 m kringle accompanies near-diffusion-limited encounter complex formation followed by two slower, tigh

82 lysis of the trajectories reveals on-pathway encounter complex formation, which is driven by electros

83 While the encounter complex forms quickly, the slow step of bindin

84 from the dissociation of the ligand from the encounter complex, found to be endothermic at 6 kcal/mol

85 The on-rate of the formation of the encounter complex from LDH/NADH with oxamate (a substrat

86 his ternary binding intermediate, called the encounter complex here.

87 association constant (K(a)), for the active encounter complex, i.e. the pre-associated complex that

88 via a sequence of steps: the formation of an encounter complex in a bimolecular step followed by two

89 the transition state and, by inference, any encounter complex in coupled binding and folding reactio

90 strate that a higher concentration of active encounter complex in solution leads to a faster activati

91 lvent-exposed) side chains that latch to the encounter complex in the periphery of the binding pocket

92 brium model for the formation of a transient encounter complex, in which phosphorylation of the RR pr

93 preferentially excluded from protein-protein encounter complexes, in a manner analogous to osmotic st

94 ize the mechanistic details of the transient encounter complex interactions between the N-terminal do

95 o-step ligand release mechanism involving an encounter complex intermediate, the time scales of loop

96 3 and ArkA provides insight into the role of encounter complex intermediates and nonnative hydrophobi

97 g to one another), suggesting that transient encounter complexes involving the globular domains of Ga

98 nderlying physicochemical characteristics of encounter complexes involving three protein-protein inte

99 ating that the reaction occurring within the encounter complex is also configurationally gated.

100 hydrogen bonding in the enolate-buffer acid encounter complex is an important stereochemical determi

101 ysis of this problem assumes ad hoc that the encounter complex is at quasi-steady state (QSS).

102 tep in which a noncovalent serpin-proteinase encounter complex is converted to a stable, covalent com

103 tion step in which a noncovalent AT-thrombin encounter complex is converted to a stable, covalent com

104 ion step in which a non-covalent AT-thrombin encounter complex is converted to a stable, covalent com

105 at the rate-limiting gating processes in the encounter complex is different from that in the preforme

106 The initial formation of the encounter complex is driven by long-range interactions b

107 and clavulanic acid, the correctly oriented encounter complex is even less likely in the M69V varian

108 ition pathway where formation of the initial encounter complex is followed by helix-coil transitions

109 Formation of a fluorescently silent encounter complex is followed by two conformational tigh

110 al, to previous work on substrate mimics: an encounter complex is formed between LDH.NADH and pyruvat

111 Once the encounter complex is formed between LDH/NADH and substra

112 The ET rate for the encounter complex is in agreement with rates observed in

113 rate may suggest that the DNA in the initial encounter complex is mildly bent.

114 lso guarantees that the concentration of the encounter complex is negligible compared to the reactant

115 zed using ensemble docking, showing that the encounter complex is stabilized by hydrophobic as well a

116 T complexes form in two distinct stages: an "encounter" complex largely mediated by electrostatic int

117 of protein motions present in a near-native encounter complex lead to the improved performance.

118 Folding from an unstructured encounter complex may be efficient and robust, which has

119 T lymphocytes encounter complex mechanical cues during an immune respo

120 vide a framework for understanding how other encounter complexes might guide recognition and action o

121 orm a non-specific, conformationally dynamic encounter complex, most likely centred on conserved inte

122 herein slower "tightening up" of the initial encounter complex occurs.

123 ucture of the transition state and preceding encounter complex of association at diminishing electros

124 lar dynamics (MD) to propose a model for the encounter complex of the peptide triazoles with gp120.

125 We show that the E.I encounter complex of wild type-rACT and Chtr forms both

126 l substates of IDPs in their free states, in encounter complexes of bound states, and in complexes re

127 hancement experiments demonstrated transient encounter complexes of EI(Ntr) not only with the expecte

128 Potential encounter complexes of the Ki67FHA receptor and hNIFK pe

129 orward application of conventional NMA to an encounter complex often does not improve upon NMA for an

130 We determined the crystal structure of the encounter complex on the pathway of ligand binding by Ig

131 nition ensemble in a nonspecific and dynamic encounter complex on the surface of PX.

132 n factor CREB forms an ensemble of transient encounter complexes on binding to the KIX domain of the

133 uggest a mechanism where FeP initially forms encounter complexes on the MoFeP beta-subunit surface en

134 bilize either the initial C2 domain-membrane encounter complex or the high-affinity membrane-bound co

135 Facile dissociation of the charge-separated encounter complex [PC(*-):D(*+)], also known as (solvent

136 r focuses attention on the properties of the encounter complex preceding acylation.

137 Such species is distinct from other encounter complexes previously characterized and is like

138 reveal that, without Arg(+), protein-protein encounter complexes readily form salt bridges and hydrop

139 t rates, indicating that initial RNA-protein encounter complexes refold during assembly.

140 intermediate heparin-antithrombin-factor Xa encounter complex, resulting in a several 100-fold rate

141 hotoproduct states in flavoproteins in often-encountered complex situations and more generally are im

142 Often one encounters complex situations when the spectra are sever

143 of calmodulin/4Ca(2+) to yield two extended "encounter" complexes, states A and A*, without conformat

144 The pathway begins at an encounter complex that is formed by one of the apo forms

145 hat the nucleation of annealing occurs in an encounter complex that is formed by two hairpins with on

146 e provide direct structural evidence for the encounter complex that is intrinsic to the induced fit m

147 tracts the negatively charged DNA to form an encounter complex that is stabilized by two salt bridges

148 h two aggregation-prone monomers can form an encounter complex that leads to further oligomerization

149 ake contact, followed by the formation of an encounter complex that rapidly leads to electron-transfe

150 r the initial formation of a pre-equilibrium encounter complex that subsequently relaxes to the final

151 cording to rapid equilibrium formation of an encounter complex that undergoes unimolecular electron-t

152 inding predominantly occurs via two distinct encounter complexes that are differentiated by the bindi

153 hancements also reveal an extensive array of encounter complexes that form over a large part of the c

154 ly transient, lowly populated (3-5%) dimeric encounter complexes that involve the mature dimer interf

155 We show that the affinity of the encounter complex, the rate of final complex formation,

156 te via the formation of a LDH/NADH.substrate encounter complex through a select-fit mechanism, whereb

157 one hand, it facilitates the formation of an encounter complex through long range electrostatic inter

158 ding through the formation of a weakly bound encounter complex to a well-defined bound complex.

159 The work here describes the collapse of the encounter complex to form the catalytically competent Mi

160 rect correlation with an ability for the FLP encounter complex to split hydrogen gas and abstract hyd

161 moved from the electrostatically stabilized encounter complex to the bound state having short range

162 ased smoothly as the cyt approached from the encounter complex to the bound state, with a tunneling d

163 einase in going from the initial noncovalent encounter complex to the kinetically stable complex.

164 In the encounter complex, transient nonspecific hydrophobic and

165 has led to the identification of a novel FLP encounter complex, tris-pentafluorophenyl borane-eucalyp

166 on of an ensemble of transient, non-specific encounter complexes under equilibrium conditions for a r

167 Microorganisms encounter complex unsteady flows, including algal blooms

168 f protease, we probe the nature of such rare encounter complexes using intermolecular paramagnetic re

169 the pentameric (SC-(1-325).thrombin)(2).Fbg encounter complex was generated, which explains the coag

170 anthracene-related exciplex, formed from the encounter complex, was 8 times greater and red-shifted f

171 Several important hydrogenase-ferredoxin encounter complexes were identified from this analysis,

172 cs appear to be an intrinsic property of the encounter complex where the proteins move relative to on

173 rostatic interactions in forming the initial encounter complex, whereas the high force component refl

174 ith the first step being the formation of an encounter complex which evolves into the final complex.

175 (6) and N-terminal acidic residues drive the encounter complex, while Arg(6), His(11), and C-terminal

176 of an intermediate heparin-serpin-proteinase encounter complex with a dissociation constant of approx

177 Formation of an encounter complex with CD4 binding and interactions of g

178 tructure of EndoS and provide a model of its encounter complex with its substrate, the IgG1 Fc domain

179 these disordered peptides first form a weak encounter complex with non-native interactions.

180 The encounter complex with SKDeltaK414 was approximately 10-

181 llow a common mechanism, the formation of an encounter complex with subsequent nucleophilic reactivit

182 Starting from encounter complexes with as much as 10 A rms deviation f

183 ly disordered proteins, which form transient encounter complexes with lifetimes on the order of 100 m

184 specific assembly pathways, cells frequently encounter complexes with missing or aberrant subunits th

185 Mg2+ interactions with the aptamer produce encounter complexes with strikingly different sensitivit

186 ier for reaction of the toluene/NO2(+)BF4(-) encounter complex, yet the trajectories require an extra