ライフサイエンスコーパス: end joining

1 mutations in genes related to nonhomologous end joining.

2 sion represses HRR and favors non-homologous end joining.

3 thripsis coupled to classical non-homologous end joining.

4 on in the DSB repair pathway, non-homologous end joining.

5 dentified in patients, impedes nonhomologous end joining.

6 -strand DNA breaks (DSBs) via non-homologous end joining.

7 , indicative of Cas9-directed non-homologous end joining.

8 tion, which typically arise by nonhomologous end joining.

9 letions (indels) via mutagenic nonhomologous end joining.

10 icated DNA repair via microhomology-mediated end joining.

11 ns in base excision repair and nonhomologous end joining.

12 akpoints resembling repair by non-homologous end joining.

13 ion, with a repair bias toward nonhomologous end joining.

14 poor substrates for classical non-homologous end joining.

15 ) at the extreme C-terminus are required for end joining.

16 at DSBs occurs predominantly via reciprocal end joining.

17 evolutionary loss of classical nonhomologous end joining.

18 replication and DSB repair by non-homologous end joining.

19 le-strand breaks, facilitating nonhomologous end-joining.

20 dependent repair and classical nonhomologous end-joining.

21 ous recombination and microhomology-mediated end-joining.

22 mulated HDR, and promoted error-prone distal end-joining.

23 igated by DNA Ligase IV during Nonhomologous end-joining.

24 combination (HR) or mutagenic non-homologous end-joining(1).

25 via the mutagenic alternative non-homologous end joining (A-NHEJ) pathway.

26 Importantly, NHEJ instead of alternative end-joining (A-EJ) was revealed as the predominant mecha

27 antly mediated by alternative non-homologous end-joining activity that may employ either DNA ligase 3

28 P inhibitor sensitivity of BRCA1-null cells, end-joining activity, and immunoglobulin class switching

29 Moreover, Red1 exhibited nonhomologous DNA end-joining activity, thus revealing an unexpected role

30 a single predominant microhomology-mediated end joining allele (PreMA) repair outcome.

31 mologous end joining (cNHEJ) and alternative end joining (Alt EJ).

32 tified a role for macroH2A1.1 in alternative end joining (alt-EJ), which accounts for Xi anaphase def

33 mologous end joining (C-NHEJ) or alternative end joining (ALT-EJ)], which cause distinct rearrangemen

34 now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, LIG3, and PARP1

35 and XPF-dependent alternative nonhomologous end joining (alt-NHEJ), which did not generate fragile t

36 motes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism.

37 rough the microhomology-mediated alternative-end-joining (Alt-EJ) pathway during class switch recombi

38 5% of CSR can be achieved by the alternative end-joining (Alt-EJ) pathway that preferentially uses mi

39 Alternative end-joining (alt-EJ) repair of DNA double-strand breaks

40 a) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal tra

41 DNA repair pathways, such as non-homologous end joining and homologous recombination, may be importa

42 lei, combined with the lack of nonhomologous end joining and markers for positive selection, has stal

43 homologous recombination over non-homologous end joining and potentially other mutagenic pathways of

44 as previously shown to suppress pathological end joining and promote homologous recombination.

45 NONO and XLF are both required for efficient end joining and radioresistance in cell-based assays.

46 occurred via both alternative nonhomologous end-joining and homologous recombination pathways.

47 ge, which suppresses repair by nonhomologous end-joining and homologous recombination.

48 in cells fully proficient for non-homologous end-joining and is not compensated by DNA ligases 3 or 4

49 and repair efficiency, but not nonhomologous end-joining, and decreased the formation of Rad51 foci.

50 endent protein kinase-mediated nonhomologous end-joining, and, when combined with olaparib, caused ab

51 gene conversion and classical nonhomologous end-joining are the most physiologically predominant for

52 are preferentially repaired via error-prone end joining as depletion of EXO1 diverts repair away fro

53 SET is required for efficient non-homologous end joining as well as homologous recombination.

54 ibe an improved SFPQ*NONO-dependent in vitro end joining assay.

55 fitness decreases and microhomology-mediated end joining becomes active, generating deletions in the

56 on NHEJ repair intermediates compromise the end joining by DNA ligase I or the DNA ligase IV/XRCC4 c

57 mic repeats (CRISPR)/Cas9 and non-homologous end-joining by deleting the repeat region, with the risk

58 , we found that the canonical non-homologous end joining (C-NHEJ) factor XLF promotes these rearrange

59 Classical nonhomologous end joining (C-NHEJ) is a major mammalian DNA double-str

60 EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end joining (ALT-EJ)

61 break repair via the canonical nonhomologous end joining (c-NHEJ) pathway.

62 Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (D

63 facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) p

64 within S regions by classical nonhomologous end joining (C-NHEJ).

65 ngement mediated by canonical non-homologous end joining (C-NHEJ).

66 combination (HR) and classical nonhomologous end joining (C-NHEJ).

67 Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB rep

68 II (RNAP II) and the classical nonhomologous end-joining (C-NHEJ) proteins, including PNKP, along wit

69 in wild-type versus classical nonhomologous end-joining (C-NHEJ)-deficient NSPCs reveals that both C

70 le in ICL repair was seen for non-homologous end-joining (cku-80) or base excision repair (nth-1, exo

71 ; and inhibitors of classical non-homologous end joining (cNHEJ) and alternative end joining (Alt EJ)

72 Classical non-homologous end joining (cNHEJ) and homologous recombination compete

73 is required for the canonical nonhomologous end joining (cNHEJ).

74 it (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor(1).

75 nit (DNA-PKcs), is a classical nonhomologous end-joining (cNHEJ) factor.

76 The classical nonhomologous end-joining (cNHEJ) pathway is a major DNA double-strand

77 ally mediated by the classical nonhomologous end-joining (cNHEJ) pathway.

78 Tel1/ATM kinase signaling and non-homologous end joining, consistent with the role of Xrs2 as a chape

79 represent favored substrates for MH-mediated end-joining contributing to the robustness and resection

80 p97-ATX3 complex affects the non-homologous end joining DNA repair pathway and hypersensitises human

81 EJ) rather than the canonical non-homologous end joining DNA repair pathway.

82 S-S junctions are joined via a nonhomologous end joining DNA repair process.

83 s in the PGBD5 transposase domain as well as end-joining DNA repair and induced structural rearrangem

84 s found to be involved in the non-homologous end-joining DNA repair process and in poly ADP-ribose po

85 and play a functional role in nonhomologous end-joining DNA repair.

86 uld potentially be mediated by either of two end-joining (EJ) repair pathways [canonical nonhomologou

87 n quickly repaired by ligase (Lig)3-mediated end-joining (EJ).

88 editing method, combined with non-homologous end joining, enabling permanent chromosomal integration

89 This result suggests that non-homologous end-joining, even in haploid cells where homologous chro

90 ks, CMG removal results in fork breakage and end joining events involving deletions and templated ins

91 paralog of XRCC4 and XLF, PAXX nonhomologous end joining factor (PAXX).

92 ant for limiting the accumulation of the pro-end joining factor 53BP1 at DSBs in S and G(2) cell cycl

93 f H4 regulates binding of the non-homologous end joining factor 53BP1, which engages chromatin throug

94 part through antagonism of the nonhomologous end-joining factor 53BP1.

95 authors demonstrate that the non-homologous end-joining factor XLF promotes the stability of replica

96 tem was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in opium poppy (Pa

97 The homology-mediated end joining (HMEJ) approach has been shown to improve kn

98 DNA reporter cassettes by homology-mediated end joining (HMEJ) at high frequency at a double strand

99 ibiting cnLOH, suggesting that POLQ promotes end joining in cis, which limits breaks available for re

100 d antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase.

101 ng the involvement of microhomology-mediated end joining in their generation.

102 a high level of precision by non-homologous end-joining in mammalian cells.

103 importance of TDP2-dependent non-homologous end-joining in protecting both gene transcription and ge

104 s and active enhancers, and are processed by end-joining in the absence of a canonical DNA-damage res

105 endent DNA ligase dedicated to nonhomologous end joining, in complexes with ATP that highlight large

106 ards faster and more accurate non-homologous end-joining, including in post-mitotic primary neurons.

107 d a potential microhomology or nonhomologous end joining integration mechanism at the single-nucleoti

108 y homologous recombination and nonhomologous end joining is critical for maintaining genome integrity

109 n homology-directed repair and nonhomologous end joining is important for neuronal cells.

110 repair of stalled replication forks and DNA end joining-it fills a unique niche in restoring genomic

111 In nonhomologous end joining, Ku loads onto broken DNA via a channel cons

112 Ligase 3-mediated end-joining maintains genome stability of human embryoni

113 dent manner, establishing that nonhomologous end-joining maintains rDNA integrity during meiosis.

114 suggested fundamental role of nonhomologous end joining mechanism during eccDNA formation.

115 ng broken ends, among them the nonhomologous end-joining mechanism that utilizes a DNA ligase.

116 in various mutations, microhomology-mediated end joining (MMEJ) creates precise deletions based on th

117 on is mediated by the microhomology-mediated end joining (MMEJ) pathway.

118 were repaired through microhomology-mediated end joining (MMEJ) rather than the canonical non-homolog

119 Of interest, robust microhomology-mediated end joining (MMEJ) was observed with DNA substrates bear

120 Microhomology-mediated end joining (MMEJ), an error-prone pathway for DNA doubl

121 rected repair (HDR)-, microhomology-mediated end joining (MMEJ)-, and nonhomologous end joining (NHEJ

122 null mutation in the microhomology-mediated end-joining (MMEJ) component, polymerase theta/mutagen-s

123 protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs).

124 nally, we developed a microhomology-mediated end-joining (MMEJ) reporter and showed that Fen1 partici

125 pair pathway known as microhomology-mediated end-joining (MMEJ).

126 d-joining (NHEJ), and microhomology-mediated end-joining (MMEJ).

127 fied a third pathway, microhomology-mediated end-joining (MMEJ).

128 owed the mechanism of microhomology-mediated end joining mostly, since microhomologies between human

129 ways used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR).

130 wo major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR).

131 ration of knockout alleles via nonhomologous end joining (NHEJ) and knock-in alleles via homology-dir

132 Homology-directed repair and non-homologous end joining (NHEJ) are the two major DSB repair pathways

133 ologous recombination (HR) and nonhomologous end joining (NHEJ) at the same chromosomal site, we repo

134 for DNA damage signaling and non-homologous end joining (NHEJ) at unprotected telomeres.

135 Finally, I find that all non-homologous end joining (NHEJ) defective cells (whether deficient in

136 XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protei

137 cal (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-strand break (DSB)

138 ncomplementary DNA ends during nonhomologous end joining (NHEJ) for the repair of double-strand break

139 te in the BRCT domain impairs non-homologous end joining (NHEJ) in cell.

140 -strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku het

141 Non-homologous end joining (NHEJ) is a major DNA double-strand break (D

142 A cell-based assay shows that nonhomologous end joining (NHEJ) is compromised in cells with ablated

143 Non-homologous end joining (NHEJ) is the main repair pathway for DNA do

144 Although non-homologous end joining (NHEJ) is the most used DSBs repair pathway

145 Non-homologous end joining (NHEJ) is the predominant pathway that repai

146 Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism o

147 however, the preponderance of non-homologous end joining (NHEJ) mediated repair events over homology

148 e hypothesize that inhibiting non-homologous end joining (NHEJ) or enhancing homology-directed repair

149 s) are repaired by either the non-homologous end joining (NHEJ) or homologous recombination (HR) path

150 undergo DNA repair either via non-homologous end joining (NHEJ) or, in the presence of a template, ho

151 ing repair by the error-prone non-homologous end joining (NHEJ) pathway.

152 nappropriate activation of the nonhomologous end joining (NHEJ) pathway.

153 studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alve

154 plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage res

155 lication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of vira

156 While non-homologous end joining (NHEJ) repair results in various mutations,

157 enzyme, which are involved in nonhomologous end joining (NHEJ) repair, enhance amplification of vira

158 rom a moderate attenuation of non-homologous end joining (NHEJ) repair, the role of DEK in DNA repair

159 ing checkpoint activation and non-homologous end joining (NHEJ) repair.

160 Non-homologous end joining (NHEJ) repairs DNA double strand breaks in n

161 ologous recombination (HR) and nonhomologous end joining (NHEJ) through the investigation of the deSU

162 plays a key role in mediating non-homologous end joining (NHEJ), a major repair pathway for DNA doubl

163 During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into

164 and organisms via error-prone nonhomologous end joining (NHEJ), but the efficiency of precise sequen

165 (NER), mismatch repair (MMR), non-homologous end joining (NHEJ), homologous recombination (HR) and in

166 air mechanism in human cells, non-homologous end joining (NHEJ), rejoins broken DNA ends by direct li

167 Kcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-strand breaks t

168 ogy-directed repair (HDR) and non-homologous end joining (NHEJ), respectively.

169 are repaired predominantly by non-homologous end joining (NHEJ), which directly ligates DNA ends.

170 iated end joining (MMEJ)-, and nonhomologous end joining (NHEJ)-based strategies for the knock-in of

171 is a critical component of the nonhomologous end joining (NHEJ)-mediated DNA double-strand break (DSB

172 e involvement of WT TDP-43 in non-homologous end joining (NHEJ)-mediated DSB repair, where it acts as

173 mouse liver is mainly through non-homologous end joining (NHEJ)-mediated knock-in.

174 s competing with HDR, such as non-homologous end joining (NHEJ).

175 he majority process of precise nonhomologous end joining (NHEJ).

176 ected recombination (HDR) and non-homologous end joining (NHEJ).

177 are predominantly repaired by non-homologous end joining (NHEJ).

178 ingle-strand break repair and non-homologous end joining (NHEJ).

179 rescued by the inactivation of nonhomologous end joining (NHEJ).

180 classical, versus alternative, nonhomologous end joining (NHEJ).

181 talytic subunit (DNA-PKcs) and nonhomologous end joining (NHEJ).

182 double-strand break repair by non-homologous end joining (NHEJ).

183 me (DNA-PK) in the process of non-homologous end joining (NHEJ).

184 are predominantly repaired by non-homologous end joining (NHEJ).

185 logy-directed repair (HDR) or non-homologous end joining (NHEJ).

186 t OA-NO(2) inhibits HR and not nonhomologous end joining (NHEJ).

187 LINP1's ability to facilitate non-homologous end joining (NHEJ). We characterized LINP1 structure and

188 two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is

189 coprotein suppresses canonical nonhomologous end-joining (NHEJ) and promotes error-prone MMEJ, provid

190 pair by promoting Ku-dependent nonhomologous end-joining (NHEJ) at the expense of homologous recombin

191 re rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppress

192 TRADD facilitates non-homologous end-joining (NHEJ) by recruiting NHEJ repair factors 53B

193 ed with the components of the non-homologous end-joining (NHEJ) complex and participated in the NHEJ-

194 d that it is not suppressed by nonhomologous end-joining (NHEJ) components, arguing that nick process

195 ned inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently i

196 ic gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatme

197 by the competing error-prone non-homologous end-joining (NHEJ) DNA repair pathway.

198 Hypomorphic mutations in the nonhomologous end-joining (NHEJ) DNA repair protein DNA ligase IV (LIG

199 an integral component of the non-homologous end-joining (NHEJ) DSB repair pathway.

200 mice and ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin class-switch re

201 As the non-homologous end-joining (NHEJ) factor, Ku70/80 (Ku), is quickly recr

202 y homologous recombination and nonhomologous end-joining (NHEJ) genes.

203 In humans, nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA dou

204 Non-homologous end-joining (NHEJ) is the most prominent DNA double stra

205 Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand brea

206 Furthermore, coexpression the nonhomologous end-joining (NHEJ) machinery from the closely related ar

207 ng terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex s

208 deletions are products of the nonhomologous end-joining (NHEJ) pathway and require Top1cc removal fr

209 The nonhomologous end-joining (NHEJ) pathway is the primary repair pathway

210 The non homologous end-joining (NHEJ) pathway of double-strand break (DSB)

211 sertion-deletions (INDELs) by non-homologous end-joining (NHEJ) pathway underlies the mechanistic bas

212 icipates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by filling small sequence ga

213 portant components for the nonhomologous DNA end-joining (NHEJ) pathway.

214 d the participation of various nonhomologous end-joining (NHEJ) pathways.

215 ogous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways.

216 Non-homologous end-joining (NHEJ) plays an important role in double-str

217 by genetically eliminating Ku nonhomologous end-joining (NHEJ) protein, indicating that Ctp1-depende

218 we show that FBXW7 facilitates nonhomologous end-joining (NHEJ) repair and that FBXW7 depletion cause

219 w that Ku70, a core protein of nonhomologous end-joining (NHEJ) repair pathway, can directly interact

220 ologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways but exclusively for h

221 ologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways, with defective local

222 ed repair (HDR) and decreased non-homologous end-joining (NHEJ) repair, suggesting that Wwox contribu

223 ith a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the improvement in ce

224 homologous recombination (HR), nonhomologous end-joining (NHEJ), and microhomology-mediated end-joini

225 fidelity (HF) and error-prone non-homologous end-joining (NHEJ), as well as between proximal and dist

226 diesterase 2 (TDP2)-dependent non-homologous end-joining (NHEJ), but whether this process suppresses

227 logous recombination (HR) and non-homologous end-joining (NHEJ)-mediated repair.

228 -resection, and DSB repair by non-homologous end-joining (NHEJ).

229 DNA damage sites to facilitate nonhomologous end-joining (NHEJ).

230 channelled through repair by non-homologous end-joining (NHEJ).

231 B) repair pathways, including non-homologous end-joining (NHEJ).

232 itulate DSB repair via MMEJ or nonhomologous end-joining (NHEJ).

233 ile counteracting error-prone non-homologous end joining of DNA double-strand breaks.

234 rs impairs Ku80 removal after non-homologous end joining of DSBs.

235 ins that polymerize into filaments by end-to-end joining of hetero-oligomeric complexes.

236 where successful deletion and non-homologous end joining of up to 725 kb reframed the DMD gene.

237 ly mimic a DNA DSB, enabling us to study the end-joining of two fluorescently labeled DNA with the T4

238 ation restart-bypass mechanism terminated by end joining or by microhomology-mediated template switch

239 are generally repaired through nonhomologous end joining or homologous recombination.

240 oved to allow repair by either nonhomologous end joining or homology-directed repair.

241 hrough either the error-prone non-homologous end joining or the homology directed repair pathways.

242 double strand break repair by nonhomologous end joining, particularly in nonreplicating cells contai

243 DNA polymerase theta mediates an end joining pathway (TMEJ) that repairs chromosome break

244 NA double-strand breaks by the nonhomologous end joining pathway is central for proper development of

245 NA break (DSB) repair via the non-homologous end joining pathway, as unrepaired DSBs are the primary

246 Kcs, which is integral to the non-homologous end joining pathway, thus negatively regulates ATM activ

247 (DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect and repair DNA

248 the main nuclease in the non-homologous DNA end-joining pathway (NHEJ).

249 ndrome) codes for a canonical non-homologous end-joining pathway factor, that the RNA polymerase II c

250 dicated an impaired ability of the canonical end-joining pathway in Lsh-deficient B cells.

251 gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair.

252 NA sequence that depend on the nonhomologous end-joining pathway of DSB repair.

253 The 53BP1-dependent end-joining pathway plays a critical role in double stra

254 As a member of the non-homologous end-joining pathway, it is also involved in repairing a

255 ty of the break were due to a non-homologous end-joining pathway, while larger deletions were process

256 dis through disruption of the non-homologous end-joining pathway, with three individual evolutionary

257 f microhomology-all signs of the alternative end-joining pathway.

258 NA ends by the host cell's nonhomologous DNA end-joining pathway.

259 plexes that participate in the nonhomologous end-joining pathway.

260 ial DNA repair proteins in the nonhomologous end-joining pathway.

261 strand breaks by the classical nonhomologous end-joining pathway.

262 homologous recombination and non-homologous end joining pathways.

263 PCs reveals that both C-NHEJ and alternative end-joining pathways can generate translocations by join

264 d in the absence of functional nonhomologous end-joining pathways.

265 s (DSBs) are preferentially repaired through end-joining processes that generally lead to mixtures of

266 eleterious single-strand annealing (SSA) and end-joining processes that led to the loss of large chro

267 logous recombination and other nonhomologous end-joining processes.

268 on that arose through microhomology-mediated end joining rather than nonallelic homologous recombinat

269 A and helps to facilitate the non-homologous end-joining reaction.

270 ates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phos

271 lizes CRISPR/Cas9 and microhomology-mediated end joining repair for efficient tagging.

272 pression of DSB initiating and nonhomologous end joining repair machinery in newborn neurons in the d

273 phosphorylation of DNA-PK, a non-homologous end joining repair protein, in Hec-108 cells.

274 Non-homologous end joining repair-based BCL11A enhancer editing approac

275 ologous compared with microhomology-mediated end joining repair.

276 We show that although end-joining repair mechanisms may cause the system to br

277 ently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regenerating the ta

278 Resistance alleles that form by end-joining repair typically disrupt the haplolethal tar

279 timately become substrates for nonhomologous end-joining repair, leading to large-scale genomic rearr

280 epair and, to a lesser extent, nonhomologous end-joining repair.

281 As microhomology-mediated end-joining requires annealing of single-strand DNA ends

282 homologous recombination and non-homologous end joining, respectively, were transcriptionally activa

283 homologous recombination and non-homologous end joining, respectively.

284 ively restore Fancf function via error-prone end joining resulting in a 27% increased survival in the

285 d synthesis-dependent microhomology-mediated end joining (SD-MMEJ), predicts that differences between

286 nology and reveal general patterns of broken end joining that can provide insights into DNA repair me

287 ligase activity for classical non-homologous end joining (the predominant DNA double-strand break rep

288 DNA polymerase theta (Pol theta)-mediated end joining (TMEJ) has been implicated in the repair of

289 epair pathway, referred to as Theta Mediated End Joining (TMEJ).

290 stress, the highly mutagenic theta-mediated end-joining (TMEJ) pathway, which requires DNA polymeras

291 ic transformation relies on a combination of end joining to insert foreign DNA and HDR to repair coll

292 t MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs in a site-speci

293 ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fus

294 A ligase 1 in replication and non-homologous end-joining uniquely position and capacitate this ligase

295 one H3 from the genome during non-homologous end joining was promoted by both ATM and the ATP-depende

296 In addition to non-homologous end joining, we detect signatures of replication-associa

297 ase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by pol

298 mon repair outcome is microhomology-mediated end joining, which occurs during the first cell cycle in

299 DSBs are resolved to promote long-range DNA end-joining while suppressing genomic instability inhere

300 omoting both this deletion rearrangement and end joining without insertion/deletion mutations.