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1 rimary role in acute responses to this toxic endobiotic.
2 protecting organisms from multiple xeno- and endobiotics.
3 he hydroxyls and primary amines of xeno- and endobiotics.
4 aged in the metabolism of numerous xeno- and endobiotics.
5 metabolic activation of both xenobiotics and endobiotics.
6 e uptake and secretion of cationic drugs and endobiotics.
9 P450 are versatile enzymes that function in endobiotic and xenobiotic metabolism and undergo meaning
13 minate by glucuronidation a broad variety of endobiotic and xenobiotic substrates, which include bili
14 d by an impaired metabolic detoxification of endobiotics and a persistent microbial-induced immune re
16 germ-free mice have reduced levels of active endobiotics and that distinct gut microbial Loop 1 and F
17 ontrol glucose production, detoxification of endobiotics and xenobiotics, and the regulation of prost
18 etion and lipophilicity) of a broad range of endobiotics and xenobiotics, which could plausibly have
22 ification and elimination of xenobiotics and endobiotics by modulating the expression of genes encodi
23 metabolism and excretion of xenobiotics and endobiotics by regulating the expression of drug-metabol
25 zes a range of potentially harmful drugs and endobiotic chemicals but must complex with the nuclear r
26 the conjugation of lipophilic exobiotic and endobiotic compounds, which leads to the excretion of hy
29 eptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of to
34 ndrostane receptor (CAR) modulates xeno- and endobiotic hepatotoxicity by regulating detoxification p
35 ility of gut microbial enzymes in sustaining endobiotic homeostasis and indicate that therapeutic dis
36 re important in the elimination of xeno- and endobiotics, including the natural biladienone pigment b
37 ane X receptor (PXR) mediates xenobiotic and endobiotic metabolism as well as hepatocyte proliferatio
38 a physiological sensor in the modulation of endobiotic metabolism for hormones, bile acids, choleste
39 knowledge of PXR expression and its role in endobiotic metabolism related to MASH development, which
46 immunomodulatory control by interactions of endobiotic metabolites with diet, microbiota and the imm
47 es P450 (P450s), are enzymes that metabolize endobiotics (physiologically active steroids and fatty a
48 uman carboxylesterase 1 (hCE1) is a drug and endobiotic-processing serine hydrolase that exhibits rel
52 this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes.
56 o conjugate xenobiotics, including drugs and endobiotics such as metabolic byproducts, hormones, and