ライフサイエンスコーパス: endocardial

1 %), activation mapping demonstrated residual endocardial (3/11; 27.2%) or epicardial (8/11; 72.7%) co

2 hythm was performed (2518 points [1615-3752] endocardial, 5049+/-2580 points epicardial) and identifi

3 velopment of a minimally invasive epicardial/endocardial ablation approach (Hybrid Convergent) to ach

4 ONVERGE trial (Convergence of Epicardial and Endocardial Ablation for the Treatment of Symptomatic Pe

5 lly epicardial access is only performed when endocardial ablation has failed.

6 endocardial+epicardial ablation versus only endocardial ablation in the first procedure in patients

7 fully characterize the AF mechanism and why endocardial ablation may not be sufficient.

8 ss rate to achieve bidirectional block using endocardial ablation only with minimal need for epicardi

9 The addition of Bmp2 during endocardial ablation partially rescued myocyte different

10 y and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation

11 afety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial F

12 le to injury where it is closest to areas of endocardial ablation.

13 procedures, especially in IVT patients with endocardial ablation.

14 Endocardial ablations at 180 W reached depths of 10.7+/-

15 Endocardial ablations were performed at 140 to 180 W for

16 Endocardial abnormalities cause reduced cardiomyocyte pr

17 f IVT procedures, and 50% of procedures with endocardial access only.

18 Three apical LVS-VAs exhibited an eccentric endocardial activation pattern that was from the basal t

19 rfused hearts, the calculated epicardial and endocardial activation patterns showed good qualitative

20 Endocardial activation patterns were classified as chaot

21 during sympathetic stimulation, and regional endocardial activation recovery interval patterns were s

22 Endocardial activation slowing during SR may differentia

23 troanatomic mapping in 12 patients showed an endocardial activation time significantly longer in pati

24 A minimal endocardial activation velocity cutoff <=0.1 m/s differe

25 aled infarction, the spatial distribution of endocardial activation velocity was compared between SR

26 ow conduction and delayed quasi-simultaneous endocardial activation.

27 During a process we term "coronary-endocardial anchoring," new coronaries respond by sprout

28 A total of 109 endocardial and 9 epicardial locations were paced in 9 p

29 ought to determine the long-term outcomes of endocardial and adjuvant epicardial CA in nonischemic di

30 h nonischemic dilated cardiomyopathy and VT, endocardial and adjuvant epicardial CA is effective in a

31 The latest activation times (LATs) for LV endocardial and biventricular epicardial tissue were cal

32 ve robust Notch signaling hyperactivation in endocardial and endothelial cells, including increased p

33 CCM deficiency dramatically alters endocardial and endothelial gene expression, including i

34 o had failed ablation attempts from multiple endocardial and epicardial (1 patient) sites.

35 technique was evaluated that estimates both endocardial and epicardial activation from body surface

36 standard criteria for mitral line block with endocardial and epicardial activation mapping.

37 LV endocardial and epicardial activation recovery intervals

38 he purpose of this study was to characterize endocardial and epicardial dispersion of repolarization

39 ry intervals significantly decreased, and LV endocardial and epicardial DOR increased during sympathe

40 Healthy swine underwent endocardial and epicardial linear ablation using a novel

41 ere midrange between those of the idiopathic endocardial and epicardial LVOT VAs, and more similar to

42 l LVOT VAs when compared with the idiopathic endocardial and epicardial LVOT VAs.

43 With combined endocardial and epicardial mapping, the isthmus could be

44 imes require catheter ablation from both the endocardial and epicardial sides for their elimination,

45 sometimes require catheter ablation from the endocardial and epicardial sides for their elimination,

46 required simultaneous ablation from both the endocardial and epicardial sides.

47 s rhythm and ventricular stimulation from 27 endocardial and epicardial sites.

48 tial maps during sinus rhythm and localizing endocardial and epicardial stimulation sites.

49 y2(+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall

50 ion, and essential cell-cell interactions of endocardial and myocardial cells throughout heart develo

51 ind that the OFT expands via accrual of both endocardial and myocardial cells.

52 Endocardial and myocardial progenitors originate in dist

53 ed proliferation and impaired recruitment of endocardial and neural crest cells during the early stag

54 ression and active proliferation of adjacent endocardial and smooth muscle cells.

55 METHOD AND In 7 sheep, left ventricular endocardial and transmural mapping was performed 84 week

56 Although endocardial and vascular endothelium are molecularly sim

57 djustments applied for covariables, midwall, endocardial, and epicardial GLS were significant predict

58 variable adjusted hazard ratios for midwall, endocardial, and epicardial GLS, while accounting for fa

59 Inhibition of endocardial angiogenesis results in reduced endocardial

60 quent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicard

61 ronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal co

62 impulse and rotor modulation (FIRM) with an endocardial basket catheter was used in all cases.

63 Endocardial bipolar DS area >22.5 cm(2) best predicted s

64 ltage areas, whereas 18% had no identifiable endocardial bipolar DS areas.

65 We performed endocardial bipolar EVM-guided EMBs in 29 patients and w

66 endor independent and uses speckle tracking (endocardial border detection) on ultrasound (MRI) imagin

67 ejection fraction (EF) by manual tracing of endocardial borders is time consuming and operator depen

68 ithms that allow near automated detection of endocardial boundaries and measurement of LV volumes and

69 either manual or automated identification of endocardial boundaries followed by model-based calculati

70 At sites with endocardial BV >1.50 mV, the optimal endocardial UV cuto

71 are associated with transmural scar with low endocardial BV, the additional use of endocardial UV at

72 Endocardial capillary density was reduced with evidence

73 The limited effectiveness of endocardial catheter ablation (CA) for persistent and lo

74 bipolar radiofrequency instruments, required endocardial catheter ablation to complete the linear abl

75 so determined the ability of clinically used endocardial catheters to identify AF mechanisms using cl

76 served an initial decrease in myocardial and endocardial cavity volumes at day 3, followed by ventric

77 on modulates OFT morphogenesis by triggering endocardial cell accumulation that induces OFT lumen exp

78 to demonstrate its ability to identify each endocardial cell and chamber-specific CM.

79 g cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity in zebrafish and may also hel

80 f cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity, partly through regulating F-

81 the ECM (extracellular matrix) between the 2 endocardial cell monolayers, undergo endothelial-to-mese

82 cular phenotype by enhancing endothelial and endocardial cell proliferation and stabilizing endocardi

83 proaches, a population of human pre-valvular endocardial cells (HPVCs) can be derived from pluripoten

84 -type injury site consists of Runx1-positive endocardial cells and thrombocytes that induce expressio

85 ebrafish heart valve formation, we show that endocardial cells are converging to the valve-forming ar

86 Hbegf expression in embryonic endocardial cells could be readily activated through a R

87 With this potential, human endocardial cells could provide unique therapeutic oppor

88 Here we show in mouse that endocardial cells form a primitive vascular plexus surro

89 required for development of the hPSC-derived endocardial cells identified a novel role for BMP10 in t

90 We find that initially atrioventricular endocardial cells migrate collectively into the cardiac

91 9b expression is similarly restricted to the endocardial cells overlying the developing heart valves

92 action-responsive transcriptional changes in endocardial cells to regulate cardiac chamber maturation

93 ive transcription factor KLF2 is required in endocardial cells to regulate the mesenchymal cell respo

94 However, endocardial cells were present and retained expression o

95 receptor Acvrl1 is required for addition of endocardial cells, but not for their proliferation, indi

96 s and flow directionality on the behavior of endocardial cells, the specialized endothelial cells of

97 To access human endocardial cells, we generated a human pluripotent stem

98 es with diphtheria toxin efficiently ablated endocardial cells, which significantly attenuated the pe

99 e identified: inflammatory, fibroblastic and endocardial cells.

100 me generates higher junctional forces within endocardial cells.

101 (cTSD; the difference between epicardial and endocardial circumferential strain) in a genotyped cohor

102 MR imaging data should expect slightly less endocardial complexity in Chinese American patients and

103 fractal dimension (FD), which is a marker of endocardial complexity.

104 Adding fast endocardial conduction to this model altered %dLV and %d

105 was used to assess the relationship between endocardial contact electrogram amplitude and histologic

106 of IMAT on scar tissue identification during endocardial contact mapping and optimal voltage-based ma

107 endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and de

108 de novo source of tissue macrophages in the endocardial cushion, the primordium of the cardiac valve

109 proceeds through coordinated steps by which endocardial cushions (ECs) form thin, elongated and stra

110 During valvulogenesis, globular endocardial cushions elongate and remodel into highly or

111 Intrinsic endocardial defects contribute to abnormal endothelial-t

112 Endocardial deletion of Efnb2 phenocopies the coronary a

113 rgeted mutant mice, we find that endothelial/endocardial deletion of Mib1-Dll4-Notch1 signaling, poss

114 ciently explain developmental defects in the endocardial-derived cardiac valve, septum, and vasculatu

115 egulatory pathway is predominantly active in endocardial-derived vessels, whilst SOXF/RBPJ and BMP-SM

116 There were no LV epicardial versus endocardial differences in activation recovery interval

117 ilbud stage resulted in severe inhibition of endocardial differentiation while there was little effec

118 on, and identify BMP as a signal involved in endocardial differentiation.

119 t, apex-to-base, circumferential, epicardial-endocardial distribution, pattern, and type of MF in 30

120 Epicardial-endocardial distributions were as follows: trabecular 26

121 There was no mechanics-derived evidence of endocardial dysfunction with hypoxia at sea level or hig

122 stimulation), but does not appear to reflect endocardial dysfunction.

123 Endothelial/endocardial (EC) Raf1(L613V) causes cardiac hypertrophy

124 Additionally, the usefulness of unipolar endocardial electroanatomic mapping to identify epicardi

125 Endocardial electrogram amplitude correlated significant

126 tected by fragmentation/fractionation of the endocardial electrograms and by 3-dimensional anatomic l

127 High-density bipolar left ventricular endocardial electrograms were collected using CARTO3v4 i

128 The novel noninvasive epicardial and endocardial electrophysiology system (NEEES) allows for

129 as well the percentage decrease in LATs for endocardial (en) versus epicardial (ep) LV pacing (defin

130 rd potassium current (Ito) in EPI but not in endocardial (ENDO) cardiomyocytes of UNx rats led to a d

131 LNA) protein is expressed, in particular, in endocardial endothelia during fetal valve morphogenesis

132 ascular endothelium are molecularly similar, endocardial endothelial cells exhibit a distinct plastic

133 othelial to mesenchymal transition involving endocardial endothelial cells is caused by dysregulated

134 lly described in heart development where the endocardial endothelial cells that line the atrioventric

135 genic cells within EFE tissue originate from endocardial endothelial cells via aberrant endothelial t

136 ICM VTs, the isthmus could be identified by endocardial entrainment in 55 (62%), compared with only

137 Our aim was to compare the efficacy of endocardial+epicardial ablation versus only endocardial

138 In 2 other BrS patients, endocardial, epicardial RV (CARTO), and body surface map

139 A combined endocardial-epicardial ablation approach for initial VT

140 had epicardial-only ablation, whereas 3 had endocardial-epicardial ablation.

141 required in symptomatic cases refractory to endocardial-epicardial approach.

142 Endocardial-epicardial dissociation and focal breakthrou

143 We defined endocardial-epicardial dissociation as phase difference

144 n persistent AF recordings shows significant Endocardial-epicardial dissociation marked temporal hete

145 Endocardial-epicardial dissociation was seen in 50.3% of

146 Of 6889 endocardial-epicardial mapping point pairs, 547 (8%) pai

147 (50+/-14 years; 79% men) underwent combined endocardial-epicardial right ventricular electroanatomic

148 nder antiarrhythmic drugs after unsuccessful endocardial/epicardial ablation.

149 efore ablation, VT was inducible in 75%, and endocardial/epicardial LAVA were present in 88%/75%.

150 Endocardial fibroelastosis (EFE) is a unique form of fib

151 Secondary outcomes included mild endocardial fibroelastosis (n = 1) and cutaneous neonata

152 cy, and secondary outcomes included isolated endocardial fibroelastosis, 1 degrees CHB at birth and s

153 ity of endothelial cells and near regions of endocardial fibrosis/disruption.

154 ine pigs underwent closed-chest placement of endocardial fiducial markers, computed tomography, and p

155 Endocardial flowers are contiguous with coronary vessels

156 Finally, endocardial flowers exhibit angiogenic features, includi

157 se previously undescribed structures, termed endocardial flowers, have a distinct endothelial phenoty

158 A low endocardial fraction shortening (eFS) was present in 17%

159 iest ventricular activation and discriminate endocardial from epicardial origin of activation with cl

160 logy and provide a rationale for considering endocardial function in regenerative strategies.

161 novo HLHS mutations associated with abnormal endocardial gene and fibronectin regulation.

162 re, we investigated how TBX20 interacts with endocardial gene networks to drive the mesenchymal and m

163 ver, when cardiac function is disrupted, OFT endocardial growth ceases, accompanied by reduced prolif

164 Here, we show that endocardial hematopoiesis is critical for cardiac valve

165 tissue interactions involved in establishing endocardial identity are poorly understood.

166 ned lesion known as Quilty effect or nodular endocardial infiltrates.

167 ned lesion known as Quilty effect or nodular endocardial infiltrates.

168 Percutaneous delivery via endocardial injection was investigated with fluoroscopic

169 ERF ablation is a promising new approach for endocardial intramural and full thickness ablation of ve

170 Endocardial Jag1 removal blocks SV capillary sprouting,

171 c valve, and septal defects, indicating that endocardial Jag1 to Notch1 signaling is required for pos

172 Mice lacking endocardial Jag1, Notch1, or RBPJ displayed enlarged val

173 Endocardial Klf2 deficiency results in defective valve f

174 Upregulation of endocardial Kruppel-like factor 2 in Adamts19 knockout m

175 eflectance of the cardiac muscle beneath the endocardial layer.

176 in showed a similar trend from epicardial to endocardial layers (epiwall: -16.0 +/- 2.9%; midwall: -1

177 egarding the safety of DCCV in patients with endocardial left atrial appendage occlusion (LAAO) devic

178 as multisite pacing, His bundle pacing, and endocardial left ventricular pacing.

179 -like tube, from which it is separated by an endocardial-like layer.

180 erence between linear (n=22) and focal (n=7) endocardial line length or volume.

181 ), we identified accessible chromatin within endocardial lineages and intersected these data with TBX

182 ides insight into the chromatin landscape of endocardial lineages during septation.

183 n enhancer drove reporter gene expression in endocardial lineages in a TBX20-binding site-dependent m

184 Selective ablation of Tbx20 in murine endocardial lineages reduced the expression of extracell

185 Endocardial LP abolition was associated with reduced VT

186 The most common indications for endocardial LV pacing were difficult CS anatomy (n =12),

187 s with CC undergoing detailed epicardial and endocardial LV tachycardia mapping and ablation were inc

188 from the coronary venous system and multiple endocardial LV/right ventricular sites.

189 and more similar to those of the idiopathic endocardial LVOT VAs than those of the idiopathic epicar

190 sional interactions provide insight into why endocardial mapping alone may not fully characterize the

191 ogram thresholds for IMAT delineation during endocardial mapping and to describe the use of endocardi

192 docardial mapping and to describe the use of endocardial mapping for delineation of IMAT dense region

193 e (16 patients and 58 VTs), left ventricular endocardial mapping was performed in sinus rhythm.

194 ions of myocardium reliably identified using endocardial mapping with thresholds of <3.7 and <0.6 mV,

195 ents (23.8%) underwent a successful repeated endocardial mapping, and ablation after epicardial mappi

196 h comparable efficacy to currently available endocardial-mapping techniques but with 2 times higher a

197 docardial voltage signals and 314 epicardial/endocardial matched pairs of points were analyzed.

198 ntricular canal undergo an EndMT to form the endocardial mesenchymal cushion that later gives rise to

199 Deployment of an endocardial mitral isthmus line (MIL) with the end point

200 ysiological signals (for example, for active endocardial monitoring).

201 indicate that the myocardium is crucial for endocardial morphogenesis and differentiation, and ident

202 st for a potential role of the myocardium in endocardial morphogenesis, we used two different zebrafi

203 d universal increment from the epicardial to endocardial myocardial wall (epiwall: -15.4 +/- 1.9%; mi

204 lts in trunk vessel deficiencies, disordered endocardial-myocardial contact and impaired heart functi

205 ur findings provide novel insight into early endocardial-myocardial interactions that can be explored

206 0.69; P<0.001) with readings obtained in the endocardial myocardium performing better than those in t

207 Heat-shock-induced bmp2b expression rescued endocardial nfatc1 expression in hand2 mutants and in my

208 for apoptosis, which resulted in the loss of endocardial nfatc1 expression.

209 Region-specific endocardial Notch activity regulates heart morphogenesis

210 Although previous studies have shown that endocardial Notch signalling non-cell-autonomously promo

211 a RBPJ-binding site, identifying Hbegf as an endocardial Notch target.

212 Thirteen patients underwent endocardial-only ablation, 2 had epicardial-only ablatio

213 ecurrent VT or persistent inducibility after endocardial-only ablation.

214 cedure duration and help choosing between an endocardial or epicardial approach.

215 ium where it is inaccessible to conventional endocardial or epicardial approaches.

216 ablation catheter safely delivers contiguous endocardial or epicardial lesions without gaps in a sing

217 tricular activation and best pace map on the endocardial or epicardial side.

218 bxiphoid approach can be an alternative when endocardial or epicardial transvenous mapping has failed

219 approach is an alternative when conventional endocardial or transvenous epicardial ablation fails in

220 ice alternatives that require intravascular, endocardial, or epicardial contact.

221 hteen goats were instrumented with an atrial endocardial pacemaker lead and a burst pacemaker.

222 Endocardial pacemaker leads and right ventricular (RV) p

223 py (CRT) delivered via left ventricular (LV) endocardial pacing (ENDO-CRT) is associated with improve

224 entional CRT underwent implantation of an LV endocardial pacing electrode and a subcutaneous pulse ge

225 pacing via a wireless left ventricular (LV) endocardial pacing electrode.

226 model and offers a potential alternative to endocardial pacing leads.

227 nized LV pacing, multisite LV pacing, and LV endocardial pacing offer promise as novel pacing options

228 acy was estimated using 552 left ventricular endocardial pacing sites pooled together and 25 VT-exit

229 0.495 muJ, which is higher than the required endocardial pacing threshold energy (0.377 muJ).

230 ced ATs and increased synchrony arising from endocardial pacing.

231 stages of myocardial differentiation rely on endocardial paracrine signaling mediated in part by Bmp2

232 docardial cell proliferation and stabilizing endocardial patterning.

233 Endocardial perfusion parameters obtained by semiautomat

234 The effects of endocardial PFA and RFA on the phrenic nerve were also c

235 the scientific basis for the first-in-human endocardial PFA studies.

236 singularities between the epicardial and the endocardial planes was significantly >0 with a median di

237 Endocardial plus adjuvant EPI ablation was performed in

238 Here, we identify a developmentally impaired endocardial population in HLHS through single-cell RNA p

239 However, the precise identification of the endocardial precursors and the mechanisms they require f

240 Because they do not depend on ELA-APJ, endocardial progenitors are able to expand and compensat

241 We show that in hand2 mutants endocardial progenitors migrate to the midline but fail

242 o pathway transcriptional regulator Yap1 and endocardial proliferation.

243 nhanced open chromatin states at endothelial/endocardial promoters.

244 ovides therapeutic vagal denervation through endocardial radiofrequency ablation for these cases.

245 Sustained obesity results in global biatrial endocardial remodeling characterized by LA enlargement,

246 (NaviStar ThermoCool Catheter for Endocardial RF Ablation in Patients With Ventricular Tac

247 rS-ECG with data from various epicardial and endocardial right ventricular activation mapping procedu

248 decremental preexcitation of the RVOT before endocardial RV mapping.

249 mapping demonstrated larger epicardial than endocardial scar and core-dense (</=0.5 mV) scar areas (

250 e relationship between calcifications within endocardial scar and VTs is unclear.

251 There was a linear correlation between endocardial scar area (<1.5 mV) and filtered QRS (r=0.41

252 ate the signal-averaged ECG (SAECG) with the endocardial scar characteristics in patients with ischem

253 ematic characterization of the LV epicardial/endocardial scar distribution and density in CC has not

254 Endocardial scar extension and density predict scar tran

255 ding of the confounding influence of IMAT on endocardial scar mapping.

256 nt correlation between the surface SAECG and endocardial scar size in patients with ischemic VTs.

257 lay and exceeded the region of corresponding endocardial scar.

258 erformed on the epicardial side in 9 VAs and endocardial side in 5 VAs.

259 ation of a lead at the left ventricular (LV) endocardial side of the interventricular septum, referre

260 sites anatomically opposite to the earliest endocardial site of activation under direct intracardiac

261 al epicardial electrograms had corresponding endocardial sites with BV <1.50 mV, and the remaining co

262 ries and a remote approach from the adjacent endocardial sites.

263 lated from the great cardiac vein and remote endocardial sites.

264 Regions of maximal endocardial slowing during SR corresponded to the VT ist

265 An upregulation of endocardial SOX17 accompanied compensation in Apj mutant

266 t tubes and genetic lineage tracing with the endocardial specific Nfatc1-Cre mouse revealed that hemo

267 To test this, we generated an in vitro, endocardial-specific ablation model using the diphtheria

268 mesenchymal cells, a phenotype reproduced by endocardial-specific loss of Wnt9b.

269 ventricular tachycardia, >10% increase in RV endocardial surface area of bipolar voltage consistent w

270 The mean endocardial surface area of these potentials was 18+/-4%

271 s derived from manually drawn epicardial and endocardial surface contours.

272 tion were driven by rapid activations on the endocardial surface that blocked and broke up transmural

273 n of a native or prosthetic heart valve, the endocardial surface, or an indwelling cardiac device.

274 al strain was measured at the epicardial and endocardial surfaces; their difference yielded the circu

275 ut our understanding of the contributions of endocardial TBX20 to heart development remains incomplet

276 ct that patients with viable fast-conducting endocardial tissue or distal Purkinje network or both, a

277 f discordance between the epicardial and the endocardial tissue.

278 ked and broke up transmurally, leading to an endocardial to epicardial activation rate gradient as LD

279 r beta-catenin are proposed to contribute to endocardial-to-mesenchymal transformation (EMT) through

280 1 (5.5-9 weeks) were detected, indicative of endocardial-to-mesenchymal transformation (EndMT) in val

281 Low endocardial unipolar voltage (UV) at sites with normal b

282 Endocardial unipolar voltage mapping serves to character

283 The endocardial unipolar voltage value (with a newly propose

284 ing could be identified by corresponding low endocardial UV <3.7 mV.

285 th low endocardial BV, the additional use of endocardial UV at normal BV sites improves the diagnosti

286 es with endocardial BV >1.50 mV, the optimal endocardial UV cutoff for identification of epicardial B

287 ion of epicardial right ventricular scar, an endocardial UV cutoff value of 3.9 mV is more accurate t

288 This study aimed to define endocardial UV cutoff values using computed tomography-d

289 signaling and intra-ventricular sprouting by endocardial Vegfa signaling.

290 n=5) during sinus rhythm, and epicardial and endocardial ventricular pacing (65 records in total).

291 nd chronic hypoxia and (2) elucidate whether endocardial versus epicardial mechanics respond differen

292 pproach from the anatomically opposite side (endocardial versus epicardial or above versus below the

293 (CMR) signal intensity and left atrial (LA) endocardial voltage after LA ablation.

294 ity was associated with reduced posterior LA endocardial voltage and infiltration of contiguous poste

295 e group (p < 0.001), consistent with reduced endocardial voltage in this region.

296 Sixty endocardial voltage maps (360+/-147 points) were perform

297 went 2 detailed sinus rhythm electroanatomic endocardial voltage maps (average 385+/-177 points per m

298 Endocardial voltage maps showed myocardial scar in 19 pa

299 A total of 8494 epicardial and 6331 endocardial voltage signals and 314 epicardial/endocardi

300 ping-guided endomyocardial biopsy showed low endocardial voltages and fibro-fatty replacement in area

301 Bipolar epicardial and endocardial voltages within scar were low (0.4 [0.2-0.55