ライフサイエンスコーパス: endocytotic

1 hanism is usually classified as fusogenic or endocytotic.

2 Epsin and AP180/CALM are endocytotic accessory proteins that have been implicated

3 orm, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the re

4 caCdc42 also increased endocytotic activity of DC, whereas dominant-negative Cd

5 e we report a simple method to visualize the endocytotic activity of LCs in living animals.

6 depolarization a basal level of constitutive endocytotic activity was observed at approximately 30% o

7 HLA-DR and CD11c, decreased CD14, increased endocytotic activity, and the ability to stimulate T cel

8 es to clathrin protein expression levels and endocytotic activity, but no detectable changes to stead

9 ther, indicating marked heterogeneity in exo-endocytotic activity.

10 esting a dynamic, light-modulated control of endocytotic activity.

11 Taken together, our results suggest that endocytotic alterations in cancer cells that affect cell

12 genetic and pharmacological approaches, that endocytotic amyloidogenic processing of APP impairs iron

13 nesis by targeting key genes involved in the endocytotic and endosomal/lysosomal pathways, and disrup

14 ng at multiple steps, including not only the endocytotic and exocytotic rates, but also the two rate

15 rs in such a pool may contribute to receptor endocytotic and exocytotic trafficking and recycling.

16 quirement for the correct functioning of the endocytotic and secretory machinery.

17 Our work therefore demonstrates that the B12 endocytotic apparatus is not only present in this airway

18 le epithelial cells have an extensive apical endocytotic apparatus that is critical for the reabsorpt

19 ne (Ser-412) in beta-arrestin1 regulates its endocytotic but not its desensitization function.

20 es display amoeboid morphologies and exhibit endocytotic cargo transport from the interstitial matern

21 nd preferentially penetrate cancer cells via endocytotic, caveosome-directed, and caveosome-independe

22 We propose that Arr1 mediates an endocytotic cell-survival activity, scavenging phosphory

23 receptor for endocytosis (HARE) mediates the endocytotic clearance of HA and other glycosaminoglycans

24 and cell biological methods to characterize endocytotic compartments that participate in trafficking

25 loop connecting PI(4,5)P2 and PA during the endocytotic cycle of synaptic vesicles and serve as a si

26 though much is understood of the transferrin endocytotic cycle, little has been uncovered of the mole

27 ortened the half-life of ERBB2 by increasing endocytotic degradation.

28 n in the "lattice network" characteristic of endocytotic domains in Drosophila presynaptic terminals.

29 Both exocytotic (NSF) and endocytotic (dynamin) ATPase/GTPase activity are require

30 uantifies the competition between fusion and endocytotic entry pathways.

31 oid precursor protein secretases in specific endocytotic environments.

32 but they did support the hypothesis that an endocytotic event(s) plays a role in the cell contact-me

33 ition by NA was due to a decreased number of endocytotic events without a change in vesicle size.

34 dependent exocytotic and Ca(+2)- independent endocytotic events.

35 This endocytotic/exocytotic coupling requires a tight link be

36 ripheral ruffles by inhibiting Rab5-mediated endocytotic/exocytotic trafficking of Rac1.

37 rol-dependent cytolysin pneumolysin as a pro-endocytotic factor in lysates, its elimination reduces t

38 Upon low-frequency electro-stimulation, endocytotic FM1-43 (SynaptoGreen) uptake in the presynap

39 in particular the lungs, and show decreased endocytotic function in fibroblasts.

40 e adjacent to the dense body could represent endocytotic images (newly forming vesicles) rather than

41 is, and suggest that calmodulin modulates an endocytotic intermediate process, which in turn affects

42 eceptor for 24p3 (24p3R) that is involved in endocytotic iron delivery has also been cloned.

43 ptic site, where they become available to an endocytotic machinery and are selectively internalized.

44 cts with several other key components of the endocytotic machinery in co-IP assays, including clathri

45 s are thought to organize the exocytotic and endocytotic machinery precisely at active zones.

46 in the development of the oocyte's powerful endocytotic machinery we determined the structure of the

47 in and AP180 are essential components of the endocytotic machinery, which controls internalization of

48 easome, the nucleus, the cytoskeleton or the endocytotic machinery.

49 g receptor binding to the AP2 protein of the endocytotic machinery.

50 out photoconversion (PC) of the fluorescent endocytotic marker FM 1-43 by using 3,3'-diaminobenzidin

51 ration of presynaptic function, assayed with endocytotic markers, followed accumulation of synapsin I

52 re crucial for penetration of the BBB via an endocytotic mechanism (transcytosis).

53 netics and a predominantly clathrin-mediated endocytotic mechanism, irrespective of dendrimer end-ter

54 e absence of protein degradation, through an endocytotic mechanism.

55 hrin-coated pits and are internalized via an endocytotic mechanism.

56 of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and re

57 s an opportunity to study clathrin-dependent endocytotic mechanisms in temporal isolation from those

58 ion into mitochondria that is independent of endocytotic mechanisms.

59 ghbors, and exchanges cargo through exo- and endocytotic mechanisms.

60 croscopy to localize major components of the endocytotic membrane retrieval machinery in the photorec

61 We found that, in sea urchin eggs, endocytotic membrane retrieval required extracellular ca

62 Cells use endocytotic membrane retrieval to compensate for excess

63 e channels plays a key role in signaling for endocytotic membrane retrieval.

64 during synaptic transmission is balanced by endocytotic membrane retrieval.

65 In addition, characterization of Drosophila endocytotic mutants provides in vivo evidence for the pr

66 ynaptic boutons, similar to known Drosophila endocytotic mutants.

67 tion that abolishes the macropinocytotic and endocytotic nanoparticle internalization pathways that o

68 hilin A1 is a protein involved in generating endocytotic necks and vesicles during synaptic endocytos

69 PS-ASOs are released from membrane-enclosed endocytotic organelles to reach target RNAs remain large

70 ways and are released from membrane-enclosed endocytotic organelles, mainly late endosomes (LEs).

71 dynamin-dependent clathrin-coated vesicular endocytotic pathway although other dynamin-independent p

72 ells through primarily the clathrin-mediated endocytotic pathway and displayed the potential of elici

73 hat is localized to endosomes throughout the endocytotic pathway and functions in constitutive exocyt

74 reatment rapidly activates an actin-mediated endocytotic pathway and targets the enzyme to the endoso

75 endosomes of the apical membrane fluid-phase endocytotic pathway and to the Golgi complex.

76 The presence of a Ca2+-dependent endocytotic pathway at the active zone opens up the foll

77 ight cross the plasma membrane also by a non-endocytotic pathway gaining direct access to the cytopla

78 C virus and found that the clathrin-mediated endocytotic pathway is essential for both infection and

79 It is envisioned that the endocytotic pathway of ligand-receptor complexes of ANP-

80 lathrin-, caveolin-, and dynamin-independent endocytotic pathway similar to the one recently describe

81 provide evidence that LCMV entry involves an endocytotic pathway that is independent of clathrin and

82 ts biological activity and is mediated by an endocytotic pathway that is independent of the microtubu

83 n of cytosol, which selectively inhibits the endocytotic pathway via coated pits, inhibited TFPI.Xa-m

84 eased Abeta42 secretion originating from the endocytotic pathway, likely with cell-line restriction.

85 s, all of which block the clathrin-dependent endocytotic pathway, significantly blocked constitutive

86 s is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to th

87 e drug carriers into cytoplasm bypassing the endocytotic pathway.

88 it is through the synthetic rather than the endocytotic pathway.

89 a-2 ligands are internalized, in part, by an endocytotic pathway.

90 FGF21 could thus be tracked along the endocytotic pathway.

91 4 could lead to significant changes in their endocytotic pathways and action mechanisms via distinct

92 are known to be internalized via a number of endocytotic pathways and are released from membrane-encl

93 vivo evidence for the presence of different endocytotic pathways at a single synapse.

94 ) pharmacological drugs inhibiting different endocytotic pathways have either only minor or no negati

95 ry to defective endocytosis, suggesting that endocytotic pathways may be generally more sensitive to

96 nctional components of the receptor-mediated endocytotic pathways to allow virus to transverse the gu

97 Slc4a4, and a number of miRNAs implicated in endocytotic pathways.

98 nt lipid domains and ultimately to different endocytotic pathways.

99 osphorothioate (PS) linkages enter cells via endocytotic pathways.

100 e accumulation of both newly synthesized and endocytotic PIN2 pools in Brefeldin A compartments (BFAC

101 rs that interfere with discrete steps of the endocytotic process and antibodies for caveolae and Golg

102 ptic AMPARs turn over through a constitutive endocytotic process and that glutamate application great

103 ibuted to cancer specific differences in the endocytotic process of receptor recycling/degradation an

104 We demonstrate that calcineurin mediates an endocytotic process that is responsible for the rapid in

105 l of receptors by means of an exocytotic and endocytotic process, respectively.

106 temperature-, and peptide sequence-dependent endocytotic process.

107 y a novel clathrin- and caveolin-independent endocytotic process.

108 nt isoforms of dynamin may regulate distinct endocytotic processes and that the PH domain contributes

109 Active endocytotic processes are required for the normal distri

110 GFP results in a dominant-negative effect on endocytotic processes in general, leading to the uptake

111 , their sensitivities to known inhibitors of endocytotic processes, and their route of uptake via con

112 observable when we blocked dynamin-mediated endocytotic processes, suggesting that PACSIN 3 specific

113 afficking and regulation of dynamin-mediated endocytotic processes.

114 ome common features with transferrin uptake (endocytotic) processes, the two systems also exhibit dis

115 ella organisms attached to M cells use their endocytotic properties to enter the cell.

116 STNB contains a domain with homology to the endocytotic protein AP50.

117 th Stoned proteins colocalize precisely with endocytotic proteins including the AP2 complex and Dynam

118 Changes in endocytotic proteins, signal transduction kinases, and c

119 in the rat adipocyte, not only reducing the endocytotic rate constant 3-4-fold and increasing the ex

120 Endocytotic rate constants (ke) for chlorate-treated and

121 Herein, we show that SCARA5 is an endocytotic receptor whose ligand repertoire includes th

122 HBP1 and plant RPG/PMI1 proteins involved in endocytotic recycling and organellar positioning and an

123 regeneration of synaptic vesicles during exo/endocytotic recycling at nerve terminals but do not prec

124 The kinetics of exo-endocytotic recycling could restrict information transfe

125 entified vesicles capable of engaging in exo-endocytotic recycling following stimulated Ca(2+) entry.

126 We show a central role for flotillin in the endocytotic recycling of Orai1 channels and that endocyt

127 We show a central role for flotillin in the endocytotic recycling of Orai1 channels and that endocyt

128 cues stoned embryonic lethality and restores endocytotic recycling to normal levels.

129 We also identify synaptic vesicle endocytotic regions close to MACs and synapses and hypot

130 r (LAMA), the scaffold protein Paxillin, the endocytotic regulator Shibire (Dynamin), and the homeodo

131 egulated in part by exocytotic insertion and endocytotic retrieval of an H(+)-ATPase to and from the

132 Our co-localization analysis detailed the endocytotic route that trafficked NOGGIN from the apical

133 The sensitivity of endocytotic routes to the spatial distribution of positi

134 ted by with-no-lysine (WNK) kinases, but the endocytotic signal and the internalization machinery hav

135 o be a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV.

136 The large endocytotic steps were associated with a conductance cha

137 ing or degradative pathways depending on the endocytotic stimulus.

138 me time, locates RRC in a common step of the endocytotic system before final receptor segregation int

139 Loading experiments with the endocytotic tracker FM4-64 showed dynamic plant membrane

140 lysis failed to uncover substantial exo- and endocytotic traffic of the channel.

141 ention, thus we hypothesized that changes in endocytotic trafficking associated with altered APP proc

142 ension in the daf-2 mutant are components of endocytotic trafficking of membrane proteins to lysosome

143 directly acts intracellularly to alter uPAS endocytotic trafficking.

144 ant for endoplasmic reticulum (ER) export or endocytotic trafficking.

145 Exo-endocytotic turnover of synaptic vesicles (SVs) at synap

146 nd low (4 degrees C) temperature, suggesting endocytotic uptake and microtubule-dependent transcytosi

147 These studies demonstrate that the endocytotic uptake of a thermally responsive ELP is sign

148 fection structures called infection threads, endocytotic uptake of bacteria, symbiotic cells carrying

149 black widow spider venom (BWSV), we observed endocytotic uptake of FM1-43.

150 ArfGAP3 in photoreceptors strongly inhibited endocytotic uptake of FM1-43.

151 imulation-induced alkalinization and reduces endocytotic uptake of FM1-43.

152 multi-functional receptor which mediates the endocytotic uptake of several ligands implicated in neur

153 ) ileum anchored receptor, cubilin, mediates endocytotic uptake of the IF complex of vitamin B(12) to

154 We have used endocytotic uptake of the styryl dye FM1-43 at synaptic

155 al permeability and that the extraintestinal endocytotic uptake of transferred particles by circulati

156 st, deflection of the cell membrane inducing endocytotic uptake, and second, microbubble jetting indu

157 lls is achieved by various routes, including endocytotic uptake, membrane-fusion, and scavenger recep

158 ficking pathway of aminoglycosides following endocytotic uptake, we administered kanamycin to neonata

159 on followed by PI entrance; however, loss of endocytotic vacuolar trafficking of Hst 5 did not reduce

160 However, this same pathway may release endocytotic vesicle contents, resulting in an inflammato

161 ane, and its subsequent association with the endocytotic vesicle fraction may have a role in muscarin

162 ted kinases indicates a role for them in the endocytotic vesicle-mediated uptake and trafficking of p

163 firming their association with this class of endocytotic vesicle.

164 ndogenous GPP130 reversibly redistributed to endocytotic vesicles after chloroquine treatment.

165 ins that correspond in size and frequency to endocytotic vesicles and coated pits.

166 overexpression reduced the size of DCVs and endocytotic vesicles but not MVs.

167 The endocytotic vesicles grow in number and size and are occ

168 ize the thyroid hormone-dependent binding of endocytotic vesicles to microfilaments.

169 ces various membranous structures (including endocytotic vesicles) of glial or axonal origin to form,

170 f GPP130 led to a pronounced accumulation in endocytotic vesicles, and endogenous GPP130 reversibly r

171 perinuclear punctate staining reminiscent of endocytotic vesicles, the carboxylated polymer revealed

172 Y-1, a cargo protein of clathrin-independent endocytotic vesicles, to facilitate efficient entry into

173 fraction in cytoplasm that contains uncoated endocytotic vesicles.

174 the scission event required for formation of endocytotic vesicles.

175 rin receptors were internalized via the same endocytotic vesicles.

176 solutes via tight junctions (TJs) and scarce endocytotic vesicles.

177 ein specifically localized to a postsynaptic endocytotic zone of excitatory synapses.