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1 or (5-HT(2C)R) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to a
2 ss of leukocytes to dramatically improve the endogenous ability of chronic SCI rats to fight off pneu
5 ated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscar
8 +) increases the affinity and potency of the endogenous agonist alpha-melanocyte-stimulating hormone
9 hat treating these cells with laminin causes endogenous agrin to localize to the cell surface, where
10 mouse cells and CRISPR/Cas9 base editing of endogenous AGS loci revealed causal roles of one AGS-spe
12 ing to introduce a dual epitope tag into the endogenous allele of each of 11 known components of cohe
14 re well tolerated by the brain, D-serine, an endogenous amino acid, offers new hope as a therapeutic
17 new study shows that anesthetics activate an endogenous analgesia neural ensemble in the central nucl
18 s of DNA interstrand crosslinks caused by an endogenous and alcohol-derived metabolite, and identify
19 tive fitness, in conjunction with additional endogenous and environmental changes, drives leukaemic t
23 were significantly associated with BP, other endogenous and food-related compounds were associated wi
24 stantial opportunity for competition between endogenous and newly-encountered substrates to influence
32 anisms from all three domains of life harbor endogenous base modifications in the form of DNA methyla
33 , as measured by single-cell live imaging of endogenous beta-catenin, and subsequent target gene tran
39 d plasma and 24-hour urine concentrations of endogenous candidate secretory solutes at baseline, usin
40 lopmental signals.SIGNIFICANCE STATEMENT The endogenous cannabinoid system plays diverse roles in bra
41 rapid, selective and sensitive detection of endogenous carbon monoxide (CO) in live mammalian cells
45 ter liposome administration, we followed the endogenous ChgA-specific immune response with specific t
46 e extend the number of vertebrate taxa where endogenous chitin production has been detected and raise
47 perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes
50 target genes by recruiting components of the endogenous chromatin-activating machinery, eliminating t
53 promoter, we used new pol II promoters from endogenous coding genes to express crRNA for Cas12a and
54 ere performed in different laboratories, the endogenous Colo-205 PTEN levels determined with 2-PIC sh
55 pable of simultaneously quantifying multiple endogenous compounds, including IBC, thiamine, N(1)-meth
56 by positive allosteric modulators, including endogenous compounds, such as cholesterol and neurostero
58 onas syringae and Klebsiella pneumoniae, and endogenous CRISPR-Cas use was enhanced with an 'anti-ant
59 e released during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infect
61 inflammatory genes in response to HFD as an endogenous defense against atherosclerosis in ApoE(-/-)
63 licitly consider grassland assembly time and endogenous disturbance regimes in studies of plant commu
66 experiments expand the toolkit for measuring endogenous dopamine release in Drosophila, introducing c
68 est that m(6)A modification protects against endogenous dsRNA formation and a deleterious innate immu
70 her mammals, yet the role that virus-derived endogenous elements may have played in the evolution of
71 regional incidence of neonatal and infantile endogenous endophthalmitis and comorbidities as well as
77 3D head-tracking, these results demonstrate endogenous expectation-driven shifts of spatial attentio
79 th a Cas12a-encoding plasmid leads to robust endogenous expression of tagged genes, with tagging effi
80 -2alpha and how decreased expression of this endogenous factor causes emphysema; its pivotal protecti
83 nder investigation in PE patients to enhance endogenous fibrinolysis, whereas blockade of leukocyte i
84 measurements, we first observe that modeled endogenous field magnitudes are comparable to those in m
89 diated Integration Cassette to determine the endogenous gene expression and subcellular localization
92 he possibility to modulate the expression of endogenous genes by directly targeting their promoters.
93 ression levels, promoters, and disruption of endogenous genes in transgenic mouse models of tauopathy
94 ns was also demonstrated by the silencing of endogenous genes that encode two subunits of magnesium c
96 exploited to functionally link BE events at endogenous genomic loci to cellular enzymatic activities
97 drop in glucose from 7 to 1 mm Inhibition of endogenous GHB formation with the GABA transaminase inhi
99 r a drug-resistant population with increased endogenous GLS2 and restored proliferative capacity.
101 ed in the same area, and after inhibition of endogenous halorhodopsin-expressing cortical neurons by
102 ight-induced inhibition of either grafted or endogenous halorhodopsin-expressing cortical neurons, lo
106 arized plasmid in control cells by using the endogenous homologous transcript as a template, indicati
110 ted hot-spot mutations localizing within the endogenous human BAF complex, identifying those that dis
111 Au@Rh-ICG-CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevat
112 erences between oral microbial metabolism of endogenous (i.e., salivary protein) and exogenous (i.e.,
117 ed influences of elevated CO(2) (eCO(2) ) on endogenous immune responses of monarch larvae to infecti
118 e applied to other cancer types in which the endogenous immune system supports maintenance therapy, l
120 or cytoprotective response, whereas Keap1-an endogenous inhibitor of Nrf2 signaling-dampens these pro
123 applications including reversibly binding to endogenous intracellular targets, modulating signaling p
124 3-methyl-but-2-enyl pyrophosphate, HMBPP] or endogenous (isopentenyl pyrophosphate, IPP) and PAg sens
125 Using Acod1(-/-) mice, we found that Acod1/endogenous itaconate does not affect PM-induced inflamma
129 ed insulin and pramlintide better mimics the endogenous kinetics of co-secreted insulin and amylin, a
133 both the Kappa Opioid Receptor (KOR) and its endogenous ligand dynorphin in mediating these processes
136 ncing of Mcl and Mincle or blockade of their endogenous ligand SAP130 revealed that these receptors'
139 nding of CTRP6 to a variety of microbial and endogenous ligands identifying CTRP6 as a novel human le
140 brane composition induced by perturbation of endogenous lipid biosynthetic pathways or exogenous appl
142 rotypic multicomponent interactions dominate endogenous LLPS, and give rise to nucleoli and other con
143 at CEMs upregulate gene expression at target endogenous loci up to 20-fold or more depending on the g
144 the first shelterin mutant engineered at the endogenous locus of human stem cells with an altered tel
145 ered ascorbate peroxidase (APEX) gene to the endogenous locus of lysosome-associated membrane protein
146 termined to be ~11%, suggesting that the 15N endogenous loss values could underestimate endogenous pr
148 iopoietin-like protein 4 (ANGPTL4), a potent endogenous LPL inhibitor, was significantly increased du
152 paration strategy for top-down proteomics of endogenous membrane proteins enabled by cloud point extr
153 teins in biological systems, the analysis of endogenous membrane proteins remains challenging due to
158 ytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses.
161 tation of these RBPs identifies thousands of endogenous mRNA targets that respond to changes in RBP l
162 we report that CRISPR-mediated repression of endogenous Myd88 can effectively modulate the host immun
165 -in HEK293 cells, allowing discrimination of endogenous NEDD8- and ubiquitin-modification sites by MS
166 asked whether pharmacological stimulation of endogenous neural precursor cells (NPCs) may promote cog
168 e allosteric modulators of NMDARs include an endogenous neurosteroid pregnenolone sulfate (PES), but
170 neuron-selective overexpression of Lypd6, an endogenous nicotinic signaling modulator, enhances ocula
173 ganisms, nucleic acid sensors also recognize endogenous nucleic acids, for example when cells are dam
174 ld reflect a role of albumin in transport of endogenous nutrient cargos required for cellular growth
178 We review evidence for dysregulation of the endogenous opioid system as a mechanism for the developm
179 groundwork for improved understanding of the endogenous opioid system that will help in developing mo
181 ptin/orphanin FQ peptide (N/OFQ; 500 nM), an endogenous opioid-like peptide, normalized GABA transmis
182 opioids in gregarious song and suggest that endogenous opioids in the mPOA may facilitate song by in
183 function of CB1R in the cerebellum, in which endogenous or exogenous activation of CB1Rs modifies aff
184 location, respectively), pre- or post-cueing endogenous or exogenous attention, while participants pe
185 hat extent such approaches replicate natural/endogenous orexin signals, which rapidly fluctuate durin
186 alate excretion is an inaccurate measure for endogenous oxalate production in PH patients and not app
189 agement was accompanied by activation of the endogenous pain modulation system, manifested by the att
190 ol for quantitative, real-time assessment of endogenous pathway activation, measured in single cells,
191 Moreover, a general approach to engender endogenous patient-specific cellular therapy, without th
192 vo stimulation with interferon-gamma induced endogenous PD-L1 expression and restricted T cell activa
193 lerate tumorigenesis, even in the absence of endogenous PD-L1; (3) PD-L1(+) T cells engaged PD-1(+) m
194 ing antagonists of opioid receptors to infer endogenous peptide activity, and genetic knockout of opi
195 As proof of principle, we have quantified an endogenous peptide of histone H4 by matrix-assisted lase
197 he possibility to selectively quantify other endogenous peptides cleaved by peptidases whose concentr
203 pically expressed polyQ proteins in vitro or endogenous polyQ proteins in Huntington's disease mouse
204 om India, here we show how a self-consistent endogenous poverty line can be derived from an agent-bas
205 ected in non-treated leaves, which indicates endogenous processing and transport through the plant.
207 sion of Brg1, in conjunction with the severe endogenous proinflammatory environment, can convert defe
208 n of these chimeras under the control of the endogenous promoter of the respective LRR-RK leads to st
209 ently tagged HSP-17 under the control of its endogenous promoter revealed that HSP-17 is expressed in
210 nced green fluorescent protein driven by the endogenous promotor for Pdgfra was shown to be a powerfu
211 N endogenous loss values could underestimate endogenous protein and AA losses by ~6% (the proportion
214 eriments were used to confirm several of the endogenous protein partners of BRD7 and BRD9, which form
215 tags could allow superresolution analysis of endogenous proteins in discrete conformational states.
216 e-preserving ExCel, which enables imaging of endogenous proteins stained by antibodies, and iterative
217 ntercellular movement of GFP and a subset of endogenous proteins through RCs during spermatogenesis,
218 embly of a synthetic peptide for trafficking endogenous proteins, this work provides insights for und
222 HLB formation, and that the large number of endogenous RD histone gene copies sequester available fa
224 lar affinity and does not interfere with the endogenous regulation of C3b deposition mediated by Fact
229 atment of diabetes mellitus, the path toward endogenous renewal of beta-cell populations has remained
234 ficient transcriptional activation of genes, endogenous retroviral elements and chimeric transcripts
237 from integrated retroviral elements, termed endogenous retroviruses (ERVs), that comprise ~8% of the
242 uble-stranded RNA (dsRNA)] together with the endogenous RNA interference (RNAi) factor ERI-6/7, a hom
243 and define enhancers but do not consider the endogenous role of an enhancer in the context of native
250 shifts in the balance between exogenous and endogenous sources of immunity to parasite attack may re
252 as a dominant-negative mutant that titrates endogenous Spc110 from the SPB causing spindle defects.
254 rminus, which contains the binding motif for endogenous Src tyrosine kinase that constitutively inhib
255 flects not only sensory inputs, but also the endogenous state when these inputs enter the brain.
256 remains challenging to trace nutrients from endogenous stores or exogenous food intake into offsprin
257 an in muscle, reflecting the mobilization of endogenous stores; in comparison, the value of Delta(15)
260 tVNS can be used as a tool for studying how endogenous subcortical neuromodulatory signaling affects
261 n the mid-1970s, an intense race to identify endogenous substances that activated the same receptors
262 nately faced the ER lumen and cytosol and an endogenous substrate resembling an alpha-helical TM.
266 trafficking when expressed in the absence of endogenous SV2A (to mimic the homozygous human condition
267 es of either sex, which had been depleted of endogenous SV2A to mimic the homozygous human condition.
268 rmore, we show that correlative Brainbow and endogenous synaptic machinery immunostaining can define
269 serine, alanine and pyruvate that drives the endogenous synthesis and accumulation of deoxysphingolip
270 scued by LA supplementation, indicating that endogenous synthesis of LA is essential for C. elegans d
272 mycobactin biosynthesis pathway a promising endogenous target for novel lead-compounds discovery.
273 espread phenomenon, definitive functions for endogenous targeted mRNAs and their relevance to modulat
279 ug entry into the testes with drugs that use endogenous transport pathways may lead to more effective
282 otility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-pre
283 irect Treg cell selection, and the nature of endogenous Treg cell ligands, focusing on evidence from
285 cal analyses revealed direct binding between endogenous TruB1 and the stem-loop structure of pri-let-
287 Reciprocal dual-affinity purification of endogenous USP13 followed by mass spectrometry demonstra
289 r function is critical for brain health, and endogenous vascular protective pathways may provide ther
290 ying enzyme such as Cas9/gRNAs that disrupts endogenous versions of an essential gene and a recoded v
291 ) N(Pro-Phe) ), to explore the allocation of endogenous versus exogenous nutrients across the capital
292 We found that both LTR retrotransposons and endogenous viral elements are silenced by ADARs [adenosi
293 overy indicates a protective capacity of the endogenous virus against the exogenous form, either via
296 (BIVV001), that is physically decoupled from endogenous VWF and has enhanced pharmacokinetic properti
298 atively, these results describe a simplistic endogenous yet previously unrealized resistance mechanis
299 Furthermore, the sensitivity of the virus to endogenous ZAP was correlated with its sensitivity to th
300 ment of the odorant responses induced by the endogenous zinc nanoparticles appears to be similar to t