ライフサイエンスコーパス: endogenous ligand

1 phosphatidylinositol (LPI) is its only known endogenous ligand.

2 tive 4-hydroxyphenyllactic acid (HPLA) as an endogenous ligand.

3 , suggesting competitive inhibition with the endogenous ligand.

4 n proposed that the Smo CRD may bind its own endogenous ligand.

5 lar background and the "natural bias" of the endogenous ligand.

6 phosphatidylinositol (LPI) is its only known endogenous ligand.

7 PA microbeads and using [(125)I]IGF-1 as the endogenous ligand.

8 ieve signaling, especially in the absence of endogenous ligand.

9 uch receptors existed, and the search for an endogenous ligand.

10 ty to minute numbers of agonists in a sea of endogenous ligands.

11 ne PPARgamma activity without competing with endogenous ligands.

12 sion of receptors in cell-based assays for 9 endogenous ligands.

13 ety of natural exogenous (e.g., dietary) and endogenous ligands.

14 a the same receptor in response to different endogenous ligands.

15 hat recognize a beta-turn structure in their endogenous ligands.

16 ding specificity between galectins and their endogenous ligands.

17 otein of human tears, binds a broad array of endogenous ligands.

18 one another's function in mast cells through endogenous ligands.

19 ceptor following binding of one but not both endogenous ligands.

20 altered in response to morphine compared to endogenous ligands.

21 PR-C with significantly higher affinity than endogenous ligands.

22 es that cannot be observed in the absence of endogenous ligands.

23 hat can be activated by exogenous as well as endogenous ligands.

24 is required for the response of PPARgamma to endogenous ligands.

25 ty to human CD80 (hCD80) and displacement of endogenous ligands.

26 directly acted on the orthosteric sites for endogenous ligands.

27 ceptor, and progesterone receptor) and their endogenous ligands.

28 vironmental AHR ligands mimic the effects of endogenous ligands.

29 es on detergent-based preparations devoid of endogenous ligands.

30 r for which short-chain fatty acids serve as endogenous ligands.

31 s were found to increase the efficacy of the endogenous ligand 3-hydroxybutyrate and enhance its pote

32 nvironmental irritants (e.g., acrolein), and endogenous ligands (4-hydroxynonenal).

33 which is only active in the presence of the endogenous ligand (acetylcholine), and thus theoreticall

34 The endogenous ligand-activated aryl hydrocarbon receptor (A

35 established; however, identification of key endogenous ligand/activator remains to be established.

36 (NO(2)-OA) acids, are among the most potent endogenous ligand activators of PPARgamma-dependent tran

37 Nitroalkene fatty acids are potent endogenous ligand activators of PPARgamma-dependent tran

38 displays higher intrinsic activity than the endogenous ligand adrenaline in cAMP accumulation, beta-

39 D) and protein crystallography (PC) if these endogenous ligands affect and stabilize insulin oligomer

40 Paradoxically, TLR activation by endogenous ligands after ischemia worsens stroke damage.

41 we developed assays to explore the effect of endogenous ligands, agonists/antagonists, and antibodies

42 ation of the hepatic expression of CB1R, its endogenous ligand anandamide, and a number of tumor-prom

43 inoid receptors 1 and 2 (CB1 and CB2), their endogenous ligands, anandamide (AEA) and 2-arachidonoylg

44 co-occupation of a single receptor with the endogenous ligand and an allosteric modulator that can a

45 co-occupation of a single receptor with the endogenous ligand and an allosteric modulator.

46 l relevance to opioid responsiveness to both endogenous ligands and exogenous drugs, and could influe

47 dow spider venom alpha-latrotoxin, but their endogenous ligands and function remain unclear.

48 L-1) family receptors recognize microbial or endogenous ligands and inflammatory mediators, respectiv

49 of transcripts encoding proteins for sensing endogenous ligands and microbes that we refer to as the

50 l for the understanding of functions of both endogenous ligands and synthetic drug molecules.

51 ifferential regulation of these processes by endogenous ligands and synthetic drugs is a poorly under

52 and identity of GPCRs that are activated by endogenous ligands and that native cells express.

53 and followed by the characterization of its endogenous ligands and the identification of the enzyme

54 diverse biological processes in response to endogenous ligands and therapeutic drugs.

55 letely understood but can involve binding of endogenous ligands and/or partner proteins at specific l

56 gh the MT(1) and 5-HT receptors have similar endogenous ligands, and agomelatine acts on both recepto

57 s in the modulation of pharmacology of their endogenous ligands, and in the development of drugs with

58 by engagement with antibody or high-affinity endogenous ligands, and that an important ThPOK cis-acti

59 various effectors upon stimulation with the endogenous ligand angiotensin-II (AngII), including the

60 siologic and pathophysiologic actions of its endogenous ligand, angiotensin II, with overactivity lea

61 Apelin receptor (Aplnr) and its endogenous ligand apelin play an important role in cardi

62 owever, it is unknown how and when PPARalpha endogenous ligands are synthesized by dopamine cells.

63 eptor, and patients deficient in CD46 or its endogenous ligands are unable to mount effective Th1 T c

64 in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selecti

65 ses levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that s

66 Dynorphin, an endogenous ligand at kappa opioid receptors (KORs), prod

67 res), a new PBS-25 complex, and CD1d with an endogenous ligand, at 1.6-1.9 A resolution, reveal that

68 now clear that PRRs can also be activated by endogenous ligands, bacterial metabolites and, following

69 rom the studies is that the phenol of Tyr in endogenous ligands bearing the H-Tyr-Pro-Trp/Phe-Phe-NH(

70 associated with differential affinity to the endogenous ligand beta-endorphin as well as alterations

71 eatment with dimethyl fumarate and the HCAR2 endogenous ligand beta-hydroxybutyrate (BHB) in wild-typ

72 ynthetic ligands have been designed to mimic endogenous ligand binding to a canonical ligand-binding

73 The GSL repertoire of endogenous ligands bound to CD1d molecules that are expr

74 osine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDN

75 thetic ligands (RASSLs), are unresponsive to endogenous ligands but can be activated by nanomolar con

76 They respond to the same set of endogenous ligands but with distinct rank-order of poten

77 ort the suggestion that TIP39 is the PTH2R's endogenous ligand, but a comprehensive comparison of TIP

78 Acetylcholine is their endogenous ligand, but they are also stimulated by nicot

79 o extends profound beta-arrestin bias to the endogenous ligand by selectively antagonizing G protein

80 ferential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secr

81 Among endogenous ligands, C1q binds to DNA and apoptotic cells

82 TLR4 also responds to endogenous ligands called danger associated molecular pa

83 s, dendritic cells, and NK cells and has two endogenous ligands, CCL19 and CCL21.

84 CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of disea

85 e human chemokine receptor CCR6 bound to its endogenous ligand CCL20 and an engineered Go.

86 on of CD244 and receptor activation with its endogenous ligand CD48 inhibited starvation- and rapamyc

87 xogenous ligands have off-target effects and endogenous ligands constantly modulate the activity of n

88 ed insights into CXCR4 interactions with its endogenous ligand CXCL12, its ability to recognize diver

89 tor and driver of cancer metastasis, and its endogenous ligand CXCL12.

90 he specification of proximal fates where all endogenous, ligand-dependent Notch signaling is blocked

91 Concomitantly, its endogenous ligand, diazepam-binding inhibitor (DBI), is

92 onist ligands, which we propose as RORgammat endogenous ligands, driving both innate and adaptive IL-

93 kappa-Opioid receptors (KORs) and their endogenous ligand dynorphin are involved in stress-induc

94 both the Kappa Opioid Receptor (KOR) and its endogenous ligand dynorphin in mediating these processes

95 ion of kappa opioid receptors (KORs) and its endogenous ligand dynorphin in the mesolimbic circuitry

96 ed syncytin 1 (SYN-1), apelin receptor early endogenous ligand (ELABELA), and the chromosome 19 micro

97 and anti-inflammatory responses and that an endogenous ligand engages IL-18Ralpha to deliver an inhi

98 reproductive system by interacting with the endogenous ligand estradiol (E2).

99 stems such as the GLP-1R where more than one endogenous ligand exists.

100 Ligation of TLR-5 to endogenous ligands expressed in RA synovial fluid contri

101 Similarly, AhR signaling via the endogenous ligand FICZ reduced the inflammatory response

102 tified Manduca Contactin (MsContactin) as an endogenous ligand for APPL, consistent with previous wor

103 ive despite its inability to compete against endogenous ligand for binding to AR in vitro, suggesting

104 ansfected CNTN1, suggesting that CNTN1 is an endogenous ligand for CASPR2.

105 -dihydroxycholesterol (7alpha,25-OHC) as the endogenous ligand for EBI2, which provides a tool for me

106 Neuropeptide S (NPS) is the endogenous ligand for GPR154, now referred to as neurope

107 Dynorphin A (Dyn A) is an endogenous ligand for kappa opioid receptors.

108 -HT(3) receptors releases acetylcholine, the endogenous ligand for nicotinic acetylcholine receptors.

109 Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which

110 d-Serine is an endogenous ligand for NMDARs generated from l-serine by

111 and helped establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated

112 -adenosine monophosphate (2'3'-cGAMP) is the endogenous ligand for STING, but is rapidly metabolized

113 lindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR

114 ependent manner, and BMP4 is the predominant endogenous ligand for the Dragon coreceptor.

115 (N/OFQ)) is the 17-amino acid neuropeptide, endogenous ligand for the G-protein-coupled receptor (NO

116 Ghrelin is an endogenous ligand for the GH secretagogue receptor 1a (G

117 itional status and anorectic actions, as the endogenous ligand for the guanylyl cyclase 2C receptor h

118 e neuregulin-1 gene, encoding an established endogenous ligand for the HER3 receptor, is activated th

119 Dynorphin, the endogenous ligand for the kappa (kappa) opioid receptor

120 We show that an endogenous ligand for the natural killer (NK) cell recep

121 Apelin, the endogenous ligand for the novel G protein-coupled recept

122 Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preferen

123 /OFQ) is a 17 amino acid peptide that is the endogenous ligand for the ORL1/NOP receptor.

124 Apelin-36 was discovered as the endogenous ligand for the previously orphan receptor APJ

125 Apelin is the endogenous ligand for the previously orphaned G protein-

126 Apelin is the endogenous ligand for the previously orphaned G-protein-

127 The endogenous ligand for the receptor may be beta-hydroxybu

128 Sphingosine 1-phosphate (S1P) is the endogenous ligand for the sphingosine 1-phosphate recept

129 ction as agonist activators, a high affinity endogenous ligand for this receptor that is involved in

130 MD-2 is a soluble endogenous ligand for TLR4 and a receptor for lipopolysa

131 (HA) is released following injury, and is an endogenous ligand for TLR4 as well as CD44.

132 dence that resistin is a clinically relevant endogenous ligand for TLR4, which promotes tumor progres

133 that cholesteryl ester hydroperoxides are an endogenous ligand for TLR4.

134 HPETE, and we hypothesized that it may be an endogenous ligand for TRPV1 in sensory neurons innervati

135 orphyrin IX (PPIX) is considered a conserved endogenous ligand for TSPO.

136 ity in brain and liver, increasing levels of endogenous ligands for cannabinoid and alpha-type peroxi

137 Two endogenous ligands for cannabinoid CB1 receptors, ananda

138 Enkephalins, endogenous ligands for delta opioid receptors (DORs), ar

139 rcine spleen extracts and show that they are endogenous ligands for EBI2.

140 inogenesis include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC).

141 dy, we show that BMP-2, BMP-4, and BMP-6 are endogenous ligands for HJV in hepatoma-derived cell line

142 acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate l

143 Although endogenous ligands for Siglec-F have yet to be biochemic

144 The endogenous ligands for the chemokine receptors are pepti

145 ot until 1999 that BAs were discovered to be endogenous ligands for the nuclear receptor FXR.

146 These lipids are endogenous ligands for the nuclear receptor PPARalpha, a

147 d with loss of guanylin and uroguanylin, the endogenous ligands for the tumor suppressor guanylyl cyc

148 rphine-like analgesics exist, the search for endogenous ligands for these receptors, and early attemp

149 The endogenous ligands for TLR4 that lead to impaired entero

150 The long endogenous ligand found inside the binding groove of chC

151 ased microbial translocation, and release of endogenous ligands from damaged cells (such as CD4 T cel

152 hese binding sites are assumed accessible to endogenous ligands from the aqueous phase.

153 The endogenous ligand ghrelin, a 28 amino acid peptide with

154 dation product GLP1(9-36)NH(2) of the potent endogenous ligand GLP-1(7-36)NH(2).

155 ponse to distinct peptide ligands, including endogenous ligands glucagon-like peptide-1, oxyntomoduli

156 ic architecture for signaling induced by the endogenous ligand glutamate confirms that the central co

157 ompletely in the continued presence of their endogenous ligand glutamate; however, it is not clear wh

158 , we examined the activation profiles of the endogenous ligand, GnRH and a well-known marketed analog

159 Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intr

160 omain 2 (ECL2) in the selectivity toward the endogenous ligand has been confirmed.

161 is limited and whether LPA is its preferred endogenous ligand has been questioned in the literature,

162 ed, verification of activity of its putative endogenous ligands has proven elusive so far.

163 tionship between P- and L-selectin and their endogenous ligands have underscored the ability of incre

164 r in isc DCs, most likely in response to the endogenous ligand heat shock protein 70, which was found

165 absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF).

166 is an orphan nuclear receptor with no known endogenous ligands; however, recent studies on a series

167 bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a

168 nding of CTRP6 to a variety of microbial and endogenous ligands identifying CTRP6 as a novel human le

169 y upon binding of Hcy and displacement of an endogenous ligand in both enzymes.

170 This study suggests an important role for an endogenous ligand in innate sensing of MVA and demonstra

171 it of nAChRs and the levels of two PPARalpha endogenous ligands in a Ca(2+)-dependent manner.

172 ator-activated receptor alpha (PPARalpha) by endogenous ligands in liver that remain unmetabolized in

173 livery utilize ligands that must out-compete endogenous ligands in order to bind to the active site f

174 ew the role of Toll-like receptors and their endogenous ligands in various renal diseases, particular

175 Soluble endogenous ligands, including oxidized low-density lipop

176 ovalently bound synthetic antagonists nor by endogenous ligands indicating non-overlapping binding wi

177 ere we show that Zalpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal letha

178 Its endogenous ligand is unknown.

179 itivity of Drosophila sweet neurons to their endogenous ligands is actively limited by IR76b and unco

180 coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on

181 al structure of CD1d complexed to a natural, endogenous ligand, isoglobotrihexosylceramide (iGb3), il

182 In addition, activation of AHR by the endogenous ligand kynurenine inhibited cell proliferatio

183 ectively, whereas it binds weakly to another endogenous ligand, L-serine-O-phosphate (L-SOP), which a

184 and approximately 3180 bioactive molecules (endogenous ligands, licensed drugs and key pharmacologic

185 idate the reported allosteric effects of the endogenous ligands lipoxin A4 and pregnenolone at CB1Rs.

186 es the involvement of GPR55 and its proposed endogenous ligand, lysophosphatidylinositol (LPI), in no

187 The alternative endogenous ligand macrophage migration inhibitory factor

188 Small-molecule mimetics of endogenous ligands may result in the development of comp

189 determine how the activation of PPARalpha by endogenous ligands might affect the obesity of ob/ob mic

190 However, unlike endogenous ligands, morphine fails to promote substantia

191 Encouraging results obtained with the endogenous ligand N/OFQ stimulated research towards the

192 ve for NTS2 versus NTS1 and behaves like the endogenous ligand neurotensin in the functional assay.

193 2 receptors (NPFF1-R and NPFF2-R), and their endogenous ligand NPFF, are one of only several systems

194 Overexpression of the transcript for NTRK3's endogenous ligand, NTF3, in the dorsal amygdala resulted

195 Anandamide (AEA) is an endogenous ligand of cannabinoid receptors and a well ch

196 reduced N-arachidonoylethanolamine (AEA), an endogenous ligand of CB(1)R.

197 oward the source of fractalkine (CX3CL1), an endogenous ligand of CX3CR1.

198 ion is inhibited by CXCL8, the high-affinity endogenous ligand of CXCR1 and CXCR2.

199 Dynorphin, an endogenous ligand of kappa (kappa) opioid receptors, has

200 utritional status and shown to be a specific endogenous ligand of PPARalpha, induced CYP3A4 (up to 4-

201 25-epoxycholesterol, which we identify as an endogenous ligand of PTCH1, can stimulate Hedgehog signa

202 These ubiquitin chains function as an endogenous ligand of RIG-I in human cells.

203 the newly discovered ELABELA (ELA), a second endogenous ligand of the Apelin peptide jejunum receptor

204 ELA (ELA) was recently discovered as a novel endogenous ligand of the apelin receptor (APJ), a G prot

205 ELABELA (ELA) is the second endogenous ligand of the apelin receptor (APJ).

206 Apelin is the endogenous ligand of the APJ receptor, a member of the G

207 26RFa, a novel RFamide neuropeptide, is the endogenous ligand of the former orphan receptor GPR103.

208 , a carboxylic analogue of anandamide, is an endogenous ligand of the Galpha(i/o) protein-coupled rec

209 Nociceptin/Orphanin FQ (N/OFQ) is an endogenous ligand of the N/OFQ peptide (NOP) receptor, w

210 er the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydro

211 gnaling pathway, thus establishing EDN as an endogenous ligand of TLR2.

212 High mobility group box 1 (HMGB1) (an endogenous ligand of TLR4) was localized in the nucleus

213 wherein those have recently been shown to be endogenous ligands of aryl hydrocarbon receptor (AhR; a

214 ultiple tyrosine metabolites are alternative endogenous ligands of GPR35, and GPR35 may represent a d

215 R-spondins (Rspos) are endogenous ligands of leucine-rich repeat-containing G-p

216 alpha-glycosylceramides, which are the major endogenous ligands of natural killer T cells.

217 We have identified endogenous ligands of the Ashwell receptor as glycoprote

218 ated to classical biogenic amines, represent endogenous ligands of the trace amine-associated recepto

219 d activation of leukocytes via exogenous and endogenous ligands of TLR4 results in a large number of

220 n between the two subunits and the effect of endogenous ligands on the functioning of aGPCRs is poorl

221 te or inhibit these pathways versus unbiased endogenous ligands or drugs.

222 als either directly or through production of endogenous ligands or modulation of intestinal microbiot

223 concentrations make them poor candidates as endogenous ligands or therapeutic agents.

224 sites are topographically distinct from the endogenous ligand (orthosteric) binding site, allowing f

225 sites are topographically distinct from the endogenous ligand (orthosteric) binding site, which allo

226 to prevent inappropriate exposure of TLRs to endogenous ligands, our results have important implicati

227 in the lymphoid follicles in response to its endogenous ligands, oxysterols.

228 ts in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor g

229 We have also matched targets with their endogenous ligands (peptides and small molecules), with

230 ltiple body sites, whereas the expression of endogenous ligands persist throughout hair follicle init

231 at activation of MLIV mutant isoforms by the endogenous ligand PI(3,5)P2 is strongly reduced, while a

232 ype lectin-like receptor 2 (CLEC-2), and its endogenous ligand podoplanin, which are the focus of thi

233 ated by the loss of CLEC-2 activation by its endogenous ligand, podoplanin, which is expressed on the

234 An endogenous ligand, possibly palmitic acid, serves to ill

235 To understand how these extremely weak endogenous ligands produce signals in maturing thymocyte

236 eptor-tyrosine kinases that are activated by endogenous ligands, protein S (PROS1) and growth arrest-

237 cells by increasing the availability of the endogenous ligand RA.

238 we demonstrate formation and function of the endogenous ligand-receptor complex IL-37-IL-1R8-IL-18Ral

239 With aging, sensome transcripts for endogenous ligand recognition were downregulated, wherea

240 In addition to endogenous ligands released by therapy-induced tumor des

241 es tissue remodeling and repair responses to endogenous ligands released during low-grade inflammatio

242 d by exogenous ligands from pathogens and by endogenous ligands released in inflammatory diseases.

243 rogression, however, its clinically relevant endogenous ligand remains elusive.

244 s a G-protein coupled receptor for which the endogenous ligand remains unknown.

245 nd its binding may disrupt the binding of an endogenous ligand, required for their correct function.

246 support a novel injury model in CHB, whereby endogenous ligand, Ro60-associated ssRNA, forges a nexus

247 es the cardiac glycoside-binding site and an endogenous ligand(s) and that its cardiac glycoside-bind

248 the development of obesity, indicating that endogenous ligand(s) for AhR regulate adipose homeostasi

249 o-bind with and modulate the activity of the endogenous ligand(s) for the receptor have become a majo

250 Acute sequestration of endogenous ligand(s) in WT mice infused with Digibind to

251 They were unable to bind endogenous ligand(s), but could be efficiently activated

252 RAGE interacts with the endogenous ligands S100 calgranulins and high mobility g

253 ncing of Mcl and Mincle or blockade of their endogenous ligand SAP130 revealed that these receptors'

254 t inhibition of lipolysis similar to that of endogenous ligands (SCFAs).

255 the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking

256 novel DC-SIGN-T(H)2 pathway initiated by an endogenous ligand, sFc, provides an intrinsic mechanism

257 -binding peptides, involving design from the endogenous ligand Siglec-11 and multi-platform character

258 However, little is known of the source of endogenous ligands, signaling pathways, or effectors in

259 t and innate immunity and is activated by an endogenous ligand, Spatzle (Spz).

260 C cirrhotic livers and plasma levels of its endogenous ligand, stromal cell-derived factor-1alpha (S

261 o rapidly up-regulate nicotinic responses to endogenous ligands such as ACh, or to exogenous agents s

262 Endogenous ligands such as high-mobility group box 1 (HM

263 ructures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion

264 lls not only of exogenous lipids but also of endogenous ligands, such as the self-glycosphingolipid b

265 wever, many of these receptors have multiple endogenous ligands, suggesting that "natural" bias may b

266 Ultrastructural localization of endogenous ligands support these functional findings.

267 t their binding poses were dissimilar to the endogenous ligand T4.

268 abolite with AhR agonistic properties, is an endogenous ligand that mediates AhR activation in the br

269 entified indoxyl 3-sulfate (I3S) as a potent endogenous ligand that selectively activates the human A

270 Endogenous ligands that are released from astrocytes in

271 ome pattern recognition receptors also sense endogenous ligands that are released from uninfected dyi

272 agonist-mediated release and/or synthesis of endogenous ligands that can activate downstream receptor

273 However, little is known about the endogenous ligands that engage ErbB4, the neural process

274 nscription factor modulated by exogenous and endogenous ligands that is important in the homeostasis

275 t also an important target for exogenous and endogenous ligands that modulate receptor function.

276 Endogenous ligands that modulate the activity of native

277 EGFR is activated by numerous endogenous ligands that promote cellular growth, prolife

278 eveloped a rapid and marked imbalance in the endogenous ligands that signal Tie-2, similar to that se

279 n severely limited by the low potency of its endogenous ligands, the crossover of function of these o

280 kappa-opioid receptor (KOP-r) system and its endogenous ligands, the dynorphins, are involved in the

281 Without known endogenous ligands, they have long been referred to as '

282 Furthermore, the endogenous ligand thrombospondin-1, responsible for the

283 s hyaluronan (HA) fragment that functions as endogenous ligand to cell surface receptors CD44 and TLR

284 that human cardiac myosin (HCM) acted as an endogenous ligand to directly stimulate human TLRs 2 and

285 In vitro, we identified hepatocyte DNA as an endogenous ligand to TLR9 that promoted cDCs to secrete

286 onstrated that 3T3-L1 adipocytes can present endogenous ligands to NKT cells, leading to IFN-gamma pr

287 racellular glycoprotein that associates with endogenous ligands to promote tumor cell migration leadi

288 The discovery of endogenous ligands, together with structural investigati

289 Human serum albumin is an endogenous ligand transport protein whose long circulato

290 tivating receptors that, on binding to their endogenous ligands, trigger the killing of tumor cell ta

291 ng that PPARalpha receptors are saturated by endogenous ligand under basal conditions.

292 r (UT) and differentiates the effects of the endogenous ligands urotensin II (UII) and urotensin II-r

293 f a set of chemokine receptors with multiple endogenous ligands using assays for G protein signaling,

294 effects and assess possible contributions of endogenous ligands, we isolated primary tumor cells from

295 The net biologic effect of AHR activation by endogenous ligands, which can be mimicked by environment

296 hen it was presenting a series of permissive endogenous ligands, while other lipid ligands were nonpe

297 SL displayed a >100-fold loss of activity to endogenous ligands, while responding to the distinct lig

298 n-1 antagonists compete with substance P, an endogenous ligand with a high density of receptors in th

299 ignaling can distinguish between agonist and endogenous ligands with exquisite selectivity, and show

300 onal biochemical assays, we pair 17 proposed endogenous ligands with five orphan GPCRs that are assoc